| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Osteitis | D010000 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
15-epi-lxa4;15r-lxa4
15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-epi-lxa4;15r-lxa4?
15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Immunol. (2)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Antimicrob. Agents Chemother. (1)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4
PubChem Associated disorders and diseases
What pathways are associated with 15-epi-lxa4;15r-lxa4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-epi-lxa4;15r-lxa4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-epi-lxa4;15r-lxa4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 15-epi-lxa4;15r-lxa4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Gewirtz AT et al. | LXA4, aspirin-triggered 15-epi-LXA4, and their analogs selectively downregulate PMN azurophilic degranulation. | 1999 | Am. J. Physiol. | pmid:10199831 |
| Levy BD et al. | Polyisoprenyl phosphate (PIPP) signaling regulates phospholipase D activity: a 'stop' signaling switch for aspirin-triggered lipoxin A4. | 1999 | FASEB J. | pmid:10224233 |
| Spokas EG et al. | Leukotrienes, lipoxins, and hydroxyeicosatetraenoic acids. | 1999 | Methods Mol. Biol. | pmid:10343320 |
| Serhan CN et al. | Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators. | 1999 | Clin. Chem. Lab. Med. | pmid:10353476 |
| Schaldach CM et al. | Lipoxin A4: a new class of ligand for the Ah receptor. | 1999 | Biochemistry | pmid:10360957 |
| Hachicha M et al. | Lipoxin (LX)A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor 1alpha-initiated neutrophil responses and trafficking: regulators of a cytokine-chemokine axis. | 1999 | J. Exp. Med. | pmid:10377187 |
| Clish CB et al. | Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393980 |
| Besse A et al. | Prostaglandin E2 regulates macrophage colony stimulating factor secretion by human bone marrow stromal cells. | 1999 | Biochim. Biophys. Acta | pmid:10395955 |
| Chiang N et al. | Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. | 1999 | J. Clin. Invest. | pmid:10430612 |
| Kikuta Y et al. | Purification and characterization of recombinant rat hepatic CYP4F1. | 1999 | Arch. Biochem. Biophys. | pmid:10486137 |
| Titos E et al. | Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4). | 1999 | Am. J. Physiol. | pmid:10564079 |
| Filep JG et al. | Anti-inflammatory actions of lipoxin A(4) stable analogs are demonstrable in human whole blood: modulation of leukocyte adhesion molecules and inhibition of neutrophil-endothelial interactions. | 1999 | Blood | pmid:10590058 |
| Bandeira-Melo C et al. | Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. | 2000 | J. Immunol. | pmid:10623853 |
| Godson C et al. | Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages. | 2000 | J. Immunol. | pmid:10657608 |
| Bandeira-Melo C et al. | Cutting edge: lipoxin (LX) A4 and aspirin-triggered 15-epi-LXA4 block allergen-induced eosinophil trafficking. | 2000 | J. Immunol. | pmid:10679058 |
| Sodin-Semrl S et al. | Lipoxin A4 inhibits IL-1 beta-induced IL-6, IL-8, and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases. | 2000 | J. Immunol. | pmid:10679106 |
| Pouliot M and Serhan CN | Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor-alpha-initiated neutrophil responses and trafficking: novel regulators of a cytokine-chemokine axis relevant to periodontal diseases. | 1999 | J. Periodont. Res. | pmid:10685363 |
| Desplat V et al. | Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines. | 1999 | Mediators Inflamm. | pmid:10704149 |
| Chiang N et al. | Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation. | 2000 | J. Exp. Med. | pmid:10748237 |
| Tornhamre S et al. | 15-Lipoxygenation of leukotriene A(4). Studies Of 12- and 15-lipoxygenase efficiency to catalyze lipoxin formation. | 2000 | Biochim. Biophys. Acta | pmid:10760478 |
| Pouliot M et al. | Lipoxin A(4) analogues inhibit leukocyte recruitment to Porphyromonas gingivalis: a role for cyclooxygenase-2 and lipoxins in periodontal disease. | 2000 | Biochemistry | pmid:10769133 |
| Clish CB et al. | Local and systemic delivery of an aspirin-triggered lipoxin stable analog inhibits neutrophil trafficking. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818463 |
| Clish CB et al. | Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation. | 2000 | J. Biol. Chem. | pmid:10837478 |
| Denizot Y et al. | Effect of cytokines and lipid mediators on the synthesis of interleukin 1 beta by human bone marrow stromal cells. | 2000 | Cytokine | pmid:10857767 |
| McMahon B et al. | Lipoxin A4 antagonizes the mitogenic effects of leukotriene D4 in human renal mesangial cells. Differential activation of MAP kinases through distinct receptors. | 2000 | J. Biol. Chem. | pmid:10869343 |
| Sanak M et al. | Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. | 2000 | Eur. Respir. J. | pmid:10933083 |
| Serhan CN and Clish CB | Aspirin triggered lipid mediators: novel inhibitors of leucocyte trafficking. | 2000 | Thorax | pmid:10992546 |
| Maderna P et al. | Influence of lipoxin A(4) and other lipoxygenase-derived eicosanoids on tissue factor expression. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:11003574 |
| Kang Y et al. | Mutations of serine 236-237 and tyrosine 302 residues in the human lipoxin A4 receptor intracellular domains result in sustained signaling. | 2000 | Biochemistry | pmid:11063592 |
| Desplat V et al. | Effects of lipoxygenase metabolites of arachidonic acid on the growth of human blood CD34(+) progenitors. | 2000 | Blood Cells Mol. Dis. | pmid:11112380 |
| Gronert K et al. | Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. | 2001 | Am. J. Pathol. | pmid:11141472 |
| Kikuta Y et al. | Expression and catalytic activity of mouse leukotriene B4 omega-hydroxylase, CYP4F14. | 2000 | Arch. Biochem. Biophys. | pmid:11185557 |
| Serhan CN et al. | Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4. | 2001 | J. Immunol. | pmid:11238602 |
| Wada K et al. | Inosine monophosphate and aspirin-triggered 15-epi-lipoxin A4 act in concert to regulate neutrophil trafficking: additive actions of two new endogenous anti-inflammatory mediators. | 2001 | J. Hematother. Stem Cell Res. | pmid:11276361 |
| Fierro IM and Serhan CN | Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins. | 2001 | Braz. J. Med. Biol. Res. | pmid:11323741 |
| Levy BD et al. | Lipid mediator class switching during acute inflammation: signals in resolution. | 2001 | Nat. Immunol. | pmid:11429545 |
| Wardle N | New vistas in anti-inflammatory therapy. | 2001 | Nephron | pmid:11474222 |
| McMahon B et al. | Lipoxins: revelations on resolution. | 2001 | Trends Pharmacol. Sci. | pmid:11478982 |
| Goh J et al. | Lipoxin A(4) and aspirin-triggered 15-epi-lipoxin A(4) antagonize TNF-alpha-stimulated neutrophil-enterocyte interactions in vitro and attenuate TNF-alpha-induced chemokine release and colonocyte apoptosis in human intestinal mucosa ex vivo. | 2001 | J. Immunol. | pmid:11509622 |
| Qiu FH et al. | Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils. | 2001 | FASEB J. | pmid:11687510 |
| Goulet JL et al. | Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. | 2001 | J. Immunol. | pmid:11714834 |
| Aliberti J et al. | Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity. | 2002 | Nat. Immunol. | pmid:11743584 |
| Vachier I et al. | Endogenous anti-inflammatory mediators from arachidonate in human neutrophils. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11779156 |
| Fierro IM et al. | Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4). | 2002 | J. Pharmacol. Exp. Ther. | pmid:11805195 |
| Resnati M et al. | The fibrinolytic receptor for urokinase activates the G protein-coupled chemotactic receptor FPRL1/LXA4R. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11818541 |
| Gewirtz AT et al. | Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. | 2002 | J. Immunol. | pmid:11994483 |
| Aliberti J and Sher A | Positive and negative regulation of pathogen induced dendritic cell function by G-protein coupled receptors. | 2002 | Mol. Immunol. | pmid:12009566 |
| Bonnans C et al. | Lipoxins are potential endogenous antiinflammatory mediators in asthma. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12045128 |
| Maderna P et al. | Lipoxins induce actin reorganization in monocytes and macrophages but not in neutrophils: differential involvement of rho GTPases. | 2002 | Am. J. Pathol. | pmid:12057930 |