| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Osteitis | D010000 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
15-epi-lxa4;15r-lxa4
15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-epi-lxa4;15r-lxa4?
15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Immunol. (2)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Antimicrob. Agents Chemother. (1)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4
PubChem Associated disorders and diseases
What pathways are associated with 15-epi-lxa4;15r-lxa4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-epi-lxa4;15r-lxa4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-epi-lxa4;15r-lxa4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 15-epi-lxa4;15r-lxa4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hill DJ et al. | Trout thrombocytes contain 12- but not 5-lipoxygenase activity. | 1999 | Biochim. Biophys. Acta | pmid:9931438 |
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| Clà ria J et al. | Altered biosynthesis of leukotrienes and lipoxins and host defense disorders in patients with cirrhosis and ascites. | 1998 | Gastroenterology | pmid:9649470 |
| Gewirtz AT et al. | Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs. | 1998 | J. Clin. Invest. | pmid:9576749 |
| Gronert K et al. | Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. | 1998 | J. Exp. Med. | pmid:9547339 |
| Gronert K et al. | Characterization of human neutrophil and endothelial cell ligand-operated extracellular acidification rate by microphysiometry: impact of reoxygenation. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9536019 |
| Takano T et al. | Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues. | 1998 | J. Clin. Invest. | pmid:9466977 |
| Scalia R et al. | Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: role of P-selectin. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9275235 |
| Stahl GL et al. | Eicosanoid production from porcine neutrophils and platelets: differential production with various agonists. | 1997 | Am. J. Physiol. | pmid:9227410 |
| Takano T et al. | Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. | 1997 | J. Exp. Med. | pmid:9151906 |
| Serhan CN | Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity? | 1997 | Prostaglandins | pmid:9112289 |
| Maddox JF et al. | Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. | 1997 | J. Biol. Chem. | pmid:9054386 |
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| Brady HR | Complex roles for P-selectin in the pathophysiology of glomerulonephritis. | 1996 | Curr. Opin. Nephrol. Hypertens. | pmid:8937811 |
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| Feng Z et al. | Leukotriene B4 modulates in vivo expression of delayed-type hypersensitivity by a receptor-mediated mechanism: regulation by lipoxin A4. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8768752 |
| Romano M et al. | Activation of human monocytes and the acute monocytic leukemia cell line (THP-1) by lipoxins involves unique signaling pathways for lipoxin A4 versus lipoxin B4: evidence for differential Ca2+ mobilization. | 1996 | J. Immunol. | pmid:8757340 |
| Mayadas TN et al. | Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice. | 1996 | Kidney Int. | pmid:8731099 |
| Papayianni A et al. | Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. | 1996 | J. Immunol. | pmid:8690917 |
| Tang DG et al. | Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8643560 |
| Lin KT et al. | Identification and characterization of a high-affinity leukotriene B4 receptor on guinea pig T lymphocytes and its regulation by lipoxin A4. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8627545 |
| Maddox JF and Serhan CN | Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction. | 1996 | J. Exp. Med. | pmid:8551217 |
| Sumimoto H et al. | Formation of a novel 20-hydroxylated metabolite of lipoxin A4 by human neutrophil microsomes. | 1993 | FEBS Lett. | pmid:8422907 |
| Lerner R et al. | Lipoxin A4 induces hyperadhesiveness in human endothelial cells for neutrophils. | 1993 | Blood | pmid:8393356 |
| Fiore S et al. | Induction of functional lipoxin A4 receptors in HL-60 cells. | 1993 | Blood | pmid:8389617 |
| Levy BD et al. | Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins. | 1993 | J. Clin. Invest. | pmid:8376607 |
| Colgan SP et al. | Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers. | 1993 | J. Clin. Invest. | pmid:8326019 |
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| Knight J et al. | Effect of lipoxins and other eicosanoids on phagocytosis and intracellular calcium mobilisation in rainbow trout (Oncorhynchus mykiss) leukocytes. | 1993 | J. Leukoc. Biol. | pmid:8245703 |
| Bratt J et al. | Lipoxin A4 induces neutrophil-dependent cytotoxicity for human endothelial cells. | 1994 | Scand. J. Immunol. | pmid:8146594 |
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| Fiore S et al. | Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. | 1994 | J. Exp. Med. | pmid:8006586 |
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| Papayianni A et al. | Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis. | 1995 | Kidney Int. | pmid:7543622 |
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