| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Osteitis | D010000 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
15-epi-lxa4;15r-lxa4
15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-epi-lxa4;15r-lxa4?
15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4
PubChem Associated disorders and diseases
What pathways are associated with 15-epi-lxa4;15r-lxa4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-epi-lxa4;15r-lxa4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-epi-lxa4;15r-lxa4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with 15-epi-lxa4;15r-lxa4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee TH et al. | Identification of lipoxin A4 and its relationship to the sulfidopeptide leukotrienes C4, D4, and E4 in the bronchoalveolar lavage fluids obtained from patients with selected pulmonary diseases. | 1990 | Am. Rev. Respir. Dis. | pmid:2161628 |
| Serhan CN and Sheppard KA | Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro. | 1990 | J. Clin. Invest. | pmid:2155925 |
| Conti P et al. | Lipoxins A4 and B4 inhibit leukotriene B4 generation from human neutrophil leukocyte suspensions. | 1990 | Immunol. Lett. | pmid:2167876 |
| Grandordy BM et al. | Lipoxin A4 inhibits phosphoinositide hydrolysis in human neutrophils. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2157419 |
| Nigam S et al. | Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. | 1990 | J. Cell. Physiol. | pmid:2162850 |
| Serhan CN | High-performance liquid chromatography separation and determination of lipoxins. | 1990 | Meth. Enzymol. | pmid:2233343 |
| Lindström P et al. | Rapid adhesive responses of endothelial cells and of neutrophils induced by leukotriene B4 are mediated by leucocytic adhesion protein CD18. | 1990 | Scand. J. Immunol. | pmid:1972589 |
| Steinhilber D and Roth HJ | New series of lipoxins isolated from human eosinophils. | 1989 | FEBS Lett. | pmid:2507350 |
| Serhan CN | On the relationship between leukotriene and lipoxin production by human neutrophils: evidence for differential metabolism of 15-HETE and 5-HETE. | 1989 | Biochim. Biophys. Acta | pmid:2546590 |
| Lee TH et al. | Lipoxin A4 and lipoxin B4 inhibit chemotactic responses of human neutrophils stimulated by leukotriene B4 and N-formyl-L-methionyl-L-leucyl-L-phenylalanine. | 1989 | Clin. Sci. | pmid:2548801 |
| Brezinski ME et al. | Lipoxins stimulate prostacyclin generation by human endothelial cells. | 1989 | FEBS Lett. | pmid:2494071 |
| Garrick R et al. | Transformation of leukotriene A4 to lipoxins by rat kidney mesangial cell. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2547366 |
| Nicolaou KC et al. | Identification of a novel 7-cis-11-trans-lipoxin A4 generated by human neutrophils: total synthesis, spasmogenic activities and comparison with other geometric isomers of lipoxins A4 and B4. | 1989 | Biochim. Biophys. Acta | pmid:2713393 |
| Badr KF et al. | Lipoxin A4 antagonizes cellular and in vivo actions of leukotriene D4 in rat glomerular mesangial cells: evidence for competition at a common receptor. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2541448 |
| Busija DW et al. | Lipoxins A4 and B4 dilate cerebral arterioles of newborn pigs. | 1989 | Am. J. Physiol. | pmid:2916679 |
| Hedqvist P et al. | Lipoxin A4 inhibits leukotriene B4-induced inflammation in the hamster cheek pouch. | 1989 | Acta Physiol. Scand. | pmid:2557732 |
| Ng CF et al. | Agonist-dependent generation of lipoxins from rat basophilic leukemia cell (RBL-1). | 1989 | Biochim. Biophys. Acta | pmid:2503031 |
| Walstra P et al. | Evidence for lipoxin formation by bovine polymorphonuclear leukocytes via triple dioxygenation of arachidonic acid. | 1988 | FEBS Lett. | pmid:3125064 |
| Edenius C et al. | Transcellular conversion of endogenous arachidonic acid to lipoxins in mixed human platelet-granulocyte suspensions. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2849436 |
| Jacques CA et al. | The contractile activities of lipoxin A4 and lipoxin B4 for guinea-pig airway tissues. | 1988 | Br. J. Pharmacol. | pmid:2852525 |
| Borgeat P and Picard S | 19-Hydroxyprostaglandin B2 as an internal standard for on-line extraction-high-performance liquid chromatography analysis of lipoxygenase products. | 1988 | Anal. Biochem. | pmid:2841889 |
| Brasseur R et al. | Conformational analysis of lipoxin A, lipoxin B and their trans-isomers. | 1988 | Biochim. Biophys. Acta | pmid:3365446 |
| Feuerstein G and Siren AL | Mesenteric vascular responses to i.v. administration of lipoxin A4 and lipoxin B4 in the conscious rat. | 1988 | FEBS Lett. | pmid:3366247 |
| Lefer AM et al. | Lipoxins A4 and B4: comparison of icosanoids having bronchoconstrictor and vasodilator actions but lacking platelet aggregatory activity. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3186729 |
| Sok DE et al. | Soybean lipoxygenase-catalyzed formation of lipoxin A and lipoxin B isomers from arachidonic acid via 5,15-dihydroperoxyeicosatetraenoic acid. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132921 |
| Samuelsson B et al. | Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. | 1987 | Science | pmid:2820055 |
| Palmblad J et al. | The effects of lipoxin A and lipoxin B on functional responses of human granulocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593338 |
| Ramstedt U et al. | Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: studies on stereospecificity of inhibition and mode of action. | 1987 | J. Immunol. | pmid:3782800 |
| Ueda N et al. | Lipoxin synthesis by arachidonate 5-lipoxygenase purified from porcine leukocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3579953 |
| Badr KF et al. | The action of lipoxin-A on glomerular microcirculatory dynamics in the rat. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593345 |
| Dahlén SE et al. | Biological activities of lipoxin A include lung strip contraction and dilation of arterioles in vivo. | 1987 | Acta Physiol. Scand. | pmid:3630737 |
| Serhan CN et al. | Formation of lipoxin A by granulocytes from eosinophilic donors. | 1987 | FEBS Lett. | pmid:3109942 |
| Conti P et al. | Lipoxin A augments release of thromboxane from human polymorphonuclear leukocyte suspensions. | 1987 | FEBS Lett. | pmid:3121389 |
| Hansson A et al. | Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2418836 |
| Puustinen T et al. | Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase. | 1986 | FEBS Lett. | pmid:3770188 |
| Serhan CN et al. | Lipoxin A. Stereochemistry and biosynthesis. | 1986 | J. Biol. Chem. | pmid:3097008 |
| Fitzsimmons BJ et al. | The lipoxins. Stereochemical identification and determination of their biosynthesis. | 1985 | J. Biol. Chem. | pmid:2997152 |
| Ramstedt U et al. | Action of novel eicosanoids lipoxin A and B on human natural killer cell cytotoxicity: effects on intracellular cAMP and target cell binding. | 1985 | J. Immunol. | pmid:2995494 |
| Serhan CN et al. | Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6089195 |
| Serhan CN et al. | Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422933 |
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