| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Osteitis | D010000 | 10 associated lipids |
| Asthma | D001249 | 52 associated lipids |
15-epi-lxa4;15r-lxa4
15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with 15-epi-lxa4;15r-lxa4?
15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Immunol. (2)
- Am. J. Physiol. Lung Cell Mol. Physiol. (1)
- Antimicrob. Agents Chemother. (1)
- Others (6)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4
PubChem Associated disorders and diseases
What pathways are associated with 15-epi-lxa4;15r-lxa4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with 15-epi-lxa4;15r-lxa4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with 15-epi-lxa4;15r-lxa4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with 15-epi-lxa4;15r-lxa4?
Knock-out
Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with 15-epi-lxa4;15r-lxa4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nascimento-Silva V et al. | Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15901601 |
| Uski TK and Högestätt ED | Effects of various cyclooxygenase and lipoxygenase metabolites on guinea-pig cerebral arteries. | 1992 | Gen. Pharmacol. | pmid:1592217 |
| Lu C et al. | [Transfection of Lipoxin A4 receptor-like protein gene enhanced the inhibitory effect of Lipoxin A4 on human lung fibroblasts proliferation induced by connective tissue growth factor]. | 2005 | Zhonghua Er Ke Za Zhi | pmid:15924723 |
| Karp CL and Cooper AM | An oily, sustained counter-regulatory response to TB. | 2005 | J. Clin. Invest. | pmid:15931386 |
| Bafica A et al. | Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production. | 2005 | J. Clin. Invest. | pmid:15931391 |
| Gangemi S et al. | Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels. | 2005 | Exp. Gerontol. | pmid:15935589 |
| Wu SH et al. | High dose of lipoxin A4 induces apoptosis in rat renal interstitial fibroblasts. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15936930 |
| Wu SH et al. | Lipoxin A4 inhibits TNF-alpha-induced production of interleukins and proliferation of rat mesangial cells. | 2005 | Kidney Int. | pmid:15954894 |
| Christie PE et al. | The effects of lipoxin A4 on airway responses in asthmatic subjects. | 1992 | Am. Rev. Respir. Dis. | pmid:1595991 |
| Levy BD et al. | Diminished lipoxin biosynthesis in severe asthma. | 2005 | Am. J. Respir. Crit. Care Med. | pmid:15961693 |
| Devchand PR | Lipoxin agonists: turn right! to path of resolving neutrophil. | 2005 | Mem. Inst. Oswaldo Cruz | pmid:15962099 |
| Romano M | Lipoxin analogs and lipoxin formation in vivo. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15979293 |
| Gronert K | Lipoxins in the eye and their role in wound healing. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15979295 |
| Filep JG et al. | Lipoxins and aspirin-triggered lipoxins in neutrophil adhesion and signal transduction. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15979865 |
| Gavins FN et al. | A twist in anti-inflammation: annexin 1 acts via the lipoxin A4 receptor. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15982865 |
| Guilford WJ and Parkinson JF | Second-generation beta-oxidation resistant 3-oxa-lipoxin A4 analogs. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15985364 |
| Serhan CN | Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16005201 |
| Clà ria J and Planagumà A | Liver: the formation and actions of aspirin-triggered lipoxins. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16006110 |
| Wallace JL et al. | Lipoxins in gastric mucosal health and disease. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16024242 |
| Titos E et al. | Inhibition of 5-lipoxygenase-activating protein abrogates experimental liver injury: role of Kupffer cells. | 2005 | J. Leukoc. Biol. | pmid:16033810 |
| Simões RL and Fierro IM | Involvement of the Rho-kinase/myosin light chain kinase pathway on human monocyte chemotaxis induced by ATL-1, an aspirin-triggered lipoxin A4 synthetic analog. | 2005 | J. Immunol. | pmid:16034127 |
| Schröder H | New signaling routes for an old drug: lipoxin A4 might mediate heme oxygenase-1 induction by aspirin. Focus on "Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells". | 2005 | Am. J. Physiol., Cell Physiol. | pmid:16100387 |
| Fiore S et al. | Lipoxin A4 biology in the human synovium. Role of the ALX signaling pathways in modulation of inflammatory arthritis. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16125377 |
| Conti P et al. | Role of lipoxins A4 and B4 in the generation of arachidonic acid metabolites by rat mast cells and their effect on [3H]serotonin release. | 1992 | Immunol. Lett. | pmid:1612634 |
| Rodgers K et al. | Lipoxin A4 modifies platelet-derived growth factor-induced pro-fibrotic gene expression in human renal mesangial cells. | 2005 | Am. J. Pathol. | pmid:16127149 |
| Cezar-de-Mello PF et al. | Aspirin-triggered Lipoxin A4 inhibition of VEGF-induced endothelial cell migration involves actin polymerization and focal adhesion assembly. | 2006 | Oncogene | pmid:16132039 |
| Wu SH et al. | Lipoxin A4 inhibits proliferation of human lung fibroblasts induced by connective tissue growth factor. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16141446 |
| Brezinski DA et al. | Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy. | 1992 | Circulation | pmid:1617790 |
| Tornhamre S et al. | Conversion of 5,6-dihydroxyeicosatetraenoic acids. A novel pathway for lipoxin formation by human platelets. | 1992 | FEBS Lett. | pmid:1618303 |
| Chiang N et al. | Aspirin has a gender-dependent impact on antiinflammatory 15-epi-lipoxin A4 formation: a randomized human trial. | 2006 | Arterioscler. Thromb. Vasc. Biol. | pmid:16293793 |
| Kowal-Bielecka O et al. | Cyclooxygenase- and lipoxygenase-derived eicosanoids in bronchoalveolar lavage fluid from patients with scleroderma lung disease: an imbalance between proinflammatory and antiinflammatory lipid mediators. | 2005 | Arthritis Rheum. | pmid:16320329 |
| Wu SH et al. | Lipoxin A4 inhibits connective tissue growth factor-induced production of chemokines in rat mesangial cells. | 2006 | Kidney Int. | pmid:16408113 |
| Machado FS et al. | Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. | 2006 | Nat. Med. | pmid:16415877 |
| Reville K et al. | Lipoxin A4 redistributes myosin IIA and Cdc42 in macrophages: implications for phagocytosis of apoptotic leukocytes. | 2006 | J. Immunol. | pmid:16424219 |
| Mangino MJ et al. | Lipoxin biosynthesis in inflammatory bowel disease. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16516812 |
| Wallace JL | Commonality of defensive roles of COX-2 in the lung and gut. | 2006 | Am. J. Pathol. | pmid:16565482 |
| Bonnans C et al. | Lipoxin A(4) regulates bronchial epithelial cell responses to acid injury. | 2006 | Am. J. Pathol. | pmid:16565483 |
| Lee TH et al. | Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: structure-function relationships. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1659416 |
| Stenke L et al. | Deficient lipoxin synthesis: a novel platelet dysfunction in myeloproliferative disorders with special reference to blastic crisis of chronic myelogenous leukemia. | 1991 | Blood | pmid:1659470 |
| Romano M | Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins. | 2006 | Inflamm Allergy Drug Targets | pmid:16613567 |
| Parkinson JF | Lipoxin and synthetic lipoxin analogs: an overview of anti-inflammatory functions and new concepts in immunomodulation. | 2006 | Inflamm Allergy Drug Targets | pmid:16613568 |
| Perretti M and D'Acquisto F | Novel aspects of annexin 1 and glucocorticoid biology: intersection with nitric oxide and the lipoxin receptor. | 2006 | Inflamm Allergy Drug Targets | pmid:16613569 |
| Wallace JL | Nitric oxide, aspirin-triggered lipoxins and NO-aspirin in gastric protection. | 2006 | Inflamm Allergy Drug Targets | pmid:16613572 |
| Schwab JM and Serhan CN | Lipoxins and new lipid mediators in the resolution of inflammation. | 2006 | Curr Opin Pharmacol | pmid:16750421 |
| Starosta V et al. | Anti-inflammatory cytokines in cystic fibrosis lung disease. | 2006 | Eur. Respir. J. | pmid:16807263 |
| Birnbaum Y et al. | Augmentation of myocardial production of 15-epi-lipoxin-a4 by pioglitazone and atorvastatin in the rat. | 2006 | Circulation | pmid:16908763 |
| Menezes-de-Lima O et al. | Lipoxin A4 inhibits acute edema in mice: implications for the anti-edematogenic mechanism induced by aspirin. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:16939877 |
| Wada K et al. | Leukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation. | 2006 | FASEB J. | pmid:16940150 |
| Levy BD | Myocardial 15-epi-lipoxin A4 generation provides a new mechanism for the immunomodulatory effects of statins and thiazolidinediones. | 2006 | Circulation | pmid:16940203 |
| Chiang N et al. | The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. | 2006 | Pharmacol. Rev. | pmid:16968948 |