15-epi-lxa4;15r-lxa4

15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 15-epi-lxa4;15r-lxa4?

15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4

PubChem Associated disorders and diseases

What pathways are associated with 15-epi-lxa4;15r-lxa4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 15-epi-lxa4;15r-lxa4?

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What functions are associated with 15-epi-lxa4;15r-lxa4?


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What lipids are associated with 15-epi-lxa4;15r-lxa4?

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What genes are associated with 15-epi-lxa4;15r-lxa4?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 15-epi-lxa4;15r-lxa4?

Knock-out

Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).

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NCBI Entrez Crosslinks

All references with 15-epi-lxa4;15r-lxa4

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Authors Title Published Journal PubMed Link
Chen H et al. Lipoxin A(4), a potential anti-inflammatory drug targeting the skin. 2011 J. Dermatol. Sci. pmid:21334856
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Das UN Is lipoxins A4 a better alternative to anti-TNF-alpha antibody to prevent and treat diabetic macular edema and retinopathy? 2010 Med. Sci. Monit. pmid:20802423
Wu SH et al. Lipoxin A(4) inhibits transition of epithelial to mesenchymal cells in proximal tubules. 2010 Am. J. Nephrol. pmid:20714129
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Spite M and Serhan CN Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. 2010 Circ. Res. pmid:21071715
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Chen QH et al. 15-Epi-lipoxin A(4) inhibits the progression of endometriosis in a murine model. 2010 Fertil. Steril. pmid:19268934
Wu Y et al. Neuroprotective effect of lipoxin A4 methyl ester in a rat model of permanent focal cerebral ischemia. 2010 J. Mol. Neurosci. pmid:20401639
Kure I et al. Lipoxin A(4) reduces lipopolysaccharide-induced inflammation in macrophages and intestinal epithelial cells through inhibition of nuclear factor-kappaB activation. 2010 J. Pharmacol. Exp. Ther. pmid:19846590
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Bhavsar PK et al. Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma. 2010 Respir. Res. pmid:20529300
Chan MM and Moore AR Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production. 2010 J. Immunol. pmid:20435922
Wu SH et al. Reversed changes of lipoxin A4 and leukotrienes in children with asthma in different severity degree. 2010 Pediatr. Pulmonol. pmid:20232472
Zhou G et al. Atorvastatin reduces plaque vulnerability in an atherosclerotic rabbit model by altering the 5-lipoxygenase pathway. 2010 Cardiology pmid:20234134
Maderna P et al. FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis. 2010 FASEB J. pmid:20570963
Duffy CD et al. Synthesis and biological evaluation of pyridine-containing lipoxin A4 analogues. 2010 ChemMedChem pmid:20127785
Prieto P et al. Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways. 2010 Cell Death Differ. pmid:20094061
Wu SH et al. NF-kappaB is involved in inhibition of lipoxin A4 on dermal inflammation and hyperplasia induced by mezerein. 2010 Exp. Dermatol. pmid:20100194
Dufton N et al. Anti-inflammatory role of the murine formyl-peptide receptor 2: ligand-specific effects on leukocyte responses and experimental inflammation. 2010 J. Immunol. pmid:20107188
Sanchez Y et al. The unexpected role for the aryl hydrocarbon receptor on susceptibility to experimental toxoplasmosis. 2010 J. Biomed. Biotechnol. pmid:20111744
Pamplona FA et al. Aspirin-triggered lipoxin induces CB1-dependent catalepsy in mice. 2010 Neurosci. Lett. pmid:20036315
Morris T et al. Dichotomy in duration and severity of acute inflammatory responses in humans arising from differentially expressed proresolution pathways. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20421472
Simões RL et al. A synthetic analog of 15-epi-lipoxin A4 inhibits human monocyte apoptosis: involvement of ERK-2 and PI3-kinase. 2010 Prostaglandins Other Lipid Mediat. pmid:20004734
Marcheselli VL et al. Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:19931440
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Beck-Speier I et al. Oxymetazoline inhibits and resolves inflammatory reactions in human neutrophils. 2009 J. Pharmacol. Sci. pmid:19609065
Grumbach Y et al. LXA4 stimulates ZO-1 expression and transepithelial electrical resistance in human airway epithelial (16HBE14o-) cells. 2009 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:18849442
Forsman H and Dahlgren C Lipoxin A(4) metabolites/analogues from two commercial sources have no effects on TNF-alpha-mediated priming or activation through the neutrophil formyl peptide receptors. 2009 Scand. J. Immunol. pmid:19751275
Carvalho RR et al. Effect of mangiferin on the development of periodontal disease: involvement of lipoxin A4, anti-chemotaxic action in leukocyte rolling. 2009 Chem. Biol. Interact. pmid:19026997
Perretti M and D'Acquisto F Annexin A1 and glucocorticoids as effectors of the resolution of inflammation. 2009 Nat. Rev. Immunol. pmid:19104500
Chen Q et al. The inhibitory effect of 15-R-LXA4 on experimental endometriosis. 2009 Eur. J. Obstet. Gynecol. Reprod. Biol. pmid:19523744
Liu S et al. Effects of lipoxin A(4) on CoCl(2)-induced angiogenesis and its possible mechanisms in human umbilical vein endothelial cells. 2009 Pharmacology pmid:19478549
Liu SJ et al. [Protective effects and its mechanism of lipoxins on human umbilical vein endothelial cells under hypoxia]. 2009 Zhonghua Fu Chan Ke Za Zhi pmid:19570467
Karim MJ et al. Anti-inflammatory effects of lipoxins on lipopolysaccharide-induced uveitis in rats. 2009 J Ocul Pharmacol Ther pmid:20021273
Wu SH et al. Inverse temporal changes of lipoxin A4 and leukotrienes in children with Henoch-Schönlein purpura. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19264468