15-epi-lxa4;15r-lxa4

15-epi-lxa4;15r-lxa4 is a lipid of Fatty Acyls (FA) class. 15-epi-lxa4;15r-lxa4 is associated with abnormalities such as Pneumonia, Septicemia, Cystic Fibrosis, Subarachnoid Hemorrhage and Obesity. The involved functions are known as Protective Agents, Signal Transduction, cytokine biosynthesis, Inflammation and Anabolism. 15-epi-lxa4;15r-lxa4 often locates in Blood, Immune system and Heart tissue. The associated genes with 15-epi-lxa4;15r-lxa4 are IL2 gene, CXCL13 gene and CMKLR1 gene. The related lipids are Steroids. The related experimental models are Knock-out.

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Introduction

To understand associated biological information of 15-epi-lxa4;15r-lxa4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with 15-epi-lxa4;15r-lxa4?

15-epi-lxa4;15r-lxa4 is suspected in Cystic Fibrosis, Asthma, Chagas Cardiomyopathy, Pneumonia, Septicemia, Subarachnoid Hemorrhage and other diseases in descending order of the highest number of associated sentences.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-epi-lxa4;15r-lxa4

PubChem Associated disorders and diseases

What pathways are associated with 15-epi-lxa4;15r-lxa4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with 15-epi-lxa4;15r-lxa4?

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What functions are associated with 15-epi-lxa4;15r-lxa4?


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What lipids are associated with 15-epi-lxa4;15r-lxa4?

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What genes are associated with 15-epi-lxa4;15r-lxa4?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with 15-epi-lxa4;15r-lxa4?

Knock-out

Knock-out are used in the study 'Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.' (Ortiz-Muñoz G et al., 2014).

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NCBI Entrez Crosslinks

All references with 15-epi-lxa4;15r-lxa4

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Authors Title Published Journal PubMed Link
Walstra P et al. Evidence for lipoxin formation by bovine polymorphonuclear leukocytes via triple dioxygenation of arachidonic acid. 1988 FEBS Lett. pmid:3125064
Jacques CA et al. The contractile activities of lipoxin A4 and lipoxin B4 for guinea-pig airway tissues. 1988 Br. J. Pharmacol. pmid:2852525
Brasseur R et al. Conformational analysis of lipoxin A, lipoxin B and their trans-isomers. 1988 Biochim. Biophys. Acta pmid:3365446
Feuerstein G and Siren AL Mesenteric vascular responses to i.v. administration of lipoxin A4 and lipoxin B4 in the conscious rat. 1988 FEBS Lett. pmid:3366247
Lefer AM et al. Lipoxins A4 and B4: comparison of icosanoids having bronchoconstrictor and vasodilator actions but lacking platelet aggregatory activity. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3186729
Steinhilber D and Roth HJ New series of lipoxins isolated from human eosinophils. 1989 FEBS Lett. pmid:2507350
Lee TH et al. Lipoxin A4 and lipoxin B4 inhibit chemotactic responses of human neutrophils stimulated by leukotriene B4 and N-formyl-L-methionyl-L-leucyl-L-phenylalanine. 1989 Clin. Sci. pmid:2548801
Garrick R et al. Transformation of leukotriene A4 to lipoxins by rat kidney mesangial cell. 1989 Biochem. Biophys. Res. Commun. pmid:2547366
Nicolaou KC et al. Identification of a novel 7-cis-11-trans-lipoxin A4 generated by human neutrophils: total synthesis, spasmogenic activities and comparison with other geometric isomers of lipoxins A4 and B4. 1989 Biochim. Biophys. Acta pmid:2713393
Busija DW et al. Lipoxins A4 and B4 dilate cerebral arterioles of newborn pigs. 1989 Am. J. Physiol. pmid:2916679