15-hpete

15-hpete is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 724 references associated with 15-hpete in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 15-hpete

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-hpete

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Total 1

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Lanefelt F and Martinsson A Ethanol dependent interaction between prostaglandins and lipoxygenase products in human peripheral lymphocytes. 1985 Acta Pharmacol Toxicol (Copenh) pmid:2986412
Dahlén SE et al. Biological activities of lipoxin A include lung strip contraction and dilation of arterioles in vivo. 1987 Acta Physiol. Scand. pmid:3630737
Weitberg AB Hydroxy- and hydroperoxy-6,8,11,14-eicosatetraenoic acids induce sister chromatid exchanges in cultured mammalian cells. 1990 Am. J. Med. Sci. pmid:2105055
Henrich WL et al. Inhibition of renin secretion from rat renal cortical slices by (R)-12-HETE. 1992 Am. J. Physiol. pmid:1415738
Christman CW et al. Effects of 15-hydroperoxy-eicosatetraenoic acid (15-HPETE) on cerebral arterioles of cats. 1984 Am. J. Physiol. pmid:6437243
Johnson HG et al. 15-Hydroxyeicosatetraenoic acid is a potent inflammatory mediator and agonist of canine tracheal mucus secretion. 1985 Am. Rev. Respir. Dis. pmid:3923884
Vaidyanathan VV and Sastry PS Preparation of hydroperoxy fatty acids. 1994 Anal. Biochem. pmid:8080099
Bösterling B and Trudell JR Production of 5- and 15-hydroperoxyeicosatetraenoic acid from arachidonic acid by halothane-free radicals generated by UV-irradiation. 1984 Anesthesiology pmid:6696254
Murota S et al. The control of vascular endothelial cell injury. 1990 Ann. N. Y. Acad. Sci. pmid:2248437
Goodwin JS and Behrens T Role of lipoxygenase metabolites of arachidonic acid in T cell activation. 1988 Ann. N. Y. Acad. Sci. pmid:2837956
Vanderhoek JY Role of the 15-lipoxygenase in the immune system. 1988 Ann. N. Y. Acad. Sci. pmid:3132881
Kato Y and Osawa T Detection of oxidized phospholipid-protein adducts using anti-15-hydroperoxyeicosatetraenoic acid-modified protein antibody: contribution of esterified fatty acid-protein adduct to oxidative modification of LDL. 1998 Arch. Biochem. Biophys. pmid:9500842
Yeh HC et al. Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases. 2007 Arch. Biochem. Biophys. pmid:17459323
Marshall PJ and Kulmacz RJ Prostaglandin H synthase: distinct binding sites for cyclooxygenase and peroxidase substrates. 1988 Arch. Biochem. Biophys. pmid:3140729
Weiss RH et al. Transformation of an arachidonic acid hydroperoxide into epoxyhydroxy and trihydroxy fatty acids by liver microsomal cytochrome P-450. 1987 Arch. Biochem. Biophys. pmid:3813540
Bates EJ et al. Inhibitory effects of arachidonic acid (20:4,n-6) and its monohydroperoxy- and hydroxy-metabolites on procoagulant activity in endothelial cells. 1995 Atherosclerosis pmid:7488327
Sok DE et al. Mechanisms of leukotriene formation: hemoglobin-catalyzed transformation of 15-HPETE into 8,15-DiHETE and 14,15-DiHETE isomers. 1983 Biochem. Biophys. Res. Commun. pmid:6301444
Thomas G and Ramwell P Induction of vascular relaxation by hydroperoxides. 1986 Biochem. Biophys. Res. Commun. pmid:3021120
Sok DE et al. Enzymatic formation of 14,15-leukotriene A and C(14)-sulfur-linked peptides. 1982 Biochem. Biophys. Res. Commun. pmid:6280711
Kim MR et al. Inactivation of potato lipoxygenase by hydroperoxy acids as suicide substrates. 1989 Biochem. Biophys. Res. Commun. pmid:2511843
Tebbey PW and Buttke TM Independent arachidonic acid-mediated gene regulatory pathways in lymphocytes. 1993 Biochem. Biophys. Res. Commun. pmid:8102055
Vedelago HR and Mahadevappa VG Differential effects of 15-HPETE on arachidonic acid metabolism in collagen-stimulated human platelets. 1988 Biochem. Biophys. Res. Commun. pmid:3122753
Lagarde M et al. Inhibition of thrombin-induced platelet arachidonic acid release by 15-hydroperoxy-arachidonic acid. 1981 Biochem. Biophys. Res. Commun. pmid:7259783
Garrick R et al. Transformation of leukotriene A4 to lipoxins by rat kidney mesangial cell. 1989 Biochem. Biophys. Res. Commun. pmid:2547366
Cashman JR et al. Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids. 1988 Biochem. Biophys. Res. Commun. pmid:3415693
Andrianarison RH et al. Positional specificity of a Lupinus albus lipoxygenase in relation to enzyme concentration and effect of a double dioxygenation product of arachidonic acid. 1990 Biochem. Biophys. Res. Commun. pmid:2123103
Foley TD 5-HPETE is a potent inhibitor of neuronal Na+, K(+)-ATPase activity. 1997 Biochem. Biophys. Res. Commun. pmid:9199200
Serhan CN et al. Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes. 1984 Biochem. Biophys. Res. Commun. pmid:6422933
Raza H et al. Specific high affinity binding of lipoxygenase metabolites of arachidonic acid by liver fatty acid binding protein. 1989 Biochem. Biophys. Res. Commun. pmid:2500117
Calzada C et al. Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. 1997 Biochem. J. pmid:9230133
Trigona WL et al. Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells. 2006 Biochem. J. pmid:16209660
Prabhu KS et al. Microsomal glutathione S-transferase A1-1 with glutathione peroxidase activity from sheep liver: molecular cloning, expression and characterization. 2001 Biochem. J. pmid:11716762
Clark SR et al. Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover. 2005 Biochem. J. pmid:15461587
Iwahashi H et al. Radical adducts of nitrosobenzene and 2-methyl-2-nitrosopropane with 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical. Identification by h.p.l.c.-e.p.r. and liquid chromatography-thermospray-m.s. 1991 Biochem. J. pmid:1646600
Humes JL et al. Regulation of macrophage eicosanoid production by hydroperoxy-and hydroxy-eicosatetraenoic acids. 1986 Biochem. J. pmid:3082323
Mahipal SV et al. Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis. 2007 Biochem. Pharmacol. pmid:17517376
Smith CV and Reilly MH Formation of pentane versus 1-pentanol in the ferrous sulfate-initiated decomposition of 15-hydroperoxyeicosatetraenoic acid in hypoxic and hyperoxic conditions. 1989 Biochem. Pharmacol. pmid:2706024
Vanderhoek JY et al. Regulation of leukocyte and platelet lipoxygenases by hydroxyeicosanoids. 1982 Biochem. Pharmacol. pmid:6816247
Hecker M et al. Preparative HPLC purification of prostaglandin endoperoxides and isolation of novel cyclooxygenase-derived arachidonic acid metabolites. 1987 Biochem. Pharmacol. pmid:3105538
Hosni M et al. Diethyldithiocarbamate (ditiocarb sodium) effect on arachidonic acid metabolism in human mononuclear cells. Glutathione peroxidase-like activity. 1992 Biochem. Pharmacol. pmid:1314059
Gryglewski RJ et al. On the mechanism of antithrombotic action of flavonoids. 1987 Biochem. Pharmacol. pmid:3101704
Reynolds CH Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. 1988 Biochem. Pharmacol. pmid:3144281
Landino LM and Marnett LJ Mechanism of hydroperoxide reduction by mangano-prostaglandin endoperoxide synthase. 1996 Biochemistry pmid:8611568
Wu G et al. Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation. 2007 Biochemistry pmid:17209563
Wecksler AT et al. Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. 2009 Biochemistry pmid:19469483
Ruddat VC et al. Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1. 2004 Biochemistry pmid:15476400
Gerzer R et al. Activation of soluble guanylate cyclase by arachidonic acid and 15-lipoxygenase products. 1986 Biochim. Biophys. Acta pmid:2871867
Gulliksson M et al. Expression of 15-lipoxygenase type-1 in human mast cells. 2007 Biochim. Biophys. Acta pmid:17662651
Hamberg M et al. Novel biological transformations of 15-Ls-hydroperoxy-5,8,11,13-eicosatetraenoic acid. 1986 Biochim. Biophys. Acta pmid:3089290
Trudell JR et al. Hypoxia potentiates killing of hepatocyte monolayers by leukotrienes, hydroperoxyeicosatetraenoic acids, or calcium ionophore A23187. 1984 Biochim. Biophys. Acta pmid:6322862
Ng CF et al. Agonist-dependent generation of lipoxins from rat basophilic leukemia cell (RBL-1). 1989 Biochim. Biophys. Acta pmid:2503031
Kishimoto K et al. Suicide inactivation of porcine leukocyte 12-lipoxygenase associated with its incorporation of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid derivative. 1996 Biochim. Biophys. Acta pmid:8608163
RÃ¥dmark O et al. Hemoprotein catalysis of leukotriene formation. 1984 Biochim. Biophys. Acta pmid:6696937
Mayer B et al. Possible inhibitory function of endogenous 15-hydroperoxyeicosatetraenoic acid on prostacyclin formation in bovine aortic endothelial cells. 1986 Biochim. Biophys. Acta pmid:3081039
Esterbauer H et al. Studies on the mechanism of formation of 4-hydroxynonenal during microsomal lipid peroxidation. 1986 Biochim. Biophys. Acta pmid:3081043
Kühn H et al. Overexpression, purification and characterization of human recombinant 15-lipoxygenase. 1993 Biochim. Biophys. Acta pmid:8334154
Fruteau de Laclos B and Borgeat P Conditions for the formation of the oxo derivatives of arachidonic acid from platelet 12-lipoxygenase and soybean 15-lipoxygenase. 1988 Biochim. Biophys. Acta pmid:3124882
Kiran Kumar YV et al. Differential effects of 15-HPETE and 15-HETE on BHK-21 cell proliferation and macromolecular composition. 1993 Biochim. Biophys. Acta pmid:8384883
Bordet JC et al. Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. 1988 Biochim. Biophys. Acta pmid:3124885