15-hpete

15-hpete is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 724 references associated with 15-hpete in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for 15-hpete

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-hpete

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Total 1

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Authors Title Published Journal PubMed Link
Piomelli D The ligand that came from within. 2001 Trends Pharmacol. Sci. pmid:11165666
Yoshinaga M et al. 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells. 2004 Prostaglandins Other Lipid Mediat. pmid:15165036
Kalyankrishna S et al. Arachidonic acid-derived oxidation products initiate apoptosis in vascular smooth muscle cells. 2002 Prostaglandins Other Lipid Mediat. pmid:12428675
Hung ND et al. Anti-inflammatory action of arachidonoyl lysophosphatidylcholine or 15-hydroperoxy derivative in zymosan A-induced peritonitis. 2009 Prostaglandins Other Lipid Mediat. pmid:19819343
Van Diest MJ et al. Influence of hypercholesterolaemia on the reactivity of isolated rabbit arteries to 15-lipoxygenase metabolites of arachidonic acid: comparison with platelet-derived agents and vasodilators. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8848433
Rock C and Moos PJ Selenoprotein P protects cells from lipid hydroperoxides generated by 15-LOX-1. 2010 Oct-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:20826080
Sakai K et al. 12-Hydroperoxyeicosatetraenoic acid (12-HPETE) and 15-HPETE stimulate melatonin synthesis in rat pineals. 1988 Prostaglandins pmid:3187058
Trachte GJ et al. Potent constriction of cat coronary arteries by hydroperoxides of arachidonic acid and its blockade by anti-inflammatory agents. 1979 Prostaglandins pmid:547310
Van Diest MJ et al. Cyclo-oxygenase blockers influence the effects of 15-lipoxygenase metabolites of arachidonic acid in isolated canine blood vessels. 1986 Prostaglandins pmid:3094100
Goetzl EJ et al. Unique aspects of the modulation of human neutrophil function by 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid. 1980 Prostaglandins pmid:6247746
Kühn H Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)XY-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)XY-9Z,11E-octadecadienoic acid. 1996 Prog. Lipid Res. pmid:9082450
Maas RL and Brash AR Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytes. 1983 Proc. Natl. Acad. Sci. U.S.A. pmid:6304687
Capdevila J et al. Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6801662
Hwang SW et al. Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10823958
Serhan CN et al. On the stereochemistry and biosynthesis of lipoxin B. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3083410
Tang DG et al. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8643560
Vijil C et al. Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generation. 2014 PLoS ONE pmid:24533104
Suzuki Y et al. Gamma-aminobutyric acid-induced contraction of the dog basilar artery. 1984 Pharmacology pmid:6463098
d'Ischia M et al. Interactions of nitric oxide with lipid peroxidation products under aerobic conditions: inhibitory effects on the formation of malondialdehyde and related thiobarbituric acid-reactive substances. 2000 Nitric Oxide pmid:10733868
Kobayashi M et al. [Effects of 15-hydroperoxy arachidonic acid and non-purified hydroperoxides from arachidonic acid to rabbit blood vessels (author's transl)]. 1980 Nihon Ronen Igakkai Zasshi pmid:7373935
Rabier M et al. 15-Lipoxygenase products stimulate prolactin secretion from a cloned strain of rat pituitary cells. 1988 Neuroendocrinology pmid:3131692
Bizzozero OA et al. Lipid peroxidation scavengers prevent the carbonylation of cytoskeletal brain proteins induced by glutathione depletion. 2007 Neurochem. Res. pmid:17551832
Marnett LJ et al. Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom. 1984 Mol. Pharmacol. pmid:6434940
Chansel D et al. Modulation of renin synthesis by lipoxygenase products in cultured human mesangial cells. 1989 Mol. Cell. Endocrinol. pmid:2545491
McCarty M Can dietary selenium reduce leukotriene production? 1984 Med. Hypotheses pmid:6323934
Huang S et al. Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells. 1999 Kidney Int. pmid:10231436
Takahashi M et al. Vascular effects of 15-hydroperoxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid on canine arteries. 1985 Jpn. J. Pharmacol. pmid:3925206
Uotila P et al. Relaxing effects of 15-lipoxygenase products of arachidonic acid on rat aorta. 1987 J. Pharmacol. Exp. Ther. pmid:3116200
Koide T et al. Possible mechanisms of 15-hydroperoxyarachidonic acid-induced contraction of the canine basilar artery in vitro. 1982 J. Pharmacol. Exp. Ther. pmid:6804622
Matsuda H et al. Pharmacodynamics of 15(S)-hydroperoxyeicosatetraenoic (15-HPETE) and 15(S)-hydroxyeicosatetraenoic acid (15-HETE) in isolated arteries from guinea pig, rabbit, rat and human. 1995 J. Pharmacol. Exp. Ther. pmid:7791089
Van Diest MJ et al. 15-lipoxygenase metabolites of arachidonic acid evoke contractions and relaxations in isolated canine arteries: role of thromboxane receptors, endothelial cells and cyclooxygenase. 1991 J. Pharmacol. Exp. Ther. pmid:1824864
Shimizu T et al. Activation of the arachidonate 5-lipoxygenase pathway in the canine basilar artery after experimental subarachnoidal hemorrhage. 1988 J. Neurochem. pmid:2843605
Mochizuki-Oda N et al. Arachidonic acid activates cation channels in bovine adrenal chromaffin cells. 1993 J. Neurochem. pmid:7693870
Koide T et al. Alterations of the eicosanoid synthetic capacity of rat brain microvessels following ischemia: relevance to ischemic brain edema. 1985 J. Neurochem. pmid:3964837
Furukawa K et al. The restorative action of coenzyme Q10 in 2,4-dinitrophenol-depressed electrical and contractile activities of guinea-pig heart. 1983 J. Mol. Cell. Cardiol. pmid:6355490
Navab M et al. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1. 2000 J. Lipid Res. pmid:10974056
Navab M et al. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3. 2000 J. Lipid Res. pmid:10974057
Gualde N et al. Induction of suppressor cells from peripheral blood T cells by 15-hydroperoxyeicosatetraenoic acid (15-HPETE). 1985 J. Immunol. pmid:2931484
Balboa MA et al. Amplification mechanisms of inflammation: paracrine stimulation of arachidonic acid mobilization by secreted phospholipase A2 is regulated by cytosolic phospholipase A2-derived hydroperoxyeicosatetraenoic acid. 2003 J. Immunol. pmid:12847271
Ferrante JV and Ferrante A Novel role of lipoxygenases in the inflammatory response: promotion of TNF mRNA decay by 15-hydroperoxyeicosatetraenoic acid in a monocytic cell line. 2005 J. Immunol. pmid:15749845
Moghaddami N et al. Unique effect of arachidonic acid on human neutrophil TNF receptor expression: up-regulation involving protein kinase C, extracellular signal-regulated kinase, and phospholipase A2. 2003 J. Immunol. pmid:12928414
Gualde N et al. Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T cells and T cell subsets. 1985 J. Immunol. pmid:2981258
Patrono C and Pugliese F The involvement of arachidonic acid metabolism in the control of renin release. 1980 Apr-Jun J. Endocrinol. Invest. pmid:6993550
Naccache PH et al. Mono- and dihydroxyeicosatetraenoic acids alter calcium homeostasis in rabbit neutrophils. 1981 J. Clin. Invest. pmid:6262382
Kent RS et al. Regulation of vascular prostaglandin synthesis by metabolites of arachidonic acid in perfused rabbit aorta. 1983 J. Clin. Invest. pmid:6409932
Ferrante JV et al. Altered responses of human macrophages to lipopolysaccharide by hydroperoxy eicosatetraenoic acid, hydroxy eicosatetraenoic acid, and arachidonic acid. Inhibition of tumor necrosis factor production. 1997 J. Clin. Invest. pmid:9077554
Maccarrone M et al. Lipoxygenase products induce ultraweak light emission from human erythroleukemia cells. 1997 Nov-Dec J. Biolumin. Chemilumin. pmid:9509336
Tsai Al et al. Structural characterization of arachidonyl radicals formed by prostaglandin H synthase-2 and prostaglandin H synthase-1 reconstituted with mangano protoporphyrin IX. 1998 J. Biol. Chem. pmid:9461572
Fitzsimmons BJ et al. The lipoxins. Stereochemical identification and determination of their biosynthesis. 1985 J. Biol. Chem. pmid:2997152
Pfister SL et al. Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta. 1998 J. Biol. Chem. pmid:9812980
Ueda N and Yamamoto S The 6R-oxygenase activity of arachidonate 5-lipoxygenase purified from porcine leukocytes. 1988 J. Biol. Chem. pmid:3338999
Brash AR et al. Investigation of the selectivity of hydrogen abstraction in the nonenzymatic formation of hydroxyeicosatetraenoic acids and leukotrienes by autoxidation. 1985 J. Biol. Chem. pmid:2984196
Kanofsky JR Singlet oxygen production by bleomycin. A comparison with heme-containing compounds. 1986 J. Biol. Chem. pmid:2428818
Markey CM et al. Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities. 1987 J. Biol. Chem. pmid:3106353
Rao GN et al. Role of hydroperoxyeicosatetraenoic acids in oxidative stress-induced activating protein 1 (AP-1) activity. 1996 J. Biol. Chem. pmid:8910370
Bryant RW et al. Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid. 1982 J. Biol. Chem. pmid:6804460
Eling TE et al. Oxidation of glutathione to its thiyl free radical metabolite by prostaglandin H synthase. A potential endogenous substrate for the hydroperoxidase. 1986 J. Biol. Chem. pmid:3007487
Yu MK et al. Conditional expression of 15-lipoxygenase-1 inhibits the selenoenzyme thioredoxin reductase: modulation of selenoproteins by lipoxygenase enzymes. 2004 J. Biol. Chem. pmid:15123685
Björnstedt M et al. Human thioredoxin reductase directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols. 1995 J. Biol. Chem. pmid:7744824
MacMillan DK et al. Eosinophil 15-lipoxygenase is a leukotriene A4 synthase. 1994 J. Biol. Chem. pmid:7929400
Sandstrom PA et al. Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency. 1994 J. Biol. Chem. pmid:8288627
Tsai Al et al. Comparison of peroxidase reaction mechanisms of prostaglandin H synthase-1 containing heme and mangano protoporphyrin IX. 1997 J. Biol. Chem. pmid:9083007
Baker LM and Poole LB Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61. 2003 J. Biol. Chem. pmid:12514184
Wu G et al. A mechanistic study of self-inactivation of the peroxidase activity in prostaglandin H synthase-1. 1999 J. Biol. Chem. pmid:10092596
O'Donnell VB et al. Catalytic consumption of nitric oxide by prostaglandin H synthase-1 regulates platelet function. 2000 J. Biol. Chem. pmid:10993875
Kulmacz RJ et al. Heme spin states and peroxide-induced radical species in prostaglandin H synthase. 1987 J. Biol. Chem. pmid:3038886
Ueda N et al. Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids. 1986 J. Biol. Chem. pmid:3086322
Force T et al. Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores. 1991 J. Biol. Chem. pmid:1900289
Bryant RW et al. Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4. 1985 J. Biol. Chem. pmid:2982864
Hong SL et al. Tranylcypromine and 15-hydroperoxyarachidonate affect arachidonic acid release in addition to inhibition of prostacyclin synthesis in calf aortic endothelial cells. 1980 J. Biol. Chem. pmid:6776101
Maas RL et al. Investigation of the chemical conversion of hydroperoxyeicosatetraenoate to leukotriene epoxide using stereospecifically labeled arachidonic acid. Comparison with the enzymatic reaction. 1985 J. Biol. Chem. pmid:2984197
Eling TE et al. The formation of aminopyrine cation radical by the peroxidase activity of prostaglandin H synthase and subsequent reactions of the radical. 1985 J. Biol. Chem. pmid:3918042
Hopkins NK et al. Biosynthesis and metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid by human umbilical vein endothelial cells. 1984 J. Biol. Chem. pmid:6438089
Landino LM et al. Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation. 1997 J. Biol. Chem. pmid:9261177
Coffa G et al. On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant. 2005 J. Biol. Chem. pmid:16157595
Mack SR et al. The human sperm acrosome reaction does not depend on arachidonic acid metabolism via the cyclooxygenase and lipoxygenase pathways. 1992 Nov-Dec J. Androl. pmid:1338069
Yin H et al. Formation of isoprostane bicyclic endoperoxides from the autoxidation of cholesteryl arachidonate. 2002 J. Am. Chem. Soc. pmid:12083928
Brash AR et al. On the mechanism of biosynthesis of 5- and 15-series leukotrienes. 1984 J. Allergy Clin. Immunol. pmid:6088609
Soumya SJ et al. Effect of 15-lipoxygenase metabolites on angiogenesis: 15(S)-HPETE is angiostatic and 15(S)-HETE is angiogenic. 2012 Inflamm. Res. pmid:22450700
Antonipillai I et al. The inhibitory role of 12- and 15-lipoxygenase products on renin release. 1987 Hypertension pmid:3298043
Siegel MI Effect of non-steroidal anti-inflammatory drugs on arachidonic acid metabolism. 1981 Headache pmid:6796546
Uski TK and Högestätt ED Effects of various cyclooxygenase and lipoxygenase metabolites on guinea-pig cerebral arteries. 1992 Gen. Pharmacol. pmid:1592217
Gut J et al. Quantification of 5- and 15-HPETE's by direct chemical ionization mass spectrometry. 1987 Free Radic. Biol. Med. pmid:3319797
Pace-Asciak CR and Asotra S Biosynthesis, catabolism, and biological properties of HPETEs, hydroperoxide derivatives of arachidonic acid. 1989 Free Radic. Biol. Med. pmid:2514125
Iliou JP et al. Monohydroperoxidized fatty acids but not 4-hydroxynonenal induced acute cardiac cell damage. 1995 Free Radic. Biol. Med. pmid:8582650
Cao YZ et al. Altered eicosanoid biosynthesis in selenium-deficient endothelial cells. 2000 Free Radic. Biol. Med. pmid:10699749
Sandstrom PA et al. Lipid hydroperoxide-induced apoptosis: lack of inhibition by Bcl-2 over-expression. 1995 FEBS Lett. pmid:7774717
Lundberg U et al. Appearance of an arachidonic acid 15-lipoxygenase pathway upon differentiation of the human promyelocytic cell-line HL-60. 1985 FEBS Lett. pmid:3922792
Calzada C and Rice-Evans C Ruptured erythrocytes inhibit the oxidation of membranes by 15-hydroperoxy-eicosatetraenoic acid. 1993 FEBS Lett. pmid:8354383
Rouzer CA and Samuelsson B The importance of hydroperoxide activation for the detection and assay of mammalian 5-lipoxygenase. 1986 FEBS Lett. pmid:3089841
Iwaoka T and Tabata F Chemiluminescent assay of lipid peroxide in plasma using cytochrome c heme peptide. 1984 FEBS Lett. pmid:6500062
Walters FP et al. Oxidation of myoglobin in isolated adult rat cardiac myocytes by 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid. 1983 FEBS Lett. pmid:6641945
Wang J et al. Stimulation of progesterone and prostaglandin E2 production by lipoxygenase metabolites of arachidonic acid. 1989 FEBS Lett. pmid:2494061
Elhai J and Scandella CJ Arachidonic acid and other fatty acids inhibit secretion from sea urchin eggs. 1983 Exp. Cell Res. pmid:6414832
Trang T et al. Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance. 2004 Eur. J. Pharmacol. pmid:15102529
Van Diest MJ et al. Vascular interaction between 5-hydroxytryptamine and 15-lipoxygenase metabolites of arachidonic acid. 1993 Eur. J. Pharmacol. pmid:8453981
Grechkin AN et al. On the mechanism of biosynthesis of divinyl ether oxylipins by enzyme from garlic bulbs. 1997 Eur. J. Biochem. pmid:9128734
Bourdeau A et al. Effects of lipoxygenase products of arachidonate metabolism on parathyroid hormone secretion. 1994 Endocrinology pmid:8070353
Kodaman PH et al. Lipid hydroperoxides evoke antigonadotropic and antisteroidogenic activity in rat luteal cells. 1994 Endocrinology pmid:7988463
Yamazaki T et al. 15-lipoxygenase metabolite(s) of arachidonic acid mediates adrenocorticotropin action in bovine adrenal steroidogenesis. 1996 Endocrinology pmid:8770885