| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
Total
1
15-hpete
15-hpete is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 724 references associated with 15-hpete in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for 15-hpete
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-hpete
NCBI Entrez Crosslinks
All references with 15-hpete
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Nagy L et al. | Complement receptor enhancement and chemotaxis of human neutrophils and eosinophils by leukotrienes and other lipoxygenase products. | 1982 | Clin. Exp. Immunol. | pmid:6282507 |
| Kontos HA | George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury. | 1985 | Circ. Res. | pmid:2994903 |
| Whalen MM et al. | Lysophosphatidylcholine and arachidonic acid are required in the cytotoxic response of human natural killer cells to tumor target cells. | 1999 | Cell. Physiol. Biochem. | pmid:10749996 |
| Cavalieri B et al. | Ischaemic preconditioning modulates the activity of Kupffer cells during in vivo reperfusion injury of rat liver. | 2003 | Cell Biochem. Funct. | pmid:14624466 |
| Najid A et al. | Cytotoxicity of arachidonic acid and of its lipoxygenase metabolite 15-hydroperoxyeicosatetraenoic acid on human breast cancer MCF-7 cells in culture. | 1989 | Cancer Lett. | pmid:2502308 |
| McColl SR et al. | Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic acid: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins. | 1989 | Br. J. Pharmacol. | pmid:2507084 |
| Riccio MM et al. | The effect of 15-HPETE on airway responsiveness and pulmonary cell recruitment in rabbits. | 1997 | Br. J. Pharmacol. | pmid:9313932 |
| Higgs GA et al. | The inflammatory effects of hydroperoxy and hydroxy acid products of arachidonate lipoxygenase in rabbit skin. | 1981 | Br. J. Pharmacol. | pmid:6274465 |
| Folkerts G et al. | Induction in guinea-pigs of airway hyperreactivity and decreased lung beta-adrenoceptor number by 15-hydroperoxy-arachidonic acid. | 1983 | Br. J. Pharmacol. | pmid:6100841 |
| Beetens JR and Herman AG | Vitamin C increases the formation of prostacyclin by aortic rings from various species and neutralizes the inhibitory effect of 15-hydroperoxy-arachidonic acid. | 1983 | Br. J. Pharmacol. | pmid:6360278 |
| McDonald PP et al. | Activation of the human neutrophil 5-lipoxygenase by leukotriene B4. | 1992 | Br. J. Pharmacol. | pmid:1330161 |
| Augustin AJ et al. | Detection of eicosanoids in epiretinal membranes of patients suffering from proliferative vitreoretinal diseases. | 1997 | Br J Ophthalmol | pmid:9135410 |
| Davies JA and Menys VC | Effect of dazoxiben on platelet-vessel wall interaction. | 1983 | Br J Clin Pharmacol | pmid:6681703 |
| Terao J et al. | Effects of rat bile-pancreatic juice on Fe2+ induced peroxidation of phospholipids. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7765976 |
| Gerzer R et al. | Activation of soluble guanylate cyclase by arachidonic acid and 15-lipoxygenase products. | 1986 | Biochim. Biophys. Acta | pmid:2871867 |
| Gulliksson M et al. | Expression of 15-lipoxygenase type-1 in human mast cells. | 2007 | Biochim. Biophys. Acta | pmid:17662651 |
| Hamberg M et al. | Novel biological transformations of 15-Ls-hydroperoxy-5,8,11,13-eicosatetraenoic acid. | 1986 | Biochim. Biophys. Acta | pmid:3089290 |
| Manini P et al. | Ni2+ enhances Fe2+/peroxide-induced oxidation of arachidonic acid and formation of geno/cytotoxic 4-hydroxynonenal: a possible contributory mechanism in nickel toxicity and allergenicity. | 2003 | Biochim. Biophys. Acta | pmid:12667605 |
| Trudell JR et al. | Hypoxia potentiates killing of hepatocyte monolayers by leukotrienes, hydroperoxyeicosatetraenoic acids, or calcium ionophore A23187. | 1984 | Biochim. Biophys. Acta | pmid:6322862 |
| Ng CF et al. | Agonist-dependent generation of lipoxins from rat basophilic leukemia cell (RBL-1). | 1989 | Biochim. Biophys. Acta | pmid:2503031 |
| Kishimoto K et al. | Suicide inactivation of porcine leukocyte 12-lipoxygenase associated with its incorporation of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid derivative. | 1996 | Biochim. Biophys. Acta | pmid:8608163 |
| RÃ¥dmark O et al. | Hemoprotein catalysis of leukotriene formation. | 1984 | Biochim. Biophys. Acta | pmid:6696937 |
| Mayer B et al. | Possible inhibitory function of endogenous 15-hydroperoxyeicosatetraenoic acid on prostacyclin formation in bovine aortic endothelial cells. | 1986 | Biochim. Biophys. Acta | pmid:3081039 |
| Esterbauer H et al. | Studies on the mechanism of formation of 4-hydroxynonenal during microsomal lipid peroxidation. | 1986 | Biochim. Biophys. Acta | pmid:3081043 |
| Kühn H et al. | Overexpression, purification and characterization of human recombinant 15-lipoxygenase. | 1993 | Biochim. Biophys. Acta | pmid:8334154 |
| Fruteau de Laclos B and Borgeat P | Conditions for the formation of the oxo derivatives of arachidonic acid from platelet 12-lipoxygenase and soybean 15-lipoxygenase. | 1988 | Biochim. Biophys. Acta | pmid:3124882 |
| Kiran Kumar YV et al. | Differential effects of 15-HPETE and 15-HETE on BHK-21 cell proliferation and macromolecular composition. | 1993 | Biochim. Biophys. Acta | pmid:8384883 |
| Bordet JC et al. | Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. | 1988 | Biochim. Biophys. Acta | pmid:3124885 |
| Landino LM and Marnett LJ | Mechanism of hydroperoxide reduction by mangano-prostaglandin endoperoxide synthase. | 1996 | Biochemistry | pmid:8611568 |
| Wu G et al. | Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation. | 2007 | Biochemistry | pmid:17209563 |
| Wecksler AT et al. | Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. | 2009 | Biochemistry | pmid:19469483 |
| Ruddat VC et al. | Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1. | 2004 | Biochemistry | pmid:15476400 |
| Mahipal SV et al. | Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis. | 2007 | Biochem. Pharmacol. | pmid:17517376 |
| Smith CV and Reilly MH | Formation of pentane versus 1-pentanol in the ferrous sulfate-initiated decomposition of 15-hydroperoxyeicosatetraenoic acid in hypoxic and hyperoxic conditions. | 1989 | Biochem. Pharmacol. | pmid:2706024 |
| Vanderhoek JY et al. | Regulation of leukocyte and platelet lipoxygenases by hydroxyeicosanoids. | 1982 | Biochem. Pharmacol. | pmid:6816247 |
| Hecker M et al. | Preparative HPLC purification of prostaglandin endoperoxides and isolation of novel cyclooxygenase-derived arachidonic acid metabolites. | 1987 | Biochem. Pharmacol. | pmid:3105538 |
| Hosni M et al. | Diethyldithiocarbamate (ditiocarb sodium) effect on arachidonic acid metabolism in human mononuclear cells. Glutathione peroxidase-like activity. | 1992 | Biochem. Pharmacol. | pmid:1314059 |
| Gryglewski RJ et al. | On the mechanism of antithrombotic action of flavonoids. | 1987 | Biochem. Pharmacol. | pmid:3101704 |
| Reynolds CH | Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. | 1988 | Biochem. Pharmacol. | pmid:3144281 |
| Calzada C et al. | Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. | 1997 | Biochem. J. | pmid:9230133 |
| Trigona WL et al. | Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells. | 2006 | Biochem. J. | pmid:16209660 |
| Prabhu KS et al. | Microsomal glutathione S-transferase A1-1 with glutathione peroxidase activity from sheep liver: molecular cloning, expression and characterization. | 2001 | Biochem. J. | pmid:11716762 |
| Clark SR et al. | Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover. | 2005 | Biochem. J. | pmid:15461587 |
| Iwahashi H et al. | Radical adducts of nitrosobenzene and 2-methyl-2-nitrosopropane with 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical. Identification by h.p.l.c.-e.p.r. and liquid chromatography-thermospray-m.s. | 1991 | Biochem. J. | pmid:1646600 |
| Humes JL et al. | Regulation of macrophage eicosanoid production by hydroperoxy-and hydroxy-eicosatetraenoic acids. | 1986 | Biochem. J. | pmid:3082323 |
| Sok DE et al. | Mechanisms of leukotriene formation: hemoglobin-catalyzed transformation of 15-HPETE into 8,15-DiHETE and 14,15-DiHETE isomers. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6301444 |
| Thomas G and Ramwell P | Induction of vascular relaxation by hydroperoxides. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3021120 |
| Sok DE et al. | Enzymatic formation of 14,15-leukotriene A and C(14)-sulfur-linked peptides. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6280711 |
| Kim MR et al. | Inactivation of potato lipoxygenase by hydroperoxy acids as suicide substrates. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2511843 |
| Tebbey PW and Buttke TM | Independent arachidonic acid-mediated gene regulatory pathways in lymphocytes. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8102055 |
| Vedelago HR and Mahadevappa VG | Differential effects of 15-HPETE on arachidonic acid metabolism in collagen-stimulated human platelets. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3122753 |
| Lagarde M et al. | Inhibition of thrombin-induced platelet arachidonic acid release by 15-hydroperoxy-arachidonic acid. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7259783 |
| Garrick R et al. | Transformation of leukotriene A4 to lipoxins by rat kidney mesangial cell. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2547366 |
| Cashman JR et al. | Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3415693 |
| Andrianarison RH et al. | Positional specificity of a Lupinus albus lipoxygenase in relation to enzyme concentration and effect of a double dioxygenation product of arachidonic acid. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2123103 |
| Foley TD | 5-HPETE is a potent inhibitor of neuronal Na+, K(+)-ATPase activity. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9199200 |
| Serhan CN et al. | Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422933 |
| Raza H et al. | Specific high affinity binding of lipoxygenase metabolites of arachidonic acid by liver fatty acid binding protein. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2500117 |
| Bates EJ et al. | Inhibitory effects of arachidonic acid (20:4,n-6) and its monohydroperoxy- and hydroxy-metabolites on procoagulant activity in endothelial cells. | 1995 | Atherosclerosis | pmid:7488327 |
| Kato Y and Osawa T | Detection of oxidized phospholipid-protein adducts using anti-15-hydroperoxyeicosatetraenoic acid-modified protein antibody: contribution of esterified fatty acid-protein adduct to oxidative modification of LDL. | 1998 | Arch. Biochem. Biophys. | pmid:9500842 |
| Yeh HC et al. | Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases. | 2007 | Arch. Biochem. Biophys. | pmid:17459323 |
| Marshall PJ and Kulmacz RJ | Prostaglandin H synthase: distinct binding sites for cyclooxygenase and peroxidase substrates. | 1988 | Arch. Biochem. Biophys. | pmid:3140729 |
| Weiss RH et al. | Transformation of an arachidonic acid hydroperoxide into epoxyhydroxy and trihydroxy fatty acids by liver microsomal cytochrome P-450. | 1987 | Arch. Biochem. Biophys. | pmid:3813540 |
| Murota S et al. | The control of vascular endothelial cell injury. | 1990 | Ann. N. Y. Acad. Sci. | pmid:2248437 |
| Goodwin JS and Behrens T | Role of lipoxygenase metabolites of arachidonic acid in T cell activation. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837956 |
| Vanderhoek JY | Role of the 15-lipoxygenase in the immune system. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3132881 |
| Bösterling B and Trudell JR | Production of 5- and 15-hydroperoxyeicosatetraenoic acid from arachidonic acid by halothane-free radicals generated by UV-irradiation. | 1984 | Anesthesiology | pmid:6696254 |
| Vaidyanathan VV and Sastry PS | Preparation of hydroperoxy fatty acids. | 1994 | Anal. Biochem. | pmid:8080099 |
| Johnson HG et al. | 15-Hydroxyeicosatetraenoic acid is a potent inflammatory mediator and agonist of canine tracheal mucus secretion. | 1985 | Am. Rev. Respir. Dis. | pmid:3923884 |
| Henrich WL et al. | Inhibition of renin secretion from rat renal cortical slices by (R)-12-HETE. | 1992 | Am. J. Physiol. | pmid:1415738 |
| Christman CW et al. | Effects of 15-hydroperoxy-eicosatetraenoic acid (15-HPETE) on cerebral arterioles of cats. | 1984 | Am. J. Physiol. | pmid:6437243 |
| Weitberg AB | Hydroxy- and hydroperoxy-6,8,11,14-eicosatetraenoic acids induce sister chromatid exchanges in cultured mammalian cells. | 1990 | Am. J. Med. Sci. | pmid:2105055 |
| Dahlén SE et al. | Biological activities of lipoxin A include lung strip contraction and dilation of arterioles in vivo. | 1987 | Acta Physiol. Scand. | pmid:3630737 |
| Lanefelt F and Martinsson A | Ethanol dependent interaction between prostaglandins and lipoxygenase products in human peripheral lymphocytes. | 1985 | Acta Pharmacol Toxicol (Copenh) | pmid:2986412 |
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