MeSH term | MeSH ID | Detail |
---|---|---|
Hypertension | D006973 | 115 associated lipids |
Total
1
15-hpete is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with 15-hpete
MeSH term | MeSH ID | Detail |
---|---|---|
Hypertension | D006973 | 115 associated lipids |
Authors | Title | Published | Journal | PubMed Link |
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Vijil C et al. | Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generation. | 2014 | PLoS ONE | pmid:24533104 |
Soumya SJ et al. | Effect of 15-lipoxygenase metabolites on angiogenesis: 15(S)-HPETE is angiostatic and 15(S)-HETE is angiogenic. | 2012 | Inflamm. Res. | pmid:22450700 |
Rock C and Moos PJ | Selenoprotein P protects cells from lipid hydroperoxides generated by 15-LOX-1. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20826080 |
Hung ND et al. | Anti-inflammatory action of arachidonoyl lysophosphatidylcholine or 15-hydroperoxy derivative in zymosan A-induced peritonitis. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19819343 |
Wecksler AT et al. | Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. | 2009 | Biochemistry | pmid:19469483 |
Mahipal SV et al. | Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis. | 2007 | Biochem. Pharmacol. | pmid:17517376 |
Gulliksson M et al. | Expression of 15-lipoxygenase type-1 in human mast cells. | 2007 | Biochim. Biophys. Acta | pmid:17662651 |
Bizzozero OA et al. | Lipid peroxidation scavengers prevent the carbonylation of cytoskeletal brain proteins induced by glutathione depletion. | 2007 | Neurochem. Res. | pmid:17551832 |
Yeh HC et al. | Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases. | 2007 | Arch. Biochem. Biophys. | pmid:17459323 |
Wu G et al. | Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation. | 2007 | Biochemistry | pmid:17209563 |
Trigona WL et al. | Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells. | 2006 | Biochem. J. | pmid:16209660 |
Ferrante JV and Ferrante A | Novel role of lipoxygenases in the inflammatory response: promotion of TNF mRNA decay by 15-hydroperoxyeicosatetraenoic acid in a monocytic cell line. | 2005 | J. Immunol. | pmid:15749845 |
Clark SR et al. | Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover. | 2005 | Biochem. J. | pmid:15461587 |
Coffa G et al. | On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant. | 2005 | J. Biol. Chem. | pmid:16157595 |
Yoshinaga M et al. | 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165036 |
Yu MK et al. | Conditional expression of 15-lipoxygenase-1 inhibits the selenoenzyme thioredoxin reductase: modulation of selenoproteins by lipoxygenase enzymes. | 2004 | J. Biol. Chem. | pmid:15123685 |
Trang T et al. | Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance. | 2004 | Eur. J. Pharmacol. | pmid:15102529 |
Ruddat VC et al. | Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1. | 2004 | Biochemistry | pmid:15476400 |
Manini P et al. | Ni2+ enhances Fe2+/peroxide-induced oxidation of arachidonic acid and formation of geno/cytotoxic 4-hydroxynonenal: a possible contributory mechanism in nickel toxicity and allergenicity. | 2003 | Biochim. Biophys. Acta | pmid:12667605 |
Balboa MA et al. | Amplification mechanisms of inflammation: paracrine stimulation of arachidonic acid mobilization by secreted phospholipase A2 is regulated by cytosolic phospholipase A2-derived hydroperoxyeicosatetraenoic acid. | 2003 | J. Immunol. | pmid:12847271 |
Moghaddami N et al. | Unique effect of arachidonic acid on human neutrophil TNF receptor expression: up-regulation involving protein kinase C, extracellular signal-regulated kinase, and phospholipase A2. | 2003 | J. Immunol. | pmid:12928414 |
Baker LM and Poole LB | Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61. | 2003 | J. Biol. Chem. | pmid:12514184 |
Cavalieri B et al. | Ischaemic preconditioning modulates the activity of Kupffer cells during in vivo reperfusion injury of rat liver. | 2003 | Cell Biochem. Funct. | pmid:14624466 |
Yin H et al. | Formation of isoprostane bicyclic endoperoxides from the autoxidation of cholesteryl arachidonate. | 2002 | J. Am. Chem. Soc. | pmid:12083928 |
Kalyankrishna S et al. | Arachidonic acid-derived oxidation products initiate apoptosis in vascular smooth muscle cells. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428675 |
Prabhu KS et al. | Microsomal glutathione S-transferase A1-1 with glutathione peroxidase activity from sheep liver: molecular cloning, expression and characterization. | 2001 | Biochem. J. | pmid:11716762 |
Piomelli D | The ligand that came from within. | 2001 | Trends Pharmacol. Sci. | pmid:11165666 |
Hwang SW et al. | Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10823958 |
Navab M et al. | Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1. | 2000 | J. Lipid Res. | pmid:10974056 |
Navab M et al. | Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3. | 2000 | J. Lipid Res. | pmid:10974057 |
O'Donnell VB et al. | Catalytic consumption of nitric oxide by prostaglandin H synthase-1 regulates platelet function. | 2000 | J. Biol. Chem. | pmid:10993875 |
d'Ischia M et al. | Interactions of nitric oxide with lipid peroxidation products under aerobic conditions: inhibitory effects on the formation of malondialdehyde and related thiobarbituric acid-reactive substances. | 2000 | Nitric Oxide | pmid:10733868 |
Cao YZ et al. | Altered eicosanoid biosynthesis in selenium-deficient endothelial cells. | 2000 | Free Radic. Biol. Med. | pmid:10699749 |
Wu G et al. | A mechanistic study of self-inactivation of the peroxidase activity in prostaglandin H synthase-1. | 1999 | J. Biol. Chem. | pmid:10092596 |
Huang S et al. | Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells. | 1999 | Kidney Int. | pmid:10231436 |
Whalen MM et al. | Lysophosphatidylcholine and arachidonic acid are required in the cytotoxic response of human natural killer cells to tumor target cells. | 1999 | Cell. Physiol. Biochem. | pmid:10749996 |
Tsai Al et al. | Structural characterization of arachidonyl radicals formed by prostaglandin H synthase-2 and prostaglandin H synthase-1 reconstituted with mangano protoporphyrin IX. | 1998 | J. Biol. Chem. | pmid:9461572 |
Pfister SL et al. | Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta. | 1998 | J. Biol. Chem. | pmid:9812980 |
Kato Y and Osawa T | Detection of oxidized phospholipid-protein adducts using anti-15-hydroperoxyeicosatetraenoic acid-modified protein antibody: contribution of esterified fatty acid-protein adduct to oxidative modification of LDL. | 1998 | Arch. Biochem. Biophys. | pmid:9500842 |
Maccarrone M et al. | Lipoxygenase products induce ultraweak light emission from human erythroleukemia cells. | 1997 Nov-Dec | J. Biolumin. Chemilumin. | pmid:9509336 |
Calzada C et al. | Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. | 1997 | Biochem. J. | pmid:9230133 |
Riccio MM et al. | The effect of 15-HPETE on airway responsiveness and pulmonary cell recruitment in rabbits. | 1997 | Br. J. Pharmacol. | pmid:9313932 |
Augustin AJ et al. | Detection of eicosanoids in epiretinal membranes of patients suffering from proliferative vitreoretinal diseases. | 1997 | Br J Ophthalmol | pmid:9135410 |
Tsai Al et al. | Comparison of peroxidase reaction mechanisms of prostaglandin H synthase-1 containing heme and mangano protoporphyrin IX. | 1997 | J. Biol. Chem. | pmid:9083007 |
Grechkin AN et al. | On the mechanism of biosynthesis of divinyl ether oxylipins by enzyme from garlic bulbs. | 1997 | Eur. J. Biochem. | pmid:9128734 |
Foley TD | 5-HPETE is a potent inhibitor of neuronal Na+, K(+)-ATPase activity. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9199200 |
Ferrante JV et al. | Altered responses of human macrophages to lipopolysaccharide by hydroperoxy eicosatetraenoic acid, hydroxy eicosatetraenoic acid, and arachidonic acid. Inhibition of tumor necrosis factor production. | 1997 | J. Clin. Invest. | pmid:9077554 |
Landino LM et al. | Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation. | 1997 | J. Biol. Chem. | pmid:9261177 |
Landino LM and Marnett LJ | Mechanism of hydroperoxide reduction by mangano-prostaglandin endoperoxide synthase. | 1996 | Biochemistry | pmid:8611568 |
Kühn H | Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)XY-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)XY-9Z,11E-octadecadienoic acid. | 1996 | Prog. Lipid Res. | pmid:9082450 |
Van Diest MJ et al. | Influence of hypercholesterolaemia on the reactivity of isolated rabbit arteries to 15-lipoxygenase metabolites of arachidonic acid: comparison with platelet-derived agents and vasodilators. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8848433 |
Rao GN et al. | Role of hydroperoxyeicosatetraenoic acids in oxidative stress-induced activating protein 1 (AP-1) activity. | 1996 | J. Biol. Chem. | pmid:8910370 |
Tang DG et al. | Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8643560 |
Yamazaki T et al. | 15-lipoxygenase metabolite(s) of arachidonic acid mediates adrenocorticotropin action in bovine adrenal steroidogenesis. | 1996 | Endocrinology | pmid:8770885 |
Kishimoto K et al. | Suicide inactivation of porcine leukocyte 12-lipoxygenase associated with its incorporation of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid derivative. | 1996 | Biochim. Biophys. Acta | pmid:8608163 |
Sandstrom PA et al. | Lipid hydroperoxide-induced apoptosis: lack of inhibition by Bcl-2 over-expression. | 1995 | FEBS Lett. | pmid:7774717 |
Björnstedt M et al. | Human thioredoxin reductase directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols. | 1995 | J. Biol. Chem. | pmid:7744824 |
Terao J et al. | Effects of rat bile-pancreatic juice on Fe2+ induced peroxidation of phospholipids. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7765976 |
Bates EJ et al. | Inhibitory effects of arachidonic acid (20:4,n-6) and its monohydroperoxy- and hydroxy-metabolites on procoagulant activity in endothelial cells. | 1995 | Atherosclerosis | pmid:7488327 |
Iliou JP et al. | Monohydroperoxidized fatty acids but not 4-hydroxynonenal induced acute cardiac cell damage. | 1995 | Free Radic. Biol. Med. | pmid:8582650 |
Matsuda H et al. | Pharmacodynamics of 15(S)-hydroperoxyeicosatetraenoic (15-HPETE) and 15(S)-hydroxyeicosatetraenoic acid (15-HETE) in isolated arteries from guinea pig, rabbit, rat and human. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7791089 |
MacMillan DK et al. | Eosinophil 15-lipoxygenase is a leukotriene A4 synthase. | 1994 | J. Biol. Chem. | pmid:7929400 |
Bourdeau A et al. | Effects of lipoxygenase products of arachidonate metabolism on parathyroid hormone secretion. | 1994 | Endocrinology | pmid:8070353 |
Sandstrom PA et al. | Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency. | 1994 | J. Biol. Chem. | pmid:8288627 |
Kodaman PH et al. | Lipid hydroperoxides evoke antigonadotropic and antisteroidogenic activity in rat luteal cells. | 1994 | Endocrinology | pmid:7988463 |
Vaidyanathan VV and Sastry PS | Preparation of hydroperoxy fatty acids. | 1994 | Anal. Biochem. | pmid:8080099 |
Tebbey PW and Buttke TM | Independent arachidonic acid-mediated gene regulatory pathways in lymphocytes. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8102055 |
Calzada C and Rice-Evans C | Ruptured erythrocytes inhibit the oxidation of membranes by 15-hydroperoxy-eicosatetraenoic acid. | 1993 | FEBS Lett. | pmid:8354383 |
Mochizuki-Oda N et al. | Arachidonic acid activates cation channels in bovine adrenal chromaffin cells. | 1993 | J. Neurochem. | pmid:7693870 |
Kühn H et al. | Overexpression, purification and characterization of human recombinant 15-lipoxygenase. | 1993 | Biochim. Biophys. Acta | pmid:8334154 |
Van Diest MJ et al. | Vascular interaction between 5-hydroxytryptamine and 15-lipoxygenase metabolites of arachidonic acid. | 1993 | Eur. J. Pharmacol. | pmid:8453981 |
Kiran Kumar YV et al. | Differential effects of 15-HPETE and 15-HETE on BHK-21 cell proliferation and macromolecular composition. | 1993 | Biochim. Biophys. Acta | pmid:8384883 |
Mack SR et al. | The human sperm acrosome reaction does not depend on arachidonic acid metabolism via the cyclooxygenase and lipoxygenase pathways. | 1992 Nov-Dec | J. Androl. | pmid:1338069 |
Uski TK and Högestätt ED | Effects of various cyclooxygenase and lipoxygenase metabolites on guinea-pig cerebral arteries. | 1992 | Gen. Pharmacol. | pmid:1592217 |
Hosni M et al. | Diethyldithiocarbamate (ditiocarb sodium) effect on arachidonic acid metabolism in human mononuclear cells. Glutathione peroxidase-like activity. | 1992 | Biochem. Pharmacol. | pmid:1314059 |
Henrich WL et al. | Inhibition of renin secretion from rat renal cortical slices by (R)-12-HETE. | 1992 | Am. J. Physiol. | pmid:1415738 |
McDonald PP et al. | Activation of the human neutrophil 5-lipoxygenase by leukotriene B4. | 1992 | Br. J. Pharmacol. | pmid:1330161 |
Iwahashi H et al. | Radical adducts of nitrosobenzene and 2-methyl-2-nitrosopropane with 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical. Identification by h.p.l.c.-e.p.r. and liquid chromatography-thermospray-m.s. | 1991 | Biochem. J. | pmid:1646600 |
Force T et al. | Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores. | 1991 | J. Biol. Chem. | pmid:1900289 |
Van Diest MJ et al. | 15-lipoxygenase metabolites of arachidonic acid evoke contractions and relaxations in isolated canine arteries: role of thromboxane receptors, endothelial cells and cyclooxygenase. | 1991 | J. Pharmacol. Exp. Ther. | pmid:1824864 |
Murota S et al. | The control of vascular endothelial cell injury. | 1990 | Ann. N. Y. Acad. Sci. | pmid:2248437 |
Weitberg AB | Hydroxy- and hydroperoxy-6,8,11,14-eicosatetraenoic acids induce sister chromatid exchanges in cultured mammalian cells. | 1990 | Am. J. Med. Sci. | pmid:2105055 |
Andrianarison RH et al. | Positional specificity of a Lupinus albus lipoxygenase in relation to enzyme concentration and effect of a double dioxygenation product of arachidonic acid. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2123103 |
Kim MR et al. | Inactivation of potato lipoxygenase by hydroperoxy acids as suicide substrates. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2511843 |
McColl SR et al. | Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic acid: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins. | 1989 | Br. J. Pharmacol. | pmid:2507084 |
Smith CV and Reilly MH | Formation of pentane versus 1-pentanol in the ferrous sulfate-initiated decomposition of 15-hydroperoxyeicosatetraenoic acid in hypoxic and hyperoxic conditions. | 1989 | Biochem. Pharmacol. | pmid:2706024 |
Garrick R et al. | Transformation of leukotriene A4 to lipoxins by rat kidney mesangial cell. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2547366 |
Pace-Asciak CR and Asotra S | Biosynthesis, catabolism, and biological properties of HPETEs, hydroperoxide derivatives of arachidonic acid. | 1989 | Free Radic. Biol. Med. | pmid:2514125 |
Ng CF et al. | Agonist-dependent generation of lipoxins from rat basophilic leukemia cell (RBL-1). | 1989 | Biochim. Biophys. Acta | pmid:2503031 |
Wang J et al. | Stimulation of progesterone and prostaglandin E2 production by lipoxygenase metabolites of arachidonic acid. | 1989 | FEBS Lett. | pmid:2494061 |
Najid A et al. | Cytotoxicity of arachidonic acid and of its lipoxygenase metabolite 15-hydroperoxyeicosatetraenoic acid on human breast cancer MCF-7 cells in culture. | 1989 | Cancer Lett. | pmid:2502308 |
Raza H et al. | Specific high affinity binding of lipoxygenase metabolites of arachidonic acid by liver fatty acid binding protein. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2500117 |
Chansel D et al. | Modulation of renin synthesis by lipoxygenase products in cultured human mesangial cells. | 1989 | Mol. Cell. Endocrinol. | pmid:2545491 |
Ueda N and Yamamoto S | The 6R-oxygenase activity of arachidonate 5-lipoxygenase purified from porcine leukocytes. | 1988 | J. Biol. Chem. | pmid:3338999 |
Vedelago HR and Mahadevappa VG | Differential effects of 15-HPETE on arachidonic acid metabolism in collagen-stimulated human platelets. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3122753 |
Marshall PJ and Kulmacz RJ | Prostaglandin H synthase: distinct binding sites for cyclooxygenase and peroxidase substrates. | 1988 | Arch. Biochem. Biophys. | pmid:3140729 |
Goodwin JS and Behrens T | Role of lipoxygenase metabolites of arachidonic acid in T cell activation. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837956 |
Vanderhoek JY | Role of the 15-lipoxygenase in the immune system. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3132881 |
Reynolds CH | Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. | 1988 | Biochem. Pharmacol. | pmid:3144281 |
Fruteau de Laclos B and Borgeat P | Conditions for the formation of the oxo derivatives of arachidonic acid from platelet 12-lipoxygenase and soybean 15-lipoxygenase. | 1988 | Biochim. Biophys. Acta | pmid:3124882 |