| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypertension | D006973 | 115 associated lipids |
Total
1
15-hpete
15-hpete is a lipid of Fatty Acyls (FA) class.
Cross Reference
There are no associated biomedical information in the current reference collection.
Current reference collection contains 724 references associated with 15-hpete in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.
Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.
Here are additional resources we collected from PubChem and MeSH for 15-hpete
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with 15-hpete
NCBI Entrez Crosslinks
All references with 15-hpete
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Vijil C et al. | Arachidonate 15-lipoxygenase enzyme products increase platelet aggregation and thrombin generation. | 2014 | PLoS ONE | pmid:24533104 |
| Soumya SJ et al. | Effect of 15-lipoxygenase metabolites on angiogenesis: 15(S)-HPETE is angiostatic and 15(S)-HETE is angiogenic. | 2012 | Inflamm. Res. | pmid:22450700 |
| Rock C and Moos PJ | Selenoprotein P protects cells from lipid hydroperoxides generated by 15-LOX-1. | 2010 Oct-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20826080 |
| Hung ND et al. | Anti-inflammatory action of arachidonoyl lysophosphatidylcholine or 15-hydroperoxy derivative in zymosan A-induced peritonitis. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19819343 |
| Wecksler AT et al. | Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. | 2009 | Biochemistry | pmid:19469483 |
| Mahipal SV et al. | Effect of 15-lipoxygenase metabolites, 15-(S)-HPETE and 15-(S)-HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis. | 2007 | Biochem. Pharmacol. | pmid:17517376 |
| Gulliksson M et al. | Expression of 15-lipoxygenase type-1 in human mast cells. | 2007 | Biochim. Biophys. Acta | pmid:17662651 |
| Bizzozero OA et al. | Lipid peroxidation scavengers prevent the carbonylation of cytoskeletal brain proteins induced by glutathione depletion. | 2007 | Neurochem. Res. | pmid:17551832 |
| Yeh HC et al. | Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases. | 2007 | Arch. Biochem. Biophys. | pmid:17459323 |
| Wu G et al. | Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation. | 2007 | Biochemistry | pmid:17209563 |
| Trigona WL et al. | Thioredoxin reductase regulates the induction of haem oxygenase-1 expression in aortic endothelial cells. | 2006 | Biochem. J. | pmid:16209660 |
| Ferrante JV and Ferrante A | Novel role of lipoxygenases in the inflammatory response: promotion of TNF mRNA decay by 15-hydroperoxyeicosatetraenoic acid in a monocytic cell line. | 2005 | J. Immunol. | pmid:15749845 |
| Clark SR et al. | Depletion of iNOS-derived nitric oxide by prostaglandin H synthase-2 in inflammation-activated J774.2 macrophages through lipohydroperoxidase turnover. | 2005 | Biochem. J. | pmid:15461587 |
| Coffa G et al. | On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant. | 2005 | J. Biol. Chem. | pmid:16157595 |
| Yoshinaga M et al. | 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165036 |
| Yu MK et al. | Conditional expression of 15-lipoxygenase-1 inhibits the selenoenzyme thioredoxin reductase: modulation of selenoproteins by lipoxygenase enzymes. | 2004 | J. Biol. Chem. | pmid:15123685 |
| Trang T et al. | Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance. | 2004 | Eur. J. Pharmacol. | pmid:15102529 |
| Ruddat VC et al. | Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1. | 2004 | Biochemistry | pmid:15476400 |
| Manini P et al. | Ni2+ enhances Fe2+/peroxide-induced oxidation of arachidonic acid and formation of geno/cytotoxic 4-hydroxynonenal: a possible contributory mechanism in nickel toxicity and allergenicity. | 2003 | Biochim. Biophys. Acta | pmid:12667605 |
| Balboa MA et al. | Amplification mechanisms of inflammation: paracrine stimulation of arachidonic acid mobilization by secreted phospholipase A2 is regulated by cytosolic phospholipase A2-derived hydroperoxyeicosatetraenoic acid. | 2003 | J. Immunol. | pmid:12847271 |
| Moghaddami N et al. | Unique effect of arachidonic acid on human neutrophil TNF receptor expression: up-regulation involving protein kinase C, extracellular signal-regulated kinase, and phospholipase A2. | 2003 | J. Immunol. | pmid:12928414 |
| Baker LM and Poole LB | Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61. | 2003 | J. Biol. Chem. | pmid:12514184 |
| Cavalieri B et al. | Ischaemic preconditioning modulates the activity of Kupffer cells during in vivo reperfusion injury of rat liver. | 2003 | Cell Biochem. Funct. | pmid:14624466 |
| Yin H et al. | Formation of isoprostane bicyclic endoperoxides from the autoxidation of cholesteryl arachidonate. | 2002 | J. Am. Chem. Soc. | pmid:12083928 |
| Kalyankrishna S et al. | Arachidonic acid-derived oxidation products initiate apoptosis in vascular smooth muscle cells. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428675 |
| Prabhu KS et al. | Microsomal glutathione S-transferase A1-1 with glutathione peroxidase activity from sheep liver: molecular cloning, expression and characterization. | 2001 | Biochem. J. | pmid:11716762 |
| Piomelli D | The ligand that came from within. | 2001 | Trends Pharmacol. Sci. | pmid:11165666 |
| Hwang SW et al. | Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10823958 |
| Navab M et al. | Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1. | 2000 | J. Lipid Res. | pmid:10974056 |
| Navab M et al. | Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3. | 2000 | J. Lipid Res. | pmid:10974057 |
| O'Donnell VB et al. | Catalytic consumption of nitric oxide by prostaglandin H synthase-1 regulates platelet function. | 2000 | J. Biol. Chem. | pmid:10993875 |
| d'Ischia M et al. | Interactions of nitric oxide with lipid peroxidation products under aerobic conditions: inhibitory effects on the formation of malondialdehyde and related thiobarbituric acid-reactive substances. | 2000 | Nitric Oxide | pmid:10733868 |
| Cao YZ et al. | Altered eicosanoid biosynthesis in selenium-deficient endothelial cells. | 2000 | Free Radic. Biol. Med. | pmid:10699749 |
| Wu G et al. | A mechanistic study of self-inactivation of the peroxidase activity in prostaglandin H synthase-1. | 1999 | J. Biol. Chem. | pmid:10092596 |
| Huang S et al. | Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells. | 1999 | Kidney Int. | pmid:10231436 |
| Whalen MM et al. | Lysophosphatidylcholine and arachidonic acid are required in the cytotoxic response of human natural killer cells to tumor target cells. | 1999 | Cell. Physiol. Biochem. | pmid:10749996 |
| Tsai Al et al. | Structural characterization of arachidonyl radicals formed by prostaglandin H synthase-2 and prostaglandin H synthase-1 reconstituted with mangano protoporphyrin IX. | 1998 | J. Biol. Chem. | pmid:9461572 |
| Pfister SL et al. | Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta. | 1998 | J. Biol. Chem. | pmid:9812980 |
| Kato Y and Osawa T | Detection of oxidized phospholipid-protein adducts using anti-15-hydroperoxyeicosatetraenoic acid-modified protein antibody: contribution of esterified fatty acid-protein adduct to oxidative modification of LDL. | 1998 | Arch. Biochem. Biophys. | pmid:9500842 |
| Maccarrone M et al. | Lipoxygenase products induce ultraweak light emission from human erythroleukemia cells. | 1997 Nov-Dec | J. Biolumin. Chemilumin. | pmid:9509336 |
| Calzada C et al. | Low concentrations of lipid hydroperoxides prime human platelet aggregation specifically via cyclo-oxygenase activation. | 1997 | Biochem. J. | pmid:9230133 |
| Riccio MM et al. | The effect of 15-HPETE on airway responsiveness and pulmonary cell recruitment in rabbits. | 1997 | Br. J. Pharmacol. | pmid:9313932 |
| Augustin AJ et al. | Detection of eicosanoids in epiretinal membranes of patients suffering from proliferative vitreoretinal diseases. | 1997 | Br J Ophthalmol | pmid:9135410 |
| Tsai Al et al. | Comparison of peroxidase reaction mechanisms of prostaglandin H synthase-1 containing heme and mangano protoporphyrin IX. | 1997 | J. Biol. Chem. | pmid:9083007 |
| Grechkin AN et al. | On the mechanism of biosynthesis of divinyl ether oxylipins by enzyme from garlic bulbs. | 1997 | Eur. J. Biochem. | pmid:9128734 |
| Foley TD | 5-HPETE is a potent inhibitor of neuronal Na+, K(+)-ATPase activity. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9199200 |
| Ferrante JV et al. | Altered responses of human macrophages to lipopolysaccharide by hydroperoxy eicosatetraenoic acid, hydroxy eicosatetraenoic acid, and arachidonic acid. Inhibition of tumor necrosis factor production. | 1997 | J. Clin. Invest. | pmid:9077554 |
| Landino LM et al. | Mutational analysis of the role of the distal histidine and glutamine residues of prostaglandin-endoperoxide synthase-2 in peroxidase catalysis, hydroperoxide reduction, and cyclooxygenase activation. | 1997 | J. Biol. Chem. | pmid:9261177 |
| Landino LM and Marnett LJ | Mechanism of hydroperoxide reduction by mangano-prostaglandin endoperoxide synthase. | 1996 | Biochemistry | pmid:8611568 |
| Kühn H | Biosynthesis, metabolization and biological importance of the primary 15-lipoxygenase metabolites 15-hydro(pero)XY-5Z,8Z,11Z,13E-eicosatetraenoic acid and 13-hydro(pero)XY-9Z,11E-octadecadienoic acid. | 1996 | Prog. Lipid Res. | pmid:9082450 |
| Van Diest MJ et al. | Influence of hypercholesterolaemia on the reactivity of isolated rabbit arteries to 15-lipoxygenase metabolites of arachidonic acid: comparison with platelet-derived agents and vasodilators. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8848433 |
| Rao GN et al. | Role of hydroperoxyeicosatetraenoic acids in oxidative stress-induced activating protein 1 (AP-1) activity. | 1996 | J. Biol. Chem. | pmid:8910370 |
| Tang DG et al. | Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8643560 |
| Yamazaki T et al. | 15-lipoxygenase metabolite(s) of arachidonic acid mediates adrenocorticotropin action in bovine adrenal steroidogenesis. | 1996 | Endocrinology | pmid:8770885 |
| Kishimoto K et al. | Suicide inactivation of porcine leukocyte 12-lipoxygenase associated with its incorporation of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid derivative. | 1996 | Biochim. Biophys. Acta | pmid:8608163 |
| Sandstrom PA et al. | Lipid hydroperoxide-induced apoptosis: lack of inhibition by Bcl-2 over-expression. | 1995 | FEBS Lett. | pmid:7774717 |
| Björnstedt M et al. | Human thioredoxin reductase directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols. | 1995 | J. Biol. Chem. | pmid:7744824 |
| Terao J et al. | Effects of rat bile-pancreatic juice on Fe2+ induced peroxidation of phospholipids. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7765976 |
| Bates EJ et al. | Inhibitory effects of arachidonic acid (20:4,n-6) and its monohydroperoxy- and hydroxy-metabolites on procoagulant activity in endothelial cells. | 1995 | Atherosclerosis | pmid:7488327 |
| Iliou JP et al. | Monohydroperoxidized fatty acids but not 4-hydroxynonenal induced acute cardiac cell damage. | 1995 | Free Radic. Biol. Med. | pmid:8582650 |
| Matsuda H et al. | Pharmacodynamics of 15(S)-hydroperoxyeicosatetraenoic (15-HPETE) and 15(S)-hydroxyeicosatetraenoic acid (15-HETE) in isolated arteries from guinea pig, rabbit, rat and human. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7791089 |
| MacMillan DK et al. | Eosinophil 15-lipoxygenase is a leukotriene A4 synthase. | 1994 | J. Biol. Chem. | pmid:7929400 |
| Bourdeau A et al. | Effects of lipoxygenase products of arachidonate metabolism on parathyroid hormone secretion. | 1994 | Endocrinology | pmid:8070353 |
| Sandstrom PA et al. | Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency. | 1994 | J. Biol. Chem. | pmid:8288627 |
| Kodaman PH et al. | Lipid hydroperoxides evoke antigonadotropic and antisteroidogenic activity in rat luteal cells. | 1994 | Endocrinology | pmid:7988463 |
| Vaidyanathan VV and Sastry PS | Preparation of hydroperoxy fatty acids. | 1994 | Anal. Biochem. | pmid:8080099 |
| Tebbey PW and Buttke TM | Independent arachidonic acid-mediated gene regulatory pathways in lymphocytes. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8102055 |
| Calzada C and Rice-Evans C | Ruptured erythrocytes inhibit the oxidation of membranes by 15-hydroperoxy-eicosatetraenoic acid. | 1993 | FEBS Lett. | pmid:8354383 |
| Mochizuki-Oda N et al. | Arachidonic acid activates cation channels in bovine adrenal chromaffin cells. | 1993 | J. Neurochem. | pmid:7693870 |
| Kühn H et al. | Overexpression, purification and characterization of human recombinant 15-lipoxygenase. | 1993 | Biochim. Biophys. Acta | pmid:8334154 |
| Van Diest MJ et al. | Vascular interaction between 5-hydroxytryptamine and 15-lipoxygenase metabolites of arachidonic acid. | 1993 | Eur. J. Pharmacol. | pmid:8453981 |
| Kiran Kumar YV et al. | Differential effects of 15-HPETE and 15-HETE on BHK-21 cell proliferation and macromolecular composition. | 1993 | Biochim. Biophys. Acta | pmid:8384883 |
| Mack SR et al. | The human sperm acrosome reaction does not depend on arachidonic acid metabolism via the cyclooxygenase and lipoxygenase pathways. | 1992 Nov-Dec | J. Androl. | pmid:1338069 |
| Uski TK and Högestätt ED | Effects of various cyclooxygenase and lipoxygenase metabolites on guinea-pig cerebral arteries. | 1992 | Gen. Pharmacol. | pmid:1592217 |
| Hosni M et al. | Diethyldithiocarbamate (ditiocarb sodium) effect on arachidonic acid metabolism in human mononuclear cells. Glutathione peroxidase-like activity. | 1992 | Biochem. Pharmacol. | pmid:1314059 |
| Henrich WL et al. | Inhibition of renin secretion from rat renal cortical slices by (R)-12-HETE. | 1992 | Am. J. Physiol. | pmid:1415738 |
| McDonald PP et al. | Activation of the human neutrophil 5-lipoxygenase by leukotriene B4. | 1992 | Br. J. Pharmacol. | pmid:1330161 |
| Iwahashi H et al. | Radical adducts of nitrosobenzene and 2-methyl-2-nitrosopropane with 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical. Identification by h.p.l.c.-e.p.r. and liquid chromatography-thermospray-m.s. | 1991 | Biochem. J. | pmid:1646600 |
| Force T et al. | Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores. | 1991 | J. Biol. Chem. | pmid:1900289 |
| Van Diest MJ et al. | 15-lipoxygenase metabolites of arachidonic acid evoke contractions and relaxations in isolated canine arteries: role of thromboxane receptors, endothelial cells and cyclooxygenase. | 1991 | J. Pharmacol. Exp. Ther. | pmid:1824864 |
| Murota S et al. | The control of vascular endothelial cell injury. | 1990 | Ann. N. Y. Acad. Sci. | pmid:2248437 |
| Weitberg AB | Hydroxy- and hydroperoxy-6,8,11,14-eicosatetraenoic acids induce sister chromatid exchanges in cultured mammalian cells. | 1990 | Am. J. Med. Sci. | pmid:2105055 |
| Andrianarison RH et al. | Positional specificity of a Lupinus albus lipoxygenase in relation to enzyme concentration and effect of a double dioxygenation product of arachidonic acid. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2123103 |
| Kim MR et al. | Inactivation of potato lipoxygenase by hydroperoxy acids as suicide substrates. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2511843 |
| McColl SR et al. | Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic acid: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins. | 1989 | Br. J. Pharmacol. | pmid:2507084 |
| Smith CV and Reilly MH | Formation of pentane versus 1-pentanol in the ferrous sulfate-initiated decomposition of 15-hydroperoxyeicosatetraenoic acid in hypoxic and hyperoxic conditions. | 1989 | Biochem. Pharmacol. | pmid:2706024 |
| Garrick R et al. | Transformation of leukotriene A4 to lipoxins by rat kidney mesangial cell. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2547366 |
| Pace-Asciak CR and Asotra S | Biosynthesis, catabolism, and biological properties of HPETEs, hydroperoxide derivatives of arachidonic acid. | 1989 | Free Radic. Biol. Med. | pmid:2514125 |
| Ng CF et al. | Agonist-dependent generation of lipoxins from rat basophilic leukemia cell (RBL-1). | 1989 | Biochim. Biophys. Acta | pmid:2503031 |
| Wang J et al. | Stimulation of progesterone and prostaglandin E2 production by lipoxygenase metabolites of arachidonic acid. | 1989 | FEBS Lett. | pmid:2494061 |
| Najid A et al. | Cytotoxicity of arachidonic acid and of its lipoxygenase metabolite 15-hydroperoxyeicosatetraenoic acid on human breast cancer MCF-7 cells in culture. | 1989 | Cancer Lett. | pmid:2502308 |
| Raza H et al. | Specific high affinity binding of lipoxygenase metabolites of arachidonic acid by liver fatty acid binding protein. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2500117 |
| Chansel D et al. | Modulation of renin synthesis by lipoxygenase products in cultured human mesangial cells. | 1989 | Mol. Cell. Endocrinol. | pmid:2545491 |
| Ueda N and Yamamoto S | The 6R-oxygenase activity of arachidonate 5-lipoxygenase purified from porcine leukocytes. | 1988 | J. Biol. Chem. | pmid:3338999 |
| Vedelago HR and Mahadevappa VG | Differential effects of 15-HPETE on arachidonic acid metabolism in collagen-stimulated human platelets. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3122753 |
| Goodwin JS and Behrens T | Role of lipoxygenase metabolites of arachidonic acid in T cell activation. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837956 |
| Vanderhoek JY | Role of the 15-lipoxygenase in the immune system. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3132881 |
| Reynolds CH | Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. | 1988 | Biochem. Pharmacol. | pmid:3144281 |
| Fruteau de Laclos B and Borgeat P | Conditions for the formation of the oxo derivatives of arachidonic acid from platelet 12-lipoxygenase and soybean 15-lipoxygenase. | 1988 | Biochim. Biophys. Acta | pmid:3124882 |
| Bordet JC et al. | Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. | 1988 | Biochim. Biophys. Acta | pmid:3124885 |