15-hpete

15-hpete is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 724 references associated with 15-hpete in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 15-hpete

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-hpete

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Total 1

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Authors Title Published Journal PubMed Link
Vedelago HR and Mahadevappa VG Differential effects of 15-HPETE on arachidonic acid metabolism in collagen-stimulated human platelets. 1988 Biochem. Biophys. Res. Commun. pmid:3122753
Goodwin JS and Behrens T Role of lipoxygenase metabolites of arachidonic acid in T cell activation. 1988 Ann. N. Y. Acad. Sci. pmid:2837956
Vanderhoek JY Role of the 15-lipoxygenase in the immune system. 1988 Ann. N. Y. Acad. Sci. pmid:3132881
Fruteau de Laclos B and Borgeat P Conditions for the formation of the oxo derivatives of arachidonic acid from platelet 12-lipoxygenase and soybean 15-lipoxygenase. 1988 Biochim. Biophys. Acta pmid:3124882
Bordet JC et al. Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. 1988 Biochim. Biophys. Acta pmid:3124885
Uotila P et al. Relaxing effects of 15-lipoxygenase products of arachidonic acid on rat aorta. 1987 J. Pharmacol. Exp. Ther. pmid:3116200
Hecker M et al. Preparative HPLC purification of prostaglandin endoperoxides and isolation of novel cyclooxygenase-derived arachidonic acid metabolites. 1987 Biochem. Pharmacol. pmid:3105538
Gut J et al. Quantification of 5- and 15-HPETE's by direct chemical ionization mass spectrometry. 1987 Free Radic. Biol. Med. pmid:3319797
Markey CM et al. Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities. 1987 J. Biol. Chem. pmid:3106353
Kulmacz RJ et al. Heme spin states and peroxide-induced radical species in prostaglandin H synthase. 1987 J. Biol. Chem. pmid:3038886
Antonipillai I et al. The inhibitory role of 12- and 15-lipoxygenase products on renin release. 1987 Hypertension pmid:3298043
Weiss RH et al. Transformation of an arachidonic acid hydroperoxide into epoxyhydroxy and trihydroxy fatty acids by liver microsomal cytochrome P-450. 1987 Arch. Biochem. Biophys. pmid:3813540
Dahlén SE et al. Biological activities of lipoxin A include lung strip contraction and dilation of arterioles in vivo. 1987 Acta Physiol. Scand. pmid:3630737
Gryglewski RJ et al. On the mechanism of antithrombotic action of flavonoids. 1987 Biochem. Pharmacol. pmid:3101704
Thomas G and Ramwell P Induction of vascular relaxation by hydroperoxides. 1986 Biochem. Biophys. Res. Commun. pmid:3021120
Gerzer R et al. Activation of soluble guanylate cyclase by arachidonic acid and 15-lipoxygenase products. 1986 Biochim. Biophys. Acta pmid:2871867
Kanofsky JR Singlet oxygen production by bleomycin. A comparison with heme-containing compounds. 1986 J. Biol. Chem. pmid:2428818
Hamberg M et al. Novel biological transformations of 15-Ls-hydroperoxy-5,8,11,13-eicosatetraenoic acid. 1986 Biochim. Biophys. Acta pmid:3089290
Eling TE et al. Oxidation of glutathione to its thiyl free radical metabolite by prostaglandin H synthase. A potential endogenous substrate for the hydroperoxidase. 1986 J. Biol. Chem. pmid:3007487
Van Diest MJ et al. Cyclo-oxygenase blockers influence the effects of 15-lipoxygenase metabolites of arachidonic acid in isolated canine blood vessels. 1986 Prostaglandins pmid:3094100
Serhan CN et al. On the stereochemistry and biosynthesis of lipoxin B. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3083410
Ueda N et al. Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids. 1986 J. Biol. Chem. pmid:3086322
Rouzer CA and Samuelsson B The importance of hydroperoxide activation for the detection and assay of mammalian 5-lipoxygenase. 1986 FEBS Lett. pmid:3089841
Mayer B et al. Possible inhibitory function of endogenous 15-hydroperoxyeicosatetraenoic acid on prostacyclin formation in bovine aortic endothelial cells. 1986 Biochim. Biophys. Acta pmid:3081039
Esterbauer H et al. Studies on the mechanism of formation of 4-hydroxynonenal during microsomal lipid peroxidation. 1986 Biochim. Biophys. Acta pmid:3081043
Humes JL et al. Regulation of macrophage eicosanoid production by hydroperoxy-and hydroxy-eicosatetraenoic acids. 1986 Biochem. J. pmid:3082323
Kontos HA George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury. 1985 Circ. Res. pmid:2994903
Fitzsimmons BJ et al. The lipoxins. Stereochemical identification and determination of their biosynthesis. 1985 J. Biol. Chem. pmid:2997152
Lundberg U et al. Appearance of an arachidonic acid 15-lipoxygenase pathway upon differentiation of the human promyelocytic cell-line HL-60. 1985 FEBS Lett. pmid:3922792
Gualde N et al. Induction of suppressor cells from peripheral blood T cells by 15-hydroperoxyeicosatetraenoic acid (15-HPETE). 1985 J. Immunol. pmid:2931484
Johnson HG et al. 15-Hydroxyeicosatetraenoic acid is a potent inflammatory mediator and agonist of canine tracheal mucus secretion. 1985 Am. Rev. Respir. Dis. pmid:3923884
Brash AR et al. Investigation of the selectivity of hydrogen abstraction in the nonenzymatic formation of hydroxyeicosatetraenoic acids and leukotrienes by autoxidation. 1985 J. Biol. Chem. pmid:2984196
Takahashi M et al. Vascular effects of 15-hydroperoxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid on canine arteries. 1985 Jpn. J. Pharmacol. pmid:3925206
Bryant RW et al. Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4. 1985 J. Biol. Chem. pmid:2982864
Maas RL et al. Investigation of the chemical conversion of hydroperoxyeicosatetraenoate to leukotriene epoxide using stereospecifically labeled arachidonic acid. Comparison with the enzymatic reaction. 1985 J. Biol. Chem. pmid:2984197
Eling TE et al. The formation of aminopyrine cation radical by the peroxidase activity of prostaglandin H synthase and subsequent reactions of the radical. 1985 J. Biol. Chem. pmid:3918042
Lanefelt F and Martinsson A Ethanol dependent interaction between prostaglandins and lipoxygenase products in human peripheral lymphocytes. 1985 Acta Pharmacol Toxicol (Copenh) pmid:2986412
Gualde N et al. Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T cells and T cell subsets. 1985 J. Immunol. pmid:2981258
Koide T et al. Alterations of the eicosanoid synthetic capacity of rat brain microvessels following ischemia: relevance to ischemic brain edema. 1985 J. Neurochem. pmid:3964837
Suzuki Y et al. Gamma-aminobutyric acid-induced contraction of the dog basilar artery. 1984 Pharmacology pmid:6463098
Trudell JR et al. Hypoxia potentiates killing of hepatocyte monolayers by leukotrienes, hydroperoxyeicosatetraenoic acids, or calcium ionophore A23187. 1984 Biochim. Biophys. Acta pmid:6322862
McCarty M Can dietary selenium reduce leukotriene production? 1984 Med. Hypotheses pmid:6323934
Iwaoka T and Tabata F Chemiluminescent assay of lipid peroxide in plasma using cytochrome c heme peptide. 1984 FEBS Lett. pmid:6500062
Marnett LJ et al. Mechanism of the stimulation of prostaglandin H synthase and prostacyclin synthase by the antithrombotic and antimetastatic agent, nafazatrom. 1984 Mol. Pharmacol. pmid:6434940
Brash AR et al. On the mechanism of biosynthesis of 5- and 15-series leukotrienes. 1984 J. Allergy Clin. Immunol. pmid:6088609
Christman CW et al. Effects of 15-hydroperoxy-eicosatetraenoic acid (15-HPETE) on cerebral arterioles of cats. 1984 Am. J. Physiol. pmid:6437243
Bösterling B and Trudell JR Production of 5- and 15-hydroperoxyeicosatetraenoic acid from arachidonic acid by halothane-free radicals generated by UV-irradiation. 1984 Anesthesiology pmid:6696254
RÃ¥dmark O et al. Hemoprotein catalysis of leukotriene formation. 1984 Biochim. Biophys. Acta pmid:6696937
Hopkins NK et al. Biosynthesis and metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid by human umbilical vein endothelial cells. 1984 J. Biol. Chem. pmid:6438089
Serhan CN et al. Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes. 1984 Biochem. Biophys. Res. Commun. pmid:6422933
Sok DE et al. Mechanisms of leukotriene formation: hemoglobin-catalyzed transformation of 15-HPETE into 8,15-DiHETE and 14,15-DiHETE isomers. 1983 Biochem. Biophys. Res. Commun. pmid:6301444
Maas RL and Brash AR Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytes. 1983 Proc. Natl. Acad. Sci. U.S.A. pmid:6304687
Elhai J and Scandella CJ Arachidonic acid and other fatty acids inhibit secretion from sea urchin eggs. 1983 Exp. Cell Res. pmid:6414832
Walters FP et al. Oxidation of myoglobin in isolated adult rat cardiac myocytes by 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid. 1983 FEBS Lett. pmid:6641945
Davies JA and Menys VC Effect of dazoxiben on platelet-vessel wall interaction. 1983 Br J Clin Pharmacol pmid:6681703
Furukawa K et al. The restorative action of coenzyme Q10 in 2,4-dinitrophenol-depressed electrical and contractile activities of guinea-pig heart. 1983 J. Mol. Cell. Cardiol. pmid:6355490
Folkerts G et al. Induction in guinea-pigs of airway hyperreactivity and decreased lung beta-adrenoceptor number by 15-hydroperoxy-arachidonic acid. 1983 Br. J. Pharmacol. pmid:6100841
Kent RS et al. Regulation of vascular prostaglandin synthesis by metabolites of arachidonic acid in perfused rabbit aorta. 1983 J. Clin. Invest. pmid:6409932
Beetens JR and Herman AG Vitamin C increases the formation of prostacyclin by aortic rings from various species and neutralizes the inhibitory effect of 15-hydroperoxy-arachidonic acid. 1983 Br. J. Pharmacol. pmid:6360278
Sok DE et al. Enzymatic formation of 14,15-leukotriene A and C(14)-sulfur-linked peptides. 1982 Biochem. Biophys. Res. Commun. pmid:6280711
Capdevila J et al. Cytochrome P-450-dependent oxygenation of arachidonic acid to hydroxyicosatetraenoic acids. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6801662
Vanderhoek JY et al. Regulation of leukocyte and platelet lipoxygenases by hydroxyeicosanoids. 1982 Biochem. Pharmacol. pmid:6816247
Nagy L et al. Complement receptor enhancement and chemotaxis of human neutrophils and eosinophils by leukotrienes and other lipoxygenase products. 1982 Clin. Exp. Immunol. pmid:6282507
Bryant RW et al. Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid. 1982 J. Biol. Chem. pmid:6804460
Koide T et al. Possible mechanisms of 15-hydroperoxyarachidonic acid-induced contraction of the canine basilar artery in vitro. 1982 J. Pharmacol. Exp. Ther. pmid:6804622
Lagarde M et al. Inhibition of thrombin-induced platelet arachidonic acid release by 15-hydroperoxy-arachidonic acid. 1981 Biochem. Biophys. Res. Commun. pmid:7259783
Higgs GA et al. The inflammatory effects of hydroperoxy and hydroxy acid products of arachidonate lipoxygenase in rabbit skin. 1981 Br. J. Pharmacol. pmid:6274465
Naccache PH et al. Mono- and dihydroxyeicosatetraenoic acids alter calcium homeostasis in rabbit neutrophils. 1981 J. Clin. Invest. pmid:6262382
Siegel MI Effect of non-steroidal anti-inflammatory drugs on arachidonic acid metabolism. 1981 Headache pmid:6796546
Patrono C and Pugliese F The involvement of arachidonic acid metabolism in the control of renin release. 1980 Apr-Jun J. Endocrinol. Invest. pmid:6993550
Hong SL et al. Tranylcypromine and 15-hydroperoxyarachidonate affect arachidonic acid release in addition to inhibition of prostacyclin synthesis in calf aortic endothelial cells. 1980 J. Biol. Chem. pmid:6776101
Kobayashi M et al. [Effects of 15-hydroperoxy arachidonic acid and non-purified hydroperoxides from arachidonic acid to rabbit blood vessels (author's transl)]. 1980 Nihon Ronen Igakkai Zasshi pmid:7373935
Goetzl EJ et al. Unique aspects of the modulation of human neutrophil function by 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid. 1980 Prostaglandins pmid:6247746
Trachte GJ et al. Potent constriction of cat coronary arteries by hydroperoxides of arachidonic acid and its blockade by anti-inflammatory agents. 1979 Prostaglandins pmid:547310
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