15-hpete

15-hpete is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 724 references associated with 15-hpete in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for 15-hpete

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with 15-hpete

MeSH term MeSH ID Detail
Hypertension D006973 115 associated lipids
Total 1

NCBI Entrez Crosslinks

All references with 15-hpete

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Authors Title Published Journal PubMed Link
Landino LM and Marnett LJ Mechanism of hydroperoxide reduction by mangano-prostaglandin endoperoxide synthase. 1996 Biochemistry pmid:8611568
Van Diest MJ et al. Influence of hypercholesterolaemia on the reactivity of isolated rabbit arteries to 15-lipoxygenase metabolites of arachidonic acid: comparison with platelet-derived agents and vasodilators. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8848433
Rao GN et al. Role of hydroperoxyeicosatetraenoic acids in oxidative stress-induced activating protein 1 (AP-1) activity. 1996 J. Biol. Chem. pmid:8910370
Tang DG et al. Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8643560
Kishimoto K et al. Suicide inactivation of porcine leukocyte 12-lipoxygenase associated with its incorporation of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid derivative. 1996 Biochim. Biophys. Acta pmid:8608163
Sandstrom PA et al. Lipid hydroperoxide-induced apoptosis: lack of inhibition by Bcl-2 over-expression. 1995 FEBS Lett. pmid:7774717
Björnstedt M et al. Human thioredoxin reductase directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols. 1995 J. Biol. Chem. pmid:7744824
Terao J et al. Effects of rat bile-pancreatic juice on Fe2+ induced peroxidation of phospholipids. 1995 Biosci. Biotechnol. Biochem. pmid:7765976
Bates EJ et al. Inhibitory effects of arachidonic acid (20:4,n-6) and its monohydroperoxy- and hydroxy-metabolites on procoagulant activity in endothelial cells. 1995 Atherosclerosis pmid:7488327
Iliou JP et al. Monohydroperoxidized fatty acids but not 4-hydroxynonenal induced acute cardiac cell damage. 1995 Free Radic. Biol. Med. pmid:8582650
Matsuda H et al. Pharmacodynamics of 15(S)-hydroperoxyeicosatetraenoic (15-HPETE) and 15(S)-hydroxyeicosatetraenoic acid (15-HETE) in isolated arteries from guinea pig, rabbit, rat and human. 1995 J. Pharmacol. Exp. Ther. pmid:7791089
MacMillan DK et al. Eosinophil 15-lipoxygenase is a leukotriene A4 synthase. 1994 J. Biol. Chem. pmid:7929400
Bourdeau A et al. Effects of lipoxygenase products of arachidonate metabolism on parathyroid hormone secretion. 1994 Endocrinology pmid:8070353
Sandstrom PA et al. Lipid hydroperoxides induce apoptosis in T cells displaying a HIV-associated glutathione peroxidase deficiency. 1994 J. Biol. Chem. pmid:8288627
Kodaman PH et al. Lipid hydroperoxides evoke antigonadotropic and antisteroidogenic activity in rat luteal cells. 1994 Endocrinology pmid:7988463
Vaidyanathan VV and Sastry PS Preparation of hydroperoxy fatty acids. 1994 Anal. Biochem. pmid:8080099
Tebbey PW and Buttke TM Independent arachidonic acid-mediated gene regulatory pathways in lymphocytes. 1993 Biochem. Biophys. Res. Commun. pmid:8102055
Calzada C and Rice-Evans C Ruptured erythrocytes inhibit the oxidation of membranes by 15-hydroperoxy-eicosatetraenoic acid. 1993 FEBS Lett. pmid:8354383
Mochizuki-Oda N et al. Arachidonic acid activates cation channels in bovine adrenal chromaffin cells. 1993 J. Neurochem. pmid:7693870
Kühn H et al. Overexpression, purification and characterization of human recombinant 15-lipoxygenase. 1993 Biochim. Biophys. Acta pmid:8334154
Van Diest MJ et al. Vascular interaction between 5-hydroxytryptamine and 15-lipoxygenase metabolites of arachidonic acid. 1993 Eur. J. Pharmacol. pmid:8453981
Kiran Kumar YV et al. Differential effects of 15-HPETE and 15-HETE on BHK-21 cell proliferation and macromolecular composition. 1993 Biochim. Biophys. Acta pmid:8384883
Mack SR et al. The human sperm acrosome reaction does not depend on arachidonic acid metabolism via the cyclooxygenase and lipoxygenase pathways. 1992 Nov-Dec J. Androl. pmid:1338069
Uski TK and Högestätt ED Effects of various cyclooxygenase and lipoxygenase metabolites on guinea-pig cerebral arteries. 1992 Gen. Pharmacol. pmid:1592217
Hosni M et al. Diethyldithiocarbamate (ditiocarb sodium) effect on arachidonic acid metabolism in human mononuclear cells. Glutathione peroxidase-like activity. 1992 Biochem. Pharmacol. pmid:1314059
Henrich WL et al. Inhibition of renin secretion from rat renal cortical slices by (R)-12-HETE. 1992 Am. J. Physiol. pmid:1415738
McDonald PP et al. Activation of the human neutrophil 5-lipoxygenase by leukotriene B4. 1992 Br. J. Pharmacol. pmid:1330161
Iwahashi H et al. Radical adducts of nitrosobenzene and 2-methyl-2-nitrosopropane with 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical. Identification by h.p.l.c.-e.p.r. and liquid chromatography-thermospray-m.s. 1991 Biochem. J. pmid:1646600
Force T et al. Noncyclooxygenase metabolites of arachidonic acid amplify the vasopressin-induced Ca2+ signal in glomerular mesangial cells by releasing Ca2+ from intracellular stores. 1991 J. Biol. Chem. pmid:1900289
Van Diest MJ et al. 15-lipoxygenase metabolites of arachidonic acid evoke contractions and relaxations in isolated canine arteries: role of thromboxane receptors, endothelial cells and cyclooxygenase. 1991 J. Pharmacol. Exp. Ther. pmid:1824864
Murota S et al. The control of vascular endothelial cell injury. 1990 Ann. N. Y. Acad. Sci. pmid:2248437
Weitberg AB Hydroxy- and hydroperoxy-6,8,11,14-eicosatetraenoic acids induce sister chromatid exchanges in cultured mammalian cells. 1990 Am. J. Med. Sci. pmid:2105055
Andrianarison RH et al. Positional specificity of a Lupinus albus lipoxygenase in relation to enzyme concentration and effect of a double dioxygenation product of arachidonic acid. 1990 Biochem. Biophys. Res. Commun. pmid:2123103
Kim MR et al. Inactivation of potato lipoxygenase by hydroperoxy acids as suicide substrates. 1989 Biochem. Biophys. Res. Commun. pmid:2511843
McColl SR et al. Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic acid: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins. 1989 Br. J. Pharmacol. pmid:2507084
Smith CV and Reilly MH Formation of pentane versus 1-pentanol in the ferrous sulfate-initiated decomposition of 15-hydroperoxyeicosatetraenoic acid in hypoxic and hyperoxic conditions. 1989 Biochem. Pharmacol. pmid:2706024
Garrick R et al. Transformation of leukotriene A4 to lipoxins by rat kidney mesangial cell. 1989 Biochem. Biophys. Res. Commun. pmid:2547366
Pace-Asciak CR and Asotra S Biosynthesis, catabolism, and biological properties of HPETEs, hydroperoxide derivatives of arachidonic acid. 1989 Free Radic. Biol. Med. pmid:2514125
Ng CF et al. Agonist-dependent generation of lipoxins from rat basophilic leukemia cell (RBL-1). 1989 Biochim. Biophys. Acta pmid:2503031
Wang J et al. Stimulation of progesterone and prostaglandin E2 production by lipoxygenase metabolites of arachidonic acid. 1989 FEBS Lett. pmid:2494061
Najid A et al. Cytotoxicity of arachidonic acid and of its lipoxygenase metabolite 15-hydroperoxyeicosatetraenoic acid on human breast cancer MCF-7 cells in culture. 1989 Cancer Lett. pmid:2502308
Raza H et al. Specific high affinity binding of lipoxygenase metabolites of arachidonic acid by liver fatty acid binding protein. 1989 Biochem. Biophys. Res. Commun. pmid:2500117
Chansel D et al. Modulation of renin synthesis by lipoxygenase products in cultured human mesangial cells. 1989 Mol. Cell. Endocrinol. pmid:2545491
Sakai K et al. 12-Hydroperoxyeicosatetraenoic acid (12-HPETE) and 15-HPETE stimulate melatonin synthesis in rat pineals. 1988 Prostaglandins pmid:3187058
Ueda N and Yamamoto S The 6R-oxygenase activity of arachidonate 5-lipoxygenase purified from porcine leukocytes. 1988 J. Biol. Chem. pmid:3338999
Shimizu T et al. Activation of the arachidonate 5-lipoxygenase pathway in the canine basilar artery after experimental subarachnoidal hemorrhage. 1988 J. Neurochem. pmid:2843605
Rabier M et al. 15-Lipoxygenase products stimulate prolactin secretion from a cloned strain of rat pituitary cells. 1988 Neuroendocrinology pmid:3131692
Cashman JR et al. Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids. 1988 Biochem. Biophys. Res. Commun. pmid:3415693
Marshall PJ and Kulmacz RJ Prostaglandin H synthase: distinct binding sites for cyclooxygenase and peroxidase substrates. 1988 Arch. Biochem. Biophys. pmid:3140729
Reynolds CH Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. 1988 Biochem. Pharmacol. pmid:3144281