Ingenol 3-angelate

Ingenol 3-angelate is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 455 references associated with Ingenol 3-angelate in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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All references with Ingenol 3-angelate

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Authors Title Published Journal PubMed Link
pmid:
Ogbourne SM et al. Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death. 2004 Cancer Res. pmid:15087400
Gillespie SK et al. Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells. 2004 Mol. Cancer Ther. pmid:15634659
Hampson P et al. PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. 2005 Blood pmid:15845901
Cozzi SJ et al. Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway. 2006 Cancer Res. pmid:17047072
Challacombe JM et al. Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate. 2006 J. Immunol. pmid:17114487
pmid:17115221
pmid:17264770
pmid:18265980
Serova M et al. Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells. 2008 Mol. Cancer Ther. pmid:18413805
Benhadji KA et al. Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells. 2008 Br. J. Cancer pmid:19034280
pmid:19178487
pmid:19388934
Ghoul A et al. Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. 2009 Cancer Res. pmid:19417139
pmid:19428919
pmid:19467365
pmid:19922462
Li L et al. The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. 2010 Cancer Res. pmid:20460505
pmid:20467815
Lee WY et al. Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta. 2010 J. Biol. Chem. pmid:20472553

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