| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Ogbourne SM et al. | Antitumor activity of 3-ingenyl angelate: plasma membrane and mitochondrial disruption and necrotic cell death. | 2004 | Cancer Res. | pmid:15087400 |
| Gillespie SK et al. | Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells. | 2004 | Mol. Cancer Ther. | pmid:15634659 |
| Hampson P et al. | PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. | 2005 | Blood | pmid:15845901 |
| Cozzi SJ et al. | Induction of senescence in diterpene ester-treated melanoma cells via protein kinase C-dependent hyperactivation of the mitogen-activated protein kinase pathway. | 2006 | Cancer Res. | pmid:17047072 |
| Challacombe JM et al. | Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate. | 2006 | J. Immunol. | pmid:17114487 |
| pmid:17115221 | ||||
| pmid:17264770 | ||||
| pmid:18265980 | ||||
| Serova M et al. | Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells. | 2008 | Mol. Cancer Ther. | pmid:18413805 |
| Benhadji KA et al. | Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells. | 2008 | Br. J. Cancer | pmid:19034280 |
| pmid:19178487 | ||||
| pmid:19388934 | ||||
| Ghoul A et al. | Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. | 2009 | Cancer Res. | pmid:19417139 |
| pmid:19428919 | ||||
| pmid:19467365 | ||||
| pmid:19922462 | ||||
| Li L et al. | The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. | 2010 | Cancer Res. | pmid:20460505 |
| pmid:20467815 | ||||
| Lee WY et al. | Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta. | 2010 | J. Biol. Chem. | pmid:20472553 |
| pmid:20546215 | ||||
| pmid:21325841 | ||||
| pmid:22055282 | ||||
| Cozzi SJ et al. | Ingenol mebutate field-directed treatment of UVB-damaged skin reduces lesion formation and removes mutant p53 patches. | 2012 | J. Invest. Dermatol. | pmid:22189786 |
| Fallen RS and Gooderham M | Ingenol mebutate: an introduction. | 2012 | Skin Therapy Lett. | pmid:22358305 |
| Lebwohl M et al. | Ingenol mebutate gel for actinic keratosis. | 2012 | N. Engl. J. Med. | pmid:22417254 |
| pmid:22538622 | ||||
| pmid:22618984 | ||||
| pmid:22828167 | ||||
| Cozzi SJ et al. | Effective treatment of squamous cell carcinomas with ingenol mebutate gel in immunologically intact SKH1 mice. | 2013 | Arch. Dermatol. Res. | pmid:22871992 |
| Doan HQ et al. | Ingenol mebutate: potential for further development of cancer immunotherapy. | 2012 | J Drugs Dermatol | pmid:23134979 |
| pmid:23134983 | ||||
| pmid:23228300 | ||||
| pmid:23228305 | ||||
| pmid:23231025 | ||||
| pmid:23302940 | ||||
| pmid:23362492 | ||||
| pmid:23550994 | ||||
| pmid:23553119 | ||||
| pmid:23673300 | ||||
| Song X et al. | RasGRPs are targets of the anti-cancer agent ingenol-3-angelate. | 2013 | PLoS ONE | pmid:23991094 |
| Liang X et al. | Syntheses, biological evaluation and SAR of ingenol mebutate analogues for treatment of actinic keratosis and non-melanoma skin cancer. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23993332 |
| pmid:24005145 | ||||
| pmid:24048430 | ||||
| Edwards SK et al. | N-benzyladriamycin-14-valerate (AD 198) exhibits potent anti-tumor activity on TRAF3-deficient mouse B lymphoma and human multiple myeloma. | 2013 | BMC Cancer | pmid:24131623 |
| pmid:24509965 | ||||
| pmid:24595570 | ||||
| pmid:24742851 | ||||
| pmid:24918567 | ||||
| pmid:25016953 |
Ingenol 3-angelate
Ingenol 3-angelate is a lipid of Fatty Acyls (FA) class.
Cross Reference
