Malonyl-coa

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Current reference collection contains 3249 references associated with Malonyl-coa in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Malonyl-coa

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonyl-coa

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Angina Pectoris D000787 27 associated lipids
Body Weight D001835 333 associated lipids
Cleft Lip D002971 8 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Hyperinsulinism D006946 27 associated lipids
Hypoglycemia D007003 13 associated lipids
Per page 10 20 | Total 20

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Authors Title Published Journal PubMed Link
Swanson ST et al. Roles of the N- and C-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes: insights from expression of chimaeric proteins and mutation of conserved histidine residues. 1998 Biochem. J. pmid:9794789
Saggerson ED and Carpenter CA The effect of malonyl-CoA on overt and latent carnitine acyltransferase activities in rat liver and adipocyte mitochondria. 1983 Biochem. J. pmid:6860313
Kasumov T et al. Probing peroxisomal beta-oxidation and the labelling of acetyl-CoA proxies with [1-(13C)]octanoate and [3-(13C)]octanoate in the perfused rat liver. 2005 Biochem. J. pmid:15773815
Ghadiminejad I and Saggerson ED A study of properties and abundance of the components of liver carnitine palmitoyltransferases in mitochondrial inner and outer membranes. Effects of hypothyroidism, fasting and a ketotic diabetic state. 1991 Biochem. J. pmid:1872797
A'Bháird NN and Ramsay RR Malonyl-CoA inhibition of peroxisomal carnitine octanoyltransferase. 1992 Biochem. J. pmid:1530596
Kolodziej MP and Zammit VA Sensitivity of inhibition of rat liver mitochondrial outer-membrane carnitine palmitoyltransferase by malonyl-CoA to chemical- and temperature-induced changes in membrane fluidity. 1990 Biochem. J. pmid:2268270
McGarry JD et al. Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues. Demonstration of the presence of malonyl-CoA in non-hepatic tissues of the rat. 1983 Biochem. J. pmid:6615466
Baquet A et al. Comparison of the effects of various amino acids on glycogen synthesis, lipogenesis and ketogenesis in isolated rat hepatocytes. 1991 Biochem. J. pmid:1989589
Ramsay RR et al. Carnitine palmitoyltransferase in human erythrocyte membrane. Properties and malonyl-CoA sensitivity. 1991 Biochem. J. pmid:2039446
Ghadiminejad I and Saggerson ED The relationship of rat liver overt carnitine palmitoyltransferase to the mitochondrial malonyl-CoA binding entity and to the latent palmitoyltransferase. 1990 Biochem. J. pmid:2241911
Buckley MG and Rath EA Regulation of fatty acid synthesis and malonyl-CoA content in mouse brown adipose tissue in response to cold-exposure, starvation or re-feeding. 1987 Biochem. J. pmid:2888457
Cook GA et al. Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats. 1980 Biochem. J. pmid:7236248
Ontko JA and Johns ML Evaluation of malonyl-CoA in the regulation of long-chain fatty acid oxidation in the liver. Evidence for an unidentified regulatory component of the system. 1980 Biochem. J. pmid:7236249
Kashfi K and Cook GA Proteinase treatment of intact hepatic mitochondria has differential effects on inhibition of carnitine palmitoyltransferase by different inhibitors. 1992 Biochem. J. pmid:1554374
Jordan BR and Harwood JL Fatty acid elongation by a particulate fraction from germinating pea. 1980 Biochem. J. pmid:7283974
Schofield PS et al. Altered interactions between lipogenesis and fatty acid oxidation in regenerating rat liver. 1987 Biochem. J. pmid:3593202
Zierz S and Engel AG Different sites of inhibition of carnitine palmitoyltransferase by malonyl-CoA, and by acetyl-CoA and CoA, in human skeletal muscle. 1987 Biochem. J. pmid:3663146
Guzmán M et al. Flexibility of zonation of fatty acid oxidation in rat liver. 1995 Biochem. J. pmid:7487941
McGarry JD and Brown NF Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity. 2000 Biochem. J. pmid:10861226
Hamilton C and Saggerson ED Malonyl-CoA metabolism in cardiac myocytes. 2000 Biochem. J. pmid:10926826
Roughan PG et al. On the control of long-chain-fatty acid synthesis in isolated intact spinach (Spinacia oleracea) chloroplasts. 1979 Biochem. J. pmid:534525
Park EA et al. Insulin regulates enzyme activity, malonyl-CoA sensitivity and mRNA abundance of hepatic carnitine palmitoyltransferase-I. 1995 Biochem. J. pmid:7575418
Broadway NM and Saggerson ED Solubilization and separation of two distinct carnitine acyltransferases from hepatic microsomes: characterization of the malonyl-CoA-sensitive enzyme. 1995 Biochem. J. pmid:7575437
Mikkelsen J et al. Amino acid sequence around the active-site serine residue in the acyltransferase domain of goat mammary fatty acid synthetase. 1985 Biochem. J. pmid:3922356
Walker KA and Harwood JL Localization of chloroplastic fatty acid synthesis de novo in the stroma. 1985 Biochem. J. pmid:3994672
Mikkelsen J et al. Evidence that the medium-chain acyltransferase of lactating-goat mammary-gland fatty acid synthetase is identical with the acetyl/malonyltransferase. 1985 Biochem. J. pmid:4004809
Bird MI et al. Carnitine acyltransferase activities in rat brain mitochondria. Bimodal distribution, kinetic constants, regulation by malonyl-CoA and developmental pattern. 1985 Biochem. J. pmid:3977877
Mills SE et al. Interaction of malonyl-CoA and related compounds with mitochondria from different rat tissues. Relationship between ligand binding and inhibition of carnitine palmitoyltransferase I. 1983 Biochem. J. pmid:6615474
Zammit VA Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro. 1983 Biochem. J. pmid:6870813
Stephens TW et al. Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I. 1983 Biochem. J. pmid:6882380
Cook GA et al. Malonyl-CoA inhibition of carnitine palmitoyltransferase: interpretation of I50 and K1 values. 1983 Biochem. J. pmid:6882381
Henninger C et al. Effects of fenofibrate treatment on fatty acid oxidation in liver mitochondria of obese Zucker rats. 1987 Biochem. Pharmacol. pmid:3663237
Planavila A et al. Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice. 2005 Biochem. Pharmacol. pmid:15794940
Lilly K et al. Effect of etomoxiryl-CoA on different carnitine acyltransferases. 1992 Biochem. Pharmacol. pmid:1739421
Wahle KW et al. Biosynthesis of branched-chain fatty acids by preparations from bovine adipose tissue [proceedings]. 1978 Biochem. Soc. Trans. pmid:744376
Cook GA and Weakley LJ Effects of starvation on the carnitine palmitoyltransferase of hepatic peroxisomes. 1990 Biochem. Soc. Trans. pmid:2083787
Jones CT and Wahle KW Aspects of lipid metabolism in the foetal, neonatal and adult monogastric mammal. 1980 Biochem. Soc. Trans. pmid:6105107
Mynatt RL and Cook GA Modulation of the malonyl-CoA sensitivity of hepatic carnitine palmitoyltransferase (CPT) by phospholipids. 1994 Biochem. Soc. Trans. pmid:7958184
McGarry JD Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between. 2001 Biochem. Soc. Trans. pmid:11356162
Eaton S et al. Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux. 2001 Biochem. Soc. Trans. pmid:11356163
Jiffri E et al. Altered renal intermediary metabolism and the onset of renal dysfunction in the streptozotocin diabetic rat. 1996 Biochem. Soc. Trans. pmid:8736922
Broadway NM et al. Microsomal malonyl-CoA-sensitive carnitine acyltransferase. 2001 Biochem. Soc. Trans. pmid:11356165
Zammit VA et al. Structure-function relationships of the liver and muscle isoforms of carnitine palmitoyltransferase I. 2001 Biochem. Soc. Trans. pmid:11356169
Hegardt FG et al. Post-transcriptional regulation of rat carnitine octanoyltransferase. 2001 Biochem. Soc. Trans. pmid:11356174
McGarry JD Malonyl-CoA and carnitine palmitoyltransferase I: an expanding partnership. 1995 Biochem. Soc. Trans. pmid:8566378
Broadway NM and Saggerson ED Microsomal carnitine acyltransferases. 1995 Biochem. Soc. Trans. pmid:8566389
Fraser F et al. Evidence that both the acyl-CoA- and malonyl-CoA binding sites of mitochondrial overt carnitine palmitoyltransferase (CPT I) are exposed on the cytosolic face of the outer membrane. 1996 Biochem. Soc. Trans. pmid:8736842
Lane MD et al. Role of malonyl-CoA in the hypothalamic control of food intake and energy expenditure. 2005 Biochem. Soc. Trans. pmid:16246046
Ruderman NB et al. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. 2003 Biochem. Soc. Trans. pmid:12546685
Hopkins TA et al. AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart. 2003 Biochem. Soc. Trans. pmid:12546686
Bergseth S et al. Is carnitine palmitoyltransferase inhibited by a malonyl-CoA-binding unit in the mitochondria? 1986 Biochem. Soc. Trans. pmid:3743880
Frayn KN The glucose-fatty acid cycle: a physiological perspective. 2003 Biochem. Soc. Trans. pmid:14641007
Carreras CW and Khosla C Purification and in vitro reconstitution of the essential protein components of an aromatic polyketide synthase. 1998 Biochemistry pmid:9518007
Meehan MJ et al. FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF. 2011 Biochemistry pmid:21069965
Martinez MA et al. A novel role of malonyl-ACP in lipid homeostasis. 2010 Biochemistry pmid:20201588
Shi J et al. Deletion of the conserved first 18 N-terminal amino acid residues in rat liver carnitine palmitoyltransferase I abolishes malonyl-CoA sensitivity and binding. 1998 Biochemistry pmid:9692998
Rangan VS et al. Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro. 2001 Biochemistry pmid:11535054
Reeves CD et al. Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations. 2001 Biochemistry pmid:11747421
Nicot C et al. Pig liver carnitine palmitoyltransferase I, with low Km for carnitine and high sensitivity to malonyl-CoA inhibition, is a natural chimera of rat liver and muscle enzymes. 2001 Biochemistry pmid:11329295
Florova G et al. Enzymes involved in fatty acid and polyketide biosynthesis in Streptomyces glaucescens: role of FabH and FabD and their acyl carrier protein specificity. 2002 Biochemistry pmid:12173933
Zheng X et al. Substrate binding induces a cooperative conformational change in the 12S subunit of transcarboxylase: Raman crystallographic evidence. 2002 Biochemistry pmid:12196011
Witkowski A et al. Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase. 2002 Biochemistry pmid:12196027
Child CJ et al. Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies. 1996 Biochemistry pmid:8823160
Suzuki H et al. Proposed mechanism and functional amino acid residues of malonyl-CoA:anthocyanin 5-O-glucoside-6'''-O-malonyltransferase from flowers of Salvia splendens, a member of the versatile plant acyltransferase family. 2003 Biochemistry pmid:12578391
Prigge ST et al. The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII. 2003 Biochemistry pmid:12549938
Liou GF et al. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. 2003 Biochemistry pmid:12515555
Shi J et al. The first 28 N-terminal amino acid residues of human heart muscle carnitine palmitoyltransferase I are essential for malonyl CoA sensitivity and high-affinity binding. 2000 Biochemistry pmid:10651636
Jez JM et al. Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. 2000 Biochemistry pmid:10653632
Fujii I et al. Enzymatic synthesis of 1,3,6,8-tetrahydroxynaphthalene solely from malonyl coenzyme A by a fungal iterative type I polyketide synthase PKS1. 2000 Biochemistry pmid:10913297
Jackson VN et al. Specificity of the interactions between Glu-3, Ser-24, and Gln-30 within the N-terminal segment of rat liver mitochondrial overt carnitine palmitoyltransferase (L-CPT I) in determining the malonyl-CoA sensitivity of the enzyme. 2001 Biochemistry pmid:11724576
Mazur MT et al. Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase. 2003 Biochemistry pmid:14621984
Hoenke S et al. Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase. 2000 Biochemistry pmid:11052675
Singh SP et al. Role of the electrophilic lipid peroxidation product 4-hydroxynonenal in the development and maintenance of obesity in mice. 2008 Biochemistry pmid:18311940
Tseng CC et al. Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase. 2004 Biochemistry pmid:14744141
Relat J et al. Pig muscle carnitine palmitoyltransferase I (CPTI beta), with low Km for carnitine and low sensitivity to malonyl-CoA inhibition, has kinetic characteristics similar to those of the rat liver (CPTI alpha) enzyme. 2004 Biochemistry pmid:15449958
Preisig-Müller R et al. Plant polyketide synthases leading to stilbenoids have a domain catalyzing malonyl-CoA:CO2 exchange, malonyl-CoA decarboxylation, and covalent enzyme modification and a site for chain lengthening. 1997 Biochemistry pmid:9204882
de Vries Y et al. Functional characterization of mitochondrial carnitine palmitoyltransferases I and II expressed in the yeast Pichia pastoris. 1997 Biochemistry pmid:9136891
Dunn BJ et al. Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases. 2014 Biochemistry pmid:24871074
Sleboda J et al. Short-term regulation of carnitine palmitoyltransferase I in cultured rat hepatocytes: spontaneous inactivation and reactivation by fatty acids. 1999 Biochim. Biophys. Acta pmid:9989283
Pande SV et al. Freeze-thawing causes masking of membrane-bound outer carnitine palmitoyltransferase activity: implications for studies on carnitine palmitoyltransferases deficiency. 1990 Biochim. Biophys. Acta pmid:2344445
Morash AJ et al. Intertissue regulation of carnitine palmitoyltransferase I (CPTI): mitochondrial membrane properties and gene expression in rainbow trout (Oncorhynchus mykiss). 2008 Biochim. Biophys. Acta pmid:18359285
Guzmán M and Castro J Ethanol increases the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in short-term hepatocyte incubations. 1989 Biochim. Biophys. Acta pmid:2713390
Skrede S and Bremer J Acylcarnitine formation and fatty acid oxidation in hepatocytes from rats treated with tetradecylthioacetic acid (a 3-thia fatty acid). 1993 Biochim. Biophys. Acta pmid:8466948
Gambert S et al. Regulation of intermediary metabolism in rat cardiac myocyte by extracellular glycerol. 2005 Biochim. Biophys. Acta pmid:16153888
Bolton P and Harwood JL Some characteristics of soluble fatty acid synthesis in germinating pea seeds. 1977 Biochim. Biophys. Acta pmid:20971
Veerkamp JH and Van Moerkerk HT The effect of malonyl-CoA on fatty acid oxidation in rat muscle and liver mitochondria. 1982 Biochim. Biophys. Acta pmid:7066363
Lund H and Woldegiorgis G Carnitine palmitoyltransferase: separation of enzyme activity and malonyl-CoA binding in rat liver mitochondria. 1986 Biochim. Biophys. Acta pmid:3756194
Bergseth S et al. Carnitine palmitoyltransferase: activation and inactivation in liver mitochondria from fed, fasted, hypo- and hyperthyroid rats. 1986 Biochim. Biophys. Acta pmid:3707984
Lund H et al. Effects of thyroid state and fasting on the concentrations of CoA and malonyl-CoA in rat liver. 1986 Biochim. Biophys. Acta pmid:3707992
Bremer J The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA. 1981 Biochim. Biophys. Acta pmid:7295757
Deana R et al. Submitochondrial localization and partial purification of the succinylCoA: 3-hydroxy-3-methylglutarate coenzyme A transferase from rat liver. 1981 Biochim. Biophys. Acta pmid:6946836
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Cassagne C et al. Fatty acid biosynthesis in the peripheral nervous system of normal and Trembler mice. 1986 Biochim. Biophys. Acta pmid:3947661
Sire O et al. Preventive effect of clofibrate on carnitine palmitoyltransferase I inhibition and mitochondrial membrane phospholipid depletion induced by galactosamine. 1986 Biochim. Biophys. Acta pmid:3947665
Demirkapi N et al. Evidence against cytochrome b5 involvement in liver microsomal fatty acid elongation. 1991 Biochim. Biophys. Acta pmid:2009301
Vandhana S et al. Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors. 2013 Biochim. Biophys. Acta pmid:23816424
Katsurada A et al. Effects of dietary nutrients on substrate and effector levels of lipogenic enzymes, and lipogenesis from tritiated water in rat liver. 1986 Biochim. Biophys. Acta pmid:2875738
Bhatia H et al. miR-107 orchestrates ER stress induction and lipid accumulation by post-transcriptional regulation of fatty acid synthase in hepatocytes. 2014 Biochim. Biophys. Acta pmid:24560669
Bieber LL and Wagner M Effect of pH and acyl-CoA chain length on the conversion of heart mitochondrial CPT-I/CPTo to a high affinity, malonyl-CoA-inhibited state. 1996 Biochim. Biophys. Acta pmid:8765129