Malonyl-coa

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 3249 references associated with Malonyl-coa in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Malonyl-coa

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonyl-coa

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Angina Pectoris D000787 27 associated lipids
Body Weight D001835 333 associated lipids
Cleft Lip D002971 8 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Hyperinsulinism D006946 27 associated lipids
Hypoglycemia D007003 13 associated lipids
Per page 10 20 | Total 20

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Authors Title Published Journal PubMed Link
Sleboda J et al. Short-term regulation of carnitine palmitoyltransferase I in cultured rat hepatocytes: spontaneous inactivation and reactivation by fatty acids. 1999 Biochim. Biophys. Acta pmid:9989283
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Bremer J et al. Carnitine palmitoyltransferase. Activation by palmitoyl-CoA and inactivation by malonyl-CoA. 1985 Biochim. Biophys. Acta pmid:3967042
Bernert JT and Sprecher H The effect of bovine serum albumin on partial reactions of palmitoyl-CoA chain elongation by rat liver microsomes. 1978 Biochim. Biophys. Acta pmid:30485
Ghadiminejad I and Saggerson D A proportion of rat liver mitochondrial carnitine palmitoyltransferase can be made activatable by malonyl-CoA. 1991 Biochim. Biophys. Acta pmid:1911872
Kim YS and Kolattukudy PE Malonyl-CoA decarboxylase from the mammary gland of lactating rat. Purification, properties and subcellular localization. 1978 Biochim. Biophys. Acta pmid:718970
Bernert JT and Sprecher H Factors regulating the elongation of palmitic and stearic acid by rat liver microsomes. 1979 Biochim. Biophys. Acta pmid:476133
Yoshida S and Bourre JM Condensation activity for polyunsaturated fatty acids with malonyl-CoA in rat brain microsomes. Characteristics and developmental change. 1992 Biochim. Biophys. Acta pmid:1536871
Guzmán M and Castro J Ethanol increases the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA in short-term hepatocyte incubations. 1989 Biochim. Biophys. Acta pmid:2713390
Skrede S and Bremer J Acylcarnitine formation and fatty acid oxidation in hepatocytes from rats treated with tetradecylthioacetic acid (a 3-thia fatty acid). 1993 Biochim. Biophys. Acta pmid:8466948
Gambert S et al. Regulation of intermediary metabolism in rat cardiac myocyte by extracellular glycerol. 2005 Biochim. Biophys. Acta pmid:16153888
Traufeller K et al. Different sensitivities of CPT I and CPT II for inhibition by l-aminocarnitine in human skeletal muscle. 2004 Biochim. Biophys. Acta pmid:14871492
Santarelli X et al. Arginyl residues are involved in acyl-CoA binding to the elongase from etiolated leek seedlings. 1998 Biochim. Biophys. Acta pmid:9555095
Fiol CJ et al. Effect of malonyl-CoA on the kinetics and substrate cooperativity of membrane-bound carnitine palmitoyltransferase of rat heart mitochondria. 1987 Biochim. Biophys. Acta pmid:3689805
Ravel D et al. Essential fatty acid interconversion during gestation in the rat. 1985 Biochim. Biophys. Acta pmid:3917686
MENON GK et al. Enzymic synthesis and reduction of malonyl semialdehyde-coenzyme A. 1960 Biochim. Biophys. Acta pmid:13769478
Guzmán M and Castro J Effects of endurance exercise on carnitine palmitoyltransferase I from rat heart, skeletal muscle and liver mitochondria. 1988 Biochim. Biophys. Acta pmid:3196751
Kashfi K and Cook GA Temperature effects on malonyl-CoA inhibition of carnitine palmitoyltransferase I. 1995 Biochim. Biophys. Acta pmid:7619853
Cassagne C et al. Fatty acid biosynthesis in the peripheral nervous system of normal and Trembler mice. 1986 Biochim. Biophys. Acta pmid:3947661
Sire O et al. Preventive effect of clofibrate on carnitine palmitoyltransferase I inhibition and mitochondrial membrane phospholipid depletion induced by galactosamine. 1986 Biochim. Biophys. Acta pmid:3947665
Vandhana S et al. Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors. 2013 Biochim. Biophys. Acta pmid:23816424
Takamura Y et al. Malonyl-CoA: acetyl-CoA cycling. A new micromethod for determination of acyl-CoAs with malonate decarboxylase. 1985 Biochim. Biophys. Acta pmid:3978111
McGarry JD et al. Characteristics of fatty acid oxidation in rat liver homogenates and the inhibitory effect of malonyl-CoA. 1978 Biochim. Biophys. Acta pmid:698234
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McGarry JD et al. New insights into the mitochondrial carnitine palmitoyltransferase enzyme system. 1991 Biochimie pmid:2031961
López M et al. Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intake. 2007 Bioessays pmid:17295284
Adams SH et al. Expression and possible role of muscle-type carnitine palmitoyltransferase I during sperm development in the rat. 1998 Biol. Reprod. pmid:9828184
Valsangkar D and Downs SM A requirement for fatty acid oxidation in the hormone-induced meiotic maturation of mouse oocytes. 2013 Biol. Reprod. pmid:23863407
De Spiegeleer BM et al. High performance liquid chromatography stability study of malonyl-coenzyme A, using statistical experimental designs. 1989 Biomed. Chromatogr. pmid:2804428
Gilibili RR et al. Development and validation of a highly sensitive LC-MS/MS method for simultaneous quantitation of acetyl-CoA and malonyl-CoA in animal tissues. 2011 Biomed. Chromatogr. pmid:21381064
Bengtsson C et al. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. 2011 Bioorg. Med. Chem. pmid:21515056
Abe T et al. Structure function analysis of benzalacetone synthase from Rheum palmatum. 2007 Bioorg. Med. Chem. Lett. pmid:17383877
Gao BW et al. Rapid preparation of (methyl)malonyl coenzyme A and enzymatic formation of unusual polyketides by type III polyketide synthase from Aquilaria sinensis. 2015 Bioorg. Med. Chem. Lett. pmid:25677661
Wallace DM et al. Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors. 2007 Bioorg. Med. Chem. Lett. pmid:17234415
Jia Y and Zhong JJ Enhanced production of ansamitocin P-3 by addition of Mg2+ in fermentation of Actinosynnema pretiosum. 2011 Bioresour. Technol. pmid:21907573
Wu J et al. Efficient biosynthesis of (2S)-pinocembrin from d-glucose by integrating engineering central metabolic pathways with a pH-shift control strategy. 2016 Bioresour. Technol. pmid:27450982
Chohnan S et al. Changes in size of intracellular pools of coenzyme A and its thioesters in Escherichia coli K-12 cells to various carbon sources and stresses. 1998 Biosci. Biotechnol. Biochem. pmid:9692193
Hayashi O and Satoh K Differences in concentrations of acetyl-CoA and malonyl-CoA in shoots and roots of Zea mays. 2008 Biosci. Biotechnol. Biochem. pmid:18323644
Kajikawa M et al. Functional analysis of a beta-ketoacyl-CoA synthase gene, MpFAE2, by gene silencing in the liverwort Marchantia polymorpha L. 2003 Biosci. Biotechnol. Biochem. pmid:12723610
Hayashi O and Satoh K Determination of acetyl-CoA and malonyl-CoA in germinating rice seeds using the LC-MS/MS technique. 2006 Biosci. Biotechnol. Biochem. pmid:17090944
Sugden MC et al. Lipogenesis in response to an oral glucose load in fed and starved rats. 1981 Biosci. Rep. pmid:7295901
Maharjan S et al. Metabolic engineering of Streptomyces venezuelae for malonyl-CoA biosynthesis to enhance heterologous production of polyketides. 2010 Biotechnol. Lett. pmid:19838628
Zhang X et al. Improving fatty acid production in Escherichia coli through the overexpression of malonyl coA-acyl carrier protein transacylase. 2012 Jan-Feb Biotechnol. Prog. pmid:22038854
Celato A et al. A new case of malonic aciduria with a presymptomatic diagnosis and an early treatment. 2013 Brain Dev. pmid:23177061
Salles J et al. Fatty acid synthase expression during peripheral nervous system myelination. 2002 Brain Res. Mol. Brain Res. pmid:12007831
Onay-Besikci A and Sambandam N Malonyl CoA control of fatty acid oxidation in the newborn heart in response to increased fatty acid supply. 2006 Can. J. Physiol. Pharmacol. pmid:17218986
Li JN et al. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. 2001 Cancer Res. pmid:11245456
Brusselmans K et al. RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells. 2005 Cancer Res. pmid:16061653
Pizer ES et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. 2000 Cancer Res. pmid:10667561
Maurer I and Zierz S Carnitine palmitoyltransferase in patients with cardiac ischemia due to atherosclerotic coronary artery disease and in patients with idiopathic dilated cardiomyopathy. 1997 May-Jun Cardiology pmid:9129847
Kudej RK et al. Second window of preconditioning normalizes palmitate use for oxidation and improves function during low-flow ischaemia. 2011 Cardiovasc. Res. pmid:21835931
Folmes CD and Lopaschuk GD Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. 2007 Cardiovasc. Res. pmid:17126822
Ussher JR and Lopaschuk GD The malonyl CoA axis as a potential target for treating ischaemic heart disease. 2008 Cardiovasc. Res. pmid:18499682
Ussher JR et al. Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury. 2012 Cardiovasc. Res. pmid:22436846
Zhabyeyev P et al. Pressure-overload-induced heart failure induces a selective reduction in glucose oxidation at physiological afterload. 2013 Cardiovasc. Res. pmid:23257023
Mercier R et al. Excess membrane synthesis drives a primitive mode of cell proliferation. 2013 Cell pmid:23452849
Unger RH The hyperleptinemia of obesity-regulator of caloric surpluses. 2004 Cell pmid:15084251
Giordano A et al. tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1. 2005 Cell Death Differ. pmid:15846373
Dean JT et al. Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt. 2009 Cell Metab. pmid:19490907
Kelley DE Pulling in more fat. 2005 Cell Metab. pmid:16271525
Neschen S et al. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice. 2005 Cell Metab. pmid:16054099
López M et al. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. 2008 Cell Metab. pmid:18460330
Zammit VA and Arduini A The AMPK-malonyl-CoA-CPT1 axis in the control of hypothalamic neuronal function. 2008 Cell Metab. pmid:18762014
Zhang S and Kim KH Essential role of acetyl-CoA carboxylase in the glucose-induced insulin secretion in a pancreatic beta-cell line. 1998 Cell. Signal. pmid:9502115
Awakawa T et al. Physically discrete beta-lactamase-type thioesterase catalyzes product release in atrochrysone synthesis by iterative type I polyketide synthase. 2009 Chem. Biol. pmid:19549600
Zhou P et al. Polyketide synthase acyl carrier protein (ACP) as a substrate and a catalyst for malonyl ACP biosynthesis. 1999 Chem. Biol. pmid:10421763
Matharu AL et al. MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor. 1998 Chem. Biol. pmid:9862793
Jensen K et al. Polyketide proofreading by an acyltransferase-like enzyme. 2012 Chem. Biol. pmid:22444588
Kage H et al. An iterative type I polyketide synthase initiates the biosynthesis of the antimycoplasma agent micacocidin. 2013 Chem. Biol. pmid:23790487
Ellis JM and Wolfgang MJ A genetically encoded metabolite sensor for malonyl-CoA. 2012 Chem. Biol. pmid:23102226
Hitchman TS et al. Catalytic self-acylation of type II polyketide synthase acyl carrier proteins. 1998 Chem. Biol. pmid:9479478
Hamed RB et al. Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. 2010 Chem. Commun. (Camb.) pmid:20162132
Tosin M et al. Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates. 2009 Chembiochem pmid:19507202
Musiol EM et al. The ATâ‚‚ domain of KirCI loads malonyl extender units to the ACPs of the kirromycin PKS. 2013 Chembiochem pmid:23828654
Awakawa T et al. 4-Hydroxy-3-methyl-6-(1-methyl-2-oxoalkyl)pyran-2-one synthesis by a type III polyketide synthase from Rhodospirillum centenum. 2013 Chembiochem pmid:23609937
Kantor PF et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. 2000 Circ. Res. pmid:10720420
Zordoky BN et al. AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation. 2014 Circ. Res. pmid:25001074
Lewandowski ED et al. Acute liver carnitine palmitoyltransferase I overexpression recapitulates reduced palmitate oxidation of cardiac hypertrophy. 2013 Circ. Res. pmid:22982985
Kolwicz SC et al. Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy. 2012 Circ. Res. pmid:22730442
Dyck JR et al. Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. 2004 Circ. Res. pmid:15105298
Dagher Z et al. Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. 2001 Circ. Res. pmid:11420304
Goodman SI et al. Methylmalonic/beta-hydroxy-n-valeric aciduria due to methylmalonyl-CoA mutase deficiency. 1978 Clin. Chim. Acta pmid:28187
Wen J and Kerr RG Purification and characterization of the fatty acid synthase from Bugula neritina. 2001 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:11250539
Gutières S et al. Cloning and tissue distribution of a carnitine palmitoyltransferase I gene in rainbow trout (Oncorhynchus mykiss). 2003 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:12781981
Lavarías S et al. Partial characterization of a malonyl-CoA-sensitive carnitine O-palmitoyltransferase I from Macrobrachium borellii (Crustacea: Palaemonidae). 2009 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:19171199
McGrath RP Unusual case of metabolic acidosis. 1989 Crit. Care Med. pmid:2909311
Schujman GE et al. FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis. 2003 Dev. Cell pmid:12737802
Chen S et al. More direct evidence for a malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic beta-cell signaling. 1994 Diabetes pmid:8013751
Ido Y et al. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. 2002 Diabetes pmid:11756336
Prentki M and Corkey BE Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? 1996 Diabetes pmid:8593930
Beynen AC et al. Opposite effects of insulin and glucagon in acute hormonal control of hepatic lipogenesis. 1979 Diabetes pmid:467808
Herrero L et al. Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion. 2005 Diabetes pmid:15677504
Prentki M et al. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. 2002 Diabetes pmid:12475783
Bandyopadhyay GK et al. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. 2006 Diabetes pmid:16873691
Nolan CJ et al. Fatty acid signaling in the beta-cell and insulin secretion. 2006 Diabetes pmid:17130640
López M et al. Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA. 2006 Diabetes pmid:16644689
McGarry JD and Foster DW Effects of exogenous fatty acid concentration on glucagon-induced changes in hepatic fatty acid metabolism. 1980 Diabetes pmid:7380110
BÃ¥venholm PN et al. Fatty acid oxidation and the regulation of malonyl-CoA in human muscle. 2000 Diabetes pmid:10909961
Dean D et al. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. 2000 Diabetes pmid:10923628
Go Y et al. Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis. 2016 Diabetes pmid:27385159