Malonyl-coa

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 3249 references associated with Malonyl-coa in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Malonyl-coa

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonyl-coa

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Adenocarcinoma D000230 166 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Ketosis D007662 13 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Weight Gain D015430 101 associated lipids
Hypoglycemia D007003 13 associated lipids
Starvation D013217 47 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Angina Pectoris D000787 27 associated lipids
Hyperinsulinism D006946 27 associated lipids
Placental Insufficiency D010927 6 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Loss D015431 56 associated lipids
Myocardial Stunning D017682 10 associated lipids
Cleft Lip D002971 8 associated lipids
Mitochondrial Myopathies D017240 13 associated lipids
Per page 10 20 | Total 20

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Authors Title Published Journal PubMed Link
Yee AJ and Turcotte LP Insulin fails to alter plasma LCFA metabolism in muscle perfused at similar glucose uptake. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:12067845
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Richards JG et al. Substrate utilization during graded aerobic exercise in rainbow trout. 2002 J. Exp. Biol. pmid:12089210
Hirsch J The search for new ways to treat obesity. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12093927
Shafrir E et al. Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus. 2002 May-Jun Diabetes Metab. Res. Rev. pmid:12112940
Ghanevati M and Jaworski JG Engineering and mechanistic studies of the Arabidopsis FAE1 beta-ketoacyl-CoA synthase, FAE1 KCS. 2002 Eur. J. Biochem. pmid:12135493
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Zheng X et al. Substrate binding induces a cooperative conformational change in the 12S subunit of transcarboxylase: Raman crystallographic evidence. 2002 Biochemistry pmid:12196011
Witkowski A et al. Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase. 2002 Biochemistry pmid:12196027
Poirier M et al. Probing the link between citrate and malonyl-CoA in perfused rat hearts. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12234788
Verhoeyen ME et al. Increasing antioxidant levels in tomatoes through modification of the flavonoid biosynthetic pathway. 2002 J. Exp. Bot. pmid:12324533
Pan Y et al. The extreme C terminus of rat liver carnitine palmitoyltransferase I is not involved in malonyl-CoA sensitivity but in initial protein folding. 2002 J. Biol. Chem. pmid:12351641
Schwarzer D et al. Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12384573
Onay-Besikci A et al. Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12388233
Dyck JR and Lopaschuk GD Malonyl CoA control of fatty acid oxidation in the ischemic heart. 2002 J. Mol. Cell. Cardiol. pmid:12392882
Park SH et al. Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle. 2002 J. Appl. Physiol. pmid:12433937
Steinberg GR et al. AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:12441311
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Jensen MD Fatty acid oxidation in human skeletal muscle. 2002 J. Clin. Invest. pmid:12464664
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Prentki M et al. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. 2002 Diabetes pmid:12475783
Morillas M et al. Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition. 2003 J. Biol. Chem. pmid:12499375
Liou GF et al. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. 2003 Biochemistry pmid:12515555
BÃ¥venholm PN et al. Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation. 2003 J. Clin. Endocrinol. Metab. pmid:12519834
Wang F et al. Inhibitive effect of zinc ion on fatty acid synthase from chicken liver. 2003 Int. J. Biochem. Cell Biol. pmid:12531252
Treber M et al. Identification by mutagenesis of conserved arginine and glutamate residues in the C-terminal domain of rat liver carnitine palmitoyltransferase I that are important for catalytic activity and malonyl-CoA sensitivity. 2003 J. Biol. Chem. pmid:12540837
Ruderman NB et al. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. 2003 Biochem. Soc. Trans. pmid:12546685
Hopkins TA et al. AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart. 2003 Biochem. Soc. Trans. pmid:12546686
Prigge ST et al. The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII. 2003 Biochemistry pmid:12549938
Dai J et al. Leucine-764 near the extreme C-terminal end of carnitine palmitoyltransferase I is important for activity. 2003 Biochem. Biophys. Res. Commun. pmid:12565845
Suzuki H et al. Proposed mechanism and functional amino acid residues of malonyl-CoA:anthocyanin 5-O-glucoside-6'''-O-malonyltransferase from flowers of Salvia splendens, a member of the versatile plant acyltransferase family. 2003 Biochemistry pmid:12578391
Hügler M et al. Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula. Carboxylating enzyme in the 3-hydroxypropionate cycle for autotrophic carbon fixation. 2003 Eur. J. Biochem. pmid:12581213
Cheng YQ et al. Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12598647
Lehtihet M et al. Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:12684219
Zhu H et al. Substitution of glutamate-3, valine-19, leucine-23, and serine-24 with alanine in the N-terminal region of human heart muscle carnitine palmitoyltransferase I abolishes malonyl CoA inhibition and binding. 2003 Arch. Biochem. Biophys. pmid:12706342
Kajikawa M et al. Functional analysis of a beta-ketoacyl-CoA synthase gene, MpFAE2, by gene silencing in the liverwort Marchantia polymorpha L. 2003 Biosci. Biotechnol. Biochem. pmid:12723610
Wortman MD et al. C75 inhibits food intake by increasing CNS glucose metabolism. 2003 Nat. Med. pmid:12724740
Schujman GE et al. FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis. 2003 Dev. Cell pmid:12737802
Boren J et al. The stable isotope-based dynamic metabolic profile of butyrate-induced HT29 cell differentiation. 2003 J. Biol. Chem. pmid:12750369
Gutières S et al. Cloning and tissue distribution of a carnitine palmitoyltransferase I gene in rainbow trout (Oncorhynchus mykiss). 2003 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:12781981
Napal L et al. A single amino acid change (substitution of the conserved Glu-590 with alanine) in the C-terminal domain of rat liver carnitine palmitoyltransferase I increases its malonyl-CoA sensitivity close to that observed with the muscle isoform of the enzyme. 2003 J. Biol. Chem. pmid:12826662
Molnos J et al. A continuous coupled enzyme assay for bacterial malonyl-CoA:acyl carrier protein transacylase (FabD). 2003 Anal. Biochem. pmid:12842120
Harwood HJ et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. 2003 J. Biol. Chem. pmid:12842871
Kiens B and Roepstorff C Utilization of long-chain fatty acids in human skeletal muscle during exercise. 2003 Acta Physiol. Scand. pmid:12864744
Ruderman NB et al. AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. 2003 Acta Physiol. Scand. pmid:12864749
Dawe JH et al. A template search reveals mechanistic similarities and differences in beta-ketoacyl synthases (KAS) and related enzymes. 2003 Proteins pmid:12866053
Zhang L et al. Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. 2003 J. Biol. Chem. pmid:12882974
Bezaire V et al. Regulation of CPT I activity in intermyofibrillar and subsarcolemmal mitochondria from human and rat skeletal muscle. 2004 Am. J. Physiol. Endocrinol. Metab. pmid:12954596
Pulinilkunnil T et al. Evidence for rapid "metabolic switching" through lipoprotein lipase occupation of endothelial-binding sites. 2003 J. Mol. Cell. Cardiol. pmid:12967632
Stanley WC et al. beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12969881
Focke M et al. Fatty acid biosynthesis in mitochondria of grasses: malonyl-coenzyme A is generated by a mitochondrial-localized acetyl-coenzyme A carboxylase. 2003 Plant Physiol. pmid:12972648
Duan C and Winder WW Nerve stimulation decreases malonyl-CoA in skeletal muscle. 1992 J. Appl. Physiol. pmid:1349012
Prip-Buus C et al. Evidence for an impaired long-chain fatty acid oxidation and ketogenesis in Fao hepatoma cells. 1992 Eur. J. Biochem. pmid:1356769
Kikuchi S and Kolattukudy PE Immobilization of fatty acid synthetase from Mycobacterium smegmatis by radiation-induced polymerization. 1990 Agric. Biol. Chem. pmid:1368562
MENON GK et al. Enzymic synthesis and reduction of malonyl semialdehyde-coenzyme A. 1960 Biochim. Biophys. Acta pmid:13769478
MENON GK and STERN JR Enzymic synthesis and metabolism of malonyl coenzyme A and glutaryl coenzyme A. 1960 J. Biol. Chem. pmid:13769479
VAGELOS PR and ALBERTS AW Malonyl coenzyme A-carbon dioxide exchange reaction. 1960 J. Biol. Chem. pmid:13779560
VAGELOS PR and EARL JM Propionic acid metabolism. III. beta-Hydroxypropionyl coenzyme A and malonyl semialdehyde coenzyme A, intermediates in propionate oxidation by Clostridium kluyveri. 1959 J. Biol. Chem. pmid:13840645
VAGELOS PR Propionic acid metabolism. IV. Synthesis of malonyl coenzyme A. 1960 J. Biol. Chem. pmid:13840646
HATCH MD and STUMPF PK Fat metabolism in higher plants. XVI. Acetyl coenzyme A carboxylase and acyl coenzyme A-malonyl coenzyme A transcarboxylase from wheat germ. 1961 J. Biol. Chem. pmid:13905314
Memon RA et al. In vivo effects of interferon-alpha and interferon-gamma on lipolysis and ketogenesis. 1992 Endocrinology pmid:1396316
BRODIE JD et al. The participation of malonyl coenzyme A in the biosynthesis of mevalonic acid. 1963 J. Biol. Chem. pmid:14015675
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Ruderman NB et al. Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. 2003 Endocrinology pmid:14500570
Hu Z et al. Hypothalamic malonyl-CoA as a mediator of feeding behavior. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:14532332
Eckermann C et al. Covalent binding of chloroacetamide herbicides to the active site cysteine of plant type III polyketide synthases. 2003 Phytochemistry pmid:14568070
Mazur MT et al. Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase. 2003 Biochemistry pmid:14621984
Sleeman MC and Schofield CJ Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis. 2004 J. Biol. Chem. pmid:14625287
Rosa G et al. Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects. 2003 Obes. Res. pmid:14627750
Frayn KN The glucose-fatty acid cycle: a physiological perspective. 2003 Biochem. Soc. Trans. pmid:14641007
Lee GY et al. Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level. 2004 Biochem. J. pmid:14641110
Saha AK et al. Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. 2004 Biochem. Biophys. Res. Commun. pmid:14733947
Tseng CC et al. Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase. 2004 Biochemistry pmid:14744141
Traufeller K et al. Different sensitivities of CPT I and CPT II for inhibition by l-aminocarnitine in human skeletal muscle. 2004 Biochim. Biophys. Acta pmid:14871492
Reszko AE et al. Peroxisomal fatty acid oxidation is a substantial source of the acetyl moiety of malonyl-CoA in rat heart. 2004 J. Biol. Chem. pmid:14982940
Abe I et al. The first plant type III polyketide synthase that catalyzes formation of aromatic heptaketide. 2004 FEBS Lett. pmid:15044020
Roduit R et al. A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. 2004 Diabetes pmid:15047616
Degrace P et al. Hepatic steatosis is not due to impaired fatty acid oxidation capacities in C57BL/6J mice fed the conjugated trans-10,cis-12-isomer of linoleic acid. 2004 J. Nutr. pmid:15051838
Ruderman N and Prentki M AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. 2004 Nat Rev Drug Discov pmid:15060529
Unger RH The hyperleptinemia of obesity-regulator of caloric surpluses. 2004 Cell pmid:15084251
Weiss DR and Glickman JF Characterization of fatty acid synthase activity using scintillation proximity. 2003 Assay Drug Dev Technol pmid:15090142
Dyck JR et al. Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. 2004 Circ. Res. pmid:15105298
Falk KL et al. Glucosinolate biosynthesis: demonstration and characterization of the condensing enzyme of the chain elongation cycle in Eruca sativa. 2004 Phytochemistry pmid:15110687
Minkler PE et al. Isolation and identification of two isomeric forms of malonyl-coenzyme A in commercial malonyl-coenzyme A. 2004 Anal. Biochem. pmid:15113698
Raharjo TJ et al. Cloning and over-expression of a cDNA encoding a polyketide synthase from Cannabis sativa. 2004 Plant Physiol. Biochem. pmid:15120113
Cao J et al. A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse. 2004 J. Biol. Chem. pmid:15152008
Rodriguez E et al. Engineered biosynthesis of 16-membered macrolides that require methoxymalonyl-ACP precursors in Streptomyces fradiae. 2004 Appl. Microbiol. Biotechnol. pmid:15179529
Reszko AE et al. Regulation of malonyl-CoA concentration and turnover in the normal heart. 2004 J. Biol. Chem. pmid:15181001
Chandler MP et al. Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation. 2004 Am. J. Physiol. Heart Circ. Physiol. pmid:15191896
Kerner J et al. Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme. 2004 J. Biol. Chem. pmid:15247243
Onay-Besikci A et al. gAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit hearts. 2004 J. Biol. Chem. pmid:15269215
Bederman IR et al. In vitro modeling of fatty acid synthesis under conditions simulating the zonation of lipogenic [13C]acetyl-CoA enrichment in the liver. 2004 J. Biol. Chem. pmid:15284243
A'Bháird NN and Ramsay RR Malonyl-CoA inhibition of peroxisomal carnitine octanoyltransferase. 1992 Biochem. J. pmid:1530596
Gande R et al. Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis. 2004 J. Biol. Chem. pmid:15308633
Yang N et al. C75 [4-methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid] activates carnitine palmitoyltransferase-1 in isolated mitochondria and intact cells without displacement of bound malonyl CoA. 2005 J. Pharmacol. Exp. Ther. pmid:15356215
Juárez P et al. A microsomal fatty acid synthetase from the integument of Blattella germanica synthesizes methyl-branched fatty acids, precursors to hydrocarbon and contact sex pheromone. 1992 Arch. Biochem. Biophys. pmid:1536569
Yoshida S and Bourre JM Condensation activity for polyunsaturated fatty acids with malonyl-CoA in rat brain microsomes. Characteristics and developmental change. 1992 Biochim. Biophys. Acta pmid:1536871
Roepstorff C et al. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15383373