Malonyl-coa

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Current reference collection contains 3249 references associated with Malonyl-coa in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonyl-coa

MeSH term MeSH ID Detail
Starvation D013217 47 associated lipids
Fatty Liver D005234 48 associated lipids
Weight Loss D015431 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Gain D015430 101 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 | Total 20

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Per page 10 20 50 100 | Total 927
Authors Title Published Journal PubMed Link
Reszko AE et al. Peroxisomal fatty acid oxidation is a substantial source of the acetyl moiety of malonyl-CoA in rat heart. 2004 J. Biol. Chem. pmid:14982940
Abe I et al. The first plant type III polyketide synthase that catalyzes formation of aromatic heptaketide. 2004 FEBS Lett. pmid:15044020
Roduit R et al. A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. 2004 Diabetes pmid:15047616
Degrace P et al. Hepatic steatosis is not due to impaired fatty acid oxidation capacities in C57BL/6J mice fed the conjugated trans-10,cis-12-isomer of linoleic acid. 2004 J. Nutr. pmid:15051838
Sleeman MC and Schofield CJ Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis. 2004 J. Biol. Chem. pmid:14625287
Falk KL et al. Glucosinolate biosynthesis: demonstration and characterization of the condensing enzyme of the chain elongation cycle in Eruca sativa. 2004 Phytochemistry pmid:15110687
Oguro S et al. Probing biosynthesis of plant polyketides with synthetic N-acetylcysteamine thioesters. 2004 Biochem. Biophys. Res. Commun. pmid:15530429
Nicot C et al. C75 activates malonyl-CoA sensitive and insensitive components of the CPT system. 2004 Biochem. Biophys. Res. Commun. pmid:15541339
Cheng L et al. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. 2004 Nat. Med. pmid:15475963
Bezaire V et al. Regulation of CPT I activity in intermyofibrillar and subsarcolemmal mitochondria from human and rat skeletal muscle. 2004 Am. J. Physiol. Endocrinol. Metab. pmid:12954596
Traufeller K et al. Different sensitivities of CPT I and CPT II for inhibition by l-aminocarnitine in human skeletal muscle. 2004 Biochim. Biophys. Acta pmid:14871492
Rodriguez E et al. Engineered biosynthesis of 16-membered macrolides that require methoxymalonyl-ACP precursors in Streptomyces fradiae. 2004 Appl. Microbiol. Biotechnol. pmid:15179529
Ruderman N and Prentki M AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. 2004 Nat Rev Drug Discov pmid:15060529
Raharjo TJ et al. Cloning and over-expression of a cDNA encoding a polyketide synthase from Cannabis sativa. 2004 Plant Physiol. Biochem. pmid:15120113
Minkler PE et al. Isolation and identification of two isomeric forms of malonyl-coenzyme A in commercial malonyl-coenzyme A. 2004 Anal. Biochem. pmid:15113698
Saha AK et al. Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. 2004 Biochem. Biophys. Res. Commun. pmid:14733947
Tseng CC et al. Role of the active site cysteine of DpgA, a bacterial type III polyketide synthase. 2004 Biochemistry pmid:14744141
Relat J et al. Pig muscle carnitine palmitoyltransferase I (CPTI beta), with low Km for carnitine and low sensitivity to malonyl-CoA inhibition, has kinetic characteristics similar to those of the rat liver (CPTI alpha) enzyme. 2004 Biochemistry pmid:15449958
Pulinilkunnil T et al. Evidence for rapid "metabolic switching" through lipoprotein lipase occupation of endothelial-binding sites. 2003 J. Mol. Cell. Cardiol. pmid:12967632
Stanley WC et al. beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12969881
Rosa G et al. Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects. 2003 Obes. Res. pmid:14627750
Onay-Besikci A et al. Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12388233
Gutières S et al. Cloning and tissue distribution of a carnitine palmitoyltransferase I gene in rainbow trout (Oncorhynchus mykiss). 2003 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:12781981
Focke M et al. Fatty acid biosynthesis in mitochondria of grasses: malonyl-coenzyme A is generated by a mitochondrial-localized acetyl-coenzyme A carboxylase. 2003 Plant Physiol. pmid:12972648
Boren J et al. The stable isotope-based dynamic metabolic profile of butyrate-induced HT29 cell differentiation. 2003 J. Biol. Chem. pmid:12750369
Zhu H et al. Substitution of glutamate-3, valine-19, leucine-23, and serine-24 with alanine in the N-terminal region of human heart muscle carnitine palmitoyltransferase I abolishes malonyl CoA inhibition and binding. 2003 Arch. Biochem. Biophys. pmid:12706342
Kajikawa M et al. Functional analysis of a beta-ketoacyl-CoA synthase gene, MpFAE2, by gene silencing in the liverwort Marchantia polymorpha L. 2003 Biosci. Biotechnol. Biochem. pmid:12723610
Wortman MD et al. C75 inhibits food intake by increasing CNS glucose metabolism. 2003 Nat. Med. pmid:12724740
Lehtihet M et al. Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:12684219
Schujman GE et al. FapR, a bacterial transcription factor involved in global regulation of membrane lipid biosynthesis. 2003 Dev. Cell pmid:12737802
Treber M et al. Identification by mutagenesis of conserved arginine and glutamate residues in the C-terminal domain of rat liver carnitine palmitoyltransferase I that are important for catalytic activity and malonyl-CoA sensitivity. 2003 J. Biol. Chem. pmid:12540837
Ruderman NB et al. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. 2003 Biochem. Soc. Trans. pmid:12546685
Hopkins TA et al. AMP-activated protein kinase regulation of fatty acid oxidation in the ischaemic heart. 2003 Biochem. Soc. Trans. pmid:12546686
Suzuki H et al. Proposed mechanism and functional amino acid residues of malonyl-CoA:anthocyanin 5-O-glucoside-6'''-O-malonyltransferase from flowers of Salvia splendens, a member of the versatile plant acyltransferase family. 2003 Biochemistry pmid:12578391
Hügler M et al. Characterization of acetyl-CoA/propionyl-CoA carboxylase in Metallosphaera sedula. Carboxylating enzyme in the 3-hydroxypropionate cycle for autotrophic carbon fixation. 2003 Eur. J. Biochem. pmid:12581213
Cheng YQ et al. Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12598647
Prigge ST et al. The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIII. 2003 Biochemistry pmid:12549938
Wang F et al. Inhibitive effect of zinc ion on fatty acid synthase from chicken liver. 2003 Int. J. Biochem. Cell Biol. pmid:12531252
Dai J et al. Leucine-764 near the extreme C-terminal end of carnitine palmitoyltransferase I is important for activity. 2003 Biochem. Biophys. Res. Commun. pmid:12565845
Liou GF et al. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. 2003 Biochemistry pmid:12515555
Steinberg GR et al. AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:12441311
BÃ¥venholm PN et al. Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation. 2003 J. Clin. Endocrinol. Metab. pmid:12519834
Morillas M et al. Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition. 2003 J. Biol. Chem. pmid:12499375
Zhang L et al. Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. 2003 J. Biol. Chem. pmid:12882974
Kiens B and Roepstorff C Utilization of long-chain fatty acids in human skeletal muscle during exercise. 2003 Acta Physiol. Scand. pmid:12864744
Ruderman NB et al. AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. 2003 Acta Physiol. Scand. pmid:12864749
Dawe JH et al. A template search reveals mechanistic similarities and differences in beta-ketoacyl synthases (KAS) and related enzymes. 2003 Proteins pmid:12866053
Molnos J et al. A continuous coupled enzyme assay for bacterial malonyl-CoA:acyl carrier protein transacylase (FabD). 2003 Anal. Biochem. pmid:12842120
Harwood HJ et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. 2003 J. Biol. Chem. pmid:12842871
Ruderman NB et al. Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. 2003 Endocrinology pmid:14500570
Mazur MT et al. Site-specific observation of acyl intermediate processing in thiotemplate biosynthesis by fourier transform mass spectrometry: the polyketide module of yersiniabactin synthetase. 2003 Biochemistry pmid:14621984
Eckermann C et al. Covalent binding of chloroacetamide herbicides to the active site cysteine of plant type III polyketide synthases. 2003 Phytochemistry pmid:14568070
Frayn KN The glucose-fatty acid cycle: a physiological perspective. 2003 Biochem. Soc. Trans. pmid:14641007
Napal L et al. A single amino acid change (substitution of the conserved Glu-590 with alanine) in the C-terminal domain of rat liver carnitine palmitoyltransferase I increases its malonyl-CoA sensitivity close to that observed with the muscle isoform of the enzyme. 2003 J. Biol. Chem. pmid:12826662
Hu Z et al. Hypothalamic malonyl-CoA as a mediator of feeding behavior. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:14532332
Weiss DR and Glickman JF Characterization of fatty acid synthase activity using scintillation proximity. 2003 Assay Drug Dev Technol pmid:15090142
Shafrir E et al. Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus. 2002 May-Jun Diabetes Metab. Res. Rev. pmid:12112940
Suh MC et al. What limits production of unusual monoenoic fatty acids in transgenic plants? 2002 Planta pmid:12172841
Campbell FM et al. A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. 2002 J. Biol. Chem. pmid:11734553
Ido Y et al. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. 2002 Diabetes pmid:11756336
Richards JG et al. Lipid oxidation fuels recovery from exhaustive exercise in white muscle of rainbow trout. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11742827
Nicot C et al. Pig liver carnitine palmitoyltransferase. Chimera studies show that both the N- and C-terminal regions of the enzyme are important for the unusual high malonyl-CoA sensitivity. 2002 J. Biol. Chem. pmid:11790778
Morillas M et al. Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. 2002 J. Biol. Chem. pmid:11790793
Florova G et al. Enzymes involved in fatty acid and polyketide biosynthesis in Streptomyces glaucescens: role of FabH and FabD and their acyl carrier protein specificity. 2002 Biochemistry pmid:12173933
Zheng X et al. Substrate binding induces a cooperative conformational change in the 12S subunit of transcarboxylase: Raman crystallographic evidence. 2002 Biochemistry pmid:12196011
Witkowski A et al. Mechanism of the beta-ketoacyl synthase reaction catalyzed by the animal fatty acid synthase. 2002 Biochemistry pmid:12196027
Ghanevati M and Jaworski JG Engineering and mechanistic studies of the Arabidopsis FAE1 beta-ketoacyl-CoA synthase, FAE1 KCS. 2002 Eur. J. Biochem. pmid:12135493
Hügler M et al. Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation. 2002 J. Bacteriol. pmid:11948153
Kim JY et al. Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:11934665
Salles J et al. Fatty acid synthase expression during peripheral nervous system myelination. 2002 Brain Res. Mol. Brain Res. pmid:12007831
Jez JM et al. Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11959984
Ukropec J et al. An increase in peroxisomal fatty acid oxidation is not sufficient to prevent tissue lipid accumulation in hHTg rats. 2002 Ann. N. Y. Acad. Sci. pmid:12079837
Yee AJ and Turcotte LP Insulin fails to alter plasma LCFA metabolism in muscle perfused at similar glucose uptake. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:12067845
Atkinson LL et al. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. 2002 J. Biol. Chem. pmid:12058043
Thupari JN et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12060712
Richards JG et al. Substrate utilization during graded aerobic exercise in rainbow trout. 2002 J. Exp. Biol. pmid:12089210
Hirsch J The search for new ways to treat obesity. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12093927
Verhoeyen ME et al. Increasing antioxidant levels in tomatoes through modification of the flavonoid biosynthetic pathway. 2002 J. Exp. Bot. pmid:12324533
Pan Y et al. The extreme C terminus of rat liver carnitine palmitoyltransferase I is not involved in malonyl-CoA sensitivity but in initial protein folding. 2002 J. Biol. Chem. pmid:12351641
Schwarzer D et al. Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12384573
Poirier M et al. Probing the link between citrate and malonyl-CoA in perfused rat hearts. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12234788
Dyck JR and Lopaschuk GD Malonyl CoA control of fatty acid oxidation in the ischemic heart. 2002 J. Mol. Cell. Cardiol. pmid:12392882
Jensen MD Fatty acid oxidation in human skeletal muscle. 2002 J. Clin. Invest. pmid:12464664
Rasmussen BB et al. Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. 2002 J. Clin. Invest. pmid:12464674
Tomas E et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12456889
Prentki M et al. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. 2002 Diabetes pmid:12475783
Park SH et al. Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle. 2002 J. Appl. Physiol. pmid:12433937
Martini WZ et al. Alteration of hepatic fatty acid metabolism after burn injury in pigs. 2001 Nov-Dec JPEN J Parenter Enteral Nutr pmid:11688934
Reszko AE et al. Assay of the concentration and 13C-isotopic enrichment of malonyl-coenzyme A by gas chromatography-mass spectrometry. 2001 Anal. Biochem. pmid:11673897
Rodríguez E et al. Role of an essential acyl coenzyme A carboxylase in the primary and secondary metabolism of Streptomyces coelicolor A3(2). 2001 Appl. Environ. Microbiol. pmid:11526020
Rangan VS et al. Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro. 2001 Biochemistry pmid:11535054
Surendran S et al. Malonyl CoA decarboxylase deficiency: C to T transition in intron 2 of the MCD gene. 2001 J. Neurosci. Res. pmid:11550227
Morillas M et al. Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity. 2001 J. Biol. Chem. pmid:11553629
Doenst T et al. Load-induced changes in vivo alter substrate fluxes and insulin responsiveness of rat heart in vitro. 2001 Metab. Clin. Exp. pmid:11555843
Longnus SL et al. Regulation of myocardial fatty acid oxidation by substrate supply. 2001 Am. J. Physiol. Heart Circ. Physiol. pmid:11557544
Hamdan M et al. Inhibition of mitochondrial carnitine palmitoyltransferase-1 by a trimetazidine derivative, S-15176. 2001 Pharmacol. Res. pmid:11516258
Brown NF et al. Molecular characterization of L-CPT I deficiency in six patients: insights into function of the native enzyme. 2001 J. Lipid Res. pmid:11441142
Eaton S et al. Carnitine palmitoyl transferase I and the control of beta-oxidation in heart mitochondria. 2001 Biochem. Biophys. Res. Commun. pmid:11444876
Morita H et al. Novel polyketides synthesized with a higher plant stilbene synthase. 2001 Eur. J. Biochem. pmid:11432743
Dagher Z et al. Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. 2001 Circ. Res. pmid:11420304