Malonyl-coa

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 3249 references associated with Malonyl-coa in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonyl-coa

MeSH term MeSH ID Detail
Starvation D013217 47 associated lipids
Fatty Liver D005234 48 associated lipids
Weight Loss D015431 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Insulin Resistance D007333 99 associated lipids
Weight Gain D015430 101 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Adenocarcinoma D000230 166 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 | Total 20

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Per page 10 20 50 100 | Total 927
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Keung W et al. Chronic central leptin decreases food intake and improves glucose tolerance in diet-induced obese mice independent of hypothalamic malonyl CoA levels and skeletal muscle insulin sensitivity. 2011 Endocrinology pmid:21914780
Wheeler PR et al. Enzymes for biosynthesis de novo and elongation of fatty acids in mycobacteria grown in host cells: is Mycobacterium leprae competent in fatty acid biosynthesis? 1990 J. Gen. Microbiol. pmid:2191079
Serviddio G et al. Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet. 2011 PLoS ONE pmid:21909411
Jia Y and Zhong JJ Enhanced production of ansamitocin P-3 by addition of Mg2+ in fermentation of Actinosynnema pretiosum. 2011 Bioresour. Technol. pmid:21907573
Hammerbacher A et al. Biosynthesis of the major tetrahydroxystilbenes in spruce, astringin and isorhapontin, proceeds via resveratrol and is enhanced by fungal infection. 2011 Plant Physiol. pmid:21865488
Sloan JL et al. Exome sequencing identifies ACSF3 as a cause of combined malonic and methylmalonic aciduria. 2011 Nat. Genet. pmid:21841779
Kudej RK et al. Second window of preconditioning normalizes palmitate use for oxidation and improves function during low-flow ischaemia. 2011 Cardiovasc. Res. pmid:21835931
Alfares A et al. Combined malonic and methylmalonic aciduria: exome sequencing reveals mutations in the ACSF3 gene in patients with a non-classic phenotype. 2011 J. Med. Genet. pmid:21785126
Xu P et al. Genome-scale metabolic network modeling results in minimal interventions that cooperatively force carbon flux towards malonyl-CoA. 2011 Metab. Eng. pmid:21763447
Rathnasingh C et al. Production of 3-hydroxypropionic acid via malonyl-CoA pathway using recombinant Escherichia coli strains. 2012 J. Biotechnol. pmid:21723339
Alves J et al. Cloning, expression, and enzymatic activity of Acinetobacter baumannii and Klebsiella pneumoniae acetyl-coenzyme A carboxylases. 2011 Anal. Biochem. pmid:21704013
Prip-Buus C et al. Evidence that the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA is an important site of regulation of hepatic fatty acid oxidation in the fetal and newborn rabbit. Perinatal development and effects of pancreatic hormones in cultured rabbit hepatocytes. 1990 Biochem. J. pmid:2167069
Winder WW et al. Time course of exercise-induced decline in malonyl-CoA in different muscle types. 1990 Am. J. Physiol. pmid:2166437
Gao S et al. Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding. 2011 Proc. Natl. Acad. Sci. U.S.A. pmid:21593415
Reamy AA and Wolfgang MJ Carnitine palmitoyltransferase-1c gain-of-function in the brain results in postnatal microencephaly. 2011 J. Neurochem. pmid:21592121
Bengtsson C et al. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. 2011 Bioorg. Med. Chem. pmid:21515056
Lauzier B et al. Post-translational modifications, a key process in CD36 function: lessons from the spontaneously hypertensive rat heart. 2011 J. Mol. Cell. Cardiol. pmid:21510957
Gao S et al. Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a. 2011 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:21508288
Gilibili RR et al. Development and validation of a highly sensitive LC-MS/MS method for simultaneous quantitation of acetyl-CoA and malonyl-CoA in animal tissues. 2011 Biomed. Chromatogr. pmid:21381064
Wolfgang MJ and Lane MD Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity. 2011 FEBS J. pmid:21199367
Mo S et al. Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. 2011 J. Am. Chem. Soc. pmid:21175203
Hozyasz KK et al. Malonylcarnitine in newborns with non-syndromic cleft lip with or without cleft palate. 2010 Int J Oral Sci pmid:21125791
Meehan MJ et al. FT-ICR-MS characterization of intermediates in the biosynthesis of the α-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF. 2011 Biochemistry pmid:21069965
Keung W et al. Intracerebroventricular leptin administration differentially alters cardiac energy metabolism in mice fed a low-fat and high-fat diet. 2011 J. Cardiovasc. Pharmacol. pmid:20980918
Meng X et al. Increasing fatty acid production in E. coli by simulating the lipid accumulation of oleaginous microorganisms. 2011 J. Ind. Microbiol. Biotechnol. pmid:20972897
Bolton P and Harwood JL Some characteristics of soluble fatty acid synthesis in germinating pea seeds. 1977 Biochim. Biophys. Acta pmid:20971
Geisler JG Targeting energy expenditure via fuel switching and beyond. 2011 Diabetologia pmid:20953861
Tokutake Y et al. Coenzyme A and its thioester pools in fasted and fed rat tissues. 2010 Biochem. Biophys. Res. Commun. pmid:20933504
Cook GA and Weakley LJ Effects of starvation on the carnitine palmitoyltransferase of hepatic peroxisomes. 1990 Biochem. Soc. Trans. pmid:2083787
Kashfi K et al. Effects of cholesterol loading of mouse macrophages on carnitine palmitoyltransferase activity and sensitivity to inhibition by malonyl-CoA. 1991 Biochem. Biophys. Res. Commun. pmid:2059202
Elayan IM and Winder WW Effect of glucose infusion on muscle malonyl-CoA during exercise. 1991 J. Appl. Physiol. pmid:2055826
Onorato JM et al. Liquid-liquid extraction coupled with LC/MS/MS for monitoring of malonyl-CoA in rat brain tissue. 2010 Anal Bioanal Chem pmid:20549491
Footitt EJ et al. Use of a long-chain triglyceride-restricted/medium-chain triglyceride-supplemented diet in a case of malonyl-CoA decarboxylase deficiency with cardiomyopathy. 2010 J. Inherit. Metab. Dis. pmid:20549361
Kashiwaya Y et al. A ketone ester diet increases brain malonyl-CoA and Uncoupling proteins 4 and 5 while decreasing food intake in the normal Wistar Rat. 2010 J. Biol. Chem. pmid:20529850
Morash AJ et al. Genome duplication events have led to a diversification in the CPT I gene family in fish. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20519364
Thyfault JP et al. Metabolic profiling of muscle contraction in lean compared with obese rodents. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20504904
Albaugh VL et al. Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents. 2012 Schizophr Bull pmid:20494946
Kharel MK et al. Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic. 2010 Org. Lett. pmid:20486694
Ramsay RR et al. Carnitine palmitoyltransferase in human erythrocyte membrane. Properties and malonyl-CoA sensitivity. 1991 Biochem. J. pmid:2039446
Lopaschuk GD et al. Targeting intermediary metabolism in the hypothalamus as a mechanism to regulate appetite. 2010 Pharmacol. Rev. pmid:20392806
Olson DP et al. Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20368432
Ghadiminejad I and Saggerson D Cholate separates the catalytic and malonyl-CoA-binding components of carnitine palmitoyltransferase from liver outer mitochondrial membranes. 1991 Biochim. Biophys. Acta pmid:2036450
Winder WW et al. Divergence of muscle and liver fructose 2,6-diphosphate in fasted exercising rats. 1991 Am. J. Physiol. pmid:2035632
McGarry JD et al. New insights into the mitochondrial carnitine palmitoyltransferase enzyme system. 1991 Biochimie pmid:2031961
Lin X et al. Carnitine palmitoyltransferase I control of acetogenesis, the major pathway of fatty acid {beta}-oxidation in liver of neonatal swine. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20237302
Martinez MA et al. A novel role of malonyl-ACP in lipid homeostasis. 2010 Biochemistry pmid:20201588
Liu T et al. Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. 2010 Metab. Eng. pmid:20184964
Hamed RB et al. Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles. 2010 Chem. Commun. (Camb.) pmid:20162132
Singh SP et al. Fat accumulation in Caenorhabditis elegans triggered by the electrophilic lipid peroxidation product 4-hydroxynonenal (4-HNE). 2009 Aging (Albany NY) pmid:20157589
Demirkapi N et al. Evidence against cytochrome b5 involvement in liver microsomal fatty acid elongation. 1991 Biochim. Biophys. Acta pmid:2009301
Morita H et al. A structure-based mechanism for benzalacetone synthase from Rheum palmatum. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20080733
Price NT et al. Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues. 2010 J. Biol. Chem. pmid:20061394
Guzmán-Ruiz R et al. Sensitivity of cardiac carnitine palmitoyltransferase to malonyl-CoA is regulated by leptin: similarities with a model of endogenous hyperleptinemia. 2010 Endocrinology pmid:20056820
Sucajtys-Szulc E et al. Differential effect of prolonged food restriction and fasting on hypothalamic malonyl-CoA concentration and expression of orexigenic and anorexigenic neuropeptides genes in rats. 2010 Neuropeptides pmid:20004973
Ma SM et al. Complete reconstitution of a highly reducing iterative polyketide synthase. 2009 Science pmid:19900898
Baquet A et al. Comparison of the effects of various amino acids on glycogen synthesis, lipogenesis and ketogenesis in isolated rat hepatocytes. 1991 Biochem. J. pmid:1989589
Sharma V et al. Functional effects of protein kinases and peroxynitrite on cardiac carnitine palmitoyltransferase-1 in isolated mitochondria. 2010 Mol. Cell. Biochem. pmid:19862603
Takagi M et al. Pantothenate kinase from the thermoacidophilic archaeon Picrophilus torridus. 2010 J. Bacteriol. pmid:19854913
Maharjan S et al. Metabolic engineering of Streptomyces venezuelae for malonyl-CoA biosynthesis to enhance heterologous production of polyketides. 2010 Biotechnol. Lett. pmid:19838628
Saez G et al. Gene expression and protein content in relation to intramuscular fat content in Muscovy and Pekin ducks. 2009 Poult. Sci. pmid:19834090
White JS Significance of differential effects of glucose and fructose on brain food signaling is uncertain. 2009 Biochem. Biophys. Res. Commun. pmid:19785993
Kim DH et al. Molecular characterization of flavonoid malonyltransferase from Oryza sativa. 2009 Nov-Dec Plant Physiol. Biochem. pmid:19733090
Schink B An alternative to the glyoxylate shunt. 2009 Mol. Microbiol. pmid:19682245
Fowler ZL et al. Increased malonyl coenzyme A biosynthesis by tuning the Escherichia coli metabolic network and its application to flavanone production. 2009 Appl. Environ. Microbiol. pmid:19633125
Eustáquio AS et al. Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19590008
Kitazawa H et al. Development of a high-density assay for long-chain fatty acyl-CoA elongases. 2009 Lipids pmid:19575253
Zha W et al. Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering. 2009 Metab. Eng. pmid:19558964
Miyanaga A and Horinouchi S Enzymatic synthesis of bis-5-alkylresorcinols by resorcinol-producing type III polyketide synthases. 2009 J. Antibiot. pmid:19557027
Nilsson LA et al. Prolactin suppresses malonyl-CoA concentration in human adipose tissue. 2009 Horm. Metab. Res. pmid:19551610
Awakawa T et al. Physically discrete beta-lactamase-type thioesterase catalyzes product release in atrochrysone synthesis by iterative type I polyketide synthase. 2009 Chem. Biol. pmid:19549600
Cha SH and Lane MD Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway. 2009 Biochem. Biophys. Res. Commun. pmid:19523445
Tosin M et al. Malonyl carba(dethia)- and malonyl oxa(dethia)-coenzyme A as tools for trapping polyketide intermediates. 2009 Chembiochem pmid:19507202
Dean JT et al. Resistance to diet-induced obesity in mice with synthetic glyoxylate shunt. 2009 Cell Metab. pmid:19490907
Downs SM et al. Fatty acid oxidation and meiotic resumption in mouse oocytes. 2009 Mol. Reprod. Dev. pmid:19455666
Ide T et al. Comparative study of sesame lignans (sesamin, episesamin and sesamolin) affecting gene expression profile and fatty acid oxidation in rat liver. 2009 J. Nutr. Sci. Vitaminol. pmid:19352061
Celik A et al. Decrease in malonyl-CoA and its background metabolic alterations in murine model of cancer cachexia. 2009 Oncol. Rep. pmid:19288015
Metz JG et al. Biochemical characterization of polyunsaturated fatty acid synthesis in Schizochytrium: release of the products as free fatty acids. 2009 Plant Physiol. Biochem. pmid:19272783
Lane MD and Cha SH Effect of glucose and fructose on food intake via malonyl-CoA signaling in the brain. 2009 Biochem. Biophys. Res. Commun. pmid:19265677
Katsuyama Y et al. Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa. 2009 J. Biol. Chem. pmid:19258320
Zhao Z et al. Rosiglitazone and fenofibrate improve insulin sensitivity of pre-diabetic OLETF rats by reducing malonyl-CoA levels in the liver and skeletal muscle. 2009 Life Sci. pmid:19250943
Ussher JR and Lopaschuk GD Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion. 2009 Basic Res. Cardiol. pmid:19242641
Frøsig C et al. Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle. 2009 Am. J. Physiol. Endocrinol. Metab. pmid:19190265
Wang Q et al. Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. 2009 Hepatology pmid:19177596
Lavarías S et al. Partial characterization of a malonyl-CoA-sensitive carnitine O-palmitoyltransferase I from Macrobrachium borellii (Crustacea: Palaemonidae). 2009 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:19171199
Coletta DK et al. Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial. 2009 Diabetologia pmid:19169664
Ghadiminejad I and Saggerson D A proportion of rat liver mitochondrial carnitine palmitoyltransferase can be made activatable by malonyl-CoA. 1991 Biochim. Biophys. Acta pmid:1911872
Relat J et al. A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme. 2009 FEBS J. pmid:19049515
Cha SH et al. Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18971329
Dzamko N et al. AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. 2008 J. Physiol. (Lond.) pmid:18845612
Zammit VA and Arduini A The AMPK-malonyl-CoA-CPT1 axis in the control of hypothalamic neuronal function. 2008 Cell Metab. pmid:18762014
Ghadiminejad I and Saggerson ED A study of properties and abundance of the components of liver carnitine palmitoyltransferases in mitochondrial inner and outer membranes. Effects of hypothyroidism, fasting and a ketotic diabetic state. 1991 Biochem. J. pmid:1872797
Lane MD et al. Regulation of food intake and energy expenditure by hypothalamic malonyl-CoA. 2008 Int J Obes (Lond) pmid:18719599
Lopaschuk GD AMP-activated protein kinase control of energy metabolism in the ischemic heart. 2008 Int J Obes (Lond) pmid:18719595
Deshaies Y AMP kinase: heart, cancer and the CNS--view from the chair. 2008 Int J Obes (Lond) pmid:18719594
Kerner J et al. Rat liver mitochondrial carnitine palmitoyltransferase-I, hepatic carnitine, and malonyl-CoA: effect of starvation. 2008 Arch. Physiol. Biochem. pmid:18629681
Pénicaud L et al. Effect of insulin on the properties of liver carnitine palmitoyltransferase in the starved rat: assessment by the euglycemic hyperinsulinemic clamp. 1991 Metab. Clin. Exp. pmid:1861636
Yatscoff MA et al. Myocardial hypertrophy and the maturation of fatty acid oxidation in the newborn human heart. 2008 Pediatr. Res. pmid:18614968
Singh P et al. Topological descriptors in modeling malonyl coenzyme A decarboxylase inhibitory activity: N-Alkyl-N-(1,1,1,3,3,3-hexafluoro-2-hydroxypropylphenyl)amide derivatives. 2009 J Enzyme Inhib Med Chem pmid:18608763
Saggerson D Malonyl-CoA, a key signaling molecule in mammalian cells. 2008 Annu. Rev. Nutr. pmid:18598135
Kashfi K and Cook GA Malonyl-CoA inhibits proteolysis of carnitine palmitoyltransferase. 1991 Biochem. Biophys. Res. Commun. pmid:1859420