Malonyl-coa

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Current reference collection contains 3249 references associated with Malonyl-coa in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonyl-coa

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Angina Pectoris D000787 27 associated lipids
Body Weight D001835 333 associated lipids
Cleft Lip D002971 8 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Hyperinsulinism D006946 27 associated lipids
Hypoglycemia D007003 13 associated lipids
Per page 10 20 | Total 20

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Authors Title Published Journal PubMed Link
Duan C and Winder WW Control of malonyl-CoA by glucose and insulin in perfused skeletal muscle. 1993 J. Appl. Physiol. pmid:8335589
Winder WW et al. Effect of adrenodemedullation on decline in muscle malonyl-CoA during exercise. 1993 J. Appl. Physiol. pmid:8335590
Winder WW et al. Muscle malonyl-CoA decreases during exercise. 1989 J. Appl. Physiol. pmid:2558099
Park SH et al. Effects of thyroid state on AMP-activated protein kinase and acetyl-CoA carboxylase expression in muscle. 2002 J. Appl. Physiol. pmid:12433937
Odland LM et al. Effects of high fat provision on muscle PDH activation and malonyl-CoA content in moderate exercise. 2000 J. Appl. Physiol. pmid:11090589
Winder WW and Holmes BF Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activated. 2000 J. Appl. Physiol. pmid:11090599
Maclean PS and Winder WW Caffeine decreases malonyl-CoA in isolated perfused skeletal muscle of rats. 1995 J. Appl. Physiol. pmid:7615461
Rasmussen BB et al. Postexercise recovery of skeletal muscle malonyl-CoA, acetyl-CoA carboxylase, and AMP-activated protein kinase. 1998 J. Appl. Physiol. pmid:9804562
Merrill GF et al. Influence of malonyl-CoA and palmitate concentration on rate of palmitate oxidation in rat muscle. 1998 J. Appl. Physiol. pmid:9804598
Rasmussen BB and Winder WW Effect of exercise intensity on skeletal muscle malonyl-CoA and acetyl-CoA carboxylase. 1997 J. Appl. Physiol. pmid:9338417
Duan C and Winder WW Nerve stimulation decreases malonyl-CoA in skeletal muscle. 1992 J. Appl. Physiol. pmid:1349012
Kimber NE et al. Skeletal muscle fat metabolism after exercise in humans: influence of fat availability. 2013 J. Appl. Physiol. pmid:23519231
Bao W et al. The Streptomyces peucetius dpsC gene determines the choice of starter unit in biosynthesis of the daunorubicin polyketide. 1999 J. Bacteriol. pmid:10419974
Takagi M et al. Pantothenate kinase from the thermoacidophilic archaeon Picrophilus torridus. 2010 J. Bacteriol. pmid:19854913
Smith AC and Cronan JE Dimerization of the bacterial biotin carboxylase subunit is required for acetyl coenzyme A carboxylase activity in vivo. 2012 J. Bacteriol. pmid:22037404
Menendez C et al. Presence of acetyl coenzyme A (CoA) carboxylase and propionyl-CoA carboxylase in autotrophic Crenarchaeota and indication for operation of a 3-hydroxypropionate cycle in autotrophic carbon fixation. 1999 J. Bacteriol. pmid:9973333
Furukawa H et al. Thiolactomycin resistance in Escherichia coli is associated with the multidrug resistance efflux pump encoded by emrAB. 1993 J. Bacteriol. pmid:8509326
Hügler M et al. Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation. 2002 J. Bacteriol. pmid:11948153
Thompson TE and Zeikus JG Regulation of carbon and electron flow in Propionispira arboris: relationship of catabolic enzyme levels to carbon substrates fermented during propionate formation via the methylmalonyl coenzyme A pathway. 1988 J. Bacteriol. pmid:3410821
Jackowski S and Rock CO Consequences of reduced intracellular coenzyme A content in Escherichia coli. 1986 J. Bacteriol. pmid:3519582
Revill WP et al. Purification of a malonyltransferase from Streptomyces coelicolor A3(2) and analysis of its genetic determinant. 1995 J. Bacteriol. pmid:7608065
Morishima N and Ikai A Active site organization of bacterial type I fatty acid synthetase. 1987 J. Biochem. pmid:3448090
Watanabe K et al. Fatty acid synthesis of an eicosapentaenoic acid-producing bacterium: de novo synthesis, chain elongation, and desaturation systems. 1997 J. Biochem. pmid:9378728
Kikuchi S and Kusaka T Purification of NADPH-dependent enoyl-CoA reductase involved in the malonyl-CoA dependent fatty acid elongation system of Mycobacterium smegmatis. 1984 J. Biochem. pmid:6501266
Ohashi K et al. Assay of fatty acid synthetase by mass fragmentography using [13C]malonyl-CoA. 1985 J. Biochem. pmid:4019438
Saito K et al. Steric course of deuterium incorporation from [2-2H2]malonyl-CoA into fatty acids by fatty acid synthetases. 1981 J. Biochem. pmid:7037760
Arai K et al. Propionyl-Coa induced synthesis of even-chain-length fatty acids by fatty acid synthetase from Brevibacterium ammoniagenes. 1982 J. Biochem. pmid:7068555
Kikuchi S and Kusaka T New malonyl-CoA-dependent fatty acid elongation system in Mycobacterium smegmatis. 1982 J. Biochem. pmid:7142122
Kawaguchi A et al. Substrate control of termination of fatty acid biosynthesis by fatty acid synthetase from Brevibacterium ammoniagenes. 1980 J. Biochem. pmid:7419496
Bortolami S et al. Long chain fatty acyl-CoA modulation of H(2)O (2) release at mitochondrial complex I. 2008 J. Bioenerg. Biomembr. pmid:18214656
McGarry JD et al. Hepatic malonyl-CoA levels of fed, fasted and diabetic rats as measured using a simple radioisotopic assay. 1978 J. Biol. Chem. pmid:711752
Declercq PE et al. Interaction of malonyl-CoA and 2-tetradecylglycidyl-CoA with mitochondrial carnitine palmitoyltransferase I. 1985 J. Biol. Chem. pmid:3840167
Beaty NB and Lane MD The polymerization of acetyl-CoA carboxylase. 1983 J. Biol. Chem. pmid:6138356
Antinozzi PA et al. Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis. 1998 J. Biol. Chem. pmid:9632669
Velasco G et al. Malonyl-CoA-independent acute control of hepatic carnitine palmitoyltransferase I activity. Role of Ca2+/calmodulin-dependent protein kinase II and cytoskeletal components. 1998 J. Biol. Chem. pmid:9705278
Cao J et al. A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse. 2004 J. Biol. Chem. pmid:15152008
Hoppel CL et al. The malonyl-CoA-sensitive form of carnitine palmitoyltransferase is not localized exclusively in the outer membrane of rat liver mitochondria. 1998 J. Biol. Chem. pmid:9722587
Shi J et al. A single amino acid change (substitution of glutamate 3 with alanine) in the N-terminal region of rat liver carnitine palmitoyltransferase I abolishes malonyl-CoA inhibition and high affinity binding. 1999 J. Biol. Chem. pmid:10092622
Price NT et al. Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme: differential expression of alternatively spliced variants in Drosophila tissues. 2010 J. Biol. Chem. pmid:20061394
Dreier J et al. Kinetic analysis of the actinorhodin aromatic polyketide synthase. 1999 J. Biol. Chem. pmid:10455191
Saddik M et al. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. 1993 J. Biol. Chem. pmid:7902355
Heath RJ and Rock CO Regulation of malonyl-CoA metabolism by acyl-acyl carrier protein and beta-ketoacyl-acyl carrier protein synthases in Escherichia coli. 1995 J. Biol. Chem. pmid:7797547
Guay C et al. A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion. 2007 J. Biol. Chem. pmid:17928289
Campbell FM et al. A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. 2002 J. Biol. Chem. pmid:11734553
Murthy MS and Pande SV Malonyl-CoA-sensitive and -insensitive carnitine palmitoyltransferase activities of microsomes are due to different proteins. 1994 J. Biol. Chem. pmid:8034571
Weis BC et al. Rat heart expresses two forms of mitochondrial carnitine palmitoyltransferase I. The minor component is identical to the liver enzyme. 1994 J. Biol. Chem. pmid:8034622
Morillas M et al. Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity. 2001 J. Biol. Chem. pmid:11553629
Kerner J et al. Characterization of the malonyl-CoA-sensitive carnitine palmitoyltransferase (CPTo) of a rat heart mitochondrial particle. Evidence that the catalytic unit is CPTi. 1994 J. Biol. Chem. pmid:8132545
Cook GA et al. Yonetani-Theorell analysis of hepatic carnitine palmitoyltransferase-I inhibition indicates two distinct inhibitory binding sites. 1994 J. Biol. Chem. pmid:8132614
Nicot C et al. Pig liver carnitine palmitoyltransferase. Chimera studies show that both the N- and C-terminal regions of the enzyme are important for the unusual high malonyl-CoA sensitivity. 2002 J. Biol. Chem. pmid:11790778
Morillas M et al. Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. 2002 J. Biol. Chem. pmid:11790793
Funabashi M et al. Phenolic lipids synthesized by type III polyketide synthase confer penicillin resistance on Streptomyces griseus. 2008 J. Biol. Chem. pmid:18364359
Thampy KG Formation of malonyl coenzyme A in rat heart. Identification and purification of an isozyme of A carboxylase from rat heart. 1989 J. Biol. Chem. pmid:2572585
Jackowski S et al. Acetoacetyl-acyl carrier protein synthase. A target for the antibiotic thiolactomycin. 1989 J. Biol. Chem. pmid:2651445
Kashiwaya Y et al. A ketone ester diet increases brain malonyl-CoA and Uncoupling proteins 4 and 5 while decreasing food intake in the normal Wistar Rat. 2010 J. Biol. Chem. pmid:20529850
Bian F et al. Peroxisomal and mitochondrial oxidation of fatty acids in the heart, assessed from the 13C labeling of malonyl-CoA and the acetyl moiety of citrate. 2005 J. Biol. Chem. pmid:15611129
Liu H et al. Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis. 2005 J. Biol. Chem. pmid:15579906
Fiol CJ and Bieber LL Sigmoid kinetics of purified beef heart mitochondrial carnitine palmitoyltransferase. Effect of pH and malonyl-CoA. 1984 J. Biol. Chem. pmid:6490647
Corkey BE et al. A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells. 1989 J. Biol. Chem. pmid:2689441
Lopaschuk GD et al. Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart. 1994 J. Biol. Chem. pmid:7929291
Brown NF et al. Expression of a cDNA for rat liver carnitine palmitoyltransferase I in yeast establishes that catalytic activity and malonyl-CoA sensitivity reside in a single polypeptide. 1994 J. Biol. Chem. pmid:7929364
Decaux JF et al. Decreased hepatic fatty acid oxidation at weaning in the rat is not linked to a variation of malonyl-CoA concentration. 1988 J. Biol. Chem. pmid:2893801
Funa N et al. A novel quinone-forming monooxygenase family involved in modification of aromatic polyketides. 2005 J. Biol. Chem. pmid:15701630
Boren J et al. The stable isotope-based dynamic metabolic profile of butyrate-induced HT29 cell differentiation. 2003 J. Biol. Chem. pmid:12750369
Treber M et al. Identification by mutagenesis of conserved arginine and glutamate residues in the C-terminal domain of rat liver carnitine palmitoyltransferase I that are important for catalytic activity and malonyl-CoA sensitivity. 2003 J. Biol. Chem. pmid:12540837
Borthwick K et al. The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity. 2006 J. Biol. Chem. pmid:16908527
MENON GK and STERN JR Enzymic synthesis and metabolism of malonyl coenzyme A and glutaryl coenzyme A. 1960 J. Biol. Chem. pmid:13769479
Rainwater DL and Kolattukudy PE Fatty acid biosynthesis in Mycobacterium tuberculosis var. bovis Bacillus Calmette-Guérin. Purification and characterization of a novel fatty acid synthase, mycocerosic acid synthase, which elongates n-fatty acyl-CoA with methylmalonyl-CoA. 1985 J. Biol. Chem. pmid:3880746
Walters DW and Gilbert HF Thiol/disulfide redox equilibrium and kinetic behavior of chicken liver fatty acid synthase. 1986 J. Biol. Chem. pmid:3759951
Wolfgang MJ and Lane MD The role of hypothalamic malonyl-CoA in energy homeostasis. 2006 J. Biol. Chem. pmid:17018521
Morillas M et al. Identification of conserved amino acid residues in rat liver carnitine palmitoyltransferase I critical for malonyl-CoA inhibition. Mutation of methionine 593 abolishes malonyl-CoA inhibition. 2003 J. Biol. Chem. pmid:12499375
Zhang L et al. Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. 2003 J. Biol. Chem. pmid:12882974
Harwood HJ et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. 2003 J. Biol. Chem. pmid:12842871
Miyazawa T et al. Identification of Middle Chain Fatty Acyl-CoA Ligase Responsible for the Biosynthesis of 2-Alkylmalonyl-CoAs for Polyketide Extender Unit. 2015 J. Biol. Chem. pmid:26378232
HATCH MD and STUMPF PK Fat metabolism in higher plants. XVI. Acetyl coenzyme A carboxylase and acyl coenzyme A-malonyl coenzyme A transcarboxylase from wheat germ. 1961 J. Biol. Chem. pmid:13905314
VAGELOS PR and ALBERTS AW Malonyl coenzyme A-carbon dioxide exchange reaction. 1960 J. Biol. Chem. pmid:13779560
VAGELOS PR Propionic acid metabolism. IV. Synthesis of malonyl coenzyme A. 1960 J. Biol. Chem. pmid:13840646
VAGELOS PR and EARL JM Propionic acid metabolism. III. beta-Hydroxypropionyl coenzyme A and malonyl semialdehyde coenzyme A, intermediates in propionate oxidation by Clostridium kluyveri. 1959 J. Biol. Chem. pmid:13840645
Prasad MR et al. Rat hepatic microsomal acetoacetyl-CoA reductase. A beta-ketoacyl-CoA reductase distinct from the long chain beta-ketoacyl-CoA reductase component of the microsomal fatty acid chain elongation system. 1984 J. Biol. Chem. pmid:6376489
Kudo N et al. High rates of fatty acid oxidation during reperfusion of ischemic hearts are associated with a decrease in malonyl-CoA levels due to an increase in 5'-AMP-activated protein kinase inhibition of acetyl-CoA carboxylase. 1995 J. Biol. Chem. pmid:7615556
Jin Z et al. Compartmentation of Metabolism of the C12-, C9-, and C5-n-dicarboxylates in Rat Liver, Investigated by Mass Isotopomer Analysis: ANAPLEROSIS FROM DODECANEDIOATE. 2015 J. Biol. Chem. pmid:26070565
BRODIE JD et al. The participation of malonyl coenzyme A in the biosynthesis of mevalonic acid. 1963 J. Biol. Chem. pmid:14015675
Fraser F et al. Distinct kinetics of carnitine palmitoyltransferase i in contact sites and outer membranes of rat liver mitochondria. 2001 J. Biol. Chem. pmid:11274214
Cook GA Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in Ki values. 1984 J. Biol. Chem. pmid:6480597
Cook GA et al. Ketogenesis and malonyl coenzyme A content of isolated rat hepatocytes. 1978 J. Biol. Chem. pmid:632284
Soulié JM et al. Transient kinetic studies of fatty acid synthetase. A kinetic self-editing mechanism for the loading of acetyl and malonyl residues and the role of coenzyme A. 1984 J. Biol. Chem. pmid:6706923
Napal L et al. A single amino acid change (substitution of the conserved Glu-590 with alanine) in the C-terminal domain of rat liver carnitine palmitoyltransferase I increases its malonyl-CoA sensitivity close to that observed with the muscle isoform of the enzyme. 2003 J. Biol. Chem. pmid:12826662
Gokulan K et al. Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. 2013 J. Biol. Chem. pmid:23615910
Gande R et al. Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis. 2004 J. Biol. Chem. pmid:15308633
Kerner J et al. Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme. 2004 J. Biol. Chem. pmid:15247243
Onay-Besikci A et al. gAd-globular head domain of adiponectin increases fatty acid oxidation in newborn rabbit hearts. 2004 J. Biol. Chem. pmid:15269215
Moon YA et al. Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. 2001 J. Biol. Chem. pmid:11567032
Fernandes ND and Kolattukudy PE A newly identified methyl-branched chain fatty acid synthesizing enzyme from Mycobacterium tuberculosis var. bovis BCG. 1998 J. Biol. Chem. pmid:9446591
Bederman IR et al. In vitro modeling of fatty acid synthesis under conditions simulating the zonation of lipogenic [13C]acetyl-CoA enrichment in the liver. 2004 J. Biol. Chem. pmid:15284243
Rangan VS and Smith S Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue. 1997 J. Biol. Chem. pmid:9115261
Keyes SR et al. Rat liver microsomal elongation of fatty acids. Possible involvement of cytochrome b5. 1979 J. Biol. Chem. pmid:468787
McGarry JD and Foster DW In support of the roles of malonyl-CoA and carnitine acyltransferase I in the regulation of hepatic fatty acid oxidation and ketogenesis. 1979 J. Biol. Chem. pmid:468816
McGarry JD et al. The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes. 1978 J. Biol. Chem. pmid:711753
McGarry JD et al. Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA. 1978 J. Biol. Chem. pmid:659409
Prasad MR et al. Evidence for multiple condensing enzymes in rat hepatic microsomes catalyzing the condensation of saturated, monounsaturated, and polyunsaturated acyl coenzyme A. 1986 J. Biol. Chem. pmid:3722151