Malonyl-coa

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 3249 references associated with Malonyl-coa in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Malonyl-coa

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonyl-coa

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Adenocarcinoma D000230 166 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Ketosis D007662 13 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Weight Gain D015430 101 associated lipids
Hypoglycemia D007003 13 associated lipids
Per page 10 20 | Total 20

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Shi J et al. A single amino acid change (substitution of glutamate 3 with alanine) in the N-terminal region of rat liver carnitine palmitoyltransferase I abolishes malonyl-CoA inhibition and high affinity binding. 1999 J. Biol. Chem. pmid:10092622
New KJ et al. Comparisons of flux control exerted by mitochondrial outer-membrane carnitine palmitoyltransferase over ketogenesis in hepatocytes and mitochondria isolated from suckling or adult rats. 1999 Eur. J. Biochem. pmid:10092853
Blázquez C et al. The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme. 1999 J. Neurochem. pmid:10098887
Kim YS and Kolattukudy PE Purification and properties of malonyl-CoA decarboxylase from rat liver mitochondria and its immunological comparison with the enzymes from rat brain, heart, and mammary gland. 1978 Arch. Biochem. Biophys. pmid:101148
Kozaki A and Sasaki Y Light-dependent changes in redox status of the plastidic acetyl-CoA carboxylase and its regulatory component. 1999 Biochem. J. pmid:10215591
Kim YS and Kolattukudy PE Malonyl-CoA decarboxylase from the uropygial gland of waterfowl: purification, properties, immunological comparison, and role in regulating the synthesis of multimethyl-branched fatty acids. 1978 Arch. Biochem. Biophys. pmid:102255
Abo-Hashema KA et al. Liver mitochondria, confirmed as intact by complete suppression of succinate uptake and oxidation, possess a carnitine palmitoyltransferase I that is totally inhibited by malonyl CoA. 1999 Biochem. Biophys. Res. Commun. pmid:10329463
Saha AK et al. Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo. 1999 Am. J. Physiol. pmid:10362615
Domergue F et al. Evidence that oleoyl-CoA and ATP-dependent elongations coexist in rapeseed (Brassica napus L.). 1999 Eur. J. Biochem. pmid:10406955
Kantor PF et al. Fatty acid oxidation in the reperfused ischemic heart. 1999 Am. J. Med. Sci. pmid:10408755
Jackson VN et al. Sequencing and functional expression of the malonyl-CoA-sensitive carnitine palmitoyltransferase from Drosophila melanogaster. 1999 Biochem. J. pmid:10417309
Bao W et al. The Streptomyces peucetius dpsC gene determines the choice of starter unit in biosynthesis of the daunorubicin polyketide. 1999 J. Bacteriol. pmid:10419974
Zhou P et al. Polyketide synthase acyl carrier protein (ACP) as a substrate and a catalyst for malonyl ACP biosynthesis. 1999 Chem. Biol. pmid:10421763
Sugden MC et al. Hyperthyroidism facilitates cardiac fatty acid oxidation through altered regulation of cardiac carnitine palmitoyltransferase: studies in vivo and with cardiac myocytes. 1999 Horm. Metab. Res. pmid:10422724
Dreier J et al. Kinetic analysis of the actinorhodin aromatic polyketide synthase. 1999 J. Biol. Chem. pmid:10455191
Funa N et al. A new pathway for polyketide synthesis in microorganisms. 1999 Nature pmid:10476972
Sargueil F et al. High metabolism and subsequent elongation of 3-hydroxyeicosanoyl-CoA in very-long-chain fatty acid deficient PNS of Trembler mice. 1999 Neurosci. Lett. pmid:10505644
Goodwin GW and Taegtmeyer H Regulation of fatty acid oxidation of the heart by MCD and ACC during contractile stimulation. 1999 Am. J. Physiol. pmid:10516138
Zammit VA The malonyl-CoA-long-chain acyl-CoA axis in the maintenance of mammalian cell function. 1999 Biochem. J. pmid:10527927
Laybutt DR et al. Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat. 1999 Am. J. Physiol. pmid:10600797
Morillas M et al. Identification of the two histidine residues responsible for the inhibition by malonyl-CoA in peroxisomal carnitine octanoyltransferase from rat liver. 2000 FEBS Lett. pmid:10648838
Shi J et al. The first 28 N-terminal amino acid residues of human heart muscle carnitine palmitoyltransferase I are essential for malonyl CoA sensitivity and high-affinity binding. 2000 Biochemistry pmid:10651636
Jez JM et al. Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. 2000 Biochemistry pmid:10653632
Pizer ES et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. 2000 Cancer Res. pmid:10667561
Guzmán M et al. Do cytoskeletal components control fatty acid translocation into liver mitochondria? 2000 Trends Endocrinol. Metab. pmid:10675890
Starritt EC et al. Sensitivity of CPT I to malonyl-CoA in trained and untrained human skeletal muscle. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10710500
Kantor PF et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. 2000 Circ. Res. pmid:10720420
Corkey BE et al. The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction. 2000 J. Nutr. pmid:10721892
Woldegiorgis G et al. Functional characterization of mammalian mitochondrial carnitine palmitoyltransferases I and II expressed in the yeast Pichia pastoris. 2000 J. Nutr. pmid:10721894
Hickson-Bick DL et al. Palmitate-mediated alterations in the fatty acid metabolism of rat neonatal cardiac myocytes. 2000 J. Mol. Cell. Cardiol. pmid:10731449
Jackson VN et al. Use of six chimeric proteins to investigate the role of intramolecular interactions in determining the kinetics of carnitine palmitoyltransferase I isoforms. 2000 J. Biol. Chem. pmid:10766754
Kerner J and Hoppel C Fatty acid import into mitochondria. 2000 Biochim. Biophys. Acta pmid:10856709
McGarry JD and Brown NF Reconstitution of purified, active and malonyl-CoA-sensitive rat liver carnitine palmitoyltransferase I: relationship between membrane environment and malonyl-CoA sensitivity. 2000 Biochem. J. pmid:10861226
Loftus TM et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. 2000 Science pmid:10875926
BÃ¥venholm PN et al. Fatty acid oxidation and the regulation of malonyl-CoA in human muscle. 2000 Diabetes pmid:10909961
Chien D et al. Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10913024
Fujii I et al. Enzymatic synthesis of 1,3,6,8-tetrahydroxynaphthalene solely from malonyl coenzyme A by a fungal iterative type I polyketide synthase PKS1. 2000 Biochemistry pmid:10913297
Gura T Obesity. Enzyme blocker prompts mice to shed weight. 2000 Science pmid:10917820
Dean D et al. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. 2000 Diabetes pmid:10923628
Hamilton C and Saggerson ED Malonyl-CoA metabolism in cardiac myocytes. 2000 Biochem. J. pmid:10926826
Richardson MT et al. Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase. 1999 Metab. Eng. pmid:10935930
Roduit R et al. Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell. 2000 J. Biol. Chem. pmid:10967113
Jackson VN et al. Identification of positive and negative determinants of malonyl-CoA sensitivity and carnitine affinity within the amino termini of rat liver- and muscle-type carnitine palmitoyltransferase I. 2000 J. Biol. Chem. pmid:10969089
Suh DY et al. Evidence for catalytic cysteine-histidine dyad in chalcone synthase. 2000 Biochem. Biophys. Res. Commun. pmid:10973790
Goodwin GW and Taegtmeyer H Improved energy homeostasis of the heart in the metabolic state of exercise. 2000 Am. J. Physiol. Heart Circ. Physiol. pmid:11009433
Hoenke S et al. Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase. 2000 Biochemistry pmid:11052675
Odland LM et al. Effects of high fat provision on muscle PDH activation and malonyl-CoA content in moderate exercise. 2000 J. Appl. Physiol. pmid:11090589
Winder WW and Holmes BF Insulin stimulation of glucose uptake fails to decrease palmitate oxidation in muscle if AMPK is activated. 2000 J. Appl. Physiol. pmid:11090599
McGarry JD Malonyl-CoA and satiety? Food for thought. 2000 Trends Endocrinol. Metab. pmid:11091115
Suo Z et al. Acyl-CoA hydrolysis by the high molecular weight protein 1 subunit of yersiniabactin synthetase: mutational evidence for a cascade of four acyl-enzyme intermediates during hydrolytic editing. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:11106385
Mulder H et al. Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells. 2001 J. Biol. Chem. pmid:11113153
Kennedy JA et al. Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. 2000 J. Cardiovasc. Pharmacol. pmid:11117381
Lane RH et al. Uteroplacental insufficiency alters hepatic fatty acid-metabolizing enzymes in juvenile and adult rats. 2001 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11124150
Suo Z et al. Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11134531
Wang YF et al. Crystallization and preliminary X-ray analysis of the 12S central subunit of transcarboxylase from Propionibacterium shermanii. 2001 Acta Crystallogr. D Biol. Crystallogr. pmid:11173475
Qiu X et al. Refined structures of beta-ketoacyl-acyl carrier protein synthase III. 2001 J. Mol. Biol. pmid:11243824
Li JN et al. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. 2001 Cancer Res. pmid:11245456
Wen J and Kerr RG Purification and characterization of the fatty acid synthase from Bugula neritina. 2001 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:11250539
Fraser F et al. Distinct kinetics of carnitine palmitoyltransferase i in contact sites and outer membranes of rat liver mitochondria. 2001 J. Biol. Chem. pmid:11274214
Abu-Elheiga L et al. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. 2001 Science pmid:11283375
Ruderman N and Flier JS Cell biology. Chewing the fat--ACC and energy balance. 2001 Science pmid:11286278
Guertl B et al. Metabolic cardiomyopathies. 2000 Int J Exp Pathol pmid:11298185
Nicot C et al. Pig liver carnitine palmitoyltransferase I, with low Km for carnitine and high sensitivity to malonyl-CoA inhibition, is a natural chimera of rat liver and muscle enzymes. 2001 Biochemistry pmid:11329295
McGarry JD Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between. 2001 Biochem. Soc. Trans. pmid:11356162
Eaton S et al. Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux. 2001 Biochem. Soc. Trans. pmid:11356163
Broadway NM et al. Microsomal malonyl-CoA-sensitive carnitine acyltransferase. 2001 Biochem. Soc. Trans. pmid:11356165
Zammit VA et al. Structure-function relationships of the liver and muscle isoforms of carnitine palmitoyltransferase I. 2001 Biochem. Soc. Trans. pmid:11356169
Hegardt FG et al. Post-transcriptional regulation of rat carnitine octanoyltransferase. 2001 Biochem. Soc. Trans. pmid:11356174
Kim YS et al. Malonyl-CoA decarboxylase from Mycobacterium tuberculosis and Pseudomonas fluorescens. 1979 Arch. Biochem. Biophys. pmid:114118
Dagher Z et al. Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. 2001 Circ. Res. pmid:11420304
Morita H et al. Novel polyketides synthesized with a higher plant stilbene synthase. 2001 Eur. J. Biochem. pmid:11432743
Kreuzaler F et al. Flavanone synthase from Petroselinum hortense. Molecular weight, subunit composition, size of messenger RNA, and absence of pantetheinyl residue. 1979 Eur. J. Biochem. pmid:114396
Brown NF et al. Molecular characterization of L-CPT I deficiency in six patients: insights into function of the native enzyme. 2001 J. Lipid Res. pmid:11441142
Thupari JN et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. 2001 Biochem. Biophys. Res. Commun. pmid:11444828
Eaton S et al. Carnitine palmitoyl transferase I and the control of beta-oxidation in heart mitochondria. 2001 Biochem. Biophys. Res. Commun. pmid:11444876
Hamdan M et al. Inhibition of mitochondrial carnitine palmitoyltransferase-1 by a trimetazidine derivative, S-15176. 2001 Pharmacol. Res. pmid:11516258
Rodríguez E et al. Role of an essential acyl coenzyme A carboxylase in the primary and secondary metabolism of Streptomyces coelicolor A3(2). 2001 Appl. Environ. Microbiol. pmid:11526020
Rangan VS et al. Mapping the functional topology of the animal fatty acid synthase by mutant complementation in vitro. 2001 Biochemistry pmid:11535054
Jahnke LL and Diggs K Evidence for the synthesis of the multi-positional isomers of monounsaturated fatty acid in Methylococcus capsusatus by the anaerobic pathway. 1989 FEMS Microbiol. Lett. pmid:11542184
Surendran S et al. Malonyl CoA decarboxylase deficiency: C to T transition in intron 2 of the MCD gene. 2001 J. Neurosci. Res. pmid:11550227
Morillas M et al. Structural model of the catalytic core of carnitine palmitoyltransferase I and carnitine octanoyltransferase (COT): mutation of CPT I histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity. 2001 J. Biol. Chem. pmid:11553629
Doenst T et al. Load-induced changes in vivo alter substrate fluxes and insulin responsiveness of rat heart in vitro. 2001 Metab. Clin. Exp. pmid:11555843
Longnus SL et al. Regulation of myocardial fatty acid oxidation by substrate supply. 2001 Am. J. Physiol. Heart Circ. Physiol. pmid:11557544
Moon YA et al. Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins. 2001 J. Biol. Chem. pmid:11567032
Reszko AE et al. Assay of the concentration and 13C-isotopic enrichment of malonyl-coenzyme A by gas chromatography-mass spectrometry. 2001 Anal. Biochem. pmid:11673897
Martini WZ et al. Alteration of hepatic fatty acid metabolism after burn injury in pigs. 2001 Nov-Dec JPEN J Parenter Enteral Nutr pmid:11688934
Jackson VN et al. Specificity of the interactions between Glu-3, Ser-24, and Gln-30 within the N-terminal segment of rat liver mitochondrial overt carnitine palmitoyltransferase (L-CPT I) in determining the malonyl-CoA sensitivity of the enzyme. 2001 Biochemistry pmid:11724576
Campbell FM et al. A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. 2002 J. Biol. Chem. pmid:11734553
Richards JG et al. Lipid oxidation fuels recovery from exhaustive exercise in white muscle of rainbow trout. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11742827
Reeves CD et al. Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations. 2001 Biochemistry pmid:11747421
Ido Y et al. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. 2002 Diabetes pmid:11756336
Nicot C et al. Pig liver carnitine palmitoyltransferase. Chimera studies show that both the N- and C-terminal regions of the enzyme are important for the unusual high malonyl-CoA sensitivity. 2002 J. Biol. Chem. pmid:11790778
Morillas M et al. Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. 2002 J. Biol. Chem. pmid:11790793
Kim JY et al. Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:11934665
Hügler M et al. Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation. 2002 J. Bacteriol. pmid:11948153
Jez JM et al. Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11959984
Salles J et al. Fatty acid synthase expression during peripheral nervous system myelination. 2002 Brain Res. Mol. Brain Res. pmid:12007831
Atkinson LL et al. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. 2002 J. Biol. Chem. pmid:12058043
Thupari JN et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:12060712