Malonyl-coa

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Current reference collection contains 3249 references associated with Malonyl-coa in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Malonyl-coa

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Malonyl-coa

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Adenocarcinoma D000230 166 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Fatty Liver D005234 48 associated lipids
Ketosis D007662 13 associated lipids
Body Weight D001835 333 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypothyroidism D007037 32 associated lipids
Weight Gain D015430 101 associated lipids
Hypoglycemia D007003 13 associated lipids
Per page 10 20 | Total 20

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Per page 10 20 50 100 | Total 927
Authors Title Published Journal PubMed Link
Ghadbane H et al. Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT). 2007 Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. pmid:17909282
Guay C et al. A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion. 2007 J. Biol. Chem. pmid:17928289
Thomson DM et al. LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17925454
Li S et al. Molecular analysis of the role of tyrosine 224 in the active site of Streptomyces coelicolor RppA, a bacterial type III polyketide synthase. 2007 J. Biol. Chem. pmid:17331946
Leonard E et al. Engineering central metabolic pathways for high-level flavonoid production in Escherichia coli. 2007 Appl. Environ. Microbiol. pmid:17468269
López-Viñas E et al. Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A. 2007 J. Biol. Chem. pmid:17452323
Kadokawa H et al. Links between de novo fatty acid synthesis and leptin secretion in bovine adipocytes. 2007 J. Vet. Med. Sci. pmid:17409636
Noland RC et al. Peroxisomal-mitochondrial oxidation in a rodent model of obesity-associated insulin resistance. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17638705
Ma SM et al. Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. 2007 J. Am. Chem. Soc. pmid:17696354
Cheng D et al. Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes. 2007 Protein Expr. Purif. pmid:16854592
Folmes CD and Lopaschuk GD Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. 2007 Cardiovasc. Res. pmid:17126822
Guo W et al. Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17148751
Sebastián D et al. CPT I overexpression protects L6E9 muscle cells from fatty acid-induced insulin resistance. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17062841
Szkudelski T Intracellular mediators in regulation of leptin secretion from adipocytes. 2007 Physiol Res pmid:17184148
Springob K et al. A polyketide synthase of Plumbago indica that catalyzes the formation of hexaketide pyrones. 2007 FEBS J. pmid:17229146
Harada N et al. Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice. 2007 Mol. Cell. Biol. pmid:17210641
Patil PB et al. Malonyl coenzyme A affects insulin-stimulated glucose transport in myotubes. 2007 Arch. Physiol. Biochem. pmid:17522981
Bian F et al. Competition between acetate and oleate for the formation of malonyl-CoA and mitochondrial acetyl-CoA in the perfused rat heart. 2006 J. Mol. Cell. Cardiol. pmid:17020764
Beha A et al. Muscle type-specific fatty acid metabolism in insulin resistance: an integrated in vivo study in Zucker diabetic fatty rats. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16380389
Murase T et al. Green tea extract improves running endurance in mice by stimulating lipid utilization during exercise. 2006 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:16410398
Holloway GP et al. Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise. 2006 J. Physiol. (Lond.) pmid:16357012
Kraegen EW et al. Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16234268
Bell JA et al. Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA. 2006 Diabetologia pmid:16868746
Borthwick K et al. The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity. 2006 J. Biol. Chem. pmid:16908527
Schujman GE et al. Structural basis of lipid biosynthesis regulation in Gram-positive bacteria. 2006 EMBO J. pmid:16932747
Tang GL et al. Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140. 2006 J. Nat. Prod. pmid:16562841
Lindén D et al. Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation. 2006 FASEB J. pmid:16507761
Collier CA et al. Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16478780
Kuhl JE et al. Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16434556
Cheng JF et al. Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors. 2006 J. Med. Chem. pmid:16509570
Wolfgang MJ and Lane MD The role of hypothalamic malonyl-CoA in energy homeostasis. 2006 J. Biol. Chem. pmid:17018521
Cha SH et al. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:17030788
Bandyopadhyay GK et al. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. 2006 Diabetes pmid:16873691
Saha AK et al. AMPK regulation of the growth of cultured human keratinocytes. 2006 Biochem. Biophys. Res. Commun. pmid:16949049
Hayashi O and Satoh K Determination of acetyl-CoA and malonyl-CoA in germinating rice seeds using the LC-MS/MS technique. 2006 Biosci. Biotechnol. Biochem. pmid:17090944
Nolan CJ et al. Fatty acid signaling in the beta-cell and insulin secretion. 2006 Diabetes pmid:17130640
Minkler PE et al. Quantification of malonyl-coenzyme A in tissue specimens by high-performance liquid chromatography/mass spectrometry. 2006 Anal. Biochem. pmid:16545769
Wolfgang MJ et al. The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16651524
Ruderman NB and Saha AK Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. 2006 Obesity (Silver Spring) pmid:16642960
López M et al. Tamoxifen-induced anorexia is associated with fatty acid synthase inhibition in the ventromedial nucleus of the hypothalamus and accumulation of malonyl-CoA. 2006 Diabetes pmid:16644689
Gu YG et al. Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors. 2006 J. Med. Chem. pmid:16789734
Neels JG and Olefsky JM Cell signaling. A new way to burn fat. 2006 Science pmid:16794069
Mao J et al. Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16717184
Oefner C et al. Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography. 2006 Acta Crystallogr. D Biol. Crystallogr. pmid:16699188
Pender C et al. Expression of genes regulating malonyl-CoA in human skeletal muscle. 2006 J. Cell. Biochem. pmid:16721829
Wolfgang MJ and Lane MD Control of energy homeostasis: role of enzymes and intermediates of fatty acid metabolism in the central nervous system. 2006 Annu. Rev. Nutr. pmid:16704352
Onay-Besikci A and Sambandam N Malonyl CoA control of fatty acid oxidation in the newborn heart in response to increased fatty acid supply. 2006 Can. J. Physiol. Pharmacol. pmid:17218986
Menendez JA et al. Inhibition of fatty acid synthase-dependent neoplastic lipogenesis as the mechanism of gamma-linolenic acid-induced toxicity to tumor cells: an extension to Nwankwo's hypothesis. 2005 Med. Hypotheses pmid:15607568
Trivedi OA et al. Dissecting the mechanism and assembly of a complex virulence mycobacterial lipid. 2005 Mol. Cell pmid:15749014
Kasumov T et al. Probing peroxisomal beta-oxidation and the labelling of acetyl-CoA proxies with [1-(13C)]octanoate and [3-(13C)]octanoate in the perfused rat liver. 2005 Biochem. J. pmid:15773815
King KL et al. Regulation of cardiac malonyl-CoA content and fatty acid oxidation during increased cardiac power. 2005 Am. J. Physiol. Heart Circ. Physiol. pmid:15821035
Planavila A et al. Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice. 2005 Biochem. Pharmacol. pmid:15794940
Miyahisa I et al. Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster. 2005 Appl. Microbiol. Biotechnol. pmid:15770480
Dann HM and Drackley JK Carnitine palmitoyltransferase I in liver of periparturient dairy cows: effects of prepartum intake, postpartum induction of ketosis, and periparturient disorders. 2005 J. Dairy Sci. pmid:16230690
Jeong JC et al. Exploiting the reaction flexibility of a type III polyketide synthase through in vitro pathway manipulation. 2005 J. Am. Chem. Soc. pmid:15631450
Raney MA et al. AMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15547141
Bian F et al. Peroxisomal and mitochondrial oxidation of fatty acids in the heart, assessed from the 13C labeling of malonyl-CoA and the acetyl moiety of citrate. 2005 J. Biol. Chem. pmid:15611129
Liu H et al. Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis. 2005 J. Biol. Chem. pmid:15579906
Taylor EB et al. Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15644453
Koves TR et al. Subsarcolemmal and intermyofibrillar mitochondria play distinct roles in regulating skeletal muscle fatty acid metabolism. 2005 Am. J. Physiol., Cell Physiol. pmid:15647392
Lane MD et al. Role of malonyl-CoA in the hypothalamic control of food intake and energy expenditure. 2005 Biochem. Soc. Trans. pmid:16246046
Kelley DE Pulling in more fat. 2005 Cell Metab. pmid:16271525
Hu Z et al. A role for hypothalamic malonyl-CoA in the control of food intake. 2005 J. Biol. Chem. pmid:16219771
Gambert S et al. Regulation of intermediary metabolism in rat cardiac myocyte by extracellular glycerol. 2005 Biochim. Biophys. Acta pmid:16153888
Peluso G et al. Differential carnitine/acylcarnitine translocase expression defines distinct metabolic signatures in skeletal muscle cells. 2005 J. Cell. Physiol. pmid:15515015
Faye A et al. Demonstration of N- and C-terminal domain intramolecular interactions in rat liver carnitine palmitoyltransferase 1 that determine its degree of malonyl-CoA sensitivity. 2005 Biochem. J. pmid:15498023
Brusselmans K et al. RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells. 2005 Cancer Res. pmid:16061653
Neschen S et al. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice. 2005 Cell Metab. pmid:16054099
Abu-Elheiga L et al. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16103361
Mizuarai S et al. Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis. 2005 J. Biol. Chem. pmid:16027120
Funa N et al. A novel quinone-forming monooxygenase family involved in modification of aromatic polyketides. 2005 J. Biol. Chem. pmid:15701630
Rendina AR and Cheng D Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates. 2005 Biochem. J. pmid:15715522
Oh W et al. Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:15677334
Herrero L et al. Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion. 2005 Diabetes pmid:15677504
Abe I et al. A plant type III polyketide synthase that produces pentaketide chromone. 2005 J. Am. Chem. Soc. pmid:15686354
Giordano A et al. tBid induces alterations of mitochondrial fatty acid oxidation flux by malonyl-CoA-independent inhibition of carnitine palmitoyltransferase-1. 2005 Cell Death Differ. pmid:15846373
Dowell P et al. Monitoring energy balance: metabolites of fatty acid synthesis as hypothalamic sensors. 2005 Annu. Rev. Biochem. pmid:15952896
Mingrone G et al. Leptin pulsatility in formerly obese women. 2005 FASEB J. pmid:15955844
Assifi MM et al. AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15956049
Lelliott CJ et al. Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis. 2005 FASEB J. pmid:15985534
Cha SH et al. Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16203972
Spiteller D et al. A method for trapping intermediates of polyketide biosynthesis with a nonhydrolyzable malonyl-coenzyme A analogue. 2005 Angew. Chem. Int. Ed. Engl. pmid:16208728
Roepstorff C et al. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15383373
Yang N et al. C75 [4-methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid] activates carnitine palmitoyltransferase-1 in isolated mitochondria and intact cells without displacement of bound malonyl CoA. 2005 J. Pharmacol. Exp. Ther. pmid:15356215
Shirai Y et al. Metabolic regulation of leptin production in adipocytes: a role of fatty acid synthesis intermediates. 2004 J. Nutr. Biochem. pmid:15590268
Foster DW The role of the carnitine system in human metabolism. 2004 Ann. N. Y. Acad. Sci. pmid:15590999
Yu X et al. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. 2004 Diabetologia pmid:15578153
Reszko AE et al. Peroxisomal fatty acid oxidation is a substantial source of the acetyl moiety of malonyl-CoA in rat heart. 2004 J. Biol. Chem. pmid:14982940
Abe I et al. The first plant type III polyketide synthase that catalyzes formation of aromatic heptaketide. 2004 FEBS Lett. pmid:15044020
Roduit R et al. A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. 2004 Diabetes pmid:15047616
Degrace P et al. Hepatic steatosis is not due to impaired fatty acid oxidation capacities in C57BL/6J mice fed the conjugated trans-10,cis-12-isomer of linoleic acid. 2004 J. Nutr. pmid:15051838
Sleeman MC and Schofield CJ Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis. 2004 J. Biol. Chem. pmid:14625287
Oguro S et al. Probing biosynthesis of plant polyketides with synthetic N-acetylcysteamine thioesters. 2004 Biochem. Biophys. Res. Commun. pmid:15530429
Nicot C et al. C75 activates malonyl-CoA sensitive and insensitive components of the CPT system. 2004 Biochem. Biophys. Res. Commun. pmid:15541339
Cheng L et al. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. 2004 Nat. Med. pmid:15475963
Traufeller K et al. Different sensitivities of CPT I and CPT II for inhibition by l-aminocarnitine in human skeletal muscle. 2004 Biochim. Biophys. Acta pmid:14871492
Reszko AE et al. Regulation of malonyl-CoA concentration and turnover in the normal heart. 2004 J. Biol. Chem. pmid:15181001
Unger RH The hyperleptinemia of obesity-regulator of caloric surpluses. 2004 Cell pmid:15084251
Dyck JR et al. Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. 2004 Circ. Res. pmid:15105298
Relat J et al. Pig muscle carnitine palmitoyltransferase I (CPTI beta), with low Km for carnitine and low sensitivity to malonyl-CoA inhibition, has kinetic characteristics similar to those of the rat liver (CPTI alpha) enzyme. 2004 Biochemistry pmid:15449958