Palmitoyl coenzyme a

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Introduction

To understand associated biological information of Palmitoyl coenzyme a, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Palmitoyl coenzyme a?

Palmitoyl coenzyme a is suspected in Parkinson Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Palmitoyl coenzyme a

MeSH term MeSH ID Detail
Coronary Disease D003327 70 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Starvation D013217 47 associated lipids
Hyperinsulinism D006946 27 associated lipids
Riboflavin Deficiency D012257 10 associated lipids
Insulin Resistance D007333 99 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Togaviridae Infections D014036 5 associated lipids
Total 9

PubChem Associated disorders and diseases

What pathways are associated with Palmitoyl coenzyme a

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Palmitoyl coenzyme a?

Related references are published most in these journals:

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What functions are associated with Palmitoyl coenzyme a?


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What lipids are associated with Palmitoyl coenzyme a?

Related references are published most in these journals:

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What genes are associated with Palmitoyl coenzyme a?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Palmitoyl coenzyme a?

Rodent Model

Rodent Model are used in the study 'Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels.' (Worth AJ et al., 2014).

Related references are published most in these journals:

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NCBI Entrez Crosslinks

All references with Palmitoyl coenzyme a

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Authors Title Published Journal PubMed Link
Hara A et al. Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs. 2017 Biochem. Pharmacol. pmid:28450226
Cortassa S et al. Mitochondrial respiration and ROS emission during β-oxidation in the heart: An experimental-computational study. 2017 PLoS Comput. Biol. pmid:28598967
Ritchie MK et al. Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE. 2016 J. Biol. Chem. pmid:26663084
Soupene E et al. Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA. 2016 J. Lipid Res. pmid:26621918
Albesa-Jové D et al. Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA. 2016 Nat Commun pmid:26965057
Seeßle J et al. Palmitate activation by fatty acid transport protein 4 as a model system for hepatocellular apoptosis and steatosis. 2015 Biochim. Biophys. Acta pmid:25603556
Lanyon-Hogg T et al. Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase. 2015 Anal. Biochem. pmid:26334609
Montgomery DC et al. Metabolic Regulation of Histone Acetyltransferases by Endogenous Acyl-CoA Cofactors. 2015 Chem. Biol. pmid:26190825
Kaylor JJ et al. Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium. 2015 PLoS ONE pmid:25974161
Ludzki A et al. Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling. 2015 Diabetes pmid:25845660
Tuvdendorj D et al. Triglycerides produced in the livers of fasting rabbits are predominantly stored as opposed to secreted into the plasma. 2015 Metab. Clin. Exp. pmid:25682063
Alefishat E et al. Effects of NAD at purine receptors in isolated blood vessels. 2015 Purinergic Signal. pmid:25315718
Worth AJ et al. Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels. 2014 J. Biol. Chem. pmid:25122772
Balanarasimha M et al. Ligand-regulated heterodimerization of peroxisome proliferator-activated receptor α with liver X receptor α. 2014 Biochemistry pmid:24713062
Nazarko TY et al. Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy. 2014 J. Cell Biol. pmid:24535825
Kerner J et al. Fatty acid chain elongation in palmitate-perfused working rat heart: mitochondrial acetyl-CoA is the source of two-carbon units for chain elongation. 2014 J. Biol. Chem. pmid:24558043
Turapov O et al. Oleoyl coenzyme A regulates interaction of transcriptional regulator RaaS (Rv1219c) with DNA in mycobacteria. 2014 J. Biol. Chem. pmid:25012658
Dittrich-Domergue F et al. The bifunctional protein TtFARAT from Tetrahymena thermophila catalyzes the formation of both precursors required to initiate ether lipid biosynthesis. 2014 J. Biol. Chem. pmid:24917677
Yu Y et al. Intracellular long-chain acyl CoAs activate TRPV1 channels. 2014 PLoS ONE pmid:24798548
Beaudoin MS et al. Impairments in mitochondrial palmitoyl-CoA respiratory kinetics that precede development of diabetic cardiomyopathy are prevented by resveratrol in ZDF rats. 2014 J. Physiol. (Lond.) pmid:24639481
Zhang XJ et al. Acute hyperinsulinemia and reduced plasma free fatty acid levels decrease intramuscular triglyceride synthesis. 2013 Metab. Clin. Exp. pmid:22898252
Rodríguez-Guilbe M et al. Structure, activity, and substrate selectivity of the Orf6 thioesterase from Photobacterium profundum. 2013 J. Biol. Chem. pmid:23430744
van Eunen K et al. Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload. 2013 PLoS Comput. Biol. pmid:23966849
Sarkar C et al. Neuroprotection and lifespan extension in Ppt1(-/-) mice by NtBuHA: therapeutic implications for INCL. 2013 Nat. Neurosci. pmid:24056696
Li X et al. Endothelial acyl-CoA synthetase 1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment. 2013 Arterioscler. Thromb. Vasc. Biol. pmid:23241406
Alefishat E et al. Antagonism of P2Y1-induced vasorelaxation by acyl CoA: a critical role for palmitate and 3'-phosphate. 2013 Br. J. Pharmacol. pmid:23215951
Russo SB et al. Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties. 2013 J. Biol. Chem. pmid:23530041
Gómez LA et al. Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart. 2012 Feb-Mar Mech. Ageing Dev. pmid:22322067
Zhang XJ et al. Measurement of precursor enrichment for calculating intramuscular triglyceride fractional synthetic rate. 2012 J. Lipid Res. pmid:21934122
Jennings BC and Linder ME DHHC protein S-acyltransferases use similar ping-pong kinetic mechanisms but display different acyl-CoA specificities. 2012 J. Biol. Chem. pmid:22247542
Smith BK et al. Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates. 2012 Biochem. J. pmid:22928974
Moon SH et al. Genetic ablation of calcium-independent phospholipase A(2)γ (iPLA(2)γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release. 2012 J. Biol. Chem. pmid:22778252
Son HJ et al. Roles of cysteine residues in the inhibition of human glutamate dehydrogenase by palmitoyl-CoA. 2012 BMB Rep pmid:23261056
Taylor WA et al. Human trifunctional protein alpha links cardiolipin remodeling to beta-oxidation. 2012 PLoS ONE pmid:23152787
Mauvoisin D and Mounier C Hormonal and nutritional regulation of SCD1 gene expression. 2011 Biochimie pmid:20713121
Lowther J et al. Role of a conserved arginine residue during catalysis in serine palmitoyltransferase. 2011 FEBS Lett. pmid:21514297
Jenkins CM et al. Reversible high affinity inhibition of phosphofructokinase-1 by acyl-CoA: a mechanism integrating glycolytic flux with lipid metabolism. 2011 J. Biol. Chem. pmid:21258134
Novgorodov SA et al. Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA. 2011 J. Biol. Chem. pmid:21613224
Haynes CA et al. Factors to consider in using [U-C]palmitate for analysis of sphingolipid biosynthesis by tandem mass spectrometry. 2011 J. Lipid Res. pmid:21586681
Oyanagi E et al. Protective action of L-carnitine on cardiac mitochondrial function and structure against fatty acid stress. 2011 Biochem. Biophys. Res. Commun. pmid:21791201
Willis RM et al. Characterization of a fatty acyl-CoA reductase from Marinobacter aquaeolei VT8: a bacterial enzyme catalyzing the reduction of fatty acyl-CoA to fatty alcohol. 2011 Biochemistry pmid:22035211
Borgaro JG et al. Substrate recognition by β-ketoacyl-ACP synthases. 2011 Biochemistry pmid:22017312
Schmitz-Peiffer C Targeting ceramide synthesis to reverse insulin resistance. 2010 Diabetes pmid:20876726
Mesicek J et al. Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. 2010 Cell. Signal. pmid:20406683
Lin X et al. Carnitine palmitoyltransferase I control of acetogenesis, the major pathway of fatty acid {beta}-oxidation in liver of neonatal swine. 2010 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:20237302
Raman MC et al. The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein. 2010 Biopolymers pmid:20578000
Banke NH et al. Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha. 2010 Circ. Res. pmid:20522803
Bonnefont JP et al. Long-term follow-up of bezafibrate treatment in patients with the myopathic form of carnitine palmitoyltransferase 2 deficiency. 2010 Clin. Pharmacol. Ther. pmid:20505667
Mitchell DA et al. Mutational analysis of Saccharomyces cerevisiae Erf2 reveals a two-step reaction mechanism for protein palmitoylation by DHHC enzymes. 2010 J. Biol. Chem. pmid:20851885
Aires CC et al. Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis. 2010 Biochem. Pharmacol. pmid:19854160
Hatzios SK et al. PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis. 2009 J. Biol. Chem. pmid:19276083
Rütti MF et al. An improved method to determine serine palmitoyltransferase activity. 2009 J. Lipid Res. pmid:19181628
Shiraiwa Y et al. Multifunctional role of His159in the catalytic reaction of serine palmitoyltransferase. 2009 J. Biol. Chem. pmid:19346561
Schönfeld P et al. Acyl-CoA-induced generation of reactive oxygen species in mitochondrial preparations is due to the presence of peroxisomes. 2009 Free Radic. Biol. Med. pmid:19442717
Kitazawa H et al. Development of a high-density assay for long-chain fatty acyl-CoA elongases. 2009 Lipids pmid:19575253
Ikushiro H et al. Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum. 2009 J. Biochem. pmid:19564159
Korematsu S et al. Novel mutation of early, perinatal-onset, myopathic-type very-long-chain acyl-CoA dehydrogenase deficiency. 2009 Pediatr. Neurol. pmid:19589468
Zhang XJ et al. The synthetic rate of muscle triglyceride but not phospholipid is increased in obese rabbits. 2009 Metab. Clin. Exp. pmid:19608209
HÃ¥versen L et al. Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. 2009 Atherosclerosis pmid:18599066
Aasum E et al. Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice. 2008 J. Mol. Cell. Cardiol. pmid:17931655
Vallejo DF et al. A hydrophobic loop in acyl-CoA binding protein is functionally important for binding to palmitoyl-coenzyme A: a molecular dynamics study. 2008 Int. J. Biol. Macromol. pmid:18242688
Ikushiro H et al. Acceleration of the substrate Calpha deprotonation by an analogue of the second substrate palmitoyl-CoA in Serine Palmitoyltransferase. 2008 J. Biol. Chem. pmid:18167344
Minkler PE et al. Novel isolation procedure for short-, medium-, and long-chain acyl-coenzyme A esters from tissue. 2008 Anal. Biochem. pmid:18355435
Zhang J et al. Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method. 2008 Mol. Cell Proteomics pmid:18296695
Manolopoulos P et al. Acyl derivatives of coenzyme A inhibit platelet function via antagonism at P2Y1 and P2Y12 receptors: a new finding that may influence the design of anti-thrombotic agents. 2008 Platelets pmid:18297551
Primassin S et al. Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine. 2008 Pediatr. Res. pmid:18317232
Stierum R et al. Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole. 2008 Food Chem. Toxicol. pmid:18539377
Tominaga H et al. Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18469143
Abdul-Ghani MA et al. Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance. 2008 Am. J. Physiol. Endocrinol. Metab. pmid:18593850
Hamming KS et al. Splice variant-dependent regulation of beta-cell sodium-calcium exchange by acyl-coenzyme As. 2008 Mol. Endocrinol. pmid:18635667
Tajima G et al. Development of a new enzymatic diagnosis method for very-long-chain Acyl-CoA dehydrogenase deficiency by detecting 2-hexadecenoyl-CoA production and its application in tandem mass spectrometry-based selective screening and newborn screening in Japan. 2008 Pediatr. Res. pmid:18670371
Borland LM and Allbritton NL Use of micellar electrokinetic chromatography to measure palmitoylation of a peptide. 2008 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:18926781
Hostetler HA et al. A novel high-throughput screening assay for putative antidiabetic agents through PPARalpha interactions. 2008 J Biomol Screen pmid:18812576
McMahon B and Mayhew SG Identification and properties of an inducible phenylacyl-CoA dehydrogenase in Pseudomonas putida KT2440. 2007 FEMS Microbiol. Lett. pmid:17559393
Ikushiro H et al. Molecular characterization of membrane-associated soluble serine palmitoyltransferases from Sphingobacterium multivorum and Bdellovibrio stolpii. 2007 J. Bacteriol. pmid:17557831
Bränström R et al. Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: indications for a long-chain acyl-CoA ester binding motif. 2007 Diabetologia pmid:17522836
Wein S et al. Concerted action of leptin in regulation of fatty acid oxidation in skeletal muscle and liver. 2007 Exp. Clin. Endocrinol. Diabetes pmid:17479441
Toyama T et al. Stearoyl-CoA desaturase activity is elevated by the suppression of its degradation by clofibric acid in the liver of rats. 2007 J. Pharmacol. Sci. pmid:17409633
Cowles C et al. Different mechanisms of modulation of gap junction communication by non-genotoxic carcinogens in rat liver in vivo. 2007 Toxicology pmid:17624652
Kim YB et al. A pre-steady state analysis of ligand binding to human glucokinase: evidence for a preexisting equilibrium. 2007 Biochemistry pmid:17260972
Jáuregui O et al. A new LC-ESI-MS/MS method to measure long-chain acylcarnitine levels in cultured cells. 2007 Anal. Chim. Acta pmid:17765057
Bruce CR et al. Overexpression of carnitine palmitoyltransferase I in skeletal muscle in vivo increases fatty acid oxidation and reduces triacylglycerol esterification. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17179390
Toyama T et al. Effects of pioglitazone on stearoyl-CoA desaturase in obese Zucker fa/fa rats. 2007 J. Pharmacol. Sci. pmid:17538229
Lengi AJ and Corl BA Identification and characterization of a novel bovine stearoyl-CoA desaturase isoform with homology to human SCD5. 2007 Lipids pmid:17468887
Selva DM et al. Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. 2007 J. Clin. Invest. pmid:17992261
Kaschula CH et al. Acyl CoA:retinol acyltransferase (ARAT) activity is present in bovine retinal pigment epithelium. 2006 Exp. Eye Res. pmid:16054134
Kümmel D et al. Unique self-palmitoylation activity of the transport protein particle component Bet3: a mechanism required for protein stability. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:16908848
Turpin SM et al. Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16849630
Zeng B et al. Functional characterization of a fatty acyl-CoA-binding protein (ACBP) from the apicomplexan Cryptosporidium parvum. 2006 Microbiology (Reading, Engl.) pmid:16849800
Liao Y et al. Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein. 2006 Virology pmid:16507314
Zufferey R and Ben Mamoun C Leishmania major expresses a single dihydroxyacetone phosphate acyltransferase localized in the glycosome, important for rapid growth and survival at high cell density and essential for virulence. 2006 J. Biol. Chem. pmid:16423830
Caballero MJ et al. Vegetable lipid sources affect in vitro biosynthesis of triacylglycerols and phospholipids in the intestine of sea bream (Sparus aurata). 2006 Br. J. Nutr. pmid:16512929
Muniz A et al. 11-cis-Acyl-CoA:retinol O-acyltransferase activity in the primary culture of chicken Muller cells. 2006 Biochemistry pmid:17014079
Liebig M et al. Neonatal screening for very long-chain acyl-coA dehydrogenase deficiency: enzymatic and molecular evaluation of neonates with elevated C14:1-carnitine levels. 2006 Pediatrics pmid:16950999
Cortright RN et al. Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training. 2006 Obesity (Silver Spring) pmid:16899801
Ciapaite J et al. Metabolic control of mitochondrial properties by adenine nucleotide translocator determines palmitoyl-CoA effects. Implications for a mechanism linking obesity and type 2 diabetes. 2006 FEBS J. pmid:17059463
Sternberg RM and LeBlanc GA Kinetic characterization of the inhibition of acyl coenzyme A: steroid acyltransferases by tributyltin in the eastern mud snail (Ilyanassa obsoleta). 2006 Aquat. Toxicol. pmid:16638618
Hansen JS et al. Micro method for determination of nonesterified fatty acid in whole blood obtained by fingertip puncture. 2006 Anal. Biochem. pmid:16814738
Okamura K et al. Fatty acyl-CoA as an endogenous activator of UDP-glucuronosyltransferases. 2006 Biochem. Biophys. Res. Commun. pmid:16737684
Rubink DS and Winder WW Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylase. 2005 J. Appl. Physiol. pmid:15579580