Acetyl-d-carnitine

Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2875 references associated with Acetyl-d-carnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Acetyl-d-carnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine

MeSH term MeSH ID Detail
Proteostasis Deficiencies D057165 5 associated lipids
Cleft Lip D002971 8 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Parkinson Disease D010300 53 associated lipids
Alzheimer Disease D000544 76 associated lipids
Body Weight D001835 333 associated lipids
Total 7

All references with Acetyl-d-carnitine

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Authors Title Published Journal PubMed Link
Ang JE et al. Identification of human plasma metabolites exhibiting time-of-day variation using an untargeted liquid chromatography-mass spectrometry metabolomic approach. 2012 Chronobiol. Int. pmid:22823870
Balschi JA In vivo clinical measures of intermediary metabolism are inadequate: can a new magnetic resonance spectroscopy technology do better? 2012 Circ Cardiovasc Imaging pmid:22438422
Schroeder MA et al. The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study. 2012 Circ Cardiovasc Imaging pmid:22238215
Dodd MS et al. Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy. 2014 Circ Cardiovasc Imaging pmid:25201905
Oka T et al. Change in the membranous lipid composition accelerates lipid peroxidation in young rat hearts subjected to 2 weeks of hypoxia followed by hyperoxia. 2008 Circ. J. pmid:18654026
Katz AM and Messineo FC Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium. 1981 Circ. Res. pmid:7438341
Brevetti G et al. Carnitine-related alterations in patients with intermittent claudication: indication for a focused carnitine therapy. 1996 Circulation pmid:8653874
Matsui S et al. Urinary carnitine excretion in patients with heart failure. 1994 Clin Cardiol pmid:8070147
Memeo A and Loiero M Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. 2008 Clin Drug Investig pmid:18598095
Martignoni E et al. Acetyl-L-carnitine acutely administered raises beta-endorphin and cortisol plasma levels in humans. 1988 Clin Neuropharmacol pmid:2975529
Schloss JM et al. Nutraceuticals and chemotherapy induced peripheral neuropathy (CIPN): a systematic review. 2013 Clin Nutr pmid:23647723
Pisano C et al. Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine. 2003 Clin. Cancer Res. pmid:14654561
Lancaster CS et al. Cisplatin-induced downregulation of OCTN2 affects carnitine wasting. 2010 Clin. Cancer Res. pmid:20858838
Pisano C et al. Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine. 2010 Clin. Cancer Res. pmid:20562210
Stevens RD et al. Assay for free and total carnitine in human plasma using tandem mass spectrometry. 2000 Clin. Chem. pmid:10794762
Roe DS et al. Automated analysis for free and short-chain acylcarnitine in plasma with a centrifugal analyzer. 1992 Clin. Chem. pmid:1424113
Cederblad G et al. Spectrophotometry of carnitine in biological fluids and tissue with a Cobas Bio centrifugal analyzer. 1986 Clin. Chem. pmid:3943195
Pace JA et al. Improved radiochemical assay for carnitine and its derivatives in plasma and tissue extracts. 1978 Clin. Chem. pmid:618663
Fishlock RC et al. Sources of error in determinations of carnitine and acylcarnitine in plasma. 1984 Clin. Chem. pmid:6692545
Wikoff WR et al. Metabolomics identifies perturbations in human disorders of propionate metabolism. 2007 Clin. Chem. pmid:17951291
Kidouchi K et al. Identification of glutarylcarnitine in glutaric aciduria type 1 by carboxylic acid analyzer with an ODS reverse-phase column. 1987 Clin. Chim. Acta pmid:3594917
Poorthuis BJ et al. Determination of acylcarnitines in urine of patients with inborn errors of metabolism using high-performance liquid chromatography after derivatization with 4'-bromophenacylbromide. 1993 Clin. Chim. Acta pmid:8222273
Al-Majed AA et al. Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus. 2006 Clin. Exp. Pharmacol. Physiol. pmid:16895547
Bartlett K et al. Human forearm arteriovenous differences of carnitine, short-chain acylcarnitine and long-chain acylcarnitine. 1989 Clin. Sci. pmid:2805599
Vanotti A et al. Overview on pathophysiology and newer approaches to treatment of peripheral neuropathies. 2007 CNS Drugs pmid:17696588
Wadman RI et al. Drug treatment for spinal muscular atrophy types II and III. 2012 Cochrane Database Syst Rev pmid:22513940
Wadman RI et al. Drug treatment for spinal muscular atrophy types II and III. 2011 Cochrane Database Syst Rev pmid:22161400
Flori A et al. Real-time cardiac metabolism assessed with hyperpolarized [1-(13) C]acetate in a large-animal model. 2015 May-Jun Contrast Media Mol Imaging pmid:25201079
Kanazirska MV et al. Beneficial effects of lysosome-modulating and other pharmacological and nanocarrier agents on amyloid-beta-treated cells. 2012 Curr Pharm Biotechnol pmid:23072393
Cherry CL et al. Ubisol-Aqua: coenzyme Q10 prevents antiretroviral toxic neuropathy in an in vitro model. 2010 Curr. HIV Res. pmid:20158454
Malaguarnera M Carnitine derivatives: clinical usefulness. 2012 Curr. Opin. Gastroenterol. pmid:22333562
Hall SS Treatments for fragile X syndrome: a closer look at the data. 2009 Dev Disabil Res Rev pmid:20014373
Scafidi S et al. Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain. 2010 Dev. Neurosci. pmid:21228558
Pop-Busui R et al. Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration. 2002 Diabetes pmid:12145179
Boss A et al. Noninvasive assessment of exercise-related intramyocellular acetylcarnitine in euglycemia and hyperglycemia in patients with type 1 diabetes using ¹H magnetic resonance spectroscopy: a randomized single-blind crossover study. 2011 Diabetes Care pmid:20978101
Shen W et al. R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. 2008 Diabetologia pmid:18026715
Mancinelli A et al. Disposition of L-carnitine and its short-chain esters, acetyl-L-carnitine and propionyl-L-carnitine, in the rat isolated perfused liver. 2000 Drug Metab. Dispos. pmid:11095575
Gadaleta MN et al. Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L-carnitine. 1990 Eur. J. Biochem. pmid:2154375
Aureli T et al. Entry of [(1,2-13C2)acetyl]-L-carnitine in liver tricarboxylic acid cycle and lipogenesis: a study by 13C NMR spectroscopy in conscious, freely moving rats. 1999 Eur. J. Biochem. pmid:10429215
Davis EJ et al. Pyruvate carboxylase and propionyl-CoA carboxylase as anaplerotic enzymes in skeletal muscle mitochondria. 1980 Eur. J. Biochem. pmid:6777158
Bianchi G et al. Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-L-carnitine. 2005 Eur. J. Cancer pmid:16039110
Wolf S et al. Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies. 2008 Eur. J. Cancer pmid:18571399
Tabolacci E et al. Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments. 2005 Eur. J. Hum. Genet. pmid:15741991
Bähring R et al. GABA-activated chloride currents of postnatal mouse retinal ganglion cells are blocked by acetylcholine and acetylcarnitine: how specific are ion channels in immature neurons? 1994 Eur. J. Neurosci. pmid:7952289
El-Awady el-SE et al. Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. 2011 Eur. J. Pharmacol. pmid:21034734
Christie LA et al. Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. 2009 Exp. Gerontol. pmid:19735717
Jin HW et al. Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells. 2008 Exp. Neurol. pmid:18078936
Waller AP et al. Oral acetate supplementation after prolonged moderate intensity exercise enhances early muscle glycogen resynthesis in horses. 2009 Exp. Physiol. pmid:19429643
Soczynska JK et al. Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? 2008 Expert Opin Investig Drugs pmid:18491985
Mancuso C et al. Natural antioxidants in Alzheimer's disease. 2007 Expert Opin Investig Drugs pmid:18042001

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