Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
| Cleft Lip | D002971 | 8 associated lipids |
| Amino Acid Metabolism, Inborn Errors | D000592 | 16 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tyni T et al. | Analysis of mitochondrial fatty acid oxidation intermediates by tandem mass spectrometry from intact mitochondria prepared from homogenates of cultured fibroblasts, skeletal muscle cells, and fresh muscle. | 2002 | Pediatr. Res. | pmid:12084849 |
| Van Hove JL et al. | Intravenous L-carnitine and acetyl-L-carnitine in medium-chain acyl-coenzyme A dehydrogenase deficiency and isovaleric acidemia. | 1994 | Pediatr. Res. | pmid:8134205 |
| Li X et al. | An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles. | 2016 | Part Fibre Toxicol | pmid:26772537 |
| Kopsky DJ and Hesselink JM | Nerve regeneration in neuropathic pain. | 2010 | Pain Med | pmid:21199307 |
| Xiao WH and Bennett GJ | Chemotherapy-evoked neuropathic pain: Abnormal spontaneous discharge in A-fiber and C-fiber primary afferent neurons and its suppression by acetyl-L-carnitine. | 2008 | Pain | pmid:17659836 |
| Fehér J et al. | [Metabolic therapy for early treatment of age-related macular degeneration]. | 2007 | Orv Hetil | pmid:18039616 |
| Feher J et al. | Mitotropic compounds for the treatment of age-related macular degeneration. The metabolic approach and a pilot study. | 2003 Sep-Oct | Ophthalmologica | pmid:12913326 |
| Feher J et al. | Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. | 2005 May-Jun | Ophthalmologica | pmid:15947501 |
| De Luca A et al. | Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells. | 2015 | Oncotarget | pmid:26087310 |
| Burotto M and Fojo AT | Acetyl-L-carnitine and prevention of chemotherapy-induced peripheral neuropathy: can anything work? | 2013 | Oncologist | pmid:24217999 |
| Campone M et al. | A double-blind, randomized phase II study to evaluate the safety and efficacy of acetyl-L-carnitine in the prevention of sagopilone-induced peripheral neuropathy. | 2013 | Oncologist | pmid:24105751 |
| Suchy J et al. | Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance. | 2009 | Nutr Res | pmid:19185780 |
| Kathirvel E et al. | Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease. | 2013 | Nutr Res | pmid:24176233 |
| Katoh T et al. | [Application of Metabolomics to Multiple Chemical Sensitivity Research]. | 2016 | Nihon Eiseigaku Zasshi | pmid:26832623 |
| Robinson BL et al. | Distinct effects of ketamine and acetyl L-carnitine on the dopamine system in zebrafish. | 2016 Mar-Apr | Neurotoxicol Teratol | pmid:26898327 |
| Cuevas E et al. | Acetyl L-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos. | 2013 Sep-Oct | Neurotoxicol Teratol | pmid:23896048 |
| Nagesh Babu G et al. | Chronic pretreatment with acetyl-L-carnitine and ±DL-α-lipoic acid protects against acute glutamate-induced neurotoxicity in rat brain by altering mitochondrial function. | 2011 | Neurotox Res | pmid:20217290 |
| Patel SP et al. | Acetyl-L-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery. | 2012 | Neuroscience | pmid:22445934 |
| Binienda ZK et al. | Assessment of 3-nitropropionic acid-evoked peripheral neuropathy in rats: neuroprotective effects of acetyl-l-carnitine and resveratrol. | 2010 | Neurosci. Lett. | pmid:20542088 |
| Sarkar S et al. | Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-L-carnitine. | 2015 | Neurosci. Lett. | pmid:26321151 |
| Robinson BL et al. | Opposing effects of ketamine and acetyl L-carnitine on the serotonergic system of zebrafish. | 2015 | Neurosci. Lett. | pmid:26365406 |
| Flatters SJ et al. | Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy. | 2006 | Neurosci. Lett. | pmid:16406309 |
| Masi F et al. | Effects of long-term acetyl-L-carnitine administration in rats--II: Protection against the disrupting effect of stress on the acquisition of appetitive behavior. | 2003 | Neuropsychopharmacology | pmid:12655313 |
| Tolu P et al. | Effects of long-term acetyl-L-carnitine administration in rats: I. increased dopamine output in mesocorticolimbic areas and protection toward acute stress exposure. | 2002 | Neuropsychopharmacology | pmid:12225698 |
| Cuccurazzu B et al. | Upregulation of mGlu2 receptors via NF-κB p65 acetylation is involved in the Proneurogenic and antidepressant effects of acetyl-L-carnitine. | 2013 | Neuropsychopharmacology | pmid:23670591 |
| Gago MF et al. | SANDO: two novel mutations in POLG1 gene. | 2006 | Neuromuscul. Disord. | pmid:16919951 |
| Kottlors M et al. | Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency. | 2001 | Neuromuscul. Disord. | pmid:11595519 |
| Bidzinska B et al. | Effect of different chronic intermittent stressors and acetyl-l-carnitine on hypothalamic beta-endorphin and GnRH and on plasma testosterone levels in male rats. | 1993 | Neuroendocrinology | pmid:8232773 |
| Long J et al. | Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. | 2009 | Neurochem. Res. | pmid:18846423 |
| Smeland OB et al. | Dietary supplementation with acetyl-l-carnitine in seizure treatment of pentylenetetrazole kindled mice. | 2012 | Neurochem. Int. | pmid:22709675 |
| Phillipson OT | Management of the aging risk factor for Parkinson's disease. | 2014 | Neurobiol. Aging | pmid:24246717 |
| Uziel G et al. | Carnitine stimulation of pyruvate dehydrogenase complex (PDHC) in isolated human skeletal muscle mitochondria. | 1988 | Muscle Nerve | pmid:3405240 |
| Elanchezhian R et al. | Evaluation of lenticular antioxidant and redox system components in the lenses of acetyl-L-carnitine treatment in BSO-induced glutathione deprivation. | 2009 | Mol. Vis. | pmid:19649174 |
| Muralidharan AR et al. | Deciphering the potential efficacy of acetyl-L-carnitine (ALCAR) in maintaining connexin-mediated lenticular homeostasis. | 2012 | Mol. Vis. | pmid:22876134 |
| Lau T et al. | Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant. | 2017 | Mol. Psychiatry | pmid:27240534 |
| Chiechio S et al. | L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors. | 2002 | Mol. Pharmacol. | pmid:11961116 |
| Behrend AM et al. | Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation. | 2012 | Mol. Genet. Metab. | pmid:22030098 |
| Löster H et al. | Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy. | 1999 | Mol. Cell. Biochem. | pmid:10569188 |
| Cui J et al. | Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts. | 2003 | Mol. Cell. Biochem. | pmid:14674702 |
| Hu C et al. | Inhibition of OCTN2-mediated transport of carnitine by etoposide. | 2012 | Mol. Cancer Ther. | pmid:22389472 |
| Chiechio S et al. | Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine. | 2006 | Mol Pain | pmid:16764720 |
| Notartomaso S et al. | Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. | 2017 | Mol Pain | pmid:28326943 |
| Pekkinen J et al. | Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach. | 2013 | Mol Nutr Food Res | pmid:23868375 |
| Calabrese V et al. | Redox homeostasis and cellular stress response in aging and neurodegeneration. | 2010 | Methods Mol. Biol. | pmid:20013185 |
| Cotter MA et al. | Effects of acetyl- and proprionyl-L-carnitine on peripheral nerve function and vascular supply in experimental diabetes. | 1995 | Metab. Clin. Exp. | pmid:7666797 |
| Brass EP and Beyerinck RA | Interactions of propionate and carnitine metabolism in isolated rat hepatocytes. | 1987 | Metab. Clin. Exp. | pmid:3110541 |
| Parr TB | A new technique to elevate night time growth hormone release and a potential growth hormone feedback control loop. | 2001 | Med. Hypotheses | pmid:11388776 |
| Gómez LA et al. | Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart. | 2012 Feb-Mar | Mech. Ageing Dev. | pmid:22322067 |
| Kerner J et al. | Acetyl-L-carnitine increases mitochondrial protein acetylation in the aged rat heart. | 2015 | Mech. Ageing Dev. | pmid:25660059 |
| Curti D et al. | Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. | 1989 | Mech. Ageing Dev. | pmid:2542702 |