Acetyl-d-carnitine

Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 2875 references associated with Acetyl-d-carnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Acetyl-d-carnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Alzheimer Disease D000544 76 associated lipids
Parkinson Disease D010300 53 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Cleft Lip D002971 8 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 7

All references with Acetyl-d-carnitine

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Authors Title Published Journal PubMed Link
Acetyl-L-carnitine. Monograph. 2010 Altern Med Rev pmid:20359271
Seidman MD et al. Biologic activity of mitochondrial metabolites on aging and age-related hearing loss. 2000 Am J Otol pmid:10733178
El Banani H et al. Ionic and metabolic imbalance as potential factors of ischemia reperfusion injury. 1998 Am. J. Cardiol. pmid:9737483
Malaguarnera M et al. Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. 2011 Am. J. Clin. Nutr. pmid:21310833
O'Sullivan A et al. Dietary intake patterns are reflected in metabolomic profiles: potential role in dietary assessment studies. 2011 Am. J. Clin. Nutr. pmid:21177801
Pomponi MG and Neri G Butyrate and acetyl-carnitine inhibit the cytogenetic expression of the fragile X in vitro. 1994 Am. J. Med. Genet. pmid:7943015
Parolin ML et al. Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise. 1999 Am. J. Physiol. pmid:10567017
Renstrom B et al. Mechanisms of substrate preference for oxidative metabolism during early myocardial reperfusion. 1990 Am. J. Physiol. pmid:2386216
Timmons JA et al. Metabolic responses from rest to steady state determine contractile function in ischemic skeletal muscle. 1997 Am. J. Physiol. pmid:9277374
Owens K et al. Effects of fatty acid intermediates on Na+-K+-ATPase activity of cardiac sarcolemma. 1982 Am. J. Physiol. pmid:6278956
Pande SV et al. Protective role of adenine nucleotide translocase in O2-deficient hearts. 1984 Am. J. Physiol. pmid:6331205
Putman CT et al. Pyruvate dehydrogenase activation in inactive muscle during and after maximal exercise in men. 1999 Am. J. Physiol. pmid:10070014
Howlett RA et al. Regulation of skeletal muscle glycogen phosphorylase and PDH at varying exercise power outputs. 1998 Am. J. Physiol. pmid:9688676
Fisher JS et al. Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:11739078
Schooneman MG et al. Transorgan fluxes in a porcine model reveal a central role for liver in acylcarnitine metabolism. 2015 Am. J. Physiol. Endocrinol. Metab. pmid:26037250
Roberts PA et al. Acetyl-CoA provision and the acetyl group deficit at the onset of contraction in ischemic canine skeletal muscle. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15454400
Evans MK et al. Effects of acetate infusion and hyperoxia on muscle substrate phosphorylation after onset of moderate exercise. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11701427
Starritt EC et al. Sensitivity of CPT I to malonyl-CoA in trained and untrained human skeletal muscle. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10710500
Roepstorff C et al. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15383373
St Amand TA et al. Pyruvate overrides inhibition of PDH during exercise after a low-carbohydrate diet. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10913026
Morand R et al. Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction. 2013 Anal Bioanal Chem pmid:23995505
Yergey AL et al. Thermospray liquid chromatography/mass spectrometry for the analysis of L-carnitine and its short-chain acyl derivatives. 1984 Anal. Biochem. pmid:6476364
Minkler PE and Hoppel CL Quantification of free carnitine, individual short- and medium-chain acylcarnitines, and total carnitine in plasma by high-performance liquid chromatography. 1993 Anal. Biochem. pmid:8214594
Emaus R and Bieber LL Preparation of radioactive acetyl-L-carnitine by an enzymatic exchange reaction. 1982 Anal. Biochem. pmid:6122386
Kamimori H et al. Determination of carnitine and saturated-acyl group carnitines in human urine by high-performance liquid chromatography with fluorescence detection. 1994 Anal. Biochem. pmid:8074302
Jiang Q et al. Oral acetyl-L-carnitine treatment in hepatic encephalopathy: view of evidence-based medicine. 2013 Sep-Oct Ann Hepatol pmid:24018499
Zanelli SA et al. Mechanisms of ischemic neuroprotection by acetyl-L-carnitine. 2005 Ann. N. Y. Acad. Sci. pmid:16179519
Liu J et al. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. 2002 Ann. N. Y. Acad. Sci. pmid:11976193
Hagen TM et al. Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid. 2002 Ann. N. Y. Acad. Sci. pmid:11976222
Ames BN and Liu J Delaying the mitochondrial decay of aging with acetylcarnitine. 2004 Ann. N. Y. Acad. Sci. pmid:15591008
Coccurello R et al. Valproate and acetyl-L-carnitine prevent methamphetamine-induced behavioral sensitization in mice. 2007 Ann. N. Y. Acad. Sci. pmid:18077579
Ames BN Delaying the mitochondrial decay of aging. 2004 Ann. N. Y. Acad. Sci. pmid:15247055
Beal MF Bioenergetic approaches for neuroprotection in Parkinson's disease. 2003 Ann. Neurol. pmid:12666097
Fernández Ortega MF Effect of dietary lysine level and protein restriction on the lipids and carnitine levels in the liver of pregnant rats. 1989 Ann. Nutr. Metab. pmid:2508533
Wojtecka-Lukasik E et al. Anti-inflammatory drugs modulate histamine release from mast cells induced by fibrinogen degradation products. 1988 Ann. Rheum. Dis. pmid:2452608
Ghirardi O et al. Acetyl-L-Carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin, without altering its antitumor properties. 2005 Jul-Aug Anticancer Res. pmid:16080512
Mentlein R et al. Specificity of two different purified acylcarnitine hydrolases from rat liver, their identity with other carboxylesterases, and their possible function. 1985 Arch. Biochem. Biophys. pmid:4026306
Olson MS et al. The regulation of pyruvate dehydrogenase by fatty acids in isolated rabbit heart mitochondria. 1978 Arch. Biochem. Biophys. pmid:207223
Roe CR et al. Metabolic response to carnitine in methylmalonic aciduria. An effective strategy for elimination of propionyl groups. 1983 Arch. Dis. Child. pmid:6651329
Sakuma T Alteration of urinary carnitine profile induced by benzoate administration. 1991 Arch. Dis. Child. pmid:1863104
Dundar HA et al. Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats. 2016 Arch. Med. Res. pmid:28262191
Defani MA et al. Effect of acetyl-L-carnitine on VIP-ergic neurons in the jejunum submucous plexus of diabetic rats. 2003 Arq Neuropsiquiatr pmid:14762599
Zhou X et al. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review. 2007 Asia Pac J Clin Nutr pmid:17392136
Cavallini G Male idiopathic oligoasthenoteratozoospermia. 2006 Asian J. Androl. pmid:16491265
Rajguru R Military aircrew and noise-induced hearing loss: prevention and management. 2013 Aviat Space Environ Med pmid:24459798
Arafa HM et al. Acetyl-L-carnitine ameliorates caerulein-induced acute pancreatitis in rats. 2009 Basic Clin. Pharmacol. Toxicol. pmid:19371263
Mehrotra A and Sandhir R Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation. 2014 Behav. Brain Res. pmid:24393741
Mroczkowska JE et al. Blood-brain barrier controls carnitine level in the brain: a study on a model system with RBE4 cells. 2000 Biochem. Biophys. Res. Commun. pmid:10623637
Ruggiero FM et al. Effect of aging and acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes. 1990 Biochem. Biophys. Res. Commun. pmid:2383260
Tassani V et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. 1994 Biochem. Biophys. Res. Commun. pmid:8135845
Wawrzeńczyk A et al. Effect of gamma-aminobutyric acid on the carnitine metabolism in neural cells. 1995 Biochem. Biophys. Res. Commun. pmid:7646490
Hansford RG Lipid oxidation by heart mitochondria from young adult and senescent rats. 1978 Biochem. J. pmid:637843
Brass EP and Hoppel CL Effect of carnitine on mitochondrial oxidation of palmitoylearnitine. 1980 Biochem. J. pmid:7396873
Kasumov T et al. Probing peroxisomal beta-oxidation and the labelling of acetyl-CoA proxies with [1-(13C)]octanoate and [3-(13C)]octanoate in the perfused rat liver. 2005 Biochem. J. pmid:15773815
Eaton S et al. The effect of respiratory chain impairment of beta-oxidation in rat heart mitochondria. 1996 Biochem. J. pmid:8912705
Pourfarzam M and Bartlett K Products and intermediates of the beta-oxidation of [U-14C]hexadecanedionoyl-mono-CoA by rat liver peroxisomes and mitochondria. 1991 Biochem. J. pmid:1989582
Murthy MS and Pande SV Microcompartmentation of transported carnitine, acetylcarnitine and ADP occurs in the mitochondrial matrix. Implications for transport measurements and metabolism. 1985 Biochem. J. pmid:4062871
Murthy MS et al. A carnitine/acylcarnitine translocase assay applicable to biopsied muscle specimens without requiring mitochondrial isolation. 1986 Biochem. J. pmid:3098229
Brass EP and Hoppel CL Relationship between acid-soluble carnitine and coenzyme A pools in vivo. 1980 Biochem. J. pmid:7470064
Brass EP and Stabler SP Carnitine metabolism in the vitamin B-12-deficient rat. 1988 Biochem. J. pmid:3196310
Watmough NJ et al. Skeletal muscle mitochondrial beta-oxidation. A study of the products of oxidation of [U-14C]hexadecanoate by h.p.l.c. using continuous on-line radiochemical detection. 1988 Biochem. J. pmid:3178728
Snoswell AM and Tubbs PK Deacylation of acetyl-coenzyme A and acetylcarnitine by liver preparations. 1978 Biochem. J. pmid:26333
Mawal YR et al. Restoration of hepatic cytochrome c oxidase activity and expression with acetyl-L-carnitine treatment in spf mice with an ornithine transcarbamylase deficiency. 1998 Biochem. Pharmacol. pmid:9714304
Melegh B et al. Pivampicillin-promoted excretion of pivaloylcarnitine in humans. 1987 Biochem. Pharmacol. pmid:3675603
Benzi G et al. Recovery after hypoglycemic brain injury. Action of some biological substances on the cerebral metabolism. 1983 Biochem. Pharmacol. pmid:6340690
Brass EP et al. Effect of carnitine acetyltransferase inhibition on rat hepatocyte metabolism. 1991 Biochim. Biophys. Acta pmid:1932127
Cassano P et al. Acetyl-L-carnitine feeding to unloaded rats triggers in soleus muscle the coordinated expression of genes involved in mitochondrial biogenesis. 2006 Sep-Oct Biochim. Biophys. Acta pmid:16814248
Arduini A et al. Effects of L-carnitine and its acetate and propionate esters on the molecular dynamics of human erythrocyte membrane. 1993 Biochim. Biophys. Acta pmid:8383998
Huth PJ and Shug AL Properties of carnitine transport in rat kidney cortex slices. 1980 Biochim. Biophys. Acta pmid:7437424
Horiuchi M et al. Secondary abnormality of carnitine biosynthesis results from carnitine reabsorptional system defect in juvenile visceral steatosis mice. 1997 Biochim. Biophys. Acta pmid:9540857
Mittal B and Kurup CK Purification of clofibrate-induced carnitine acetyltransferase from rat liver mitochondria. 1980 Biochim. Biophys. Acta pmid:7417471
Alexson SE et al. Inhibition of acetyl-carnitine oxidation in rat brown-adipose-tissue mitochondria by erucoyl-carnitine is due to sequestration of CoA. 1985 Biochim. Biophys. Acta pmid:3995059
Siliprandi N et al. Metabolic changes induced by maximal exercise in human subjects following L-carnitine administration. 1990 Biochim. Biophys. Acta pmid:2328258
Diep QN et al. Formation of pivaloylcarnitine in isolated rat heart cells. 1995 Biochim. Biophys. Acta pmid:7488636
Hokland BM and Bremer J Metabolism and excretion of carnitine and acylcarnitines in the perfused rat kidney. 1986 Biochim. Biophys. Acta pmid:3697382
Pochini L et al. Acetylcholine and acetylcarnitine transport in peritoneum: Role of the SLC22A4 (OCTN1) transporter. 2016 Biochim. Biophys. Acta pmid:26724204
Farrell S et al. Entry of acetyl-L-carnitine into biosynthetic pathways. 1986 Biochim. Biophys. Acta pmid:3081044
Furuichi Y et al. Imaging mass spectrometry reveals fiber-specific distribution of acetylcarnitine and contraction-induced carnitine dynamics in rat skeletal muscles. 2014 Biochim. Biophys. Acta pmid:24882639
Gross CJ et al. Uptake of L-carnitine, D-carnitine and acetyl-L-carnitine by isolated guinea-pig enterocytes. 1986 Biochim. Biophys. Acta pmid:3708005
Kurth L et al. Utilization of intracellular acylcarnitine pools by mononuclear phagocytes. 1994 Biochim. Biophys. Acta pmid:7947948
Pochini L et al. The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease. 2012 Biochim. Biophys. Acta pmid:22206629
Kølvraa S and Gregersen N In vitro studies on the oxidation of medium-chain dicarboxylic acids in rat liver. 1986 Biochim. Biophys. Acta pmid:3707982
Musicco C et al. Accumulation of overoxidized Peroxiredoxin III in aged rat liver mitochondria. 2009 Biochim. Biophys. Acta pmid:19272351
Maldonado C et al. Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. 2016 Biomed Res Int pmid:26998483
Benzerrouk R and Qureshi IA Hepatic mitochondrial proteins in congenitally hyperammonemic spf mice: effect of acetyl-L-carnitine. 2001 Biosci. Biotechnol. Biochem. pmid:11330659
Biagiotti G and Cavallini G Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie's disease: a preliminary report. 2001 BJU Int. pmid:11446848
Schreiber BD Debate forum: levocarnitine therapy is rational and justified in selected dialysis patients. 2006 Blood Purif. pmid:16361853
Wu J et al. TGF-β1 induces senescence of bone marrow mesenchymal stem cells via increase of mitochondrial ROS production. 2014 BMC Dev. Biol. pmid:24886313
Rueda JR et al. Systematic review of pharmacological treatments in fragile X syndrome. 2009 BMC Neurol pmid:19822023
Pace S et al. Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsorption. 2000 Br J Clin Pharmacol pmid:11069438
Graziano F et al. Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anaemic cancer patients. 2002 Br. J. Cancer pmid:12085175
Elliott GR et al. The effect of acute feeding of carnitine, acetyl carnitine and propionyl carnitine on basal and A23187-stimulated eicosanoid release from rat carrageenan-elicited peritoneal macrophages. 1990 Br. J. Nutr. pmid:2171633
Imai S et al. Anti-arrhythmic effects of (-)-carnitine chloride and its acetyl analogue on canine late ventricular arrhythmia induced by ligation of the coronary artery as related to improvement of mitochondrial function. 1984 Br. J. Pharmacol. pmid:6733367
Ori C et al. Effects of acetyl-L-carnitine on regional cerebral glucose metabolism in awake rats. 2002 Brain Res. pmid:12270513
Sharman EH et al. Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine. 2002 Brain Res. pmid:12445964
Ganesan R et al. New treatments for dementia. Myth, magic, and science. 1994 Can Fam Physician pmid:8019192
Callander N et al. Acetyl-L-carnitine (ALCAR) for the prevention of chemotherapy-induced peripheral neuropathy in patients with relapsed or refractory multiple myeloma treated with bortezomib, doxorubicin and low-dose dexamethasone: a study from the Wisconsin Oncology Network. 2014 Cancer Chemother. Pharmacol. pmid:25168296
Mancinelli A et al. Urinary excretion of L-carnitine and its short-chain acetyl-L-carnitine in patients undergoing carboplatin treatment. 2007 Cancer Chemother. Pharmacol. pmid:16988826
Lu Y et al. Acetylcarnitine Is a Candidate Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma. 2016 Cancer Res. pmid:26976432
Muoio DM et al. Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. 2012 Cell Metab. pmid:22560225

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