Acetyl-d-carnitine

Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 2875 references associated with Acetyl-d-carnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Acetyl-d-carnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Alzheimer Disease D000544 76 associated lipids
Parkinson Disease D010300 53 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Cleft Lip D002971 8 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 7

All references with Acetyl-d-carnitine

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Jensen MV et al. Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. 2006 J. Biol. Chem. pmid:16740637
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Emaus RK and Bieber LL A biosynthetic role for carnitine in the yeast Torulopsis bovina. 1983 J. Biol. Chem. pmid:6685127
MARQUIS NR and FRITZ IB EFFECTS OF TESTOSTERONE ON THE DISTRIBUTION OF CARNITINE, ACETYLCARNITINE, AND CARNITINE ACETYLTRANSFERASE IN TISSUES OF THE REPRODUCTIVE SYSTEM OF THE MALE RAT. 1965 J. Biol. Chem. pmid:14299647
MARQUIS NR and FRITZ IB THE DISTRIBUTION OF CARNITINE, ACETYLCARNITINE, AND CARNITINE ACETYLTRANSFERASE IN RAT TISSUES. 1965 J. Biol. Chem. pmid:14299646
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Jiang X et al. Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. 2011 J. Neurochem. pmid:21689104
Scafidi S et al. Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature rat brain. 2010 J. Neurochem. pmid:20477950
Patel SP et al. Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury. 2010 J. Neurochem. pmid:20438613
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Szutowicz A et al. Nerve growth factor and acetyl-L-carnitine evoked shifts in acetyl-CoA and cholinergic SN56 cell vulnerability to neurotoxic inputs. 2005 Jan 1-15 J. Neurosci. Res. pmid:15558747
Benzi G et al. Cerebral endogenous substrate utilization during the recovery period after profound hypoglycemia. 1984 J. Neurosci. Res. pmid:6748113
Patacchioli FR et al. Acetyl-L-carnitine reduces the age-dependent loss of glucocorticoid receptors in the rat hippocampus: an autoradiographic study. 1989 J. Neurosci. Res. pmid:2769802
Ewan EE and Hagg T Intrathecal Acetyl-L-Carnitine Protects Tissue and Improves Function after a Mild Contusive Spinal Cord Injury in Rats. 2016 J. Neurotrauma pmid:26415041
Iossa S et al. Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats. 2002 J. Nutr. pmid:11925454
Nakamura J et al. Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats. 1998 J. Pharmacol. Exp. Ther. pmid:9864270
Wu X et al. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. 1999 J. Pharmacol. Exp. Ther. pmid:10454528
Srikanth V et al. Effects of ethanol treatment on epididymal secretory products and sperm maturation in albino rats. 1999 J. Pharmacol. Exp. Ther. pmid:9918552
Stephens FB et al. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. 2007 J. Physiol. (Lond.) pmid:17331998
Mattei B et al. Pharmacologically induced enhancement of recurrent inhibition in humans: effects on motoneurone discharge patterns. 2003 J. Physiol. (Lond.) pmid:12611926
Roberts PA et al. The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle. 2002 J. Physiol. (Lond.) pmid:12433969
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Mallinson JE et al. Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. 2012 J. Physiol. (Lond.) pmid:23045346
Watt MJ et al. Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no effect on substrate phosphorylation at the onset of exercise in man. 2002 J. Physiol. (Lond.) pmid:12411537
Watt MJ et al. Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man. 2002 J. Physiol. (Lond.) pmid:12068055
Grassi B et al. Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. 2002 J. Physiol. (Lond.) pmid:11773328
Jones AR and Bubb WA Substrates for endogenous metabolism by mature boar spermatozoa. 2000 J. Reprod. Fertil. pmid:10864822
Jeulin C et al. Uptake and release of free L-carnitine by boar epididymal spermatozoa in vitro and subsequent acetylation rate. 1994 J. Reprod. Fertil. pmid:8182599
Jeulin C et al. The distribution of carnitine and acetylcarnitine in the epididymis and epididymal spermatozoa of the boar. 1987 J. Reprod. Fertil. pmid:3572883
Casillas ER et al. Distribution of carnitine and acylcarnitine in the hamster epididymis and in epididymal spermatozoa during maturation. 1984 J. Reprod. Fertil. pmid:6471048
Hinton BT et al. Effects of carnitine and some related compounds on the motility of rat spermatozoa from the caput epididymidis. 1981 J. Reprod. Fertil. pmid:7452626
Brooks DE Carnitine, acetylcarnitine and the activity of carnitine acyltransferases in seminal plasma and spermatozoa of men, rams and rats. 1979 J. Reprod. Fertil. pmid:480318
Casillas ER and Chaipayungpan S The distribution of carnitine and acetylcarnitine in the rabbit epididymis and the carnitine content of rabbit spermatozoa during maturation. 1979 J. Reprod. Fertil. pmid:480302
Golan R et al. Influence of various substrates on the acetylcarnitine:carnitine ratio in motile and immotile human spermatozoa. 1986 J. Reprod. Fertil. pmid:3761272
Ishii T et al. Anti-apoptotic effect of acetyl-l-carnitine and I-carnitine in primary cultured neurons. 2000 Jpn. J. Pharmacol. pmid:10928324
Kohjimoto Y et al. Effects of acetyl-L-carnitine on the brain lipofuscin content and emotional behavior in aged rats. 1988 Jpn. J. Pharmacol. pmid:3221536
Matsui K et al. Effect of l-carnitine chloride and its acetyl derivative on the electrophysiological derangement induced by palmityl-l-carnitine in isolated canine ventricular muscle. 1985 Jpn. J. Pharmacol. pmid:4087570
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Xu S et al. In vivo longitudinal proton magnetic resonance spectroscopy on neonatal hypoxic-ischemic rat brain injury: Neuroprotective effects of acetyl-L-carnitine. 2015 Magn Reson Med pmid:25461739
Ren J et al. Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS. 2013 Magn Reson Med pmid:22473634
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Paradies G et al. Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine. 1995 Mech. Ageing Dev. pmid:8788238
Gómez LA et al. Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart. 2012 Feb-Mar Mech. Ageing Dev. pmid:22322067
Ames BN Optimal micronutrients delay mitochondrial decay and age-associated diseases. 2010 Jul-Aug Mech. Ageing Dev. pmid:20420847
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Phillipson OT Management of the aging risk factor for Parkinson's disease. 2014 Neurobiol. Aging pmid:24246717
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