Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amino Acid Metabolism, Inborn Errors | D000592 | 16 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Cleft Lip | D002971 | 8 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ruggenenti P et al. | Oral acetyl-L-carnitine therapy and insulin resistance. | 2010 | Hypertension | pmid:20439816 |
| Abdel-aleem S et al. | Reduced effects of L-carnitine on glucose and fatty acid metabolism in myocytes isolated from diabetic rats. | 1997 | Horm. Metab. Res. | pmid:9370110 |
| Youle M and Osio M | A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. | 2007 | HIV Med. | pmid:17461852 |
| Valcour V et al. | Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection. | 2009 | HIV Med. | pmid:19200173 |
| Hanada H et al. | Acetyl-L-carnitine suppresses thyroid hormone-induced and spontaneous anuran tadpole tail shortening. | 2013 | Hereditas | pmid:23489246 |
| Engle DB et al. | Effect of acetyl-l-carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (Trk-A and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin. | 2009 | Gynecol. Oncol. | pmid:19263582 |
| Bastianetto S and Quirion R | Natural antioxidants and neurodegenerative diseases. | 2004 | Front. Biosci. | pmid:15353369 |
| Rump TJ et al. | Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain. | 2010 | Free Radic. Biol. Med. | pmid:20708681 |
| Liu J et al. | Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. | 2014 | Free Radic. Biol. Med. | pmid:24418157 |
| Sharma S et al. | Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. | 2012 | Free Radic. Biol. Med. | pmid:22583703 |
| Haorah J et al. | Stabilization of superoxide dismutase by acetyl-l-carnitine in human brain endothelium during alcohol exposure: novel protective approach. | 2011 | Free Radic. Biol. Med. | pmid:21782933 |
| Abdul HM and Butterfield DA | Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. | 2007 | Free Radic. Biol. Med. | pmid:17210450 |
| Fišar Z et al. | Effect of Simvastatin, Coenzyme Q10, Resveratrol, Acetylcysteine and Acetylcarnitine on Mitochondrial Respiration. | 2016 | Folia Biol. (Praha) | pmid:27187037 |
| Lewin LM et al. | Carnitine and acylcarnitines in semen from azoospermic patients. | 1981 | Fertil. Steril. | pmid:6114878 |
| Duru NK et al. | Semen treatment with progesterone and/or acetyl-L-carnitine does not improve sperm motility or membrane damage after cryopreservation-thawing. | 2000 | Fertil. Steril. | pmid:11020512 |
| Ferraresi R et al. | Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs. | 2006 | FEBS Lett. | pmid:17118360 |
| Paradies G et al. | The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria. | 1999 | FEBS Lett. | pmid:10431808 |
| Requero MA et al. | Differential penetration of fatty acyl-coenzyme A and fatty acylcarnitines into phospholipid monolayers. | 1995 | FEBS Lett. | pmid:8001684 |
| Paradies G et al. | Effect of aging and acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria. | 1994 | FEBS Lett. | pmid:8070566 |
| Gadaleta MN et al. | Acetyl-L-carnitine increases cytochrome oxidase subunit I mRNA content in hypothyroid rat liver. | 1990 | FEBS Lett. | pmid:2176613 |
| Palmieri L et al. | Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae. | 1999 | FEBS Lett. | pmid:10622748 |
| Carter AL et al. | Increased acetyl carnitine in rat skeletal muscle as a result of high-intensity short-duration exercise. Implications in the control of pyruvate dehydrogenase activity. | 1981 | FEBS Lett. | pmid:7238861 |
| Ferri L et al. | The mitochondrial handling of D,L-thiocarnitine and its S-acetyl derivative. | 1980 | FEBS Lett. | pmid:7461115 |
| Miñana MD et al. | Hyperammonemia decreases body fat content in rat. | 1989 | FEBS Lett. | pmid:2737286 |
| Zhang Z et al. | Acetyl-l-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells. | 2009 | FEBS Lett. | pmid:19121314 |
| Milgram NW et al. | Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests. | 2007 | FASEB J. | pmid:17622567 |
| Schroeder MA et al. | Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. | 2009 | FASEB J. | pmid:19329759 |
| Soczynska JK et al. | Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? | 2008 | Expert Opin Investig Drugs | pmid:18491985 |
| Mancuso C et al. | Natural antioxidants in Alzheimer's disease. | 2007 | Expert Opin Investig Drugs | pmid:18042001 |
| Waller AP et al. | Oral acetate supplementation after prolonged moderate intensity exercise enhances early muscle glycogen resynthesis in horses. | 2009 | Exp. Physiol. | pmid:19429643 |
| Jin HW et al. | Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells. | 2008 | Exp. Neurol. | pmid:18078936 |
| Christie LA et al. | Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. | 2009 | Exp. Gerontol. | pmid:19735717 |
| El-Awady el-SE et al. | Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. | 2011 | Eur. J. Pharmacol. | pmid:21034734 |
| Bähring R et al. | GABA-activated chloride currents of postnatal mouse retinal ganglion cells are blocked by acetylcholine and acetylcarnitine: how specific are ion channels in immature neurons? | 1994 | Eur. J. Neurosci. | pmid:7952289 |
| Tabolacci E et al. | Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments. | 2005 | Eur. J. Hum. Genet. | pmid:15741991 |
| Bianchi G et al. | Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-L-carnitine. | 2005 | Eur. J. Cancer | pmid:16039110 |
| Wolf S et al. | Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies. | 2008 | Eur. J. Cancer | pmid:18571399 |
| Gadaleta MN et al. | Reduced transcription of mitochondrial DNA in the senescent rat. Tissue dependence and effect of L-carnitine. | 1990 | Eur. J. Biochem. | pmid:2154375 |
| Aureli T et al. | Entry of [(1,2-13C2)acetyl]-L-carnitine in liver tricarboxylic acid cycle and lipogenesis: a study by 13C NMR spectroscopy in conscious, freely moving rats. | 1999 | Eur. J. Biochem. | pmid:10429215 |
| Davis EJ et al. | Pyruvate carboxylase and propionyl-CoA carboxylase as anaplerotic enzymes in skeletal muscle mitochondria. | 1980 | Eur. J. Biochem. | pmid:6777158 |
| Mancinelli A et al. | Disposition of L-carnitine and its short-chain esters, acetyl-L-carnitine and propionyl-L-carnitine, in the rat isolated perfused liver. | 2000 | Drug Metab. Dispos. | pmid:11095575 |
| Shen W et al. | R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. | 2008 | Diabetologia | pmid:18026715 |
| Boss A et al. | Noninvasive assessment of exercise-related intramyocellular acetylcarnitine in euglycemia and hyperglycemia in patients with type 1 diabetes using ¹H magnetic resonance spectroscopy: a randomized single-blind crossover study. | 2011 | Diabetes Care | pmid:20978101 |
| Pop-Busui R et al. | Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration. | 2002 | Diabetes | pmid:12145179 |
| Scafidi S et al. | Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain. | 2010 | Dev. Neurosci. | pmid:21228558 |
| Hall SS | Treatments for fragile X syndrome: a closer look at the data. | 2009 | Dev Disabil Res Rev | pmid:20014373 |
| Malaguarnera M | Carnitine derivatives: clinical usefulness. | 2012 | Curr. Opin. Gastroenterol. | pmid:22333562 |
| Cherry CL et al. | Ubisol-Aqua: coenzyme Q10 prevents antiretroviral toxic neuropathy in an in vitro model. | 2010 | Curr. HIV Res. | pmid:20158454 |
| Kanazirska MV et al. | Beneficial effects of lysosome-modulating and other pharmacological and nanocarrier agents on amyloid-beta-treated cells. | 2012 | Curr Pharm Biotechnol | pmid:23072393 |
| Flori A et al. | Real-time cardiac metabolism assessed with hyperpolarized [1-(13) C]acetate in a large-animal model. | 2015 May-Jun | Contrast Media Mol Imaging | pmid:25201079 |