Acetyl-d-carnitine

Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2875 references associated with Acetyl-d-carnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Acetyl-d-carnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine

MeSH term MeSH ID Detail
Proteostasis Deficiencies D057165 5 associated lipids
Parkinson Disease D010300 53 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cleft Lip D002971 8 associated lipids
Body Weight D001835 333 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Alzheimer Disease D000544 76 associated lipids
Total 7

All references with Acetyl-d-carnitine

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Authors Title Published Journal PubMed Link
Kidd PM A review of nutrients and botanicals in the integrative management of cognitive dysfunction. 1999 Altern Med Rev pmid:10383479
Seidman MD et al. Biologic activity of mitochondrial metabolites on aging and age-related hearing loss. 2000 Am J Otol pmid:10733178
El Banani H et al. Ionic and metabolic imbalance as potential factors of ischemia reperfusion injury. 1998 Am. J. Cardiol. pmid:9737483
Malaguarnera M et al. Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. 2011 Am. J. Clin. Nutr. pmid:21310833
O'Sullivan A et al. Dietary intake patterns are reflected in metabolomic profiles: potential role in dietary assessment studies. 2011 Am. J. Clin. Nutr. pmid:21177801
Pomponi MG and Neri G Butyrate and acetyl-carnitine inhibit the cytogenetic expression of the fragile X in vitro. 1994 Am. J. Med. Genet. pmid:7943015
Parolin ML et al. Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise. 1999 Am. J. Physiol. pmid:10567017
Renstrom B et al. Mechanisms of substrate preference for oxidative metabolism during early myocardial reperfusion. 1990 Am. J. Physiol. pmid:2386216
Timmons JA et al. Metabolic responses from rest to steady state determine contractile function in ischemic skeletal muscle. 1997 Am. J. Physiol. pmid:9277374
Owens K et al. Effects of fatty acid intermediates on Na+-K+-ATPase activity of cardiac sarcolemma. 1982 Am. J. Physiol. pmid:6278956
Pande SV et al. Protective role of adenine nucleotide translocase in O2-deficient hearts. 1984 Am. J. Physiol. pmid:6331205
Putman CT et al. Pyruvate dehydrogenase activation in inactive muscle during and after maximal exercise in men. 1999 Am. J. Physiol. pmid:10070014
Howlett RA et al. Regulation of skeletal muscle glycogen phosphorylase and PDH at varying exercise power outputs. 1998 Am. J. Physiol. pmid:9688676
Fisher JS et al. Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:11739078
Schooneman MG et al. Transorgan fluxes in a porcine model reveal a central role for liver in acylcarnitine metabolism. 2015 Am. J. Physiol. Endocrinol. Metab. pmid:26037250
Roberts PA et al. Acetyl-CoA provision and the acetyl group deficit at the onset of contraction in ischemic canine skeletal muscle. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15454400
Evans MK et al. Effects of acetate infusion and hyperoxia on muscle substrate phosphorylation after onset of moderate exercise. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11701427
Starritt EC et al. Sensitivity of CPT I to malonyl-CoA in trained and untrained human skeletal muscle. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10710500
Roepstorff C et al. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. 2005 Am. J. Physiol. Endocrinol. Metab. pmid:15383373
St Amand TA et al. Pyruvate overrides inhibition of PDH during exercise after a low-carbohydrate diet. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10913026
Morand R et al. Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction. 2013 Anal Bioanal Chem pmid:23995505
Yergey AL et al. Thermospray liquid chromatography/mass spectrometry for the analysis of L-carnitine and its short-chain acyl derivatives. 1984 Anal. Biochem. pmid:6476364
Minkler PE and Hoppel CL Quantification of free carnitine, individual short- and medium-chain acylcarnitines, and total carnitine in plasma by high-performance liquid chromatography. 1993 Anal. Biochem. pmid:8214594
Emaus R and Bieber LL Preparation of radioactive acetyl-L-carnitine by an enzymatic exchange reaction. 1982 Anal. Biochem. pmid:6122386
Kamimori H et al. Determination of carnitine and saturated-acyl group carnitines in human urine by high-performance liquid chromatography with fluorescence detection. 1994 Anal. Biochem. pmid:8074302
Jiang Q et al. Oral acetyl-L-carnitine treatment in hepatic encephalopathy: view of evidence-based medicine. 2013 Sep-Oct Ann Hepatol pmid:24018499
Zanelli SA et al. Mechanisms of ischemic neuroprotection by acetyl-L-carnitine. 2005 Ann. N. Y. Acad. Sci. pmid:16179519
Liu J et al. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. 2002 Ann. N. Y. Acad. Sci. pmid:11976193
Hagen TM et al. Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid. 2002 Ann. N. Y. Acad. Sci. pmid:11976222
Ames BN and Liu J Delaying the mitochondrial decay of aging with acetylcarnitine. 2004 Ann. N. Y. Acad. Sci. pmid:15591008
Coccurello R et al. Valproate and acetyl-L-carnitine prevent methamphetamine-induced behavioral sensitization in mice. 2007 Ann. N. Y. Acad. Sci. pmid:18077579
Ames BN Delaying the mitochondrial decay of aging. 2004 Ann. N. Y. Acad. Sci. pmid:15247055
Beal MF Bioenergetic approaches for neuroprotection in Parkinson's disease. 2003 Ann. Neurol. pmid:12666097
Fernández Ortega MF Effect of dietary lysine level and protein restriction on the lipids and carnitine levels in the liver of pregnant rats. 1989 Ann. Nutr. Metab. pmid:2508533
Wojtecka-Lukasik E et al. Anti-inflammatory drugs modulate histamine release from mast cells induced by fibrinogen degradation products. 1988 Ann. Rheum. Dis. pmid:2452608
Ghirardi O et al. Acetyl-L-Carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin, without altering its antitumor properties. 2005 Jul-Aug Anticancer Res. pmid:16080512
Mentlein R et al. Specificity of two different purified acylcarnitine hydrolases from rat liver, their identity with other carboxylesterases, and their possible function. 1985 Arch. Biochem. Biophys. pmid:4026306
Olson MS et al. The regulation of pyruvate dehydrogenase by fatty acids in isolated rabbit heart mitochondria. 1978 Arch. Biochem. Biophys. pmid:207223
Roe CR et al. Metabolic response to carnitine in methylmalonic aciduria. An effective strategy for elimination of propionyl groups. 1983 Arch. Dis. Child. pmid:6651329
Sakuma T Alteration of urinary carnitine profile induced by benzoate administration. 1991 Arch. Dis. Child. pmid:1863104
Dundar HA et al. Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats. 2016 Arch. Med. Res. pmid:28262191
Defani MA et al. Effect of acetyl-L-carnitine on VIP-ergic neurons in the jejunum submucous plexus of diabetic rats. 2003 Arq Neuropsiquiatr pmid:14762599
Zhou X et al. Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review. 2007 Asia Pac J Clin Nutr pmid:17392136
Cavallini G Male idiopathic oligoasthenoteratozoospermia. 2006 Asian J. Androl. pmid:16491265
Rajguru R Military aircrew and noise-induced hearing loss: prevention and management. 2013 Aviat Space Environ Med pmid:24459798
Arafa HM et al. Acetyl-L-carnitine ameliorates caerulein-induced acute pancreatitis in rats. 2009 Basic Clin. Pharmacol. Toxicol. pmid:19371263
Mehrotra A and Sandhir R Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation. 2014 Behav. Brain Res. pmid:24393741
Ruggiero FM et al. Effect of aging and acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes. 1990 Biochem. Biophys. Res. Commun. pmid:2383260
Tassani V et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. 1994 Biochem. Biophys. Res. Commun. pmid:8135845
Wawrzeńczyk A et al. Effect of gamma-aminobutyric acid on the carnitine metabolism in neural cells. 1995 Biochem. Biophys. Res. Commun. pmid:7646490

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