Acetyl-d-carnitine

Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 2875 references associated with Acetyl-d-carnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Acetyl-d-carnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine

MeSH term MeSH ID Detail
Proteostasis Deficiencies D057165 5 associated lipids
Parkinson Disease D010300 53 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cleft Lip D002971 8 associated lipids
Body Weight D001835 333 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Alzheimer Disease D000544 76 associated lipids
Total 7

All references with Acetyl-d-carnitine

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Authors Title Published Journal PubMed Link
Ruggiero FM et al. Effect of aging and acetyl-L-carnitine on the lipid composition of rat plasma and erythrocytes. 1990 Biochem. Biophys. Res. Commun. pmid:2383260
Hansford RG Lipid oxidation by heart mitochondria from young adult and senescent rats. 1978 Biochem. J. pmid:637843
Brass EP and Hoppel CL Effect of carnitine on mitochondrial oxidation of palmitoylearnitine. 1980 Biochem. J. pmid:7396873
Kasumov T et al. Probing peroxisomal beta-oxidation and the labelling of acetyl-CoA proxies with [1-(13C)]octanoate and [3-(13C)]octanoate in the perfused rat liver. 2005 Biochem. J. pmid:15773815
Eaton S et al. The effect of respiratory chain impairment of beta-oxidation in rat heart mitochondria. 1996 Biochem. J. pmid:8912705
Pourfarzam M and Bartlett K Products and intermediates of the beta-oxidation of [U-14C]hexadecanedionoyl-mono-CoA by rat liver peroxisomes and mitochondria. 1991 Biochem. J. pmid:1989582
Murthy MS and Pande SV Microcompartmentation of transported carnitine, acetylcarnitine and ADP occurs in the mitochondrial matrix. Implications for transport measurements and metabolism. 1985 Biochem. J. pmid:4062871
Murthy MS et al. A carnitine/acylcarnitine translocase assay applicable to biopsied muscle specimens without requiring mitochondrial isolation. 1986 Biochem. J. pmid:3098229
Brass EP and Hoppel CL Relationship between acid-soluble carnitine and coenzyme A pools in vivo. 1980 Biochem. J. pmid:7470064
Brass EP and Stabler SP Carnitine metabolism in the vitamin B-12-deficient rat. 1988 Biochem. J. pmid:3196310
Watmough NJ et al. Skeletal muscle mitochondrial beta-oxidation. A study of the products of oxidation of [U-14C]hexadecanoate by h.p.l.c. using continuous on-line radiochemical detection. 1988 Biochem. J. pmid:3178728
Snoswell AM and Tubbs PK Deacylation of acetyl-coenzyme A and acetylcarnitine by liver preparations. 1978 Biochem. J. pmid:26333
Mawal YR et al. Restoration of hepatic cytochrome c oxidase activity and expression with acetyl-L-carnitine treatment in spf mice with an ornithine transcarbamylase deficiency. 1998 Biochem. Pharmacol. pmid:9714304
Melegh B et al. Pivampicillin-promoted excretion of pivaloylcarnitine in humans. 1987 Biochem. Pharmacol. pmid:3675603
Benzi G et al. Recovery after hypoglycemic brain injury. Action of some biological substances on the cerebral metabolism. 1983 Biochem. Pharmacol. pmid:6340690
Brass EP et al. Effect of carnitine acetyltransferase inhibition on rat hepatocyte metabolism. 1991 Biochim. Biophys. Acta pmid:1932127
Cassano P et al. Acetyl-L-carnitine feeding to unloaded rats triggers in soleus muscle the coordinated expression of genes involved in mitochondrial biogenesis. 2006 Sep-Oct Biochim. Biophys. Acta pmid:16814248
Arduini A et al. Effects of L-carnitine and its acetate and propionate esters on the molecular dynamics of human erythrocyte membrane. 1993 Biochim. Biophys. Acta pmid:8383998
Huth PJ and Shug AL Properties of carnitine transport in rat kidney cortex slices. 1980 Biochim. Biophys. Acta pmid:7437424
Horiuchi M et al. Secondary abnormality of carnitine biosynthesis results from carnitine reabsorptional system defect in juvenile visceral steatosis mice. 1997 Biochim. Biophys. Acta pmid:9540857
Mittal B and Kurup CK Purification of clofibrate-induced carnitine acetyltransferase from rat liver mitochondria. 1980 Biochim. Biophys. Acta pmid:7417471
Alexson SE et al. Inhibition of acetyl-carnitine oxidation in rat brown-adipose-tissue mitochondria by erucoyl-carnitine is due to sequestration of CoA. 1985 Biochim. Biophys. Acta pmid:3995059
Siliprandi N et al. Metabolic changes induced by maximal exercise in human subjects following L-carnitine administration. 1990 Biochim. Biophys. Acta pmid:2328258
Diep QN et al. Formation of pivaloylcarnitine in isolated rat heart cells. 1995 Biochim. Biophys. Acta pmid:7488636
Hokland BM and Bremer J Metabolism and excretion of carnitine and acylcarnitines in the perfused rat kidney. 1986 Biochim. Biophys. Acta pmid:3697382
Pochini L et al. Acetylcholine and acetylcarnitine transport in peritoneum: Role of the SLC22A4 (OCTN1) transporter. 2016 Biochim. Biophys. Acta pmid:26724204
Farrell S et al. Entry of acetyl-L-carnitine into biosynthetic pathways. 1986 Biochim. Biophys. Acta pmid:3081044
Furuichi Y et al. Imaging mass spectrometry reveals fiber-specific distribution of acetylcarnitine and contraction-induced carnitine dynamics in rat skeletal muscles. 2014 Biochim. Biophys. Acta pmid:24882639
Gross CJ et al. Uptake of L-carnitine, D-carnitine and acetyl-L-carnitine by isolated guinea-pig enterocytes. 1986 Biochim. Biophys. Acta pmid:3708005
Kurth L et al. Utilization of intracellular acylcarnitine pools by mononuclear phagocytes. 1994 Biochim. Biophys. Acta pmid:7947948
Pochini L et al. The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease. 2012 Biochim. Biophys. Acta pmid:22206629
Kølvraa S and Gregersen N In vitro studies on the oxidation of medium-chain dicarboxylic acids in rat liver. 1986 Biochim. Biophys. Acta pmid:3707982
Musicco C et al. Accumulation of overoxidized Peroxiredoxin III in aged rat liver mitochondria. 2009 Biochim. Biophys. Acta pmid:19272351
Maldonado C et al. Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. 2016 Biomed Res Int pmid:26998483
Benzerrouk R and Qureshi IA Hepatic mitochondrial proteins in congenitally hyperammonemic spf mice: effect of acetyl-L-carnitine. 2001 Biosci. Biotechnol. Biochem. pmid:11330659
Biagiotti G and Cavallini G Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie's disease: a preliminary report. 2001 BJU Int. pmid:11446848
Schreiber BD Debate forum: levocarnitine therapy is rational and justified in selected dialysis patients. 2006 Blood Purif. pmid:16361853
Wu J et al. TGF-β1 induces senescence of bone marrow mesenchymal stem cells via increase of mitochondrial ROS production. 2014 BMC Dev. Biol. pmid:24886313
Rueda JR et al. Systematic review of pharmacological treatments in fragile X syndrome. 2009 BMC Neurol pmid:19822023
Pace S et al. Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsorption. 2000 Br J Clin Pharmacol pmid:11069438
Graziano F et al. Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anaemic cancer patients. 2002 Br. J. Cancer pmid:12085175
Elliott GR et al. The effect of acute feeding of carnitine, acetyl carnitine and propionyl carnitine on basal and A23187-stimulated eicosanoid release from rat carrageenan-elicited peritoneal macrophages. 1990 Br. J. Nutr. pmid:2171633
Imai S et al. Anti-arrhythmic effects of (-)-carnitine chloride and its acetyl analogue on canine late ventricular arrhythmia induced by ligation of the coronary artery as related to improvement of mitochondrial function. 1984 Br. J. Pharmacol. pmid:6733367
Ori C et al. Effects of acetyl-L-carnitine on regional cerebral glucose metabolism in awake rats. 2002 Brain Res. pmid:12270513
Sharman EH et al. Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine. 2002 Brain Res. pmid:12445964
Ganesan R et al. New treatments for dementia. Myth, magic, and science. 1994 Can Fam Physician pmid:8019192
Callander N et al. Acetyl-L-carnitine (ALCAR) for the prevention of chemotherapy-induced peripheral neuropathy in patients with relapsed or refractory multiple myeloma treated with bortezomib, doxorubicin and low-dose dexamethasone: a study from the Wisconsin Oncology Network. 2014 Cancer Chemother. Pharmacol. pmid:25168296
Mancinelli A et al. Urinary excretion of L-carnitine and its short-chain acetyl-L-carnitine in patients undergoing carboplatin treatment. 2007 Cancer Chemother. Pharmacol. pmid:16988826
Lu Y et al. Acetylcarnitine Is a Candidate Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma. 2016 Cancer Res. pmid:26976432
Muoio DM et al. Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. 2012 Cell Metab. pmid:22560225

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