Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Cleft Lip | D002971 | 8 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Amino Acid Metabolism, Inborn Errors | D000592 | 16 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Milgram NW et al. | Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests. | 2007 | FASEB J. | pmid:17622567 |
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| Paradies G et al. | The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria. | 1999 | FEBS Lett. | pmid:10431808 |
| Requero MA et al. | Differential penetration of fatty acyl-coenzyme A and fatty acylcarnitines into phospholipid monolayers. | 1995 | FEBS Lett. | pmid:8001684 |
| Paradies G et al. | Effect of aging and acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria. | 1994 | FEBS Lett. | pmid:8070566 |
| Gadaleta MN et al. | Acetyl-L-carnitine increases cytochrome oxidase subunit I mRNA content in hypothyroid rat liver. | 1990 | FEBS Lett. | pmid:2176613 |
| Palmieri L et al. | Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae. | 1999 | FEBS Lett. | pmid:10622748 |
| Carter AL et al. | Increased acetyl carnitine in rat skeletal muscle as a result of high-intensity short-duration exercise. Implications in the control of pyruvate dehydrogenase activity. | 1981 | FEBS Lett. | pmid:7238861 |
| Ferri L et al. | The mitochondrial handling of D,L-thiocarnitine and its S-acetyl derivative. | 1980 | FEBS Lett. | pmid:7461115 |
| Miñana MD et al. | Hyperammonemia decreases body fat content in rat. | 1989 | FEBS Lett. | pmid:2737286 |
| Zhang Z et al. | Acetyl-l-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells. | 2009 | FEBS Lett. | pmid:19121314 |
| Lewin LM et al. | Carnitine and acylcarnitines in semen from azoospermic patients. | 1981 | Fertil. Steril. | pmid:6114878 |
| Duru NK et al. | Semen treatment with progesterone and/or acetyl-L-carnitine does not improve sperm motility or membrane damage after cryopreservation-thawing. | 2000 | Fertil. Steril. | pmid:11020512 |
| Fišar Z et al. | Effect of Simvastatin, Coenzyme Q10, Resveratrol, Acetylcysteine and Acetylcarnitine on Mitochondrial Respiration. | 2016 | Folia Biol. (Praha) | pmid:27187037 |
| Rump TJ et al. | Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain. | 2010 | Free Radic. Biol. Med. | pmid:20708681 |
| Liu J et al. | Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. | 2014 | Free Radic. Biol. Med. | pmid:24418157 |
| Sharma S et al. | Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. | 2012 | Free Radic. Biol. Med. | pmid:22583703 |
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| Abdul HM and Butterfield DA | Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. | 2007 | Free Radic. Biol. Med. | pmid:17210450 |
| Bastianetto S and Quirion R | Natural antioxidants and neurodegenerative diseases. | 2004 | Front. Biosci. | pmid:15353369 |
| Engle DB et al. | Effect of acetyl-l-carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (Trk-A and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin. | 2009 | Gynecol. Oncol. | pmid:19263582 |
| Hanada H et al. | Acetyl-L-carnitine suppresses thyroid hormone-induced and spontaneous anuran tadpole tail shortening. | 2013 | Hereditas | pmid:23489246 |
| Youle M and Osio M | A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. | 2007 | HIV Med. | pmid:17461852 |
| Valcour V et al. | Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection. | 2009 | HIV Med. | pmid:19200173 |
| Abdel-aleem S et al. | Reduced effects of L-carnitine on glucose and fatty acid metabolism in myocytes isolated from diabetic rats. | 1997 | Horm. Metab. Res. | pmid:9370110 |
| Ruggenenti P et al. | Oral acetyl-L-carnitine therapy and insulin resistance. | 2010 | Hypertension | pmid:20439816 |
| Whaley-Connell A and Sowers JR | Hypertension and insulin resistance. | 2009 | Hypertension | pmid:19635987 |
| Ruggenenti P et al. | Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy. | 2009 | Hypertension | pmid:19620516 |
| Ghirardi O et al. | Chemotherapy-induced allodinia: neuroprotective effect of acetyl-L-carnitine. | 2005 May-Jun | In Vivo | pmid:15875786 |
| Yu M et al. | The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations. | 2017 | Int J Mol Sci | pmid:28287417 |
| Zhang R et al. | Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro. | 2012 | Int J Mol Sci | pmid:22408439 |
| Hozyasz KK et al. | Malonylcarnitine in newborns with non-syndromic cleft lip with or without cleft palate. | 2010 | Int J Oral Sci | pmid:21125791 |
| Farahpour MR and Ghayour SJ | Effect of in situ delivery of acetyl-L-carnitine on peripheral nerve regeneration and functional recovery in transected sciatic nerve in rat. | 2014 | Int J Surg | pmid:25448663 |
| Cacicedo JM et al. | Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:21345991 |
| Cheng KH et al. | Newborn screening for methylmalonic aciduria by tandem mass spectrometry: 7 years' experience from two centers in Taiwan. | 2010 | J Chin Med Assoc | pmid:20603089 |
| McMackin CJ et al. | Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. | 2007 | J Clin Hypertens (Greenwich) | pmid:17396066 |
| Rosendorff C | More light please. | 2007 | J Clin Hypertens (Greenwich) | pmid:17396072 |
| Brennan BP et al. | A placebo-controlled trial of acetyl-L-carnitine and α-lipoic acid in the treatment of bipolar depression. | 2013 | J Clin Psychopharmacol | pmid:23948785 |
| Li S et al. | Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial. | 2016 | J Diabetes Investig | pmid:27180954 |
| Kuritzky L | Managing diabetic peripheral neuropathic pain in primary care. | 2010 | J Fam Pract | pmid:20544053 |
| Bielefeld EC et al. | Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat. | 2008 | J Negat Results Biomed | pmid:18620587 |
| Tomita K et al. | Enzymatic determination of acetylcarnitine for diagnostic applications. | 2001 | J Pharm Biomed Anal | pmid:11248512 |
| De Maria P et al. | Effect of the addition of electrolytes on the partition coefficients, activity coefficients, and acid dissociation constants of carnitine and its acetyl and propionyl derivatives. | 1994 | J Pharm Sci | pmid:8071833 |
| Cavallini G et al. | Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia. | 2004 Sep-Oct | J. Androl. | pmid:15292108 |
| Hellstrom WJ | Medical management of Peyronie's disease. | 2009 Jul-Aug | J. Androl. | pmid:18974422 |
| Leblanc PJ et al. | Effects of 7 wk of endurance training on human skeletal muscle metabolism during submaximal exercise. | 2004 | J. Appl. Physiol. | pmid:15220302 |
| Howlett RA et al. | Skeletal muscle metabolism during high-intensity sprint exercise is unaffected by dichloroacetate or acetate infusion. | 1999 | J. Appl. Physiol. | pmid:10562618 |
| Vollaard NB et al. | Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance. | 2009 | J. Appl. Physiol. | pmid:19196912 |
| Jenkins DL and Griffith OW | DL-aminocarnitine and acetyl-DL-aminocarnitine. Potent inhibitors of carnitine acyltransferases and hepatic triglyceride catabolism. | 1985 | J. Biol. Chem. | pmid:3840486 |