Acetyl-d-carnitine

Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 2875 references associated with Acetyl-d-carnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Acetyl-d-carnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine

MeSH term MeSH ID Detail
Proteostasis Deficiencies D057165 5 associated lipids
Parkinson Disease D010300 53 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cleft Lip D002971 8 associated lipids
Body Weight D001835 333 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Alzheimer Disease D000544 76 associated lipids
Total 7

All references with Acetyl-d-carnitine

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Authors Title Published Journal PubMed Link
Lindquist C et al. Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats. 2017 J. Lipid Res. pmid:28473603
Tanaka Y et al. Acetyl-L-carnitine supplementation restores decreased tissue carnitine levels and impaired lipid metabolism in aged rats. 2004 J. Lipid Res. pmid:14703509
Lligona-Trulla L et al. Acetyl-L-carnitine flux to lipids in cells estimated using isotopomer spectral analysis. 1997 J. Lipid Res. pmid:9254070
Huemer M et al. Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines. 2015 J. Inherit. Metab. Dis. pmid:25762406
Pocchiari M et al. Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters. 1987 J. Gen. Virol. pmid:2433387
Samms RJ et al. Dual effects of fibroblast growth factor 21 on hepatic energy metabolism. 2015 J. Endocrinol. pmid:26294388
Hershman DL et al. Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for the prevention of taxane-induced neuropathy in women undergoing adjuvant breast cancer therapy. 2013 J. Clin. Oncol. pmid:23733756
Sima AA et al. Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat. 1996 J. Clin. Invest. pmid:8621774
Timmons JA et al. Substrate availability limits human skeletal muscle oxidative ATP regeneration at the onset of ischemic exercise. 1998 J. Clin. Invest. pmid:9421469
Hiatt WR et al. Carnitine and acylcarnitine metabolism during exercise in humans. Dependence on skeletal muscle metabolic state. 1989 J. Clin. Invest. pmid:2794054
Morigi M et al. Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury. 2015 J. Clin. Invest. pmid:25607838
Lindeboom L et al. Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection. 2014 J. Clin. Invest. pmid:25271624
Timmons JA et al. Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia. 1996 J. Clin. Invest. pmid:8609248
Murakami K et al. Alterations of urinary acetylcarnitine in valproate-treated rats: the effect of L-carnitine supplementation. 1992 J. Child Neurol. pmid:1469250
Peluso G et al. Differential carnitine/acylcarnitine translocase expression defines distinct metabolic signatures in skeletal muscle cells. 2005 J. Cell. Physiol. pmid:15515015
Zhang H et al. Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease. 2010 J. Cell. Mol. Med. pmid:20414966
Aliev G et al. Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. 2009 J. Cell. Mol. Med. pmid:18373733
Shen W et al. Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid. 2008 J. Cell. Biochem. pmid:18260126
Jensen MV et al. Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. 2006 J. Biol. Chem. pmid:16740637
Jenkins DL and Griffith OW DL-aminocarnitine and acetyl-DL-aminocarnitine. Potent inhibitors of carnitine acyltransferases and hepatic triglyceride catabolism. 1985 J. Biol. Chem. pmid:3840486
Tamai I et al. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. 1998 J. Biol. Chem. pmid:9685390
Emaus RK and Bieber LL A biosynthetic role for carnitine in the yeast Torulopsis bovina. 1983 J. Biol. Chem. pmid:6685127
MARQUIS NR and FRITZ IB EFFECTS OF TESTOSTERONE ON THE DISTRIBUTION OF CARNITINE, ACETYLCARNITINE, AND CARNITINE ACETYLTRANSFERASE IN TISSUES OF THE REPRODUCTIVE SYSTEM OF THE MALE RAT. 1965 J. Biol. Chem. pmid:14299647
MARQUIS NR and FRITZ IB THE DISTRIBUTION OF CARNITINE, ACETYLCARNITINE, AND CARNITINE ACETYLTRANSFERASE IN RAT TISSUES. 1965 J. Biol. Chem. pmid:14299646
Bian F et al. Peroxisomal and mitochondrial oxidation of fatty acids in the heart, assessed from the 13C labeling of malonyl-CoA and the acetyl moiety of citrate. 2005 J. Biol. Chem. pmid:15611129
Ganapathy ME et al. beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. 2000 J. Biol. Chem. pmid:10636865
Murthy MS and Pande SV Mechanism of carnitine acylcarnitine translocase-catalyzed import of acylcarnitines into mitochondria. 1984 J. Biol. Chem. pmid:6430896
Jensen PR et al. Tissue-specific short chain fatty acid metabolism and slow metabolic recovery after ischemia from hyperpolarized NMR in vivo. 2009 J. Biol. Chem. pmid:19861411
Leblanc PJ et al. Effects of 7 wk of endurance training on human skeletal muscle metabolism during submaximal exercise. 2004 J. Appl. Physiol. pmid:15220302
Howlett RA et al. Skeletal muscle metabolism during high-intensity sprint exercise is unaffected by dichloroacetate or acetate infusion. 1999 J. Appl. Physiol. pmid:10562618
Vollaard NB et al. Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance. 2009 J. Appl. Physiol. pmid:19196912
Cavallini G et al. Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia. 2004 Sep-Oct J. Androl. pmid:15292108
Hellstrom WJ Medical management of Peyronie's disease. 2009 Jul-Aug J. Androl. pmid:18974422
De Maria P et al. Effect of the addition of electrolytes on the partition coefficients, activity coefficients, and acid dissociation constants of carnitine and its acetyl and propionyl derivatives. 1994 J Pharm Sci pmid:8071833
Tomita K et al. Enzymatic determination of acetylcarnitine for diagnostic applications. 2001 J Pharm Biomed Anal pmid:11248512
Bielefeld EC et al. Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat. 2008 J Negat Results Biomed pmid:18620587
Kuritzky L Managing diabetic peripheral neuropathic pain in primary care. 2010 J Fam Pract pmid:20544053
Li S et al. Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial. 2016 J Diabetes Investig pmid:27180954
Brennan BP et al. A placebo-controlled trial of acetyl-L-carnitine and α-lipoic acid in the treatment of bipolar depression. 2013 J Clin Psychopharmacol pmid:23948785
McMackin CJ et al. Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. 2007 J Clin Hypertens (Greenwich) pmid:17396066
Rosendorff C More light please. 2007 J Clin Hypertens (Greenwich) pmid:17396072
Cheng KH et al. Newborn screening for methylmalonic aciduria by tandem mass spectrometry: 7 years' experience from two centers in Taiwan. 2010 J Chin Med Assoc pmid:20603089
Cacicedo JM et al. Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. 2011 Invest. Ophthalmol. Vis. Sci. pmid:21345991
Farahpour MR and Ghayour SJ Effect of in situ delivery of acetyl-L-carnitine on peripheral nerve regeneration and functional recovery in transected sciatic nerve in rat. 2014 Int J Surg pmid:25448663
Hozyasz KK et al. Malonylcarnitine in newborns with non-syndromic cleft lip with or without cleft palate. 2010 Int J Oral Sci pmid:21125791
Yu M et al. The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations. 2017 Int J Mol Sci pmid:28287417
Zhang R et al. Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro. 2012 Int J Mol Sci pmid:22408439
Ghirardi O et al. Chemotherapy-induced allodinia: neuroprotective effect of acetyl-L-carnitine. 2005 May-Jun In Vivo pmid:15875786
Whaley-Connell A and Sowers JR Hypertension and insulin resistance. 2009 Hypertension pmid:19635987
Ruggenenti P et al. Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy. 2009 Hypertension pmid:19620516

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