Acetyl-d-carnitine

Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 2875 references associated with Acetyl-d-carnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Acetyl-d-carnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Parkinson Disease D010300 53 associated lipids
Cleft Lip D002971 8 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 7

All references with Acetyl-d-carnitine

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Authors Title Published Journal PubMed Link
Jensen MV et al. Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. 2006 J. Biol. Chem. pmid:16740637
Jenkins DL and Griffith OW DL-aminocarnitine and acetyl-DL-aminocarnitine. Potent inhibitors of carnitine acyltransferases and hepatic triglyceride catabolism. 1985 J. Biol. Chem. pmid:3840486
Tamai I et al. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. 1998 J. Biol. Chem. pmid:9685390
Emaus RK and Bieber LL A biosynthetic role for carnitine in the yeast Torulopsis bovina. 1983 J. Biol. Chem. pmid:6685127
MARQUIS NR and FRITZ IB EFFECTS OF TESTOSTERONE ON THE DISTRIBUTION OF CARNITINE, ACETYLCARNITINE, AND CARNITINE ACETYLTRANSFERASE IN TISSUES OF THE REPRODUCTIVE SYSTEM OF THE MALE RAT. 1965 J. Biol. Chem. pmid:14299647
MARQUIS NR and FRITZ IB THE DISTRIBUTION OF CARNITINE, ACETYLCARNITINE, AND CARNITINE ACETYLTRANSFERASE IN RAT TISSUES. 1965 J. Biol. Chem. pmid:14299646
Bian F et al. Peroxisomal and mitochondrial oxidation of fatty acids in the heart, assessed from the 13C labeling of malonyl-CoA and the acetyl moiety of citrate. 2005 J. Biol. Chem. pmid:15611129
Murthy MS and Pande SV Mechanism of carnitine acylcarnitine translocase-catalyzed import of acylcarnitines into mitochondria. 1984 J. Biol. Chem. pmid:6430896
Jensen PR et al. Tissue-specific short chain fatty acid metabolism and slow metabolic recovery after ischemia from hyperpolarized NMR in vivo. 2009 J. Biol. Chem. pmid:19861411
Shen W et al. Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid. 2008 J. Cell. Biochem. pmid:18260126
Zhang H et al. Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease. 2010 J. Cell. Mol. Med. pmid:20414966
Aliev G et al. Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. 2009 J. Cell. Mol. Med. pmid:18373733
Peluso G et al. Differential carnitine/acylcarnitine translocase expression defines distinct metabolic signatures in skeletal muscle cells. 2005 J. Cell. Physiol. pmid:15515015
Murakami K et al. Alterations of urinary acetylcarnitine in valproate-treated rats: the effect of L-carnitine supplementation. 1992 J. Child Neurol. pmid:1469250
Sima AA et al. Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat. 1996 J. Clin. Invest. pmid:8621774
Timmons JA et al. Substrate availability limits human skeletal muscle oxidative ATP regeneration at the onset of ischemic exercise. 1998 J. Clin. Invest. pmid:9421469
Hiatt WR et al. Carnitine and acylcarnitine metabolism during exercise in humans. Dependence on skeletal muscle metabolic state. 1989 J. Clin. Invest. pmid:2794054
Morigi M et al. Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury. 2015 J. Clin. Invest. pmid:25607838
Lindeboom L et al. Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection. 2014 J. Clin. Invest. pmid:25271624
Timmons JA et al. Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia. 1996 J. Clin. Invest. pmid:8609248
Hershman DL et al. Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for the prevention of taxane-induced neuropathy in women undergoing adjuvant breast cancer therapy. 2013 J. Clin. Oncol. pmid:23733756
Samms RJ et al. Dual effects of fibroblast growth factor 21 on hepatic energy metabolism. 2015 J. Endocrinol. pmid:26294388
Pocchiari M et al. Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters. 1987 J. Gen. Virol. pmid:2433387
Huemer M et al. Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines. 2015 J. Inherit. Metab. Dis. pmid:25762406
Lindquist C et al. Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats. 2017 J. Lipid Res. pmid:28473603
Tanaka Y et al. Acetyl-L-carnitine supplementation restores decreased tissue carnitine levels and impaired lipid metabolism in aged rats. 2004 J. Lipid Res. pmid:14703509
Lligona-Trulla L et al. Acetyl-L-carnitine flux to lipids in cells estimated using isotopomer spectral analysis. 1997 J. Lipid Res. pmid:9254070
Ryckman KK et al. The influence of maternal disease on metabolites measured as part of newborn screening. 2013 J. Matern. Fetal. Neonatal. Med. pmid:23550828
Pascale E et al. Modulation of methylation in the FMR1 promoter region after long term treatment with L-carnitine and acetyl-L-carnitine. 2003 J. Med. Genet. pmid:12807975
Williams ES and Li TK The effect of chronic alcohol administration on fatty acid metabolism and pyruvate oxidation of heart mitochondria. 1977 J. Mol. Cell. Cardiol. pmid:563474
Kido Y et al. Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier. 2001 J. Neurochem. pmid:11739607
Ricciolini R et al. Role of acetyl-L-carnitine in rat brain lipogenesis: implications for polyunsaturated fatty acid biosynthesis. 1998 J. Neurochem. pmid:9832150
Hayashi H and Kato T Acetyl-CoA synthesizing enzyme activities in single nerve cell bodies of rabbit. 1978 J. Neurochem. pmid:29944
Corthay J et al. Incorporation of acetate into acetylcholine, acetylcarnitine, and amino acids in the Torpedo electric organ. 1985 J. Neurochem. pmid:4056793
Jiang X et al. Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. 2011 J. Neurochem. pmid:21689104
Scafidi S et al. Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature rat brain. 2010 J. Neurochem. pmid:20477950
Patel SP et al. Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury. 2010 J. Neurochem. pmid:20438613
Mazzocchio R et al. Enhancement of recurrent inhibition by intravenous administration of L-acetylcarnitine in spastic patients. 1990 J. Neurol. Neurosurg. Psychiatry pmid:2341845
Shenk JC et al. The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease. 2009 J. Neurol. Sci. pmid:19342064
Szutowicz A et al. Nerve growth factor and acetyl-L-carnitine evoked shifts in acetyl-CoA and cholinergic SN56 cell vulnerability to neurotoxic inputs. 2005 Jan 1-15 J. Neurosci. Res. pmid:15558747
Benzi G et al. Cerebral endogenous substrate utilization during the recovery period after profound hypoglycemia. 1984 J. Neurosci. Res. pmid:6748113
Patacchioli FR et al. Acetyl-L-carnitine reduces the age-dependent loss of glucocorticoid receptors in the rat hippocampus: an autoradiographic study. 1989 J. Neurosci. Res. pmid:2769802
Ewan EE and Hagg T Intrathecal Acetyl-L-Carnitine Protects Tissue and Improves Function after a Mild Contusive Spinal Cord Injury in Rats. 2016 J. Neurotrauma pmid:26415041
Iossa S et al. Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats. 2002 J. Nutr. pmid:11925454
Nakamura J et al. Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats. 1998 J. Pharmacol. Exp. Ther. pmid:9864270
Wu X et al. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. 1999 J. Pharmacol. Exp. Ther. pmid:10454528
Srikanth V et al. Effects of ethanol treatment on epididymal secretory products and sperm maturation in albino rats. 1999 J. Pharmacol. Exp. Ther. pmid:9918552
Mattei B et al. Pharmacologically induced enhancement of recurrent inhibition in humans: effects on motoneurone discharge patterns. 2003 J. Physiol. (Lond.) pmid:12611926
Tucek S The synthesis of acetylcholine in skeletal muscles of the rat. 1982 J. Physiol. (Lond.) pmid:7069630
Mallinson JE et al. Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. 2012 J. Physiol. (Lond.) pmid:23045346

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