Acetyl-d-carnitine

Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2875 references associated with Acetyl-d-carnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Acetyl-d-carnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Parkinson Disease D010300 53 associated lipids
Cleft Lip D002971 8 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 7

All references with Acetyl-d-carnitine

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Authors Title Published Journal PubMed Link
Stephens FB et al. New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. 2007 J. Physiol. (Lond.) pmid:17331998
van Loon LJ et al. The effects of increasing exercise intensity on muscle fuel utilisation in humans. 2001 J. Physiol. (Lond.) pmid:11579177
Tucek S The synthesis of acetylcholine in skeletal muscles of the rat. 1982 J. Physiol. (Lond.) pmid:7069630
Watt MJ et al. Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no effect on substrate phosphorylation at the onset of exercise in man. 2002 J. Physiol. (Lond.) pmid:12411537
Watt MJ et al. Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man. 2002 J. Physiol. (Lond.) pmid:12068055
Grassi B et al. Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. 2002 J. Physiol. (Lond.) pmid:11773328
Jones AR and Bubb WA Substrates for endogenous metabolism by mature boar spermatozoa. 2000 J. Reprod. Fertil. pmid:10864822
Jeulin C et al. Uptake and release of free L-carnitine by boar epididymal spermatozoa in vitro and subsequent acetylation rate. 1994 J. Reprod. Fertil. pmid:8182599
Jeulin C et al. The distribution of carnitine and acetylcarnitine in the epididymis and epididymal spermatozoa of the boar. 1987 J. Reprod. Fertil. pmid:3572883
Casillas ER et al. Distribution of carnitine and acylcarnitine in the hamster epididymis and in epididymal spermatozoa during maturation. 1984 J. Reprod. Fertil. pmid:6471048
Hinton BT et al. Effects of carnitine and some related compounds on the motility of rat spermatozoa from the caput epididymidis. 1981 J. Reprod. Fertil. pmid:7452626
Brooks DE Carnitine, acetylcarnitine and the activity of carnitine acyltransferases in seminal plasma and spermatozoa of men, rams and rats. 1979 J. Reprod. Fertil. pmid:480318
Casillas ER and Chaipayungpan S The distribution of carnitine and acetylcarnitine in the rabbit epididymis and the carnitine content of rabbit spermatozoa during maturation. 1979 J. Reprod. Fertil. pmid:480302
Golan R et al. Influence of various substrates on the acetylcarnitine:carnitine ratio in motile and immotile human spermatozoa. 1986 J. Reprod. Fertil. pmid:3761272
Ishii T et al. Anti-apoptotic effect of acetyl-l-carnitine and I-carnitine in primary cultured neurons. 2000 Jpn. J. Pharmacol. pmid:10928324
Kohjimoto Y et al. Effects of acetyl-L-carnitine on the brain lipofuscin content and emotional behavior in aged rats. 1988 Jpn. J. Pharmacol. pmid:3221536
Matsui K et al. Effect of l-carnitine chloride and its acetyl derivative on the electrophysiological derangement induced by palmityl-l-carnitine in isolated canine ventricular muscle. 1985 Jpn. J. Pharmacol. pmid:4087570
Evans AM et al. Impact of hemodialysis on endogenous plasma and muscle carnitine levels in patients with end-stage renal disease. 2004 Kidney Int. pmid:15458447
Bayles DO and Wilkinson BJ Osmoprotectants and cryoprotectants for Listeria monocytogenes. 2000 Lett. Appl. Microbiol. pmid:10728555
Hu S et al. Use of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat. 2012 Magn Reson Imaging pmid:22819176
Bales JR et al. 1H NMR studies of urine during fasting: excretion of ketone bodies and acetylcarnitine. 1986 Magn Reson Med pmid:2434822
Xu S et al. In vivo longitudinal proton magnetic resonance spectroscopy on neonatal hypoxic-ischemic rat brain injury: Neuroprotective effects of acetyl-L-carnitine. 2015 Magn Reson Med pmid:25461739
Ren J et al. Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS. 2013 Magn Reson Med pmid:22473634
Boss A et al. Skeletal muscle ¹H MRSI before and after prolonged exercise. II. visibility of free carnitine. 2012 Magn Reson Med pmid:22287218
Josan S et al. Dynamic metabolic imaging of hyperpolarized [2-(13) C]pyruvate using spiral chemical shift imaging with alternating spectral band excitation. 2014 Magn Reson Med pmid:23878057
Paradies G et al. Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine. 1995 Mech. Ageing Dev. pmid:8788238
Gómez LA et al. Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart. 2012 Feb-Mar Mech. Ageing Dev. pmid:22322067
Ames BN Optimal micronutrients delay mitochondrial decay and age-associated diseases. 2010 Jul-Aug Mech. Ageing Dev. pmid:20420847
Kerner J et al. Acetyl-L-carnitine increases mitochondrial protein acetylation in the aged rat heart. 2015 Mech. Ageing Dev. pmid:25660059
Curti D et al. Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. 1989 Mech. Ageing Dev. pmid:2542702
Parr TB A new technique to elevate night time growth hormone release and a potential growth hormone feedback control loop. 2001 Med. Hypotheses pmid:11388776
Cotter MA et al. Effects of acetyl- and proprionyl-L-carnitine on peripheral nerve function and vascular supply in experimental diabetes. 1995 Metab. Clin. Exp. pmid:7666797
Brass EP and Beyerinck RA Interactions of propionate and carnitine metabolism in isolated rat hepatocytes. 1987 Metab. Clin. Exp. pmid:3110541
Calabrese V et al. Redox homeostasis and cellular stress response in aging and neurodegeneration. 2010 Methods Mol. Biol. pmid:20013185
Pekkinen J et al. Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach. 2013 Mol Nutr Food Res pmid:23868375
Chiechio S et al. Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine. 2006 Mol Pain pmid:16764720
Notartomaso S et al. Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. 2017 Mol Pain pmid:28326943
Hu C et al. Inhibition of OCTN2-mediated transport of carnitine by etoposide. 2012 Mol. Cancer Ther. pmid:22389472
Löster H et al. Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy. 1999 Mol. Cell. Biochem. pmid:10569188
Cui J et al. Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts. 2003 Mol. Cell. Biochem. pmid:14674702
Behrend AM et al. Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation. 2012 Mol. Genet. Metab. pmid:22030098
Chiechio S et al. L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors. 2002 Mol. Pharmacol. pmid:11961116
Lau T et al. Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant. 2017 Mol. Psychiatry pmid:27240534
Elanchezhian R et al. Evaluation of lenticular antioxidant and redox system components in the lenses of acetyl-L-carnitine treatment in BSO-induced glutathione deprivation. 2009 Mol. Vis. pmid:19649174
Muralidharan AR et al. Deciphering the potential efficacy of acetyl-L-carnitine (ALCAR) in maintaining connexin-mediated lenticular homeostasis. 2012 Mol. Vis. pmid:22876134
Uziel G et al. Carnitine stimulation of pyruvate dehydrogenase complex (PDHC) in isolated human skeletal muscle mitochondria. 1988 Muscle Nerve pmid:3405240
Phillipson OT Management of the aging risk factor for Parkinson's disease. 2014 Neurobiol. Aging pmid:24246717
Smeland OB et al. Dietary supplementation with acetyl-l-carnitine in seizure treatment of pentylenetetrazole kindled mice. 2012 Neurochem. Int. pmid:22709675
Long J et al. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. 2009 Neurochem. Res. pmid:18846423
Bidzinska B et al. Effect of different chronic intermittent stressors and acetyl-l-carnitine on hypothalamic beta-endorphin and GnRH and on plasma testosterone levels in male rats. 1993 Neuroendocrinology pmid:8232773

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