Acetyl-d-carnitine

Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2875 references associated with Acetyl-d-carnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Acetyl-d-carnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Parkinson Disease D010300 53 associated lipids
Cleft Lip D002971 8 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 7

All references with Acetyl-d-carnitine

Download all related citations
Per page 10 20 50 100 | Total 877
Authors Title Published Journal PubMed Link
Lindquist C et al. Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats. 2017 J. Lipid Res. pmid:28473603
Yu M et al. The Effect of Chinese Herbal Medicine Formula mKG on Allergic Asthma by Regulating Lung and Plasma Metabolic Alternations. 2017 Int J Mol Sci pmid:28287417
Notartomaso S et al. Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain. 2017 Mol Pain pmid:28326943
Lau T et al. Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant. 2017 Mol. Psychiatry pmid:27240534
Robinson BL et al. Distinct effects of ketamine and acetyl L-carnitine on the dopamine system in zebrafish. 2016 Mar-Apr Neurotoxicol Teratol pmid:26898327
Fišar Z et al. Effect of Simvastatin, Coenzyme Q10, Resveratrol, Acetylcysteine and Acetylcarnitine on Mitochondrial Respiration. 2016 Folia Biol. (Praha) pmid:27187037
Li S et al. Effects of acetyl-L-carnitine and methylcobalamin for diabetic peripheral neuropathy: A multicenter, randomized, double-blind, controlled trial. 2016 J Diabetes Investig pmid:27180954
Huber K et al. Metabotypes with properly functioning mitochondria and anti-inflammation predict extended productive life span in dairy cows. 2016 Sci Rep pmid:27089826
Curran MW et al. Acetyl-L-carnitine (ALCAR) to enhance nerve regeneration in carpal tunnel syndrome: study protocol for a randomized, placebo-controlled trial. 2016 Trials pmid:27079660
Maldonado C et al. Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. 2016 Biomed Res Int pmid:26998483
Lu Y et al. Acetylcarnitine Is a Candidate Diagnostic and Prognostic Biomarker of Hepatocellular Carcinoma. 2016 Cancer Res. pmid:26976432
Diekman EF et al. Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency. 2016 PLoS ONE pmid:26881790
Katoh T et al. [Application of Metabolomics to Multiple Chemical Sensitivity Research]. 2016 Nihon Eiseigaku Zasshi pmid:26832623
Li X et al. An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles. 2016 Part Fibre Toxicol pmid:26772537
Pochini L et al. Acetylcholine and acetylcarnitine transport in peritoneum: Role of the SLC22A4 (OCTN1) transporter. 2016 Biochim. Biophys. Acta pmid:26724204
Ewan EE and Hagg T Intrathecal Acetyl-L-Carnitine Protects Tissue and Improves Function after a Mild Contusive Spinal Cord Injury in Rats. 2016 J. Neurotrauma pmid:26415041
Dundar HA et al. Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats. 2016 Arch. Med. Res. pmid:28262191
Flori A et al. Real-time cardiac metabolism assessed with hyperpolarized [1-(13) C]acetate in a large-animal model. 2015 May-Jun Contrast Media Mol Imaging pmid:25201079
Li S and Laher I Exercise Pills: At the Starting Line. 2015 Trends Pharmacol. Sci. pmid:26439443
Huemer M et al. Newborn screening for homocystinurias and methylation disorders: systematic review and proposed guidelines. 2015 J. Inherit. Metab. Dis. pmid:25762406
Schooneman MG et al. Transorgan fluxes in a porcine model reveal a central role for liver in acylcarnitine metabolism. 2015 Am. J. Physiol. Endocrinol. Metab. pmid:26037250
Sarkar S et al. Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-L-carnitine. 2015 Neurosci. Lett. pmid:26321151
Lindsay KL et al. Longitudinal Metabolomic Profiling of Amino Acids and Lipids across Healthy Pregnancy. 2015 PLoS ONE pmid:26716698
Robinson BL et al. Opposing effects of ketamine and acetyl L-carnitine on the serotonergic system of zebrafish. 2015 Neurosci. Lett. pmid:26365406
Samms RJ et al. Dual effects of fibroblast growth factor 21 on hepatic energy metabolism. 2015 J. Endocrinol. pmid:26294388
De Luca A et al. Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells. 2015 Oncotarget pmid:26087310
Macconi D et al. Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. 2015 PLoS ONE pmid:25993470
Li S et al. Acetyl-L-carnitine in the treatment of peripheral neuropathic pain: a systematic review and meta-analysis of randomized controlled trials. 2015 PLoS ONE pmid:25751285
Kerner J et al. Acetyl-L-carnitine increases mitochondrial protein acetylation in the aged rat heart. 2015 Mech. Ageing Dev. pmid:25660059
Morigi M et al. Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury. 2015 J. Clin. Invest. pmid:25607838
Xu S et al. In vivo longitudinal proton magnetic resonance spectroscopy on neonatal hypoxic-ischemic rat brain injury: Neuroprotective effects of acetyl-L-carnitine. 2015 Magn Reson Med pmid:25461739
Wu J et al. TGF-β1 induces senescence of bone marrow mesenchymal stem cells via increase of mitochondrial ROS production. 2014 BMC Dev. Biol. pmid:24886313
Mehrotra A and Sandhir R Mitochondrial cofactors in experimental Huntington's disease: behavioral, biochemical and histological evaluation. 2014 Behav. Brain Res. pmid:24393741
Phillipson OT Management of the aging risk factor for Parkinson's disease. 2014 Neurobiol. Aging pmid:24246717
Liu J et al. Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. 2014 Free Radic. Biol. Med. pmid:24418157
Farahpour MR and Ghayour SJ Effect of in situ delivery of acetyl-L-carnitine on peripheral nerve regeneration and functional recovery in transected sciatic nerve in rat. 2014 Int J Surg pmid:25448663
Lindeboom L et al. Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection. 2014 J. Clin. Invest. pmid:25271624
Dodd MS et al. Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy. 2014 Circ Cardiovasc Imaging pmid:25201905
Callander N et al. Acetyl-L-carnitine (ALCAR) for the prevention of chemotherapy-induced peripheral neuropathy in patients with relapsed or refractory multiple myeloma treated with bortezomib, doxorubicin and low-dose dexamethasone: a study from the Wisconsin Oncology Network. 2014 Cancer Chemother. Pharmacol. pmid:25168296
Bigford GE and Del Rossi G Supplemental substances derived from foods as adjunctive therapeutic agents for treatment of neurodegenerative diseases and disorders. 2014 Adv Nutr pmid:25022989
Furuichi Y et al. Imaging mass spectrometry reveals fiber-specific distribution of acetylcarnitine and contraction-induced carnitine dynamics in rat skeletal muscles. 2014 Biochim. Biophys. Acta pmid:24882639
Josan S et al. Dynamic metabolic imaging of hyperpolarized [2-(13) C]pyruvate using spiral chemical shift imaging with alternating spectral band excitation. 2014 Magn Reson Med pmid:23878057
Jiang Q et al. Oral acetyl-L-carnitine treatment in hepatic encephalopathy: view of evidence-based medicine. 2013 Sep-Oct Ann Hepatol pmid:24018499
Cuevas E et al. Acetyl L-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos. 2013 Sep-Oct Neurotoxicol Teratol pmid:23896048
Laird MD et al. Augmentation of normal and glutamate-impaired neuronal respiratory capacity by exogenous alternative biofuels. 2013 Transl Stroke Res pmid:24323418
Brennan BP et al. A placebo-controlled trial of acetyl-L-carnitine and α-lipoic acid in the treatment of bipolar depression. 2013 J Clin Psychopharmacol pmid:23948785
Kathirvel E et al. Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease. 2013 Nutr Res pmid:24176233
Wu SN et al. [Analysis of propionylcarnitine in blood and methylmalonic acid in urine of 162 patients with methylmalonic acidemia]. 2013 Zhonghua Yi Xue Za Zhi pmid:23663331
Rajguru R Military aircrew and noise-induced hearing loss: prevention and management. 2013 Aviat Space Environ Med pmid:24459798
Morand R et al. Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction. 2013 Anal Bioanal Chem pmid:23995505
Burotto M and Fojo AT Acetyl-L-carnitine and prevention of chemotherapy-induced peripheral neuropathy: can anything work? 2013 Oncologist pmid:24217999
Campone M et al. A double-blind, randomized phase II study to evaluate the safety and efficacy of acetyl-L-carnitine in the prevention of sagopilone-induced peripheral neuropathy. 2013 Oncologist pmid:24105751
Wang CH et al. Acetyl-l-carnitine and oxfenicine on cardiac pumping mechanics in streptozotocin-induced diabetes in male Wistar rats. 2013 PLoS ONE pmid:23922880
Babicová A et al. In vivo study of radioprotective effect of NO-synthase inhibitors and acetyl-L-carnitine. 2013 Physiol Res pmid:23869893
Hershman DL et al. Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for the prevention of taxane-induced neuropathy in women undergoing adjuvant breast cancer therapy. 2013 J. Clin. Oncol. pmid:23733756
Cuccurazzu B et al. Upregulation of mGlu2 receptors via NF-κB p65 acetylation is involved in the Proneurogenic and antidepressant effects of acetyl-L-carnitine. 2013 Neuropsychopharmacology pmid:23670591
Ryckman KK et al. The influence of maternal disease on metabolites measured as part of newborn screening. 2013 J. Matern. Fetal. Neonatal. Med. pmid:23550828
Hanada H et al. Acetyl-L-carnitine suppresses thyroid hormone-induced and spontaneous anuran tadpole tail shortening. 2013 Hereditas pmid:23489246
Russo SJ and Charney DS Next generation antidepressants. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23471996
Lodi A et al. Proton NMR-based metabolite analyses of archived serial paired serum and urine samples from myeloma patients at different stages of disease activity identifies acetylcarnitine as a novel marker of active disease. 2013 PLoS ONE pmid:23431376
Zuena AR et al. Transplacental exposure to AZT induces adverse neurochemical and behavioral effects in a mouse model: protection by L-acetylcarnitine. 2013 PLoS ONE pmid:23409035
Nasca C et al. L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23382250
Federighi G et al. Differentially expressed genes in Hirudo medicinalis ganglia after acetyl-L-carnitine treatment. 2013 PLoS ONE pmid:23308261
Ren J et al. Dynamic monitoring of carnitine and acetylcarnitine in the trimethylamine signal after exercise in human skeletal muscle by 7T 1H-MRS. 2013 Magn Reson Med pmid:22473634
Pekkinen J et al. Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach. 2013 Mol Nutr Food Res pmid:23868375
Schloss JM et al. Nutraceuticals and chemotherapy induced peripheral neuropathy (CIPN): a systematic review. 2013 Clin Nutr pmid:23647723
Gómez LA et al. Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart. 2012 Feb-Mar Mech. Ageing Dev. pmid:22322067
Hu S et al. Use of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat. 2012 Magn Reson Imaging pmid:22819176
Zaitone SA et al. Acetyl-L-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy. 2012 Pharmacol. Biochem. Behav. pmid:21958946
Mallinson JE et al. Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. 2012 J. Physiol. (Lond.) pmid:23045346
Wadman RI et al. Drug treatment for spinal muscular atrophy types II and III. 2012 Cochrane Database Syst Rev pmid:22513940
Muoio DM et al. Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. 2012 Cell Metab. pmid:22560225
Balschi JA In vivo clinical measures of intermediary metabolism are inadequate: can a new magnetic resonance spectroscopy technology do better? 2012 Circ Cardiovasc Imaging pmid:22438422
Schroeder MA et al. The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study. 2012 Circ Cardiovasc Imaging pmid:22238215
Kanazirska MV et al. Beneficial effects of lysosome-modulating and other pharmacological and nanocarrier agents on amyloid-beta-treated cells. 2012 Curr Pharm Biotechnol pmid:23072393
Malaguarnera M Carnitine derivatives: clinical usefulness. 2012 Curr. Opin. Gastroenterol. pmid:22333562
Schaevitz LR et al. Acetyl-L-carnitine improves behavior and dendritic morphology in a mouse model of Rett syndrome. 2012 PLoS ONE pmid:23227269
Morand R et al. Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. 2012 Ther Drug Monit pmid:22743351
Muralidharan AR et al. Deciphering the potential efficacy of acetyl-L-carnitine (ALCAR) in maintaining connexin-mediated lenticular homeostasis. 2012 Mol. Vis. pmid:22876134
Karalija A et al. Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats. 2012 PLoS ONE pmid:22815926
Sharma S et al. Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. 2012 Free Radic. Biol. Med. pmid:22583703
Patel SP et al. Acetyl-L-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery. 2012 Neuroscience pmid:22445934
Zhang R et al. Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro. 2012 Int J Mol Sci pmid:22408439
Hu C et al. Inhibition of OCTN2-mediated transport of carnitine by etoposide. 2012 Mol. Cancer Ther. pmid:22389472
Wu R et al. Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22328148
Boss A et al. Skeletal muscle ¹H MRSI before and after prolonged exercise. II. visibility of free carnitine. 2012 Magn Reson Med pmid:22287218
Pochini L et al. The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease. 2012 Biochim. Biophys. Acta pmid:22206629
Behrend AM et al. Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation. 2012 Mol. Genet. Metab. pmid:22030098
Ang JE et al. Identification of human plasma metabolites exhibiting time-of-day variation using an untargeted liquid chromatography-mass spectrometry metabolomic approach. 2012 Chronobiol. Int. pmid:22823870
Smeland OB et al. Dietary supplementation with acetyl-l-carnitine in seizure treatment of pentylenetetrazole kindled mice. 2012 Neurochem. Int. pmid:22709675
El-Awady el-SE et al. Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. 2011 Eur. J. Pharmacol. pmid:21034734
Mingorance C et al. Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders. 2011 Vasc Health Risk Manag pmid:21490942
Wadman RI et al. Drug treatment for spinal muscular atrophy types II and III. 2011 Cochrane Database Syst Rev pmid:22161400
Haorah J et al. Stabilization of superoxide dismutase by acetyl-l-carnitine in human brain endothelium during alcohol exposure: novel protective approach. 2011 Free Radic. Biol. Med. pmid:21782933
Jiang X et al. Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. 2011 J. Neurochem. pmid:21689104
Abdul Muneer PM et al. Methamphetamine inhibits the glucose uptake by human neurons and astrocytes: stabilization by acetyl-L-carnitine. 2011 PLoS ONE pmid:21556365
Cacicedo JM et al. Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. 2011 Invest. Ophthalmol. Vis. Sci. pmid:21345991
Malaguarnera M et al. Oral acetyl-L-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. 2011 Am. J. Clin. Nutr. pmid:21310833
O'Sullivan A et al. Dietary intake patterns are reflected in metabolomic profiles: potential role in dietary assessment studies. 2011 Am. J. Clin. Nutr. pmid:21177801
Abdul Muneer PM et al. Inhibitory effects of alcohol on glucose transport across the blood-brain barrier leads to neurodegeneration: preventive role of acetyl-L: -carnitine. 2011 Psychopharmacology (Berl.) pmid:21079922

Table of Content