Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amino Acid Metabolism, Inborn Errors | D000592 | 16 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cleft Lip | D002971 | 8 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Boss A et al. | Noninvasive assessment of exercise-related intramyocellular acetylcarnitine in euglycemia and hyperglycemia in patients with type 1 diabetes using ¹H magnetic resonance spectroscopy: a randomized single-blind crossover study. | 2011 | Diabetes Care | pmid:20978101 |
| Ames BN | Optimal micronutrients delay mitochondrial decay and age-associated diseases. | 2010 Jul-Aug | Mech. Ageing Dev. | pmid:20420847 |
| Cherry CL et al. | Ubisol-Aqua: coenzyme Q10 prevents antiretroviral toxic neuropathy in an in vitro model. | 2010 | Curr. HIV Res. | pmid:20158454 |
| Fiehn O et al. | Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. | 2010 | PLoS ONE | pmid:21170321 |
| Cheng KH et al. | Newborn screening for methylmalonic aciduria by tandem mass spectrometry: 7 years' experience from two centers in Taiwan. | 2010 | J Chin Med Assoc | pmid:20603089 |
| Binienda ZK et al. | Assessment of 3-nitropropionic acid-evoked peripheral neuropathy in rats: neuroprotective effects of acetyl-l-carnitine and resveratrol. | 2010 | Neurosci. Lett. | pmid:20542088 |
| Zhang H et al. | Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease. | 2010 | J. Cell. Mol. Med. | pmid:20414966 |
| Milazzo L et al. | Effect of antioxidants on mitochondrial function in HIV-1-related lipoatrophy: a pilot study. | 2010 | AIDS Res. Hum. Retroviruses | pmid:20977356 |
| Kopsky DJ and Hesselink JM | Nerve regeneration in neuropathic pain. | 2010 | Pain Med | pmid:21199307 |
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| Kuritzky L | Managing diabetic peripheral neuropathic pain in primary care. | 2010 | J Fam Pract | pmid:20544053 |
| Calabrese V et al. | Redox homeostasis and cellular stress response in aging and neurodegeneration. | 2010 | Methods Mol. Biol. | pmid:20013185 |
| Scafidi S et al. | Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain. | 2010 | Dev. Neurosci. | pmid:21228558 |
| Lancaster CS et al. | Cisplatin-induced downregulation of OCTN2 affects carnitine wasting. | 2010 | Clin. Cancer Res. | pmid:20858838 |
| Pisano C et al. | Metabolic approach to the enhancement of antitumor effect of chemotherapy: a key role of acetyl-L-carnitine. | 2010 | Clin. Cancer Res. | pmid:20562210 |
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| Palermo V et al. | Acetyl-L-carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission. | 2010 | Aging Cell | pmid:20550520 |
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| Ruggenenti P et al. | Oral acetyl-L-carnitine therapy and insulin resistance. | 2010 | Hypertension | pmid:20439816 |
| Patel SP et al. | Acetyl-L-carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury. | 2010 | J. Neurochem. | pmid:20438613 |
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| Waller AP et al. | Oral acetate supplementation after prolonged moderate intensity exercise enhances early muscle glycogen resynthesis in horses. | 2009 | Exp. Physiol. | pmid:19429643 |
| Suchy J et al. | Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance. | 2009 | Nutr Res | pmid:19185780 |
| Engle DB et al. | Effect of acetyl-l-carnitine on ovarian cancer cells' proliferation, nerve growth factor receptor (Trk-A and p75) expression, and the cytotoxic potential of paclitaxel and carboplatin. | 2009 | Gynecol. Oncol. | pmid:19263582 |
| Aliev G et al. | Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats. | 2009 | J. Cell. Mol. Med. | pmid:18373733 |
| Long J et al. | Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. | 2009 | Neurochem. Res. | pmid:18846423 |
| Shenk JC et al. | The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease. | 2009 | J. Neurol. Sci. | pmid:19342064 |
| Christie LA et al. | Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. | 2009 | Exp. Gerontol. | pmid:19735717 |
| Hall SS | Treatments for fragile X syndrome: a closer look at the data. | 2009 | Dev Disabil Res Rev | pmid:20014373 |
| Jensen PR et al. | Tissue-specific short chain fatty acid metabolism and slow metabolic recovery after ischemia from hyperpolarized NMR in vivo. | 2009 | J. Biol. Chem. | pmid:19861411 |
| Rueda JR et al. | Systematic review of pharmacological treatments in fragile X syndrome. | 2009 | BMC Neurol | pmid:19822023 |
| Rosca MG et al. | Mitochondria in the elderly: Is acetylcarnitine a rejuvenator? | 2009 | Adv. Drug Deliv. Rev. | pmid:19720100 |
| Whaley-Connell A and Sowers JR | Hypertension and insulin resistance. | 2009 | Hypertension | pmid:19635987 |
| Ruggenenti P et al. | Ameliorating hypertension and insulin resistance in subjects at increased cardiovascular risk: effects of acetyl-L-carnitine therapy. | 2009 | Hypertension | pmid:19620516 |
| Arafa HM et al. | Acetyl-L-carnitine ameliorates caerulein-induced acute pancreatitis in rats. | 2009 | Basic Clin. Pharmacol. Toxicol. | pmid:19371263 |
| Schroeder MA et al. | Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. | 2009 | FASEB J. | pmid:19329759 |
| Musicco C et al. | Accumulation of overoxidized Peroxiredoxin III in aged rat liver mitochondria. | 2009 | Biochim. Biophys. Acta | pmid:19272351 |
| Valcour V et al. | Acetyl-l-carnitine and nucleoside reverse transcriptase inhibitor-associated neuropathy in HIV infection. | 2009 | HIV Med. | pmid:19200173 |
| Vollaard NB et al. | Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance. | 2009 | J. Appl. Physiol. | pmid:19196912 |
| Zhang Z et al. | Acetyl-l-carnitine inhibits TNF-alpha-induced insulin resistance via AMPK pathway in rat skeletal muscle cells. | 2009 | FEBS Lett. | pmid:19121314 |
| Bielefeld EC et al. | Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat. | 2008 | J Negat Results Biomed | pmid:18620587 |
| Memeo A and Loiero M | Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study. | 2008 | Clin Drug Investig | pmid:18598095 |
| Soczynska JK et al. | Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? | 2008 | Expert Opin Investig Drugs | pmid:18491985 |
| Shen W et al. | R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. | 2008 | Diabetologia | pmid:18026715 |
| Wolf S et al. | Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies. | 2008 | Eur. J. Cancer | pmid:18571399 |
| Shen W et al. | Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid. | 2008 | J. Cell. Biochem. | pmid:18260126 |
| Jin HW et al. | Prevention of paclitaxel-evoked painful peripheral neuropathy by acetyl-L-carnitine: effects on axonal mitochondria, sensory nerve fiber terminal arbors, and cutaneous Langerhans cells. | 2008 | Exp. Neurol. | pmid:18078936 |
| Lal A et al. | Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts. | 2008 | Redox Rep. | pmid:18284845 |
| Xiao WH and Bennett GJ | Chemotherapy-evoked neuropathic pain: Abnormal spontaneous discharge in A-fiber and C-fiber primary afferent neurons and its suppression by acetyl-L-carnitine. | 2008 | Pain | pmid:17659836 |
| Oka T et al. | Change in the membranous lipid composition accelerates lipid peroxidation in young rat hearts subjected to 2 weeks of hypoxia followed by hyperoxia. | 2008 | Circ. J. | pmid:18654026 |
| Kobayashi D et al. | Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa. | 2007 | Reproduction | pmid:17965255 |
| Kotil K et al. | Neuroprotective effects of acetyl-L-carnithine in experimental chronic compression neuropathy. A prospective, randomized and placebo-control trials. | 2007 | Turk Neurosurg | pmid:17935020 |
| Youle M and Osio M | A double-blind, parallel-group, placebo-controlled, multicentre study of acetyl L-carnitine in the symptomatic treatment of antiretroviral toxic neuropathy in patients with HIV-1 infection. | 2007 | HIV Med. | pmid:17461852 |
| Zhou X et al. | Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review. | 2007 | Asia Pac J Clin Nutr | pmid:17392136 |
| Stephens FB et al. | New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle. | 2007 | J. Physiol. (Lond.) | pmid:17331998 |
| Vanotti A et al. | Overview on pathophysiology and newer approaches to treatment of peripheral neuropathies. | 2007 | CNS Drugs | pmid:17696588 |
| McMackin CJ et al. | Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. | 2007 | J Clin Hypertens (Greenwich) | pmid:17396066 |
| Rosendorff C | More light please. | 2007 | J Clin Hypertens (Greenwich) | pmid:17396072 |
| Milgram NW et al. | Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests. | 2007 | FASEB J. | pmid:17622567 |
| Coccurello R et al. | Valproate and acetyl-L-carnitine prevent methamphetamine-induced behavioral sensitization in mice. | 2007 | Ann. N. Y. Acad. Sci. | pmid:18077579 |
| Mancuso C et al. | Natural antioxidants in Alzheimer's disease. | 2007 | Expert Opin Investig Drugs | pmid:18042001 |
| Wikoff WR et al. | Metabolomics identifies perturbations in human disorders of propionate metabolism. | 2007 | Clin. Chem. | pmid:17951291 |
| Fehér J et al. | [Metabolic therapy for early treatment of age-related macular degeneration]. | 2007 | Orv Hetil | pmid:18039616 |
| Mancinelli A et al. | Urinary excretion of L-carnitine and its short-chain acetyl-L-carnitine in patients undergoing carboplatin treatment. | 2007 | Cancer Chemother. Pharmacol. | pmid:16988826 |
| Abdul HM and Butterfield DA | Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. | 2007 | Free Radic. Biol. Med. | pmid:17210450 |
| Cassano P et al. | Acetyl-L-carnitine feeding to unloaded rats triggers in soleus muscle the coordinated expression of genes involved in mitochondrial biogenesis. | 2006 Sep-Oct | Biochim. Biophys. Acta | pmid:16814248 |
| Ferraresi R et al. | Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs. | 2006 | FEBS Lett. | pmid:17118360 |
| Chiechio S et al. | Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine. | 2006 | Mol Pain | pmid:16764720 |
| Jensen MV et al. | Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. | 2006 | J. Biol. Chem. | pmid:16740637 |
| Cavallini G | Male idiopathic oligoasthenoteratozoospermia. | 2006 | Asian J. Androl. | pmid:16491265 |
| Schreiber BD | Debate forum: levocarnitine therapy is rational and justified in selected dialysis patients. | 2006 | Blood Purif. | pmid:16361853 |
| Gago MF et al. | SANDO: two novel mutations in POLG1 gene. | 2006 | Neuromuscul. Disord. | pmid:16919951 |
| Okamura N et al. | Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid. | 2006 | Pharm. Res. | pmid:16826461 |
| Al-Majed AA et al. | Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus. | 2006 | Clin. Exp. Pharmacol. Physiol. | pmid:16895547 |
| Mansour HH | Protective role of carnitine ester against radiation-induced oxidative stress in rats. | 2006 | Pharmacol. Res. | pmid:16757176 |
| Flatters SJ et al. | Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy. | 2006 | Neurosci. Lett. | pmid:16406309 |
| Hack A et al. | Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis. | 2006 | Pediatr. Res. | pmid:16690958 |
| Feher J et al. | Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. | 2005 May-Jun | Ophthalmologica | pmid:15947501 |
| Ghirardi O et al. | Chemotherapy-induced allodinia: neuroprotective effect of acetyl-L-carnitine. | 2005 May-Jun | In Vivo | pmid:15875786 |
| Ghirardi O et al. | Acetyl-L-Carnitine prevents and reverts experimental chronic neurotoxicity induced by oxaliplatin, without altering its antitumor properties. | 2005 Jul-Aug | Anticancer Res. | pmid:16080512 |
| Szutowicz A et al. | Nerve growth factor and acetyl-L-carnitine evoked shifts in acetyl-CoA and cholinergic SN56 cell vulnerability to neurotoxic inputs. | 2005 Jan 1-15 | J. Neurosci. Res. | pmid:15558747 |
| Bianchi G et al. | Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-L-carnitine. | 2005 | Eur. J. Cancer | pmid:16039110 |
| Kobayashi D et al. | Carnitine/organic cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells. | 2005 | Reproduction | pmid:16322553 |
| Zanelli SA et al. | Mechanisms of ischemic neuroprotection by acetyl-L-carnitine. | 2005 | Ann. N. Y. Acad. Sci. | pmid:16179519 |
| Pracharoenwattana I et al. | Arabidopsis peroxisomal citrate synthase is required for fatty acid respiration and seed germination. | 2005 | Plant Cell | pmid:15923350 |
| Tabolacci E et al. | Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments. | 2005 | Eur. J. Hum. Genet. | pmid:15741991 |
| Kasumov T et al. | Probing peroxisomal beta-oxidation and the labelling of acetyl-CoA proxies with [1-(13C)]octanoate and [3-(13C)]octanoate in the perfused rat liver. | 2005 | Biochem. J. | pmid:15773815 |
| Bian F et al. | Peroxisomal and mitochondrial oxidation of fatty acids in the heart, assessed from the 13C labeling of malonyl-CoA and the acetyl moiety of citrate. | 2005 | J. Biol. Chem. | pmid:15611129 |
| Roberts PA et al. | Acetyl-CoA provision and the acetyl group deficit at the onset of contraction in ischemic canine skeletal muscle. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15454400 |
| Peluso G et al. | Differential carnitine/acylcarnitine translocase expression defines distinct metabolic signatures in skeletal muscle cells. | 2005 | J. Cell. Physiol. | pmid:15515015 |
| Cavallini G et al. | Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy. | 2005 | Urology | pmid:16286128 |
| Roepstorff C et al. | Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. | 2005 | Am. J. Physiol. Endocrinol. Metab. | pmid:15383373 |
| Cavallini G et al. | Cinnoxicam and L-carnitine/acetyl-L-carnitine treatment for idiopathic and varicocele-associated oligoasthenospermia. | 2004 Sep-Oct | J. Androl. | pmid:15292108 |
| Vermeulen RC and Scholte HR | Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. | 2004 Mar-Apr | Psychosom Med | pmid:15039515 |
| Ames BN and Liu J | Delaying the mitochondrial decay of aging with acetylcarnitine. | 2004 | Ann. N. Y. Acad. Sci. | pmid:15591008 |