Acetyl-d-carnitine

Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 2875 references associated with Acetyl-d-carnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Acetyl-d-carnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Parkinson Disease D010300 53 associated lipids
Cleft Lip D002971 8 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 7

All references with Acetyl-d-carnitine

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Authors Title Published Journal PubMed Link
Evans AM et al. Impact of hemodialysis on endogenous plasma and muscle carnitine levels in patients with end-stage renal disease. 2004 Kidney Int. pmid:15458447
Tanaka Y et al. Acetyl-L-carnitine supplementation restores decreased tissue carnitine levels and impaired lipid metabolism in aged rats. 2004 J. Lipid Res. pmid:14703509
Ames BN and Liu J Delaying the mitochondrial decay of aging with acetylcarnitine. 2004 Ann. N. Y. Acad. Sci. pmid:15591008
Bastianetto S and Quirion R Natural antioxidants and neurodegenerative diseases. 2004 Front. Biosci. pmid:15353369
Ames BN Delaying the mitochondrial decay of aging. 2004 Ann. N. Y. Acad. Sci. pmid:15247055
Feher J et al. Mitotropic compounds for the treatment of age-related macular degeneration. The metabolic approach and a pilot study. 2003 Sep-Oct Ophthalmologica pmid:12913326
Defani MA et al. Effect of acetyl-L-carnitine on VIP-ergic neurons in the jejunum submucous plexus of diabetic rats. 2003 Arq Neuropsiquiatr pmid:14762599
Pisano C et al. Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine. 2003 Clin. Cancer Res. pmid:14654561
Pascale E et al. Modulation of methylation in the FMR1 promoter region after long term treatment with L-carnitine and acetyl-L-carnitine. 2003 J. Med. Genet. pmid:12807975
Masi F et al. Effects of long-term acetyl-L-carnitine administration in rats--II: Protection against the disrupting effect of stress on the acquisition of appetitive behavior. 2003 Neuropsychopharmacology pmid:12655313
Mattei B et al. Pharmacologically induced enhancement of recurrent inhibition in humans: effects on motoneurone discharge patterns. 2003 J. Physiol. (Lond.) pmid:12611926
Arafa HM and Sayed-Ahmed MM Protective role of carnitine esters against alcohol-induced gastric lesions in rats. 2003 Pharmacol. Res. pmid:12860448
Cui J et al. Effects of L-carnitine and its derivatives on postischemic cardiac function, ventricular fibrillation and necrotic and apoptotic cardiomyocyte death in isolated rat hearts. 2003 Mol. Cell. Biochem. pmid:14674702
Beal MF Bioenergetic approaches for neuroprotection in Parkinson's disease. 2003 Ann. Neurol. pmid:12666097
Ori C et al. Effects of acetyl-L-carnitine on regional cerebral glucose metabolism in awake rats. 2002 Brain Res. pmid:12270513
Sharman EH et al. Reversal of biochemical and behavioral parameters of brain aging by melatonin and acetyl L-carnitine. 2002 Brain Res. pmid:12445964
Roberts PA et al. The temporal relationship between glycogen phosphorylase and activation of the pyruvate dehydrogenase complex during adrenaline infusion in resting canine skeletal muscle. 2002 J. Physiol. (Lond.) pmid:12433969
Tolu P et al. Effects of long-term acetyl-L-carnitine administration in rats: I. increased dopamine output in mesocorticolimbic areas and protection toward acute stress exposure. 2002 Neuropsychopharmacology pmid:12225698
Pop-Busui R et al. Dissection of metabolic, vascular, and nerve conduction interrelationships in experimental diabetic neuropathy by cyclooxygenase inhibition and acetyl-L-carnitine administration. 2002 Diabetes pmid:12145179
Graziano F et al. Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anaemic cancer patients. 2002 Br. J. Cancer pmid:12085175
Chiechio S et al. L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors. 2002 Mol. Pharmacol. pmid:11961116
Iossa S et al. Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats. 2002 J. Nutr. pmid:11925454
Fisher JS et al. Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin. 2002 Am. J. Physiol. Endocrinol. Metab. pmid:11739078
Liu J et al. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. 2002 Ann. N. Y. Acad. Sci. pmid:11976193
Hagen TM et al. Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid. 2002 Ann. N. Y. Acad. Sci. pmid:11976222
Watt MJ et al. Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no effect on substrate phosphorylation at the onset of exercise in man. 2002 J. Physiol. (Lond.) pmid:12411537
Watt MJ et al. Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man. 2002 J. Physiol. (Lond.) pmid:12068055
Tyni T et al. Analysis of mitochondrial fatty acid oxidation intermediates by tandem mass spectrometry from intact mitochondria prepared from homogenates of cultured fibroblasts, skeletal muscle cells, and fresh muscle. 2002 Pediatr. Res. pmid:12084849
Hagen TM et al. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11854487
Liu J et al. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11854488
Grassi B et al. Oxygen uptake on-kinetics in dog gastrocnemius in situ following activation of pyruvate dehydrogenase by dichloroacetate. 2002 J. Physiol. (Lond.) pmid:11773328
Liu J et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11854529
Calvani M et al. [L-acetylcarnitine treatment on fragile X patients hyperactive behaviour]. 2001 Rev Neurol pmid:12447823
Tomita K et al. Enzymatic determination of acetylcarnitine for diagnostic applications. 2001 J Pharm Biomed Anal pmid:11248512
Kido Y et al. Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier. 2001 J. Neurochem. pmid:11739607
van Loon LJ et al. The effects of increasing exercise intensity on muscle fuel utilisation in humans. 2001 J. Physiol. (Lond.) pmid:11579177
Biagiotti G and Cavallini G Acetyl-L-carnitine vs tamoxifen in the oral therapy of Peyronie's disease: a preliminary report. 2001 BJU Int. pmid:11446848
Benzerrouk R and Qureshi IA Hepatic mitochondrial proteins in congenitally hyperammonemic spf mice: effect of acetyl-L-carnitine. 2001 Biosci. Biotechnol. Biochem. pmid:11330659
Parr TB A new technique to elevate night time growth hormone release and a potential growth hormone feedback control loop. 2001 Med. Hypotheses pmid:11388776
Evans MK et al. Effects of acetate infusion and hyperoxia on muscle substrate phosphorylation after onset of moderate exercise. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11701427
Kottlors M et al. Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency. 2001 Neuromuscul. Disord. pmid:11595519
Ishii T et al. Anti-apoptotic effect of acetyl-l-carnitine and I-carnitine in primary cultured neurons. 2000 Jpn. J. Pharmacol. pmid:10928324
Jones AR and Bubb WA Substrates for endogenous metabolism by mature boar spermatozoa. 2000 J. Reprod. Fertil. pmid:10864822
Stevens RD et al. Assay for free and total carnitine in human plasma using tandem mass spectrometry. 2000 Clin. Chem. pmid:10794762
Bayles DO and Wilkinson BJ Osmoprotectants and cryoprotectants for Listeria monocytogenes. 2000 Lett. Appl. Microbiol. pmid:10728555
Mroczkowska JE et al. Blood-brain barrier controls carnitine level in the brain: a study on a model system with RBE4 cells. 2000 Biochem. Biophys. Res. Commun. pmid:10623637
Ganapathy ME et al. beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. 2000 J. Biol. Chem. pmid:10636865
Pace S et al. Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsorption. 2000 Br J Clin Pharmacol pmid:11069438
Mancinelli A et al. Disposition of L-carnitine and its short-chain esters, acetyl-L-carnitine and propionyl-L-carnitine, in the rat isolated perfused liver. 2000 Drug Metab. Dispos. pmid:11095575
Seidman MD et al. Biologic activity of mitochondrial metabolites on aging and age-related hearing loss. 2000 Am J Otol pmid:10733178
Masterson C and Wood C Pea chloroplast carnitine acetyltransferase. 2000 Proc. Biol. Sci. pmid:10670945
Starritt EC et al. Sensitivity of CPT I to malonyl-CoA in trained and untrained human skeletal muscle. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10710500
St Amand TA et al. Pyruvate overrides inhibition of PDH during exercise after a low-carbohydrate diet. 2000 Am. J. Physiol. Endocrinol. Metab. pmid:10913026
Duru NK et al. Semen treatment with progesterone and/or acetyl-L-carnitine does not improve sperm motility or membrane damage after cryopreservation-thawing. 2000 Fertil. Steril. pmid:11020512
Acetyl-L-carnitine. 1999 Altern Med Rev pmid:10608918
Howlett RA et al. Skeletal muscle metabolism during high-intensity sprint exercise is unaffected by dichloroacetate or acetate infusion. 1999 J. Appl. Physiol. pmid:10562618
Parolin ML et al. Regulation of skeletal muscle glycogen phosphorylase and PDH during maximal intermittent exercise. 1999 Am. J. Physiol. pmid:10567017
Paradies G et al. The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria. 1999 FEBS Lett. pmid:10431808
Kidd PM A review of nutrients and botanicals in the integrative management of cognitive dysfunction. 1999 Altern Med Rev pmid:10383479
Wu X et al. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. 1999 J. Pharmacol. Exp. Ther. pmid:10454528
Palmieri L et al. Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae. 1999 FEBS Lett. pmid:10622748
Löster H et al. Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy. 1999 Mol. Cell. Biochem. pmid:10569188
Srikanth V et al. Effects of ethanol treatment on epididymal secretory products and sperm maturation in albino rats. 1999 J. Pharmacol. Exp. Ther. pmid:9918552
Aureli T et al. Entry of [(1,2-13C2)acetyl]-L-carnitine in liver tricarboxylic acid cycle and lipogenesis: a study by 13C NMR spectroscopy in conscious, freely moving rats. 1999 Eur. J. Biochem. pmid:10429215
Putman CT et al. Pyruvate dehydrogenase activation in inactive muscle during and after maximal exercise in men. 1999 Am. J. Physiol. pmid:10070014
Mawal YR et al. Restoration of hepatic cytochrome c oxidase activity and expression with acetyl-L-carnitine treatment in spf mice with an ornithine transcarbamylase deficiency. 1998 Biochem. Pharmacol. pmid:9714304
Nakamura J et al. Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats. 1998 J. Pharmacol. Exp. Ther. pmid:9864270
Ricciolini R et al. Role of acetyl-L-carnitine in rat brain lipogenesis: implications for polyunsaturated fatty acid biosynthesis. 1998 J. Neurochem. pmid:9832150
Hagen TM et al. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. 1998 Proc. Natl. Acad. Sci. U.S.A. pmid:9689120
Tamai I et al. Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. 1998 J. Biol. Chem. pmid:9685390
Timmons JA et al. Substrate availability limits human skeletal muscle oxidative ATP regeneration at the onset of ischemic exercise. 1998 J. Clin. Invest. pmid:9421469
El Banani H et al. Ionic and metabolic imbalance as potential factors of ischemia reperfusion injury. 1998 Am. J. Cardiol. pmid:9737483
Howlett RA et al. Regulation of skeletal muscle glycogen phosphorylase and PDH at varying exercise power outputs. 1998 Am. J. Physiol. pmid:9688676
Horiuchi M et al. Secondary abnormality of carnitine biosynthesis results from carnitine reabsorptional system defect in juvenile visceral steatosis mice. 1997 Biochim. Biophys. Acta pmid:9540857
Capecchi PL et al. Carnitines increase plasma levels of adenosine and ATP in humans. 1997 Vasc Med pmid:9546959
Lligona-Trulla L et al. Acetyl-L-carnitine flux to lipids in cells estimated using isotopomer spectral analysis. 1997 J. Lipid Res. pmid:9254070
Abdel-aleem S et al. Reduced effects of L-carnitine on glucose and fatty acid metabolism in myocytes isolated from diabetic rats. 1997 Horm. Metab. Res. pmid:9370110
Timmons JA et al. Metabolic responses from rest to steady state determine contractile function in ischemic skeletal muscle. 1997 Am. J. Physiol. pmid:9277374
Valoti M et al. Effects of carnitine and its derivatives on gastric acid secretion in rats. 1996 Nov-Dec Pharmacol. Res. pmid:9076846
Eaton S et al. The effect of respiratory chain impairment of beta-oxidation in rat heart mitochondria. 1996 Biochem. J. pmid:8912705
Brevetti G et al. Carnitine-related alterations in patients with intermittent claudication: indication for a focused carnitine therapy. 1996 Circulation pmid:8653874
Sima AA et al. Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat. 1996 J. Clin. Invest. pmid:8621774
Timmons JA et al. Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia. 1996 J. Clin. Invest. pmid:8609248
Itoh T et al. Effect of carnitine administration on glycine metabolism in patients with isovaleric acidemia: significance of acetylcarnitine determination to estimate the proper carnitine dose. 1996 Tohoku J. Exp. Med. pmid:8875766
Requero MA et al. Differential penetration of fatty acyl-coenzyme A and fatty acylcarnitines into phospholipid monolayers. 1995 FEBS Lett. pmid:8001684
Virmani MA et al. Protective actions of L-carnitine and acetyl-L-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors. 1995 Pharmacol. Res. pmid:8736490
Cotter MA et al. Effects of acetyl- and proprionyl-L-carnitine on peripheral nerve function and vascular supply in experimental diabetes. 1995 Metab. Clin. Exp. pmid:7666797
Paradies G et al. Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine. 1995 Mech. Ageing Dev. pmid:8788238
Diep QN et al. Formation of pivaloylcarnitine in isolated rat heart cells. 1995 Biochim. Biophys. Acta pmid:7488636
Wawrzeńczyk A et al. Effect of gamma-aminobutyric acid on the carnitine metabolism in neural cells. 1995 Biochem. Biophys. Res. Commun. pmid:7646490
Pomponi MG and Neri G Butyrate and acetyl-carnitine inhibit the cytogenetic expression of the fragile X in vitro. 1994 Am. J. Med. Genet. pmid:7943015
Paradies G et al. Effect of aging and acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria. 1994 FEBS Lett. pmid:8070566
Matsui S et al. Urinary carnitine excretion in patients with heart failure. 1994 Clin Cardiol pmid:8070147
Ganesan R et al. New treatments for dementia. Myth, magic, and science. 1994 Can Fam Physician pmid:8019192
Jeulin C et al. Uptake and release of free L-carnitine by boar epididymal spermatozoa in vitro and subsequent acetylation rate. 1994 J. Reprod. Fertil. pmid:8182599
De Maria P et al. Effect of the addition of electrolytes on the partition coefficients, activity coefficients, and acid dissociation constants of carnitine and its acetyl and propionyl derivatives. 1994 J Pharm Sci pmid:8071833
Bähring R et al. GABA-activated chloride currents of postnatal mouse retinal ganglion cells are blocked by acetylcholine and acetylcarnitine: how specific are ion channels in immature neurons? 1994 Eur. J. Neurosci. pmid:7952289
Van Hove JL et al. Intravenous L-carnitine and acetyl-L-carnitine in medium-chain acyl-coenzyme A dehydrogenase deficiency and isovaleric acidemia. 1994 Pediatr. Res. pmid:8134205
Tassani V et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. 1994 Biochem. Biophys. Res. Commun. pmid:8135845
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