Acetyl-d-carnitine is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Acetyl-d-carnitine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amino Acid Metabolism, Inborn Errors | D000592 | 16 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cleft Lip | D002971 | 8 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Kottlors M et al. | Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency. | 2001 | Neuromuscul. Disord. | pmid:11595519 |
| Masi F et al. | Effects of long-term acetyl-L-carnitine administration in rats--II: Protection against the disrupting effect of stress on the acquisition of appetitive behavior. | 2003 | Neuropsychopharmacology | pmid:12655313 |
| Tolu P et al. | Effects of long-term acetyl-L-carnitine administration in rats: I. increased dopamine output in mesocorticolimbic areas and protection toward acute stress exposure. | 2002 | Neuropsychopharmacology | pmid:12225698 |
| Cuccurazzu B et al. | Upregulation of mGlu2 receptors via NF-κB p65 acetylation is involved in the Proneurogenic and antidepressant effects of acetyl-L-carnitine. | 2013 | Neuropsychopharmacology | pmid:23670591 |
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| Sarkar S et al. | Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-L-carnitine. | 2015 | Neurosci. Lett. | pmid:26321151 |
| Robinson BL et al. | Opposing effects of ketamine and acetyl L-carnitine on the serotonergic system of zebrafish. | 2015 | Neurosci. Lett. | pmid:26365406 |
| Flatters SJ et al. | Acetyl-L-carnitine prevents and reduces paclitaxel-induced painful peripheral neuropathy. | 2006 | Neurosci. Lett. | pmid:16406309 |
| Patel SP et al. | Acetyl-L-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery. | 2012 | Neuroscience | pmid:22445934 |
| Nagesh Babu G et al. | Chronic pretreatment with acetyl-L-carnitine and ±DL-α-lipoic acid protects against acute glutamate-induced neurotoxicity in rat brain by altering mitochondrial function. | 2011 | Neurotox Res | pmid:20217290 |
| Robinson BL et al. | Distinct effects of ketamine and acetyl L-carnitine on the dopamine system in zebrafish. | 2016 Mar-Apr | Neurotoxicol Teratol | pmid:26898327 |
| Cuevas E et al. | Acetyl L-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos. | 2013 Sep-Oct | Neurotoxicol Teratol | pmid:23896048 |
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| Suchy J et al. | Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance. | 2009 | Nutr Res | pmid:19185780 |
| Kathirvel E et al. | Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease. | 2013 | Nutr Res | pmid:24176233 |
| Burotto M and Fojo AT | Acetyl-L-carnitine and prevention of chemotherapy-induced peripheral neuropathy: can anything work? | 2013 | Oncologist | pmid:24217999 |
| Campone M et al. | A double-blind, randomized phase II study to evaluate the safety and efficacy of acetyl-L-carnitine in the prevention of sagopilone-induced peripheral neuropathy. | 2013 | Oncologist | pmid:24105751 |
| De Luca A et al. | Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells. | 2015 | Oncotarget | pmid:26087310 |
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| Xiao WH and Bennett GJ | Chemotherapy-evoked neuropathic pain: Abnormal spontaneous discharge in A-fiber and C-fiber primary afferent neurons and its suppression by acetyl-L-carnitine. | 2008 | Pain | pmid:17659836 |
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| Li X et al. | An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles. | 2016 | Part Fibre Toxicol | pmid:26772537 |
| Tyni T et al. | Analysis of mitochondrial fatty acid oxidation intermediates by tandem mass spectrometry from intact mitochondria prepared from homogenates of cultured fibroblasts, skeletal muscle cells, and fresh muscle. | 2002 | Pediatr. Res. | pmid:12084849 |
| Van Hove JL et al. | Intravenous L-carnitine and acetyl-L-carnitine in medium-chain acyl-coenzyme A dehydrogenase deficiency and isovaleric acidemia. | 1994 | Pediatr. Res. | pmid:8134205 |
| Hack A et al. | Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis. | 2006 | Pediatr. Res. | pmid:16690958 |
| Okamura N et al. | Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid. | 2006 | Pharm. Res. | pmid:16826461 |
| Zaitone SA et al. | Acetyl-L-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy. | 2012 | Pharmacol. Biochem. Behav. | pmid:21958946 |
| Virmani MA et al. | Protective actions of L-carnitine and acetyl-L-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors. | 1995 | Pharmacol. Res. | pmid:8736490 |
| Valoti M et al. | Effects of carnitine and its derivatives on gastric acid secretion in rats. | 1996 Nov-Dec | Pharmacol. Res. | pmid:9076846 |
| Arafa HM and Sayed-Ahmed MM | Protective role of carnitine esters against alcohol-induced gastric lesions in rats. | 2003 | Pharmacol. Res. | pmid:12860448 |
| Mansour HH | Protective role of carnitine ester against radiation-induced oxidative stress in rats. | 2006 | Pharmacol. Res. | pmid:16757176 |
| Marciani P et al. | L-carnitine and carnitine ester transport in the rat small intestine. | 1991 | Pharmacol. Res. | pmid:2062791 |
| Babicová A et al. | In vivo study of radioprotective effect of NO-synthase inhibitors and acetyl-L-carnitine. | 2013 | Physiol Res | pmid:23869893 |
| Pracharoenwattana I et al. | Arabidopsis peroxisomal citrate synthase is required for fatty acid respiration and seed germination. | 2005 | Plant Cell | pmid:15923350 |
| Fiehn O et al. | Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. | 2010 | PLoS ONE | pmid:21170321 |
| Diekman EF et al. | Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency. | 2016 | PLoS ONE | pmid:26881790 |
| Lindsay KL et al. | Longitudinal Metabolomic Profiling of Amino Acids and Lipids across Healthy Pregnancy. | 2015 | PLoS ONE | pmid:26716698 |
| Macconi D et al. | Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin Resistance by Angiotensin II. | 2015 | PLoS ONE | pmid:25993470 |
| Li S et al. | Acetyl-L-carnitine in the treatment of peripheral neuropathic pain: a systematic review and meta-analysis of randomized controlled trials. | 2015 | PLoS ONE | pmid:25751285 |
| Wang CH et al. | Acetyl-l-carnitine and oxfenicine on cardiac pumping mechanics in streptozotocin-induced diabetes in male Wistar rats. | 2013 | PLoS ONE | pmid:23922880 |
| Lodi A et al. | Proton NMR-based metabolite analyses of archived serial paired serum and urine samples from myeloma patients at different stages of disease activity identifies acetylcarnitine as a novel marker of active disease. | 2013 | PLoS ONE | pmid:23431376 |
| Zuena AR et al. | Transplacental exposure to AZT induces adverse neurochemical and behavioral effects in a mouse model: protection by L-acetylcarnitine. | 2013 | PLoS ONE | pmid:23409035 |
| Federighi G et al. | Differentially expressed genes in Hirudo medicinalis ganglia after acetyl-L-carnitine treatment. | 2013 | PLoS ONE | pmid:23308261 |
| Schaevitz LR et al. | Acetyl-L-carnitine improves behavior and dendritic morphology in a mouse model of Rett syndrome. | 2012 | PLoS ONE | pmid:23227269 |
| Karalija A et al. | Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats. | 2012 | PLoS ONE | pmid:22815926 |
| Abdul Muneer PM et al. | Methamphetamine inhibits the glucose uptake by human neurons and astrocytes: stabilization by acetyl-L-carnitine. | 2011 | PLoS ONE | pmid:21556365 |
| Masterson C and Wood C | Pea chloroplast carnitine acetyltransferase. | 2000 | Proc. Biol. Sci. | pmid:10670945 |
| Hagen TM et al. | Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9689120 |
| Russo SJ and Charney DS | Next generation antidepressants. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23471996 |
| Nasca C et al. | L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23382250 |
| Wu R et al. | Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22328148 |
| Hagen TM et al. | Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11854487 |
| Liu J et al. | Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11854488 |
| Liu J et al. | Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11854529 |
| Abdul Muneer PM et al. | Inhibitory effects of alcohol on glucose transport across the blood-brain barrier leads to neurodegeneration: preventive role of acetyl-L: -carnitine. | 2011 | Psychopharmacology (Berl.) | pmid:21079922 |
| Vermeulen RC and Scholte HR | Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome. | 2004 Mar-Apr | Psychosom Med | pmid:15039515 |
| Lal A et al. | Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts. | 2008 | Redox Rep. | pmid:18284845 |
| Kobayashi D et al. | Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa. | 2007 | Reproduction | pmid:17965255 |
| Kobayashi D et al. | Carnitine/organic cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells. | 2005 | Reproduction | pmid:16322553 |
| Calvani M et al. | [L-acetylcarnitine treatment on fragile X patients hyperactive behaviour]. | 2001 | Rev Neurol | pmid:12447823 |
| Huber K et al. | Metabotypes with properly functioning mitochondria and anti-inflammation predict extended productive life span in dairy cows. | 2016 | Sci Rep | pmid:27089826 |
| Rosenthal RE et al. | Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-L-carnitine. | 1992 | Stroke | pmid:1519288 |
| Morand R et al. | Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. | 2012 | Ther Drug Monit | pmid:22743351 |
| Hori T et al. | Carnitine palmitoyltransferase 2 deficiency: the time-course of blood and urinary acylcarnitine levels during initial L-carnitine supplementation. | 2010 | Tohoku J. Exp. Med. | pmid:20543534 |
| Itoh T et al. | Effect of carnitine administration on glycine metabolism in patients with isovaleric acidemia: significance of acetylcarnitine determination to estimate the proper carnitine dose. | 1996 | Tohoku J. Exp. Med. | pmid:8875766 |
| Ponte F et al. | Protective effect of acetyl-l-carnitine and α-lipoic acid against the acute toxicity of diepoxybutane to human lymphocytes. | 2011 | Toxicology | pmid:21807063 |
| Laird MD et al. | Augmentation of normal and glutamate-impaired neuronal respiratory capacity by exogenous alternative biofuels. | 2013 | Transl Stroke Res | pmid:24323418 |
| Li S and Laher I | Exercise Pills: At the Starting Line. | 2015 | Trends Pharmacol. Sci. | pmid:26439443 |
| Curran MW et al. | Acetyl-L-carnitine (ALCAR) to enhance nerve regeneration in carpal tunnel syndrome: study protocol for a randomized, placebo-controlled trial. | 2016 | Trials | pmid:27079660 |
| Kotil K et al. | Neuroprotective effects of acetyl-L-carnithine in experimental chronic compression neuropathy. A prospective, randomized and placebo-control trials. | 2007 | Turk Neurosurg | pmid:17935020 |
| Cavallini G et al. | Acetyl-L-carnitine plus propionyl-L-carnitine improve efficacy of sildenafil in treatment of erectile dysfunction after bilateral nerve-sparing radical retropubic prostatectomy. | 2005 | Urology | pmid:16286128 |
| Mingorance C et al. | Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders. | 2011 | Vasc Health Risk Manag | pmid:21490942 |
| Capecchi PL et al. | Carnitines increase plasma levels of adenosine and ATP in humans. | 1997 | Vasc Med | pmid:9546959 |
| Wu SN et al. | [Analysis of propionylcarnitine in blood and methylmalonic acid in urine of 162 patients with methylmalonic acidemia]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:23663331 |