Acetyl-l-carnitine is a lipid of Fatty Acyls (FA) class.
We collected disease MeSH terms mapped to the references associated with Acetyl-l-carnitine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amino Acid Metabolism, Inborn Errors | D000592 | 16 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Cleft Lip | D002971 | 8 associated lipids |
| Proteostasis Deficiencies | D057165 | 5 associated lipids |
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brennan BP et al. | A placebo-controlled trial of acetyl-L-carnitine and α-lipoic acid in the treatment of bipolar depression. | 2013 | J Clin Psychopharmacol | pmid:23948785 |
| Wu SN et al. | [Analysis of propionylcarnitine in blood and methylmalonic acid in urine of 162 patients with methylmalonic acidemia]. | 2013 | Zhonghua Yi Xue Za Zhi | pmid:23663331 |
| Rajguru R | Military aircrew and noise-induced hearing loss: prevention and management. | 2013 | Aviat Space Environ Med | pmid:24459798 |
| Burotto M and Fojo AT | Acetyl-L-carnitine and prevention of chemotherapy-induced peripheral neuropathy: can anything work? | 2013 | Oncologist | pmid:24217999 |
| Campone M et al. | A double-blind, randomized phase II study to evaluate the safety and efficacy of acetyl-L-carnitine in the prevention of sagopilone-induced peripheral neuropathy. | 2013 | Oncologist | pmid:24105751 |
| Wang CH et al. | Acetyl-l-carnitine and oxfenicine on cardiac pumping mechanics in streptozotocin-induced diabetes in male Wistar rats. | 2013 | PLoS ONE | pmid:23922880 |
| Babicová A et al. | In vivo study of radioprotective effect of NO-synthase inhibitors and acetyl-L-carnitine. | 2013 | Physiol Res | pmid:23869893 |
| Hershman DL et al. | Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for the prevention of taxane-induced neuropathy in women undergoing adjuvant breast cancer therapy. | 2013 | J. Clin. Oncol. | pmid:23733756 |
| Cuccurazzu B et al. | Upregulation of mGlu2 receptors via NF-κB p65 acetylation is involved in the Proneurogenic and antidepressant effects of acetyl-L-carnitine. | 2013 | Neuropsychopharmacology | pmid:23670591 |
| Ryckman KK et al. | The influence of maternal disease on metabolites measured as part of newborn screening. | 2013 | J. Matern. Fetal. Neonatal. Med. | pmid:23550828 |
| Hanada H et al. | Acetyl-L-carnitine suppresses thyroid hormone-induced and spontaneous anuran tadpole tail shortening. | 2013 | Hereditas | pmid:23489246 |
| Russo SJ and Charney DS | Next generation antidepressants. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23471996 |
| Lodi A et al. | Proton NMR-based metabolite analyses of archived serial paired serum and urine samples from myeloma patients at different stages of disease activity identifies acetylcarnitine as a novel marker of active disease. | 2013 | PLoS ONE | pmid:23431376 |
| Zuena AR et al. | Transplacental exposure to AZT induces adverse neurochemical and behavioral effects in a mouse model: protection by L-acetylcarnitine. | 2013 | PLoS ONE | pmid:23409035 |
| Nasca C et al. | L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23382250 |
| Federighi G et al. | Differentially expressed genes in Hirudo medicinalis ganglia after acetyl-L-carnitine treatment. | 2013 | PLoS ONE | pmid:23308261 |
| Schloss JM et al. | Nutraceuticals and chemotherapy induced peripheral neuropathy (CIPN): a systematic review. | 2013 | Clin Nutr | pmid:23647723 |
| Gómez LA et al. | Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart. | 2012 Feb-Mar | Mech. Ageing Dev. | pmid:22322067 |
| Hu S et al. | Use of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat. | 2012 | Magn Reson Imaging | pmid:22819176 |
| Zaitone SA et al. | Acetyl-L-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy. | 2012 | Pharmacol. Biochem. Behav. | pmid:21958946 |
| Mallinson JE et al. | Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. | 2012 | J. Physiol. (Lond.) | pmid:23045346 |
| Wadman RI et al. | Drug treatment for spinal muscular atrophy types II and III. | 2012 | Cochrane Database Syst Rev | pmid:22513940 |
| Muoio DM et al. | Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. | 2012 | Cell Metab. | pmid:22560225 |
| Balschi JA | In vivo clinical measures of intermediary metabolism are inadequate: can a new magnetic resonance spectroscopy technology do better? | 2012 | Circ Cardiovasc Imaging | pmid:22438422 |
| Schroeder MA et al. | The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study. | 2012 | Circ Cardiovasc Imaging | pmid:22238215 |
| Kanazirska MV et al. | Beneficial effects of lysosome-modulating and other pharmacological and nanocarrier agents on amyloid-beta-treated cells. | 2012 | Curr Pharm Biotechnol | pmid:23072393 |
| Malaguarnera M | Carnitine derivatives: clinical usefulness. | 2012 | Curr. Opin. Gastroenterol. | pmid:22333562 |
| Schaevitz LR et al. | Acetyl-L-carnitine improves behavior and dendritic morphology in a mouse model of Rett syndrome. | 2012 | PLoS ONE | pmid:23227269 |
| Morand R et al. | Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. | 2012 | Ther Drug Monit | pmid:22743351 |
| Muralidharan AR et al. | Deciphering the potential efficacy of acetyl-L-carnitine (ALCAR) in maintaining connexin-mediated lenticular homeostasis. | 2012 | Mol. Vis. | pmid:22876134 |
| Karalija A et al. | Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats. | 2012 | PLoS ONE | pmid:22815926 |
| Sharma S et al. | Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. | 2012 | Free Radic. Biol. Med. | pmid:22583703 |
| Patel SP et al. | Acetyl-L-carnitine treatment following spinal cord injury improves mitochondrial function correlated with remarkable tissue sparing and functional recovery. | 2012 | Neuroscience | pmid:22445934 |
| Zhang R et al. | Neuroprotective effects of pre-treatment with l-carnitine and acetyl-L-carnitine on ischemic injury in vivo and in vitro. | 2012 | Int J Mol Sci | pmid:22408439 |
| Hu C et al. | Inhibition of OCTN2-mediated transport of carnitine by etoposide. | 2012 | Mol. Cancer Ther. | pmid:22389472 |
| Wu R et al. | Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22328148 |
| Boss A et al. | Skeletal muscle ¹H MRSI before and after prolonged exercise. II. visibility of free carnitine. | 2012 | Magn Reson Med | pmid:22287218 |
| Pochini L et al. | The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease. | 2012 | Biochim. Biophys. Acta | pmid:22206629 |
| Behrend AM et al. | Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation. | 2012 | Mol. Genet. Metab. | pmid:22030098 |
| Ang JE et al. | Identification of human plasma metabolites exhibiting time-of-day variation using an untargeted liquid chromatography-mass spectrometry metabolomic approach. | 2012 | Chronobiol. Int. | pmid:22823870 |
| Smeland OB et al. | Dietary supplementation with acetyl-l-carnitine in seizure treatment of pentylenetetrazole kindled mice. | 2012 | Neurochem. Int. | pmid:22709675 |
| El-Awady el-SE et al. | Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. | 2011 | Eur. J. Pharmacol. | pmid:21034734 |
| Nagesh Babu G et al. | Chronic pretreatment with acetyl-L-carnitine and ±DL-α-lipoic acid protects against acute glutamate-induced neurotoxicity in rat brain by altering mitochondrial function. | 2011 | Neurotox Res | pmid:20217290 |
| Mingorance C et al. | Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders. | 2011 | Vasc Health Risk Manag | pmid:21490942 |
| Wadman RI et al. | Drug treatment for spinal muscular atrophy types II and III. | 2011 | Cochrane Database Syst Rev | pmid:22161400 |
| Haorah J et al. | Stabilization of superoxide dismutase by acetyl-l-carnitine in human brain endothelium during alcohol exposure: novel protective approach. | 2011 | Free Radic. Biol. Med. | pmid:21782933 |
| Jiang X et al. | Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. | 2011 | J. Neurochem. | pmid:21689104 |
| Abdul Muneer PM et al. | Methamphetamine inhibits the glucose uptake by human neurons and astrocytes: stabilization by acetyl-L-carnitine. | 2011 | PLoS ONE | pmid:21556365 |
| Cacicedo JM et al. | Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. | 2011 | Invest. Ophthalmol. Vis. Sci. | pmid:21345991 |
| Ponte F et al. | Protective effect of acetyl-l-carnitine and α-lipoic acid against the acute toxicity of diepoxybutane to human lymphocytes. | 2011 | Toxicology | pmid:21807063 |