Acetyl-l-carnitine

Acetyl-l-carnitine is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2904 references associated with Acetyl-l-carnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for Acetyl-l-carnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Acetyl-l-carnitine

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Parkinson Disease D010300 53 associated lipids
Cleft Lip D002971 8 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 7

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Acetyl-l-carnitine

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Authors Title Published Journal PubMed Link
Laird MD et al. Augmentation of normal and glutamate-impaired neuronal respiratory capacity by exogenous alternative biofuels. 2013 Transl Stroke Res pmid:24323418
Brennan BP et al. A placebo-controlled trial of acetyl-L-carnitine and α-lipoic acid in the treatment of bipolar depression. 2013 J Clin Psychopharmacol pmid:23948785
Kathirvel E et al. Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease. 2013 Nutr Res pmid:24176233
Morand R et al. Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction. 2013 Anal Bioanal Chem pmid:23995505
Burotto M and Fojo AT Acetyl-L-carnitine and prevention of chemotherapy-induced peripheral neuropathy: can anything work? 2013 Oncologist pmid:24217999
Campone M et al. A double-blind, randomized phase II study to evaluate the safety and efficacy of acetyl-L-carnitine in the prevention of sagopilone-induced peripheral neuropathy. 2013 Oncologist pmid:24105751
Pekkinen J et al. Betaine supplementation causes increase in carnitine metabolites in the muscle and liver of mice fed a high-fat diet as studied by nontargeted LC-MS metabolomics approach. 2013 Mol Nutr Food Res pmid:23868375
Gómez LA et al. Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart. 2012 Feb-Mar Mech. Ageing Dev. pmid:22322067
Hu S et al. Use of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat. 2012 Magn Reson Imaging pmid:22819176
Mallinson JE et al. Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. 2012 J. Physiol. (Lond.) pmid:23045346
Wadman RI et al. Drug treatment for spinal muscular atrophy types II and III. 2012 Cochrane Database Syst Rev pmid:22513940
Muoio DM et al. Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. 2012 Cell Metab. pmid:22560225
Kanazirska MV et al. Beneficial effects of lysosome-modulating and other pharmacological and nanocarrier agents on amyloid-beta-treated cells. 2012 Curr Pharm Biotechnol pmid:23072393
Schaevitz LR et al. Acetyl-L-carnitine improves behavior and dendritic morphology in a mouse model of Rett syndrome. 2012 PLoS ONE pmid:23227269
Morand R et al. Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. 2012 Ther Drug Monit pmid:22743351
Muralidharan AR et al. Deciphering the potential efficacy of acetyl-L-carnitine (ALCAR) in maintaining connexin-mediated lenticular homeostasis. 2012 Mol. Vis. pmid:22876134
Karalija A et al. Neuroprotective effects of N-acetyl-cysteine and acetyl-L-carnitine after spinal cord injury in adult rats. 2012 PLoS ONE pmid:22815926
Sharma S et al. Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. 2012 Free Radic. Biol. Med. pmid:22583703
Ang JE et al. Identification of human plasma metabolites exhibiting time-of-day variation using an untargeted liquid chromatography-mass spectrometry metabolomic approach. 2012 Chronobiol. Int. pmid:22823870
Smeland OB et al. Dietary supplementation with acetyl-l-carnitine in seizure treatment of pentylenetetrazole kindled mice. 2012 Neurochem. Int. pmid:22709675