Acetyl-l-carnitine

Acetyl-l-carnitine is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 2904 references associated with Acetyl-l-carnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.

Here are additional resources we collected from PubChem and MeSH for Acetyl-l-carnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Acetyl-l-carnitine

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Parkinson Disease D010300 53 associated lipids
Cleft Lip D002971 8 associated lipids
Proteostasis Deficiencies D057165 5 associated lipids
Total 7

PubChem Biomolecular Interactions and Pathways

NCBI Entrez Crosslinks

All references with Acetyl-l-carnitine

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Authors Title Published Journal PubMed Link
Zaitone SA et al. Acetyl-L-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy. 2012 Pharmacol. Biochem. Behav. pmid:21958946
Mallinson JE et al. Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents. 2012 J. Physiol. (Lond.) pmid:23045346
Schroeder MA et al. The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study. 2012 Circ Cardiovasc Imaging pmid:22238215
Kanazirska MV et al. Beneficial effects of lysosome-modulating and other pharmacological and nanocarrier agents on amyloid-beta-treated cells. 2012 Curr Pharm Biotechnol pmid:23072393
Schaevitz LR et al. Acetyl-L-carnitine improves behavior and dendritic morphology in a mouse model of Rett syndrome. 2012 PLoS ONE pmid:23227269
Morand R et al. Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans. 2012 Ther Drug Monit pmid:22743351
Muralidharan AR et al. Deciphering the potential efficacy of acetyl-L-carnitine (ALCAR) in maintaining connexin-mediated lenticular homeostasis. 2012 Mol. Vis. pmid:22876134
Wu R et al. Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22328148
Boss A et al. Skeletal muscle ¹H MRSI before and after prolonged exercise. II. visibility of free carnitine. 2012 Magn Reson Med pmid:22287218
Pochini L et al. The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn's disease. 2012 Biochim. Biophys. Acta pmid:22206629
Behrend AM et al. Substrate oxidation and cardiac performance during exercise in disorders of long chain fatty acid oxidation. 2012 Mol. Genet. Metab. pmid:22030098
El-Awady el-SE et al. Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. 2011 Eur. J. Pharmacol. pmid:21034734
Nagesh Babu G et al. Chronic pretreatment with acetyl-L-carnitine and ±DL-α-lipoic acid protects against acute glutamate-induced neurotoxicity in rat brain by altering mitochondrial function. 2011 Neurotox Res pmid:20217290
Mingorance C et al. Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders. 2011 Vasc Health Risk Manag pmid:21490942
Wadman RI et al. Drug treatment for spinal muscular atrophy types II and III. 2011 Cochrane Database Syst Rev pmid:22161400
Haorah J et al. Stabilization of superoxide dismutase by acetyl-l-carnitine in human brain endothelium during alcohol exposure: novel protective approach. 2011 Free Radic. Biol. Med. pmid:21782933
Jiang X et al. Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. 2011 J. Neurochem. pmid:21689104
Abdul Muneer PM et al. Methamphetamine inhibits the glucose uptake by human neurons and astrocytes: stabilization by acetyl-L-carnitine. 2011 PLoS ONE pmid:21556365
Cacicedo JM et al. Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. 2011 Invest. Ophthalmol. Vis. Sci. pmid:21345991
Ponte F et al. Protective effect of acetyl-l-carnitine and α-lipoic acid against the acute toxicity of diepoxybutane to human lymphocytes. 2011 Toxicology pmid:21807063