O-octanoylcarnitine

O-octanoylcarnitine is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 212 references associated with O-octanoylcarnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for O-octanoylcarnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with O-octanoylcarnitine

MeSH term MeSH ID Detail
Starvation D013217 47 associated lipids
Ventricular Dysfunction, Left D018487 33 associated lipids
Heart Failure, Systolic D054143 3 associated lipids
Total 3

NCBI Entrez Crosslinks

All references with O-octanoylcarnitine

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Authors Title Published Journal PubMed Link
Ojuka E et al. Measurement of β-oxidation capacity of biological samples by respirometry: a review of principles and substrates. 2016 Am. J. Physiol. Endocrinol. Metab. pmid:26908505
Horscroft JA et al. Altered Oxygen Utilisation in Rat Left Ventricle and Soleus after 14 Days, but Not 2 Days, of Environmental Hypoxia. 2015 PLoS ONE pmid:26390043
Kim M et al. Association between arterial stiffness and serum L-octanoylcarnitine and lactosylceramide in overweight middle-aged subjects: 3-year follow-up study. 2015 PLoS ONE pmid:25781947
Donato AJ et al. The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction. 2014 J. Physiol. (Lond.) pmid:25038241
Stride N et al. Decreased mitochondrial oxidative phosphorylation capacity in the human heart with left ventricular systolic dysfunction. 2013 Eur. J. Heart Fail. pmid:23115323
Meadows JA and Wargo MJ Characterization of Pseudomonas aeruginosa growth on O-acylcarnitines and identification of a short-chain acylcarnitine hydrolase. 2013 Appl. Environ. Microbiol. pmid:23524670
Naccarato A et al. Identification and assay of underivatized urinary acylcarnitines by paper spray tandem mass spectrometry. 2013 Anal Bioanal Chem pmid:23907684
Morand R et al. Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction. 2013 Anal Bioanal Chem pmid:23995505
Alexandre-Gouabau MC et al. Maternal and cord blood LC-HRMS metabolomics reveal alterations in energy and polyamine metabolism, and oxidative stress in very-low birth weight infants. 2013 J. Proteome Res. pmid:23527880
Tonin AM et al. Disruption of redox homeostasis in cerebral cortex of developing rats by acylcarnitines accumulating in medium-chain acyl-CoA dehydrogenase deficiency. 2012 Int. J. Dev. Neurosci. pmid:22472139
Larsen S et al. Increased mitochondrial substrate sensitivity in skeletal muscle of patients with type 2 diabetes. 2011 Diabetologia pmid:21424396
Schönfeld P et al. Mitochondrial fatty acid oxidation and oxidative stress: lack of reverse electron transfer-associated production of reactive oxygen species. 2010 Jun-Jul Biochim. Biophys. Acta pmid:20085746
Smith EH et al. Allelic diversity in MCAD deficiency: the biochemical classification of 54 variants identified during 5 years of ACADM sequencing. 2010 Mol. Genet. Metab. pmid:20434380
Khalid JM et al. Relationship of octanoylcarnitine concentrations to age at sampling in unaffected newborns screened for medium-chain acyl-CoA dehydrogenase deficiency. 2010 Clin. Chem. pmid:20413428
De Jesús VR et al. Comparison of amino acids and acylcarnitines assay methods used in newborn screening assays by tandem mass spectrometry. 2010 Clin. Chim. Acta pmid:20122909
Arnold GL et al. Lack of genotype-phenotype correlations and outcome in MCAD deficiency diagnosed by newborn screening in New York State. 2010 Mol. Genet. Metab. pmid:20036593
Kraunsøe R et al. Mitochondrial respiration in subcutaneous and visceral adipose tissue from patients with morbid obesity. 2010 J. Physiol. (Lond.) pmid:20421291
Tsuchida H et al. Identification of a novel organic anion transporter mediating carnitine transport in mouse liver and kidney. 2010 Cell. Physiol. Biochem. pmid:20332632
Maier EM et al. Dissection of biochemical borderline phenotypes in carriers and genetic variants of medium-chain acyl-CoA dehyrogenase deficiency: implications for newborn screening [corrected]. 2009 Clin. Genet. pmid:19780764
Hsu HW et al. Spectrum of medium-chain acyl-CoA dehydrogenase deficiency detected by newborn screening. 2008 Pediatrics pmid:18450854
Rhead WJ Newborn screening for medium-chain acyl-CoA dehydrogenase deficiency: a global perspective. 2006 Apr-Jun J. Inherit. Metab. Dis. pmid:16763904
de Assis DR et al. Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats. 2006 Exp. Neurol. pmid:16203000
Baumgartner C and Baumgartner D Biomarker discovery, disease classification, and similarity query processing on high-throughput MS/MS data of inborn errors of metabolism. 2006 J Biomol Screen pmid:16314408
Ensenauer R et al. Genotypic differences of MCAD deficiency in the Asian population: novel genotype and clinical symptoms preceding newborn screening notification. 2005 May-Jun Genet. Med. pmid:15915086
Jogl G et al. Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. 2005 J. Biol. Chem. pmid:15492013
Lehotay DC et al. Blood acylcarnitine levels in normal newborns and heterozygotes for medium-chain acyl-CoA dehydrogenase deficiency: a relationship between genotype and biochemical phenotype? 2004 J. Inherit. Metab. Dis. pmid:14970748
Pourfarzam M et al. Neonatal screening for medium-chain acyl-CoA dehydrogenase deficiency. 2001 Lancet pmid:11589939
Carpenter K et al. Evaluation of newborn screening for medium chain acyl-CoA dehydrogenase deficiency in 275 000 babies. 2001 Arch. Dis. Child. Fetal Neonatal Ed. pmid:11517203
Chace DH et al. Errors caused by the use of D,L-octanoylcarnitine for blood-spot calibrators. 2001 Clin. Chem. pmid:11274033
Trumbeckaite S et al. Different sensitivity of rabbit heart and skeletal muscle to endotoxin-induced impairment of mitochondrial function. 2001 Eur. J. Biochem. pmid:11231295
Toleikis A et al. Relevance of fatty acid oxidation in regulation of the outer mitochondrial membrane permeability for ADP. 2001 FEBS Lett. pmid:11741597
Mroczkowska JE et al. Blood-brain barrier controls carnitine level in the brain: a study on a model system with RBE4 cells. 2000 Biochem. Biophys. Res. Commun. pmid:10623637
Clayton PT et al. Screening for medium chain acyl-CoA dehydrogenase deficiency using electrospray ionisation tandem mass spectrometry. 1998 Arch. Dis. Child. pmid:9797589
Zangar RC and Novak RF Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes. 1997 Arch. Biochem. Biophys. pmid:9016816
Chace DH et al. Rapid diagnosis of MCAD deficiency: quantitative analysis of octanoylcarnitine and other acylcarnitines in newborn blood spots by tandem mass spectrometry. 1997 Clin. Chem. pmid:9365395
Ziadeh R et al. Medium chain acyl-CoA dehydrogenase deficiency in Pennsylvania: neonatal screening shows high incidence and unexpected mutation frequencies. 1995 Pediatr. Res. pmid:7603790
Van Hove JL et al. Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: diagnosis by acylcarnitine analysis in blood. 1993 Am. J. Hum. Genet. pmid:8488845
Minkler PE and Hoppel CL Quantification of free carnitine, individual short- and medium-chain acylcarnitines, and total carnitine in plasma by high-performance liquid chromatography. 1993 Anal. Biochem. pmid:8214594
Schmidt-Sommerfeld E et al. Urinary medium-chain acylcarnitines in medium-chain acyl-CoA dehydrogenase deficiency, medium-chain triglyceride feeding and valproic acid therapy: sensitivity and specificity of the radioisotopic exchange/high performance liquid chromatography method. 1992 Pediatr. Res. pmid:1635814
Farquharson J et al. Direct gas chromatographic assay of urinary medium-chain fatty acylcarnitines by their thermal decomposition. 1992 Clin. Chim. Acta pmid:1576748
Squire RS Synthesis and purification of radioactive fatty acylcarnitines of high specific activity. 1991 Anal. Biochem. pmid:1952050
Bhuiyan AK and Pande SV One-step facile synthesis of radioactive acyl-CoA and acylcarnitines using rat liver outer mitochondrial membrane as the enzyme source. 1991 Biochem. Soc. Trans. pmid:1889559
Brass EP Metabolism of octanoyl- and palmitoylcarnitine by intact rat hepatocytes. 1989 Biochim. Biophys. Acta pmid:2730893
Millington DS and Roe CR Medium-chain acyl-CoA dehydrogenase deficiency. 1989 N. Engl. J. Med. pmid:2710197
Roe CR et al. Post-mortem recognition of inherited metabolic disorders from specific acylcarnitines in tissue in cases of sudden infant death. 1987 Lancet pmid:2881073
Millington DS et al. Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry. 1985 Clin. Chim. Acta pmid:3919970
Roe CR et al. Diagnostic and therapeutic implications of medium-chain acylcarnitines in the medium-chain acyl-coA dehydrogenase deficiency. 1985 Pediatr. Res. pmid:4000772
Duran M et al. Octanoylglucuronide excretion in patients with a defective oxidation of medium-chain fatty acids. 1985 Clin. Chim. Acta pmid:4064333
Kim CS et al. L-carnitine: therapeutic strategy for metabolic encephalopathy. 1984 Brain Res. pmid:6478235
Chalmers RA et al. Urinary excretion of l-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of l-carnitine. 1984 Pediatr. Res. pmid:6441143
Nakatani T et al. Effects of (+)-octanoylcarnitine on deoxyribonucleic acid synthesis in regenerating rabbit liver. 1982 Clin. Sci. pmid:7060336
Parameswaran M and Arinze IJ Phosphoenolpyruvate synthesis by fetal guinea-pig liver mitochondria. 1981 Biochim. Biophys. Acta pmid:7225415
Davis-van Thienen W and Davis EJ The effects of energetic steady state, pyruvate concentration, and octanoyl-(--)-carnitine on the relative rates of carboxylation and decarboxylation of pyruvate by rat liver mitochondria. 1981 J. Biol. Chem. pmid:7263658
Zammit VA The effect of glucagon treatment and starvation of virgin and lactating rats on the rates of oxidation of octanoyl-L-carnitine and octanoate by isolated liver mitochondria. 1980 Biochem. J. pmid:7470052
Jones CT Is there a gloxylate cycle in the liver of the fetal guinea pig? 1980 Biochem. Biophys. Res. Commun. pmid:7417292
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