Palmitoylcarnitine

Palmitoylcarnitine is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1026 references associated with Palmitoylcarnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Palmitoylcarnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Palmitoylcarnitine

MeSH term MeSH ID Detail
Coronary Disease D003327 70 associated lipids
Insulin Resistance D007333 99 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Total 3

NCBI Entrez Crosslinks

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Authors Title Published Journal PubMed Link
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pmid:10087170
New KJ et al. Comparisons of flux control exerted by mitochondrial outer-membrane carnitine palmitoyltransferase over ketogenesis in hepatocytes and mitochondria isolated from suckling or adult rats. 1999 Eur. J. Biochem. pmid:10092853
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Netticadan T et al. Palmitoyl carnitine increases intracellular calcium in adult rat cardiomyocytes. 1999 J. Mol. Cell. Cardiol. pmid:10403753
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Mutomba MC et al. Regulation of the activity of caspases by L-carnitine and palmitoylcarnitine. 2000 FEBS Lett. pmid:10922462
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Muraki K [Analyses of Ca-related ion channel currents and their involvement in Ca mobilization in smooth muscle and endothelial cells]. 2003 Nippon Yakurigaku Zasshi pmid:12673948
Szczepankowska D and Nałecz KA Palmitoylcarnitine modulates palmitoylation of proteins: implication for differentiation of neural cells. 2003 Neurochem. Res. pmid:12675156
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Crescenzo R et al. Skeletal muscle mitochondrial oxidative capacity and uncoupling protein 3 are differently influenced by semistarvation and refeeding. 2003 FEBS Lett. pmid:12782304
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Muraki K and Imaizumi Y A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. 2003 J. Pharmacol. Sci. pmid:12890891
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Garsetti DE et al. Isolation and characterization of three lysophospholipases from the murine macrophage cell line WEHI 265.1. 1992 Biochim. Biophys. Acta pmid:1450218
Young SP et al. A comparison of in vitro acylcarnitine profiling methods for the diagnosis of classical and variant short chain acyl-CoA dehydrogenase deficiency. 2003 Clin. Chim. Acta pmid:14568186
Gooding JM et al. Membrane transport of fatty acylcarnitine and free L-carnitine by rat liver microsomes. 2004 Eur. J. Biochem. pmid:15009207
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Liu H et al. Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis. 2005 J. Biol. Chem. pmid:15579906
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Silvestri E et al. Thyroid-hormone effects on putative biochemical pathways involved in UCP3 activation in rat skeletal muscle mitochondria. 2005 FEBS Lett. pmid:15757654
Nozu F et al. Changes of hepatic fatty acid metabolism produced by chronic thioacetamide administration in rats. 1992 Hepatology pmid:1592350
Wenzel U et al. Increased carnitine-dependent fatty acid uptake into mitochondria of human colon cancer cells induces apoptosis. 2005 J. Nutr. pmid:15930461
Chiodi P et al. Tissue lipid accumulation by L-aminocarnitine, an inhibitor of carnitine-palmitoyltransferase-2. Studies in intact rats and isolated mitochondria. 1992 Biochim. Biophys. Acta pmid:1627637
Sun D et al. Measurement of stable isotopic enrichment and concentration of long-chain fatty acyl-carnitines in tissue by HPLC-MS. 2006 J. Lipid Res. pmid:16301738
Wenzel U et al. Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells. 2005 Cell. Mol. Life Sci. pmid:16314920
Sobiesiak-Mirska J and Nałecz KA Palmitoylcarnitine modulates interaction between protein kinase C betaII and its receptor RACK1. 2006 FEBS J. pmid:16519693
Johnson G et al. Influence of intensity of food restriction on skeletal muscle mitochondrial energy metabolism in rats. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16621897
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Cortright RN et al. Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training. 2006 Obesity (Silver Spring) pmid:16899801
Criddle DN et al. The effects of novel vasodilator long chain acyl carnitine esters in the isolated perfused heart of the rat. 1990 Br. J. Pharmacol. pmid:1691947
Dainty IA et al. Interactions of palmitoyl carnitine with the endothelium in rat aorta. 1990 Br. J. Pharmacol. pmid:1696151
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Broderick TL Whole-body heat shock protects the ischemic rat heart by stimulating mitochondria respiration. Can. J. Physiol. Pharmacol. pmid:17111038
Fernström M et al. Reduced efficiency, but increased fat oxidation, in mitochondria from human skeletal muscle after 24-h ultraendurance exercise. 2007 J. Appl. Physiol. pmid:17234801
Leonardi R et al. Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17242360
Ma L et al. Modulation of tight junction properties relevant to fluid transport across rabbit corneal endothelium. 2007 Exp. Eye Res. pmid:17320078
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Cervinková Z et al. Inhibition of palmityl carnitine oxidation in rat liver mitochondria by tert-butyl hydroperoxide. 2008 Physiol Res pmid:17465699
Nałecz KA et al. Palmitoylcarnitine regulates estrification of lipids and promotes palmitoylation of GAP-43. 2007 FEBS Lett. pmid:17662726
Michel AD and Fonfria E Agonist potency at P2X7 receptors is modulated by structurally diverse lipids. 2007 Br. J. Pharmacol. pmid:17700717
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Primassin S et al. Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine. 2008 Pediatr. Res. pmid:18317232
Tominaga H et al. Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18469143
Lehman JJ et al. The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18487436
Abdul-Ghani MA et al. Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance. 2008 Am. J. Physiol. Endocrinol. Metab. pmid:18593850
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Endlicher R et al. Peroxidative damage of mitochondrial respiration is substrate-dependent. 2009 Physiol Res pmid:19093725
Inokuchi H et al. The effect of hyperosmosis on paracellular permeability in Caco-2 cell monolayers. 2009 Biosci. Biotechnol. Biochem. pmid:19202294
Bonnefont JP et al. Bezafibrate for an inborn mitochondrial beta-oxidation defect. 2009 N. Engl. J. Med. pmid:19228633
Hoffman DL and Brookes PS Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions. 2009 J. Biol. Chem. pmid:19366681
Wu Y et al. The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular diastolic dysfunction. 2009 J. Pharmacol. Exp. Ther. pmid:19403851
Squire RS Synthesis and purification of radioactive fatty acylcarnitines of high specific activity. 1991 Anal. Biochem. pmid:1952050
Schaeffer PJ et al. Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. 2009 Am. J. Physiol. Heart Circ. Physiol. pmid:19700627
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De Jesús VR et al. Comparison of amino acids and acylcarnitines assay methods used in newborn screening assays by tandem mass spectrometry. 2010 Clin. Chim. Acta pmid:20122909
Butler AP et al. Involvement of protein kinase C in the regulation of ornithine decarboxylase mRNA by phorbol esters in rat hepatoma cells. 1991 Exp. Cell Res. pmid:2015852
Abe K et al. Phosphorylation of coagulation factor II by phospholipid/Ca(2+)-dependent protein kinase (protein kinase C). 1991 Biochem. Biophys. Res. Commun. pmid:2039497
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Olson MS et al. The regulation of pyruvate dehydrogenase by fatty acids in isolated rabbit heart mitochondria. 1978 Arch. Biochem. Biophys. pmid:207223
Brandhonneur N et al. Ex vivo and in vivo diffusion of ropivacaine through spinal meninges: influence of absorption enhancers. 2011 Int J Pharm pmid:21056096
Doi N et al. Absorption enhancement effect of acylcarnitines through changes in tight junction protein in Caco-2 cell monolayers. 2011 Drug Metab. Pharmacokinet. pmid:21206134
Moraru II et al. Protein kinase C controls Fc gamma receptor-mediated endocytosis in human neutrophils. 1990 FEBS Lett. pmid:2147663
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Zhang XJ et al. Measurement of precursor enrichment for calculating intramuscular triglyceride fractional synthetic rate. 2012 J. Lipid Res. pmid:21934122