Palmitoylcarnitine

Palmitoylcarnitine is a lipid of Fatty Acyls (FA) class.

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Current reference collection contains 1026 references associated with Palmitoylcarnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Palmitoylcarnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Palmitoylcarnitine

MeSH term MeSH ID Detail
Coronary Disease D003327 70 associated lipids
Insulin Resistance D007333 99 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Total 3

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Ojuka E et al. Measurement of β-oxidation capacity of biological samples by respirometry: a review of principles and substrates. 2016 Am. J. Physiol. Endocrinol. Metab. pmid:26908505
Vorkas PA et al. Metabolic Phenotypes of Carotid Atherosclerotic Plaques Relate to Stroke Risk: An Exploratory Study. 2016 Eur J Vasc Endovasc Surg pmid:27231199
Al-Bakheit A et al. Accumulation of Palmitoylcarnitine and Its Effect on Pro-Inflammatory Pathways and Calcium Influx in Prostate Cancer. 2016 Prostate pmid:27403764
Cavar M et al. Trimetazidine does not alter metabolic substrate oxidation in cardiac mitochondria of target patient population. 2016 Br. J. Pharmacol. pmid:26844527
Schooneman MG et al. Transorgan fluxes in a porcine model reveal a central role for liver in acylcarnitine metabolism. 2015 Am. J. Physiol. Endocrinol. Metab. pmid:26037250
Roussel J et al. Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2+ leak in cardiomyocytes: Role of adenine nucleotide translocase. 2015 Biochim. Biophys. Acta pmid:25619687
Lou PH et al. The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases. 2014 PLoS ONE pmid:24498043
Felser A et al. Hepatic toxicity of dronedarone in mice: role of mitochondrial β-oxidation. 2014 Toxicology pmid:24881592
Shao Y et al. Lipid metabolites and their differential pro-arrhythmic profiles: of importance in the development of a new anti-arrhythmic pharmacology. 2014 Mol. Cell. Biochem. pmid:24771065
Zhang H et al. Metabolomic analysis of biochemical changes in the plasma and urine of collagen-induced arthritis in rats after treatment with Huang-Lian-Jie-Du-Tang. 2014 J Ethnopharmacol pmid:24709313
Voss U et al. Enteric neuropathy can be induced by high fat diet in vivo and palmitic acid exposure in vitro. 2013 PLoS ONE pmid:24312551
Quinlan CL et al. Sites of reactive oxygen species generation by mitochondria oxidizing different substrates. 2013 Redox Biol pmid:24024165
Kanaley JA et al. Hyperinsulinemia and skeletal muscle fatty acid trafficking. 2013 Am. J. Physiol. Endocrinol. Metab. pmid:23820622
van Eunen K et al. Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload. 2013 PLoS Comput. Biol. pmid:23966849
Gupte AA et al. High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance. 2013 Endocrinology pmid:23709089
Perevoshchikova IV et al. Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria. 2013 Free Radic. Biol. Med. pmid:23583329
Dixen K et al. ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes. 2013 Obesity (Silver Spring) pmid:23404793
Morand R et al. Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction. 2013 Anal Bioanal Chem pmid:23995505
Zhang XJ et al. Measurement of precursor enrichment for calculating intramuscular triglyceride fractional synthetic rate. 2012 J. Lipid Res. pmid:21934122
Shi X et al. Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity. 2012 J. Lipid Res. pmid:22904346
Jørgensen W et al. Progression of type 2 diabetes in GK rats affects muscle and liver mitochondria differently: pronounced reduction of complex II flux is observed in liver only. 2012 Am. J. Physiol. Endocrinol. Metab. pmid:22713504
Tonazzi A et al. Identification by site-directed mutagenesis of a hydrophobic binding site of the mitochondrial carnitine/acylcarnitine carrier involved in the interaction with acyl groups. 2012 Biochim. Biophys. Acta pmid:22365929
Nguyen UT et al. Small-molecule modulators of Listeria monocytogenes biofilm development. 2012 Appl. Environ. Microbiol. pmid:22194285
Wenderska IB et al. Palmitoyl-DL-carnitine is a multitarget inhibitor of Pseudomonas aeruginosa biofilm development. 2011 Chembiochem pmid:22045628
Brandhonneur N et al. Ex vivo and in vivo diffusion of ropivacaine through spinal meninges: influence of absorption enhancers. 2011 Int J Pharm pmid:21056096
Doi N et al. Absorption enhancement effect of acylcarnitines through changes in tight junction protein in Caco-2 cell monolayers. 2011 Drug Metab. Pharmacokinet. pmid:21206134
De Jesús VR et al. Comparison of amino acids and acylcarnitines assay methods used in newborn screening assays by tandem mass spectrometry. 2010 Clin. Chim. Acta pmid:20122909
Hoffman DL and Brookes PS Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions. 2009 J. Biol. Chem. pmid:19366681
Schaeffer PJ et al. Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. 2009 Am. J. Physiol. Heart Circ. Physiol. pmid:19700627
Wu Y et al. The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular diastolic dysfunction. 2009 J. Pharmacol. Exp. Ther. pmid:19403851
Bonnefont JP et al. Bezafibrate for an inborn mitochondrial beta-oxidation defect. 2009 N. Engl. J. Med. pmid:19228633
Inokuchi H et al. The effect of hyperosmosis on paracellular permeability in Caco-2 cell monolayers. 2009 Biosci. Biotechnol. Biochem. pmid:19202294
Endlicher R et al. Peroxidative damage of mitochondrial respiration is substrate-dependent. 2009 Physiol Res pmid:19093725
Primassin S et al. Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine. 2008 Pediatr. Res. pmid:18317232
Tominaga H et al. Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18469143
Abdul-Ghani MA et al. Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance. 2008 Am. J. Physiol. Endocrinol. Metab. pmid:18593850
Lehman JJ et al. The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18487436
Cervinková Z et al. Inhibition of palmityl carnitine oxidation in rat liver mitochondria by tert-butyl hydroperoxide. 2008 Physiol Res pmid:17465699
Nałecz KA et al. Palmitoylcarnitine regulates estrification of lipids and promotes palmitoylation of GAP-43. 2007 FEBS Lett. pmid:17662726
Ma L et al. Modulation of tight junction properties relevant to fluid transport across rabbit corneal endothelium. 2007 Exp. Eye Res. pmid:17320078
Leonardi R et al. Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17242360
Fernström M et al. Reduced efficiency, but increased fat oxidation, in mitochondria from human skeletal muscle after 24-h ultraendurance exercise. 2007 J. Appl. Physiol. pmid:17234801
Michel AD and Fonfria E Agonist potency at P2X7 receptors is modulated by structurally diverse lipids. 2007 Br. J. Pharmacol. pmid:17700717
Cortright RN et al. Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training. 2006 Obesity (Silver Spring) pmid:16899801
Johnson G et al. Influence of intensity of food restriction on skeletal muscle mitochondrial energy metabolism in rats. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16621897
Sobiesiak-Mirska J and Nałecz KA Palmitoylcarnitine modulates interaction between protein kinase C betaII and its receptor RACK1. 2006 FEBS J. pmid:16519693
Sun D et al. Measurement of stable isotopic enrichment and concentration of long-chain fatty acyl-carnitines in tissue by HPLC-MS. 2006 J. Lipid Res. pmid:16301738
Wenzel U et al. Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells. 2005 Cell. Mol. Life Sci. pmid:16314920
Liu H et al. Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis. 2005 J. Biol. Chem. pmid:15579906
Wenzel U et al. Increased carnitine-dependent fatty acid uptake into mitochondria of human colon cancer cells induces apoptosis. 2005 J. Nutr. pmid:15930461
Silvestri E et al. Thyroid-hormone effects on putative biochemical pathways involved in UCP3 activation in rat skeletal muscle mitochondria. 2005 FEBS Lett. pmid:15757654
Gooding JM et al. Membrane transport of fatty acylcarnitine and free L-carnitine by rat liver microsomes. 2004 Eur. J. Biochem. pmid:15009207
Muraki K [Analyses of Ca-related ion channel currents and their involvement in Ca mobilization in smooth muscle and endothelial cells]. 2003 Nippon Yakurigaku Zasshi pmid:12673948
Muraki K and Imaizumi Y A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. 2003 J. Pharmacol. Sci. pmid:12890891
Szczepankowska D and Nałecz KA Palmitoylcarnitine modulates palmitoylation of proteins: implication for differentiation of neural cells. 2003 Neurochem. Res. pmid:12675156
Raiman J et al. Effects of various absorption enhancers on transport of clodronate through Caco-2 cells. 2003 Int J Pharm pmid:12878401
Sekoguchi E et al. A novel mitochondrial carnitine-acylcarnitine translocase induced by partial hepatectomy and fasting. 2003 J. Biol. Chem. pmid:12882971
Young SP et al. A comparison of in vitro acylcarnitine profiling methods for the diagnosis of classical and variant short chain acyl-CoA dehydrogenase deficiency. 2003 Clin. Chim. Acta pmid:14568186
Privette JD et al. Fatty acid oxidation by skeletal muscle homogenates from morbidly obese black and white American women. 2003 Metab. Clin. Exp. pmid:12800100
Crescenzo R et al. Skeletal muscle mitochondrial oxidative capacity and uncoupling protein 3 are differently influenced by semistarvation and refeeding. 2003 FEBS Lett. pmid:12782304
St-Pierre J et al. Topology of superoxide production from different sites in the mitochondrial electron transport chain. 2002 J. Biol. Chem. pmid:12237311
Hamilton KO et al. Modulation of P-glycoprotein activity in Calu-3 cells using steroids and beta-ligands. 2001 Int J Pharm pmid:11576779
Ziolo MT et al. Effects of arrhythmogenic lipid metabolites on the L-type calcium current of diabetic vs. non-diabetic rat hearts. 2001 Mol. Cell. Biochem. pmid:11451378
Toleikis A et al. Relevance of fatty acid oxidation in regulation of the outer mitochondrial membrane permeability for ADP. 2001 FEBS Lett. pmid:11741597
Chen SC et al. Purification and characterization of secretory phospholipase B, lysophospholipase and lysophospholipase/transacylase from a virulent strain of the pathogenic fungus Cryptococcus neoformans. 2000 Biochem. J. pmid:10749672
Kulier AH et al. Multiple agents potentiate alpha1-adrenoceptor-induced conduction depression in canine cardiac purkinje fibers. 2000 Anesthesiology pmid:10839923
Mutomba MC et al. Regulation of the activity of caspases by L-carnitine and palmitoylcarnitine. 2000 FEBS Lett. pmid:10922462
Liu DZ et al. Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers. 1999 J Pharm Sci pmid:10564065
Netticadan T et al. Palmitoyl carnitine increases intracellular calcium in adult rat cardiomyocytes. 1999 J. Mol. Cell. Cardiol. pmid:10403753
New KJ et al. Comparisons of flux control exerted by mitochondrial outer-membrane carnitine palmitoyltransferase over ketogenesis in hepatocytes and mitochondria isolated from suckling or adult rats. 1999 Eur. J. Biochem. pmid:10092853
Shimazaki T et al. Absorption-enhancing effects of sodium caprate and palmitoyl carnitine in rat and human colons. 1998 Dig. Dis. Sci. pmid:9539662
Duizer E et al. Absorption enhancement, structural changes in tight junctions and cytotoxicity caused by palmitoyl carnitine in Caco-2 and IEC-18 cells. 1998 J. Pharmacol. Exp. Ther. pmid:9765361
Schmidt I and Herpin P Carnitine palmitoyltransferase I (CPT I) activity and its regulation by malonyl-CoA are modulated by age and cold exposure in skeletal muscle mitochondria from newborn pigs. 1998 J. Nutr. pmid:9566999
Nolte L et al. Carnitine palmitoyltransferase I activity monitoring in fibroblasts and leukocytes using electrospray ionization mass spectrometry. 1998 Anal. Biochem. pmid:9473275
Iossa S et al. Oxidative activity in mitochondria isolated from rat liver at different stages of development. 1998 Cell Biochem. Funct. pmid:9857488
Xu Z and Rozanski GJ K+ current inhibition by amphiphilic fatty acid metabolites in rat ventricular myocytes. 1998 Am. J. Physiol. pmid:9843728
Hara A et al. Protective effects of dilazep and its derivative K-7259 on the haemolysis induced by amphiphiles in rat erythrocytes. 1997 J. Pharm. Pharmacol. pmid:9379361
Hara A et al. Beneficial effects of dilazep on the palmitoyl-L-carnitine-induced derangements in isolated, perfused rat heart: comparison with tetrodotoxin. 1997 Jpn. J. Pharmacol. pmid:9243322
Prakobphol A et al. Palmitoyl carnitine, a lysophospholipase-transacylase inhibitor, prevents Candida adherence in vitro. 1997 FEMS Microbiol. Lett. pmid:9198287
Nałecz KA et al. Effect of palmitoylcarnitine on the cellular differentiation, proliferation and protein kinase C activity in neuroblastoma nb-2a cells. 1997 Acta Neurobiol Exp (Wars) pmid:9519544
Amacher DE and Martin BA Tetracycline-induced steatosis in primary canine hepatocyte cultures. 1997 Fundam Appl Toxicol pmid:9441722
Kang JX and Leaf A Protective effects of free polyunsaturated fatty acids on arrhythmias induced by lysophosphatidylcholine or palmitoylcarnitine in neonatal rat cardiac myocytes. 1996 Eur. J. Pharmacol. pmid:8851173
Paradies G et al. Stimulation of carnitine acylcarnitine translocase activity in heart mitochondria from hyperthyroid rats. 1996 FEBS Lett. pmid:8955359
Goñi FM et al. Palmitoylcarnitine, a surface-active metabolite. 1996 FEBS Lett. pmid:8706815
Arduini A et al. High performance liquid chromatography of long-chain acylcarnitine and phospholipids in fatty acid turnover studies. 1996 J. Lipid Res. pmid:8728329
Abiko Y et al. [A new approach to the understanding of the mechanism of ischemia/reperfusion damage in the heart and the effects of anti-ischemic drugs]. 1996 Nippon Yakurigaku Zasshi pmid:8940701
Clarke B et al. On the roles of long-chain acyl carnitine accumulation and impaired glucose utilization in ischaemic contracture development and tissue damage in the guinea-pig heart. 1996 J. Mol. Cell. Cardiol. pmid:8745225
Tune BM and Hsu CY Toxicity of cephalosporins to fatty acid metabolism in rabbit renal cortical mitochondria. 1995 Biochem. Pharmacol. pmid:7887988
Echabe I et al. An infrared investigation of palmitoyl-coenzyme A and palmitoylcarnitine interaction with perdeuterated-chain phospholipid bilayers. 1995 Eur. J. Biochem. pmid:7628471
Dumonteil E et al. Effects of palmitoyl carnitine and related metabolites on the avian Ca(2+)-ATPase and Ca2+ release channel. 1994 J. Physiol. (Lond.) pmid:7990033
Yao KW et al. The relationship between mitochondrial activation and toxicity of some substituted carboxylic acids. 1994 Chem. Biol. Interact. pmid:8168171
Fantini E et al. Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenation. 1994 J. Mol. Cell. Cardiol. pmid:7799450
Arduini A et al. Effects of L-carnitine and its acetate and propionate esters on the molecular dynamics of human erythrocyte membrane. 1993 Biochim. Biophys. Acta pmid:8383998
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Halliday GM and Lucas AD Protein kinase C transduces the signal for Langerhans' cell migration from the epidermis. 1993 Immunology pmid:8406587
el-Hayek R et al. Activation of the Ca2+ release channel of skeletal muscle sarcoplasmic reticulum by palmitoyl carnitine. 1993 Biophys. J. pmid:8218902
Eaton S et al. Intramitochondrial control of the oxidation of hexadecanoate in skeletal muscle. A study of the acyl-CoA esters which accumulate during rat skeletal-muscle mitochondrial beta-oxidation of [U-14C]hexadecanoate and [U-14C]hexadecanoyl-carnitine. 1993 Biochem. J. pmid:8424753
Chiodi P et al. Tissue lipid accumulation by L-aminocarnitine, an inhibitor of carnitine-palmitoyltransferase-2. Studies in intact rats and isolated mitochondria. 1992 Biochim. Biophys. Acta pmid:1627637
Stapleton SR et al. Palmitoyl-DL-carnitine has calcium-dependent effects on cultured neurones from rat dorsal root ganglia. 1992 Br. J. Pharmacol. pmid:1334752
Garsetti DE et al. Isolation and characterization of three lysophospholipases from the murine macrophage cell line WEHI 265.1. 1992 Biochim. Biophys. Acta pmid:1450218