Palmitoylcarnitine

Palmitoylcarnitine is a lipid of Fatty Acyls (FA) class.

Cross Reference

There are no associated biomedical information in the current reference collection.

Current reference collection contains 1026 references associated with Palmitoylcarnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

Users can download the reference list at the bottom of this page and read the reference manually to find out biomedical information.


Here are additional resources we collected from PubChem and MeSH for Palmitoylcarnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Palmitoylcarnitine

MeSH term MeSH ID Detail
Coronary Disease D003327 70 associated lipids
Insulin Resistance D007333 99 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Total 3

NCBI Entrez Crosslinks

All references with Palmitoylcarnitine

Download all related citations
Per page 10 20 50 100 | Total 302
Authors Title Published Journal PubMed Link
Felser A et al. Hepatic toxicity of dronedarone in mice: role of mitochondrial β-oxidation. 2014 Toxicology pmid:24881592
Quinlan CL et al. Sites of reactive oxygen species generation by mitochondria oxidizing different substrates. 2013 Redox Biol pmid:24024165
Al-Bakheit A et al. Accumulation of Palmitoylcarnitine and Its Effect on Pro-Inflammatory Pathways and Calcium Influx in Prostate Cancer. 2016 Prostate pmid:27403764
Leonardi R et al. Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17242360
Katoh N et al. Substrate proteins for calmodulin-sensitive and phospholipid-sensitive Ca2+-dependent protein kinases in heart, and inhibition of their phosphorylation by palmitoylcarnitine. 1981 Proc. Natl. Acad. Sci. U.S.A. pmid:6946429
Valentine MA et al. Expression of the human B-cell surface protein CD20: alteration by phorbol 12-myristate 13-acetate. 1987 Proc. Natl. Acad. Sci. U.S.A. pmid:3500472
Ellis CJ et al. Myoglobinuria: the importance of reaching a firm diagnosis--a patient with defective fatty acid oxidation. 1990 Postgrad Med J pmid:2362895
Lou PH et al. The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases. 2014 PLoS ONE pmid:24498043
Voss U et al. Enteric neuropathy can be induced by high fat diet in vivo and palmitic acid exposure in vitro. 2013 PLoS ONE pmid:24312551
van Eunen K et al. Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload. 2013 PLoS Comput. Biol. pmid:23966849
Endlicher R et al. Peroxidative damage of mitochondrial respiration is substrate-dependent. 2009 Physiol Res pmid:19093725
Cervinková Z et al. Inhibition of palmityl carnitine oxidation in rat liver mitochondria by tert-butyl hydroperoxide. 2008 Physiol Res pmid:17465699
O'Hagan DT et al. Nasal absorption enhancers for biosynthetic human growth hormone in rats. 1990 Pharm. Res. pmid:2395807
Primassin S et al. Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine. 2008 Pediatr. Res. pmid:18317232
Gregersen N Studies on the effects of saturated and unsaturated short-chain monocarboxylic acids on the energy metabolism of rat liver mitochondria. 1979 Pediatr. Res. pmid:514688
Cortright RN et al. Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training. 2006 Obesity (Silver Spring) pmid:16899801
Dixen K et al. ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes. 2013 Obesity (Silver Spring) pmid:23404793
Muraki K [Analyses of Ca-related ion channel currents and their involvement in Ca mobilization in smooth muscle and endothelial cells]. 2003 Nippon Yakurigaku Zasshi pmid:12673948
Abiko Y et al. [A new approach to the understanding of the mechanism of ischemia/reperfusion damage in the heart and the effects of anti-ischemic drugs]. 1996 Nippon Yakurigaku Zasshi pmid:8940701
Szczepankowska D and Nałecz KA Palmitoylcarnitine modulates palmitoylation of proteins: implication for differentiation of neural cells. 2003 Neurochem. Res. pmid:12675156
Bonnefont JP et al. Bezafibrate for an inborn mitochondrial beta-oxidation defect. 2009 N. Engl. J. Med. pmid:19228633
Shao Y et al. Lipid metabolites and their differential pro-arrhythmic profiles: of importance in the development of a new anti-arrhythmic pharmacology. 2014 Mol. Cell. Biochem. pmid:24771065
Ziolo MT et al. Effects of arrhythmogenic lipid metabolites on the L-type calcium current of diabetic vs. non-diabetic rat hearts. 2001 Mol. Cell. Biochem. pmid:11451378
Brosnan JT and Reid K Inhibition of palmitoylcarnitine oxidation by pyruvate in rat heart mitochondria. 1985 Metab. Clin. Exp. pmid:3999980
Privette JD et al. Fatty acid oxidation by skeletal muscle homogenates from morbidly obese black and white American women. 2003 Metab. Clin. Exp. pmid:12800100
Hara A et al. Beneficial effects of dilazep on the palmitoyl-L-carnitine-induced derangements in isolated, perfused rat heart: comparison with tetrodotoxin. 1997 Jpn. J. Pharmacol. pmid:9243322
Matsui K et al. Effect of l-carnitine chloride and its acetyl derivative on the electrophysiological derangement induced by palmityl-l-carnitine in isolated canine ventricular muscle. 1985 Jpn. J. Pharmacol. pmid:4087570
Dumonteil E et al. Effects of palmitoyl carnitine and related metabolites on the avian Ca(2+)-ATPase and Ca2+ release channel. 1994 J. Physiol. (Lond.) pmid:7990033
Muraki K and Imaizumi Y A novel action of palmitoyl-L-carnitine in human vascular endothelial cells. 2003 J. Pharmacol. Sci. pmid:12890891
Bergstrand H et al. Modulation of human basophil histamine release by protein kinase C inhibitors differs with secretagogue and with inhibitor. 1992 J. Pharmacol. Exp. Ther. pmid:1372047
Wu Y et al. The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular diastolic dysfunction. 2009 J. Pharmacol. Exp. Ther. pmid:19403851
Duizer E et al. Absorption enhancement, structural changes in tight junctions and cytotoxicity caused by palmitoyl carnitine in Caco-2 and IEC-18 cells. 1998 J. Pharmacol. Exp. Ther. pmid:9765361
Hara A et al. Protective effects of dilazep and its derivative K-7259 on the haemolysis induced by amphiphiles in rat erythrocytes. 1997 J. Pharm. Pharmacol. pmid:9379361
Wenzel U et al. Increased carnitine-dependent fatty acid uptake into mitochondria of human colon cancer cells induces apoptosis. 2005 J. Nutr. pmid:15930461
Schmidt I and Herpin P Carnitine palmitoyltransferase I (CPT I) activity and its regulation by malonyl-CoA are modulated by age and cold exposure in skeletal muscle mitochondria from newborn pigs. 1998 J. Nutr. pmid:9566999
Clarke B et al. On the roles of long-chain acyl carnitine accumulation and impaired glucose utilization in ischaemic contracture development and tissue damage in the guinea-pig heart. 1996 J. Mol. Cell. Cardiol. pmid:8745225
Netticadan T et al. Palmitoyl carnitine increases intracellular calcium in adult rat cardiomyocytes. 1999 J. Mol. Cell. Cardiol. pmid:10403753
Williams ES and Li TK The effect of chronic alcohol administration on fatty acid metabolism and pyruvate oxidation of heart mitochondria. 1977 J. Mol. Cell. Cardiol. pmid:563474
Fantini E et al. Some biochemical aspects of the protective effect of trimetazidine on rat cardiomyocytes during hypoxia and reoxygenation. 1994 J. Mol. Cell. Cardiol. pmid:7799450
Zhang XJ et al. Measurement of precursor enrichment for calculating intramuscular triglyceride fractional synthetic rate. 2012 J. Lipid Res. pmid:21934122
Shi X et al. Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity. 2012 J. Lipid Res. pmid:22904346
Sun D et al. Measurement of stable isotopic enrichment and concentration of long-chain fatty acyl-carnitines in tissue by HPLC-MS. 2006 J. Lipid Res. pmid:16301738
Arduini A et al. High performance liquid chromatography of long-chain acylcarnitine and phospholipids in fatty acid turnover studies. 1996 J. Lipid Res. pmid:8728329
Ballantyne JS and Storey KB Mitochondria from the hepatopancreas of the marine clam Mercenaria mercenaria: substrate preferences and salt and pH effects on the oxidation of palmitoyl-L-carnitine and succinate. 1984 J. Exp. Zool. pmid:6736891
Liu H et al. Cysteine-scanning mutagenesis of muscle carnitine palmitoyltransferase I reveals a single cysteine residue (Cys-305) is important for catalysis. 2005 J. Biol. Chem. pmid:15579906
Sekoguchi E et al. A novel mitochondrial carnitine-acylcarnitine translocase induced by partial hepatectomy and fasting. 2003 J. Biol. Chem. pmid:12882971
Murthy MS and Pande SV Mechanism of carnitine acylcarnitine translocase-catalyzed import of acylcarnitines into mitochondria. 1984 J. Biol. Chem. pmid:6430896
Sabbagh E et al. 3-Mercaptopropionic acid, a potent inhibitor of fatty acid oxidation in rat heart mitochondria. 1985 J. Biol. Chem. pmid:3997873
Mak IT et al. Potentiation of free radical-induced lipid peroxidative injury to sarcolemmal membranes by lipid amphiphiles. 1986 J. Biol. Chem. pmid:3003057
Bussolino F et al. Platelet-activating factor enhances complement-dependent phagocytosis of diamide-treated erythrocytes by human monocytes through activation of protein kinase C and phosphorylation of complement receptor type one (CR1). 1989 J. Biol. Chem. pmid:2600088