Palmitoylcarnitine

Palmitoylcarnitine is a lipid of Fatty Acyls (FA) class.

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There are no associated biomedical information in the current reference collection.

Current reference collection contains 1026 references associated with Palmitoylcarnitine in LipidPedia. Due to lack of full text of references or no associated biomedical terms are recognized in our current text-mining method, we cannot extract any biomedical terms related to diseases, pathways, locations, functions, genes, lipids, and animal models from the associated reference collection.

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Here are additional resources we collected from PubChem and MeSH for Palmitoylcarnitine

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Palmitoylcarnitine

MeSH term MeSH ID Detail
Coronary Disease D003327 70 associated lipids
Insulin Resistance D007333 99 associated lipids
Mitochondrial Diseases D028361 25 associated lipids
Total 3

NCBI Entrez Crosslinks

All references with Palmitoylcarnitine

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Authors Title Published Journal PubMed Link
Ojuka E et al. Measurement of β-oxidation capacity of biological samples by respirometry: a review of principles and substrates. 2016 Am. J. Physiol. Endocrinol. Metab. pmid:26908505
Vorkas PA et al. Metabolic Phenotypes of Carotid Atherosclerotic Plaques Relate to Stroke Risk: An Exploratory Study. 2016 Eur J Vasc Endovasc Surg pmid:27231199
Al-Bakheit A et al. Accumulation of Palmitoylcarnitine and Its Effect on Pro-Inflammatory Pathways and Calcium Influx in Prostate Cancer. 2016 Prostate pmid:27403764
Cavar M et al. Trimetazidine does not alter metabolic substrate oxidation in cardiac mitochondria of target patient population. 2016 Br. J. Pharmacol. pmid:26844527
Schooneman MG et al. Transorgan fluxes in a porcine model reveal a central role for liver in acylcarnitine metabolism. 2015 Am. J. Physiol. Endocrinol. Metab. pmid:26037250
Roussel J et al. Palmitoyl-carnitine increases RyR2 oxidation and sarcoplasmic reticulum Ca2+ leak in cardiomyocytes: Role of adenine nucleotide translocase. 2015 Biochim. Biophys. Acta pmid:25619687
Lou PH et al. The mechanism of Intralipid®-mediated cardioprotection complex IV inhibition by the active metabolite, palmitoylcarnitine, generates reactive oxygen species and activates reperfusion injury salvage kinases. 2014 PLoS ONE pmid:24498043
Felser A et al. Hepatic toxicity of dronedarone in mice: role of mitochondrial β-oxidation. 2014 Toxicology pmid:24881592
Shao Y et al. Lipid metabolites and their differential pro-arrhythmic profiles: of importance in the development of a new anti-arrhythmic pharmacology. 2014 Mol. Cell. Biochem. pmid:24771065
Zhang H et al. Metabolomic analysis of biochemical changes in the plasma and urine of collagen-induced arthritis in rats after treatment with Huang-Lian-Jie-Du-Tang. 2014 J Ethnopharmacol pmid:24709313
Voss U et al. Enteric neuropathy can be induced by high fat diet in vivo and palmitic acid exposure in vitro. 2013 PLoS ONE pmid:24312551
Quinlan CL et al. Sites of reactive oxygen species generation by mitochondria oxidizing different substrates. 2013 Redox Biol pmid:24024165
Kanaley JA et al. Hyperinsulinemia and skeletal muscle fatty acid trafficking. 2013 Am. J. Physiol. Endocrinol. Metab. pmid:23820622
van Eunen K et al. Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload. 2013 PLoS Comput. Biol. pmid:23966849
Gupte AA et al. High-fat feeding-induced hyperinsulinemia increases cardiac glucose uptake and mitochondrial function despite peripheral insulin resistance. 2013 Endocrinology pmid:23709089
Perevoshchikova IV et al. Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria. 2013 Free Radic. Biol. Med. pmid:23583329
Dixen K et al. ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes. 2013 Obesity (Silver Spring) pmid:23404793
Morand R et al. Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction. 2013 Anal Bioanal Chem pmid:23995505
Zhang XJ et al. Measurement of precursor enrichment for calculating intramuscular triglyceride fractional synthetic rate. 2012 J. Lipid Res. pmid:21934122
Shi X et al. Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity. 2012 J. Lipid Res. pmid:22904346
Jørgensen W et al. Progression of type 2 diabetes in GK rats affects muscle and liver mitochondria differently: pronounced reduction of complex II flux is observed in liver only. 2012 Am. J. Physiol. Endocrinol. Metab. pmid:22713504
Tonazzi A et al. Identification by site-directed mutagenesis of a hydrophobic binding site of the mitochondrial carnitine/acylcarnitine carrier involved in the interaction with acyl groups. 2012 Biochim. Biophys. Acta pmid:22365929
Nguyen UT et al. Small-molecule modulators of Listeria monocytogenes biofilm development. 2012 Appl. Environ. Microbiol. pmid:22194285
Wenderska IB et al. Palmitoyl-DL-carnitine is a multitarget inhibitor of Pseudomonas aeruginosa biofilm development. 2011 Chembiochem pmid:22045628
Brandhonneur N et al. Ex vivo and in vivo diffusion of ropivacaine through spinal meninges: influence of absorption enhancers. 2011 Int J Pharm pmid:21056096
Doi N et al. Absorption enhancement effect of acylcarnitines through changes in tight junction protein in Caco-2 cell monolayers. 2011 Drug Metab. Pharmacokinet. pmid:21206134
De Jesús VR et al. Comparison of amino acids and acylcarnitines assay methods used in newborn screening assays by tandem mass spectrometry. 2010 Clin. Chim. Acta pmid:20122909
Hoffman DL and Brookes PS Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions. 2009 J. Biol. Chem. pmid:19366681
Schaeffer PJ et al. Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. 2009 Am. J. Physiol. Heart Circ. Physiol. pmid:19700627
Wu Y et al. The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular diastolic dysfunction. 2009 J. Pharmacol. Exp. Ther. pmid:19403851
Bonnefont JP et al. Bezafibrate for an inborn mitochondrial beta-oxidation defect. 2009 N. Engl. J. Med. pmid:19228633
Inokuchi H et al. The effect of hyperosmosis on paracellular permeability in Caco-2 cell monolayers. 2009 Biosci. Biotechnol. Biochem. pmid:19202294
Endlicher R et al. Peroxidative damage of mitochondrial respiration is substrate-dependent. 2009 Physiol Res pmid:19093725
Primassin S et al. Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine. 2008 Pediatr. Res. pmid:18317232
Tominaga H et al. Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18469143
Abdul-Ghani MA et al. Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance. 2008 Am. J. Physiol. Endocrinol. Metab. pmid:18593850
Lehman JJ et al. The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18487436
Cervinková Z et al. Inhibition of palmityl carnitine oxidation in rat liver mitochondria by tert-butyl hydroperoxide. 2008 Physiol Res pmid:17465699
Nałecz KA et al. Palmitoylcarnitine regulates estrification of lipids and promotes palmitoylation of GAP-43. 2007 FEBS Lett. pmid:17662726
Ma L et al. Modulation of tight junction properties relevant to fluid transport across rabbit corneal endothelium. 2007 Exp. Eye Res. pmid:17320078
Leonardi R et al. Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17242360
Fernström M et al. Reduced efficiency, but increased fat oxidation, in mitochondria from human skeletal muscle after 24-h ultraendurance exercise. 2007 J. Appl. Physiol. pmid:17234801
Michel AD and Fonfria E Agonist potency at P2X7 receptors is modulated by structurally diverse lipids. 2007 Br. J. Pharmacol. pmid:17700717
Cortright RN et al. Skeletal muscle fat oxidation is increased in African-American and white women after 10 days of endurance exercise training. 2006 Obesity (Silver Spring) pmid:16899801
Johnson G et al. Influence of intensity of food restriction on skeletal muscle mitochondrial energy metabolism in rats. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16621897
Sobiesiak-Mirska J and Nałecz KA Palmitoylcarnitine modulates interaction between protein kinase C betaII and its receptor RACK1. 2006 FEBS J. pmid:16519693
Sun D et al. Measurement of stable isotopic enrichment and concentration of long-chain fatty acyl-carnitines in tissue by HPLC-MS. 2006 J. Lipid Res. pmid:16301738
Wenzel U et al. Increased mitochondrial palmitoylcarnitine/carnitine countertransport by flavone causes oxidative stress and apoptosis in colon cancer cells. 2005 Cell. Mol. Life Sci. pmid:16314920
Wenzel U et al. Increased carnitine-dependent fatty acid uptake into mitochondria of human colon cancer cells induces apoptosis. 2005 J. Nutr. pmid:15930461
Silvestri E et al. Thyroid-hormone effects on putative biochemical pathways involved in UCP3 activation in rat skeletal muscle mitochondria. 2005 FEBS Lett. pmid:15757654