Propionylcarnitine

Propionylcarnitine is a lipid of Fatty Acyls (FA) class. Propionylcarnitine is associated with abnormalities such as Failure to Thrive. The involved functions are known as Functional disorder. Propionylcarnitine often locates in Body tissue.

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Introduction

To understand associated biological information of Propionylcarnitine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Propionylcarnitine?

Propionylcarnitine is suspected in Failure to Thrive and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Propionylcarnitine

MeSH term MeSH ID Detail
Penile Induration D010411 4 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Pregnancy Complications D011248 19 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Starvation D013217 47 associated lipids
Reperfusion Injury D015427 65 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Body Weight D001835 333 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Propionylcarnitine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Propionylcarnitine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Propionylcarnitine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Propionylcarnitine

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Authors Title Published Journal PubMed Link
Kushnir MM et al. Serum acylcarnitines and vitamin B12 deficiency. 2002 Clin. Chem. pmid:12089192
Mister M et al. Propionyl-L-carnitine prevents renal function deterioration due to ischemia/reperfusion. 2002 Kidney Int. pmid:11849462
Orlandi A et al. Propionyl-L-carnitine reduces intimal hyperplasia after injury in normocholesterolemic rabbit carotid artery by modulating proliferation and caspase 3-dependent apoptosis of vascular smooth muscle cells. 2002 Atherosclerosis pmid:11755925
Cavallini G et al. Oral propionyl-l-carnitine and intraplaque verapamil in the therapy of advanced and resistant Peyronie's disease. 2002 BJU Int. pmid:12010235
Signorelli SS et al. Effects of ischaemic stress on leukocyte activation processes in patients with chronic peripheral occlusive arterial disease: role of L-propionyl carnitine administration. 2001 Pharmacol. Res. pmid:11592865
Barker GA et al. Effect of propionyl-L-carnitine on exercise performance in peripheral arterial disease. 2001 Med Sci Sports Exerc pmid:11528327
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Doggrell SA Pharmacotherapy of intermittent claudication. 2001 Expert Opin Pharmacother pmid:11825312
Sayed-Ahmed MM et al. Propionyl-L-carnitine as protector against adriamycin-induced cardiomyopathy. 2001 Pharmacol. Res. pmid:11419959
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Hiatt WR et al. Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication. 2001 Am. J. Med. pmid:11382369
Chace DH et al. Rapid diagnosis of methylmalonic and propionic acidemias: quantitative tandem mass spectrometric analysis of propionylcarnitine in filter-paper blood specimens obtained from newborns. 2001 Clin. Chem. pmid:11673377
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Ganapathy ME et al. beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. 2000 J. Biol. Chem. pmid:10636865
Roe DS et al. Evidence for a short-chain carnitine-acylcarnitine translocase in mitochondria specifically related to the metabolism of branched-chain amino acids. 2000 Mol. Genet. Metab. pmid:10655160
Pace S et al. Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsorption. 2000 Br J Clin Pharmacol pmid:11069438
Mancinelli A et al. Disposition of L-carnitine and its short-chain esters, acetyl-L-carnitine and propionyl-L-carnitine, in the rat isolated perfused liver. 2000 Drug Metab. Dispos. pmid:11095575
Broderick TL et al. Propionyl-L-carnitine effects on postischemic recovery of heart function and substrate oxidation in the diabetic rat. 2000 Mol. Cell. Biochem. pmid:10839205
Libert R et al. Identification of undescribed medium-chain acylcarnitines present in urine of patients with propionic and methylmalonic acidemias. 2000 Clin. Chim. Acta pmid:10767396
Sayed-Ahmed MM et al. Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid beta-oxidation in isolated heart mitochondria. 2000 Pharmacol. Res. pmid:10623482
Cipolla MJ et al. Propionyl-L-carnitine dilates human subcutaneous arteries through an endothelium-dependent mechanism. 1999 J. Vasc. Surg. pmid:10359944
Triggiani M et al. Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine. 1999 Biochem. Pharmacol. pmid:10487538
Brevetti G et al. European multicenter study on propionyl-L-carnitine in intermittent claudication. 1999 J. Am. Coll. Cardiol. pmid:10551714
Wu X et al. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. 1999 J. Pharmacol. Exp. Ther. pmid:10454528
Palmieri L et al. Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae. 1999 FEBS Lett. pmid:10622748
Löster H et al. Effects of L-carnitine and its acetyl and propionyl esters on ATP and PCr levels of isolated rat hearts perfused without fatty acids and investigated by means of 31P-NMR spectroscopy. 1999 Mol. Cell. Biochem. pmid:10569188
Stroh R et al. L-propionyl carnitine, an endogenous ester in fatty acid metabolism, exerts anti-shock and endothelial protective effects in rat splanchnic ischemia-reperfusion injury. 1998 Shock pmid:9525330
Wiseman LR and Brogden RN Propionyl-L-carnitine. 1998 Drugs Aging pmid:9534023
Giovannini L et al. Acute CYA-induced ATP depletion is prevented by pretreatment with L-propionylcarnitine in isolated and perfused rat kidney. 1998 Transplant. Proc. pmid:9723376
Terada R et al. Effects of propionyl-L-carnitine on cardiac dysfunction in streptozotocin-diabetic rats. 1998 Eur. J. Pharmacol. pmid:9797035
Brevetti G et al. Effect of propionyl-L-carnitine on quality of life in intermittent claudication. 1997 Am. J. Cardiol. pmid:9070558
El Alaoui-Talibi Z et al. Control of oxidative metabolism in volume-overloaded rat hearts: effect of propionyl-L-carnitine. 1997 Am. J. Physiol. pmid:9139943
Capecchi PL et al. Carnitines increase plasma levels of adenosine and ATP in humans. 1997 Vasc Med pmid:9546959
Davenport RJ et al. Automated chemoenzymatic synthesis of no-carrier-added [carbonyl-11C]propionyl L-carnitine for pharmacokinetic studies. 1997 Appl Radiat Isot pmid:9376826
Serjeant BE et al. Propionyl-L-carnitine in chronic leg ulcers of homozygous sickle cell disease: a pilot study. 1997 J. Am. Acad. Dermatol. pmid:9308570
Ferrari R and De Giuli F The propionyl-L-carnitine hypothesis: an alternative approach to treating heart failure. 1997 J. Card. Fail. pmid:9330130
Palomba D et al. Metabolic and renal effects of Laevo-carnitine and propionyl-carnitine in rats with subtotal nephrectomy. 1996 Sep-Oct Pharmacol. Res. pmid:9051710
Valoti M et al. Effects of carnitine and its derivatives on gastric acid secretion in rats. 1996 Nov-Dec Pharmacol. Res. pmid:9076846
Cunningham VJ et al. Uptake of [N-methyl-11C]propionyl-L-carnitine (PLC) in human myocardium. 1996 J. Pharmacol. Exp. Ther. pmid:8613961
Micheletti R et al. Effect of propionyl-L-carnitine on the mechanics of right and left papillary muscles from volume-overloaded rat hearts. 1996 J. Cardiovasc. Pharmacol. pmid:8656658
Mauriello A et al. Effect of long-term treatment with propionyl-L-carnitine on smooth muscle cell polyploidy in spontaneously hypertensive rats. 1996 Hypertension pmid:8707378
Broderick TL et al. L-propionylcarnitine enhancement of substrate oxidation and mitochondrial respiration in the diabetic rat heart. 1996 J. Mol. Cell. Cardiol. pmid:8729065
Hotta N et al. Effect of propionyl-L-carnitine on motor nerve conduction, autonomic cardiac function, and nerve blood flow in rats with streptozotocin-induced diabetes: comparison with an aldose reductase inhibitor. 1996 J. Pharmacol. Exp. Ther. pmid:8558455
Hotta N et al. Effect of propionyl-L-carnitine on oscillatory potentials in electroretinogram in streptozotocin-diabetic rats. 1996 Eur. J. Pharmacol. pmid:8891600
Taylor DJ et al. Changes in energy metabolism of calf muscle in patients with intermittent claudication assessed by 31P magnetic resonance spectroscopy: a phase II open study. 1996 Vasc Med pmid:9552578
Reggiani C et al. Effect of propionyl-L-carnitine (PLC) on the kinetic properties of the myofibrillar system in pressure overload cardiac hypertrophy. 1995 Ann. N. Y. Acad. Sci. pmid:7755261
Maresca P et al. Propionyl-L-carnitine improves mechanical performance of papillary muscle from dilated cardiomyopathic hamsters. 1995 Ann. N. Y. Acad. Sci. pmid:7755262
Li P et al. Myocyte performance during evolution of myocardial infarction in rats: effects of propionyl-L-carnitine. 1995 Am. J. Physiol. pmid:7733374
Torielli L et al. Alterations in energy metabolism of hypertrophied rat cardiomyocytes: influence of propionyl-L-carnitine. 1995 J. Cardiovasc. Pharmacol. pmid:8583777
Micheletti R et al. Effect of propionyl-l-carnitine and enalapril on cardiac function of pressure-overloaded rats during increase in load. 1995 Eur. J. Pharmacol. pmid:8605951
Davenport RJ et al. Propionyl-L-carnitine: labelling in the N-methyl position with carbon-11 and pharmacokinetic studies in rats. 1995 Nucl. Med. Biol. pmid:8535330
Odiet JA et al. Carnitine palmitoyl transferase-I activity in the aging mouse heart. 1995 Mech. Ageing Dev. pmid:7616763
Schönekess BO et al. Propionyl L-carnitine improvement of hypertrophied heart function is accompanied by an increase in carbohydrate oxidation. 1995 Circ. Res. pmid:7554119
Corsi C et al. L-propionylcarnitine effect on postexercise and postischemic hyperemia in patients affected by peripheral vascular disease. 1995 Angiology pmid:7639417
Brevetti G et al. Propionyl-L-carnitine in intermittent claudication: double-blind, placebo-controlled, dose titration, multicenter study. 1995 J. Am. Coll. Cardiol. pmid:7594063
Spagnoli LG et al. Propionyl-L-carnitine prevents the progression of atherosclerotic lesions in aged hyperlipemic rabbits. 1995 Atherosclerosis pmid:7605374
Russell RR et al. Propionyl-L-carnitine-mediated improvement in contractile function of rat hearts oxidizing acetoacetate. 1995 Am. J. Physiol. pmid:7840294
Maresca P et al. Positive action of propionyl-L-carnitine on mechanical performance of papillary muscle from Syrian hamsters with hereditary dilated cardiomyopathy. 1995 Eur. J. Pharmacol. pmid:8991805
Caruso A et al. Protective effect of propionyl-L-carnitine against PAF-induced rat paw oedema. 1995 Pharmacol. Res. pmid:7784308
Cotter MA et al. Effects of acetyl- and proprionyl-L-carnitine on peripheral nerve function and vascular supply in experimental diabetes. 1995 Metab. Clin. Exp. pmid:7666797
Schönekess BO et al. Propionyl L-carnitine improvement of hypertrophied rat heart function is associated with an increase in cardiac efficiency. 1995 Eur. J. Pharmacol. pmid:8605952
Di Lisa F et al. Contrasting effects of propionate and propionyl-L-carnitine on energy-linked processes in ischemic hearts. 1994 Am. J. Physiol. pmid:8067396
Micheletti R et al. Propionyl-L-carnitine prevents myocardial mechanical alterations due to pressure overload in rats. 1994 Am. J. Physiol. pmid:8023981
Bartels GL et al. Effects of L-propionylcarnitine on ischemia-induced myocardial dysfunction in men with angina pectoris. 1994 Am. J. Cardiol. pmid:8023775
De Maria P et al. Effect of the addition of electrolytes on the partition coefficients, activity coefficients, and acid dissociation constants of carnitine and its acetyl and propionyl derivatives. 1994 J Pharm Sci pmid:8071833
Tassani V et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. 1994 Biochem. Biophys. Res. Commun. pmid:8135845
Brass EP et al. Carnitine delays rat skeletal muscle fatigue in vitro. 1993 J. Appl. Physiol. pmid:8282608
Riva E and Leopaldi D Control of the cardiac consequences of myocardial ischemia and reperfusion by L-propionylcarnitine: age-response and dose-response studies in the rat heart. 1993 Pediatr. Res. pmid:8255679
Mancinelli R L-propionylcarnitine and synchronization of spontaneous activity in rat isolated portal vein. 1993 Arch Ital Biol pmid:8338391
Arduini A et al. Effects of L-carnitine and its acetate and propionate esters on the molecular dynamics of human erythrocyte membrane. 1993 Biochim. Biophys. Acta pmid:8383998
Micheletti R et al. Propionyl-L-carnitine limits chronic ventricular dilation after myocardial infarction in rats. 1993 Am. J. Physiol. pmid:8476087
Duncker DJ et al. L-propionylcarnitine does not affect myocardial metabolic or functional response to chronotropic and inotropic stimulation after repetitive ischemia in anesthetized pigs. 1993 J. Cardiovasc. Pharmacol. pmid:7504143
Minkler PE and Hoppel CL Quantification of free carnitine, individual short- and medium-chain acylcarnitines, and total carnitine in plasma by high-performance liquid chromatography. 1993 Anal. Biochem. pmid:8214594
Ferrari R et al. Prolonged propionyl-L-carnitine pre-treatment of rabbit: biochemical, hemodynamic and electrophysiological effects on myocardium. 1992 J. Mol. Cell. Cardiol. pmid:1625347
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Reznick AZ et al. Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation. 1992 Arch. Biochem. Biophys. pmid:1321584
Sakuma T et al. The urinary acylcarnitine profile in three cases of transient hyperammonemia of the newborn. 1992 Acta Paediatr. pmid:1498512
Motterlini R et al. Functional and metabolic effects of propionyl-L-carnitine in the isolated perfused hypertrophied rat heart. 1992 Mol. Cell. Biochem. pmid:1480142
Bartels GL et al. Acute improvement of cardiac function with intravenous L-propionylcarnitine in humans. 1992 J. Cardiovasc. Pharmacol. pmid:1383625
Yang XP et al. Hemodynamic and metabolic activities of propionyl-L-carnitine in rats with pressure-overload cardiac hypertrophy. 1992 J. Cardiovasc. Pharmacol. pmid:1383636
Brass EP et al. Effect of carnitine acetyltransferase inhibition on rat hepatocyte metabolism. 1991 Biochim. Biophys. Acta pmid:1932127
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Brevetti G et al. Muscle carnitine deficiency in patients with severe peripheral vascular disease. 1991 Circulation pmid:1914091
Sassen LM et al. L-propionylcarnitine increases postischemic blood flow but does not affect recovery of energy charge. 1991 Am. J. Physiol. pmid:1858918
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Pierce GN et al. Na(+)-H+ exchange in cardiac sarcolemmal vesicles isolated from diabetic rats. 1990 Am. J. Physiol. pmid:2154133
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Brass EP and Ruff LJ Effect of carnitine on propionate metabolism in the vitamin B-12--deficient rat. 1989 J. Nutr. pmid:2778544
Sherry AD et al. Propionate metabolism in the rat heart by 13C n.m.r. spectroscopy. 1988 Biochem. J. pmid:3178775
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Liedtke AJ et al. Effects of L-propionylcarnitine on mechanical recovery during reflow in intact hearts. 1988 Am. J. Physiol. pmid:3394817
Brass EP and Beyerinck RA Interactions of propionate and carnitine metabolism in isolated rat hepatocytes. 1987 Metab. Clin. Exp. pmid:3110541
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