Propionylcarnitine

Propionylcarnitine is a lipid of Fatty Acyls (FA) class. Propionylcarnitine is associated with abnormalities such as Failure to Thrive. The involved functions are known as Functional disorder. Propionylcarnitine often locates in Body tissue.

Cross Reference

Introduction

To understand associated biological information of Propionylcarnitine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Propionylcarnitine?

Propionylcarnitine is suspected in Failure to Thrive and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Propionylcarnitine

MeSH term MeSH ID Detail
Penile Induration D010411 4 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Pregnancy Complications D011248 19 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Starvation D013217 47 associated lipids
Reperfusion Injury D015427 65 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Body Weight D001835 333 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Propionylcarnitine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Propionylcarnitine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Propionylcarnitine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Propionylcarnitine

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Authors Title Published Journal PubMed Link
Cooper TG et al. Characteristics of the transport of carnitine into the cauda epididymidis of the rat as ascertained by luminal perfusion in vitro. 1986 Int. J. Androl. pmid:3570531
Di Biase M et al. Electrophysiologic evaluation of intravenous L-propionylcarnitine in man. 1991 Int. J. Cardiol. pmid:2055673
Lagioia R et al. Propionyl-L-carnitine: a new compound in the metabolic approach to the treatment of effort angina. 1992 Int. J. Cardiol. pmid:1737667
Tang YM et al. Urine and serum metabolomic profiling reveals that bile acids and carnitine may be potential biomarkers of primary biliary cirrhosis. 2015 Int. J. Mol. Med. pmid:26046127
Hiatt WR et al. Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease. 2011 Mar-Apr J Cardiopulm Rehabil Prev pmid:20861750
Kendler BS Supplemental conditionally essential nutrients in cardiovascular disease therapy. 2006 Jan-Feb J Cardiovasc Nurs pmid:16407731
Cheng KH et al. Newborn screening for methylmalonic aciduria by tandem mass spectrometry: 7 years' experience from two centers in Taiwan. 2010 J Chin Med Assoc pmid:20603089
D'Acquarica I et al. Enantio- and chemo-selective HPLC separations by chiral-achiral tandem-columns approach: the combination of CHIROBIOTIC TAG and SCX columns for the analysis of propionyl carnitine and related impurities. 2004 J Chromatogr A pmid:15641359
De Maria P et al. Effect of the addition of electrolytes on the partition coefficients, activity coefficients, and acid dissociation constants of carnitine and its acetyl and propionyl derivatives. 1994 J Pharm Sci pmid:8071833
Serjeant BE et al. Propionyl-L-carnitine in chronic leg ulcers of homozygous sickle cell disease: a pilot study. 1997 J. Am. Acad. Dermatol. pmid:9308570
Brevetti G et al. Propionyl-L-carnitine in intermittent claudication: double-blind, placebo-controlled, dose titration, multicenter study. 1995 J. Am. Coll. Cardiol. pmid:7594063
Brevetti G et al. European multicenter study on propionyl-L-carnitine in intermittent claudication. 1999 J. Am. Coll. Cardiol. pmid:10551714
Brass EP et al. Carnitine delays rat skeletal muscle fatigue in vitro. 1993 J. Appl. Physiol. pmid:8282608
Leipälä JA et al. Protection of the reperfused heart by L-propionylcarnitine. 1991 J. Appl. Physiol. pmid:1757378
Forny P et al. Novel Mouse Models of Methylmalonic Aciduria Recapitulate Phenotypic Traits with a Genetic Dosage Effect. 2016 J. Biol. Chem. pmid:27519416
Ganapathy ME et al. beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. 2000 J. Biol. Chem. pmid:10636865
Orlandi A et al. Propionyl-L-carnitine reduces proliferation and potentiates Bax-related apoptosis of aortic intimal smooth muscle cells by modulating nuclear factor-kappaB activity. 2007 J. Biol. Chem. pmid:17178728
Ferrari R and De Giuli F The propionyl-L-carnitine hypothesis: an alternative approach to treating heart failure. 1997 J. Card. Fail. pmid:9330130
Duncker DJ et al. L-propionylcarnitine does not affect myocardial metabolic or functional response to chronotropic and inotropic stimulation after repetitive ischemia in anesthetized pigs. 1993 J. Cardiovasc. Pharmacol. pmid:7504143
Aomine M et al. Electrophysiologic effects of a short-chain acyl carnitine, L-propionylcarnitine, on isolated canine Purkinje fibers. 1989 J. Cardiovasc. Pharmacol. pmid:2471897