Propionylcarnitine

Propionylcarnitine is a lipid of Fatty Acyls (FA) class. Propionylcarnitine is associated with abnormalities such as Failure to Thrive. The involved functions are known as Functional disorder. Propionylcarnitine often locates in Body tissue.

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Introduction

To understand associated biological information of Propionylcarnitine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Propionylcarnitine?

Propionylcarnitine is suspected in Failure to Thrive and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Propionylcarnitine

MeSH term MeSH ID Detail
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Body Weight D001835 333 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Erectile Dysfunction D007172 19 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Penile Induration D010411 4 associated lipids
Pregnancy Complications D011248 19 associated lipids
Starvation D013217 47 associated lipids
Reperfusion Injury D015427 65 associated lipids
Total 10

PubChem Associated disorders and diseases

What pathways are associated with Propionylcarnitine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Propionylcarnitine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Propionylcarnitine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Propionylcarnitine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Propionylcarnitine

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Authors Title Published Journal PubMed Link
Spagnoli LG et al. Propionyl-L-carnitine prevents the progression of atherosclerotic lesions in aged hyperlipemic rabbits. 1995 Atherosclerosis pmid:7605374
Orlandi A et al. Propionyl-L-carnitine reduces intimal hyperplasia after injury in normocholesterolemic rabbit carotid artery by modulating proliferation and caspase 3-dependent apoptosis of vascular smooth muscle cells. 2002 Atherosclerosis pmid:11755925
Al-Majed AA Carnitine deficiency provokes cisplatin-induced hepatotoxicity in rats. 2007 Basic Clin. Pharmacol. Toxicol. pmid:17309516
Tassani V et al. Anaplerotic effect of propionyl carnitine in rat heart mitochondria. 1994 Biochem. Biophys. Res. Commun. pmid:8135845
Sherry AD et al. Propionate metabolism in the rat heart by 13C n.m.r. spectroscopy. 1988 Biochem. J. pmid:3178775
Brass EP and Stabler SP Carnitine metabolism in the vitamin B-12-deficient rat. 1988 Biochem. J. pmid:3196310
Brass EP et al. Inhibition of oxidative metabolism by propionic acid and its reversal by carnitine in isolated rat hepatocytes. 1986 Biochem. J. pmid:3790065
Triggiani M et al. Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine. 1999 Biochem. Pharmacol. pmid:10487538
Brass EP et al. Effect of carnitine acetyltransferase inhibition on rat hepatocyte metabolism. 1991 Biochim. Biophys. Acta pmid:1932127
Arduini A et al. Effects of L-carnitine and its acetate and propionate esters on the molecular dynamics of human erythrocyte membrane. 1993 Biochim. Biophys. Acta pmid:8383998
Hokland BM and Bremer J Metabolism and excretion of carnitine and acylcarnitines in the perfused rat kidney. 1986 Biochim. Biophys. Acta pmid:3697382
Vargiu R et al. Positive inotropic effect of coenzyme Q10, omega-3 fatty acids and propionyl-L-carnitine on papillary muscle force-frequency responses of BIO TO-2 cardiomyopathic Syrian hamsters. 2008 Biofactors pmid:19096109
Vargiu R et al. Enhancement of shortening velocity, power, and acto-myosin crossbridge (CB) kinetics following long-term treatment with propionyl-L-carnitine, coenzyme Q10, and omega-3 fatty acids in BIO TO-2 cardiomyopathic Syrian hamsters papillary muscle. 2010 May-Jun Biofactors pmid:20533397
Origlia N et al. Protective effect of L-propionylcarnitine in chronic cyclosporine-a induced nephrotoxicity. 2006 Biomed. Pharmacother. pmid:16472963
Cavallini G et al. Oral propionyl-l-carnitine and intraplaque verapamil in the therapy of advanced and resistant Peyronie's disease. 2002 BJU Int. pmid:12010235
Pace S et al. Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsorption. 2000 Br J Clin Pharmacol pmid:11069438
Mingorance C et al. Oral supplementation of propionyl-l-carnitine reduces body weight and hyperinsulinaemia in obese Zucker rats. 2009 Br. J. Nutr. pmid:19545458
Elliott GR et al. The effect of acute feeding of carnitine, acetyl carnitine and propionyl carnitine on basal and A23187-stimulated eicosanoid release from rat carrageenan-elicited peritoneal macrophages. 1990 Br. J. Nutr. pmid:2171633
Barbieri M et al. Lack of correlation between the antiarrhythmic effect of L-propionylcarnitine on reoxygenation-induced arrhythmias and its electrophysiological properties. 1991 Br. J. Pharmacol. pmid:2043933
Laviano A et al. Carnitine administration reduces cytokine levels, improves food intake, and ameliorates body composition in tumor-bearing rats. 2011 Cancer Invest. pmid:22085273
Huang Q et al. Metabolic characterization of hepatocellular carcinoma using nontargeted tissue metabolomics. 2013 Cancer Res. pmid:23824744
Koh SG et al. Exercise intolerance during post-MI heart failure in rats: prevention with supplemental dietary propionyl-L-carnitine. 2003 Cardiovasc Drugs Ther pmid:12843682
Milio G et al. Pharmacological treatment of patients with chronic critical limb ischemia: L-propionyl-carnitine enhances the short-term effects of PGE-1. 2009 Cardiovasc Drugs Ther pmid:19548076
Lango R et al. Propionyl-L-carnitine improves hemodynamics and metabolic markers of cardiac perfusion during coronary surgery in diabetic patients. 2005 Cardiovasc Drugs Ther pmid:16187006
De Marchi S et al. Propionyl-L-carnitine improves endothelial function, microcirculation and pain management in critical limb ischemia. 2012 Cardiovasc Drugs Ther pmid:22936457
Vanella A et al. L -propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. 2000 Cell Biol. Toxicol. pmid:10917565
Zhang Y et al. Prenatal diagnosis of methylmalonic aciduria by analysis of organic acids and total homocysteine in amniotic fluid. 2008 Chin. Med. J. pmid:18298912
Schönekess BO et al. Propionyl L-carnitine improvement of hypertrophied heart function is accompanied by an increase in carbohydrate oxidation. 1995 Circ. Res. pmid:7554119
Brevetti G et al. Muscle carnitine deficiency in patients with severe peripheral vascular disease. 1991 Circulation pmid:1914091
Montisci R et al. Effect of a single IV administration of L-propionylcarnitine on myocardial microcirculation assessed by coronary flow velocity reserve measurement in patients with systemic sclerosis: a pilot study. 2007 Clin Ther pmid:17379056
Kushnir MM et al. Serum acylcarnitines and vitamin B12 deficiency. 2002 Clin. Chem. pmid:12089192
Chace DH et al. Rapid diagnosis of methylmalonic and propionic acidemias: quantitative tandem mass spectrometric analysis of propionylcarnitine in filter-paper blood specimens obtained from newborns. 2001 Clin. Chem. pmid:11673377
la Marca G et al. Rapid 2nd-tier test for measurement of 3-OH-propionic and methylmalonic acids on dried blood spots: reducing the false-positive rate for propionylcarnitine during expanded newborn screening by liquid chromatography-tandem mass spectrometry. 2007 Clin. Chem. pmid:17510301
Chapman KA et al. Increased C3-carnitine in a healthy premature infant. 2008 Clin. Chem. pmid:18957557
Wikoff WR et al. Metabolomics identifies perturbations in human disorders of propionate metabolism. 2007 Clin. Chem. pmid:17951291
De Jesús VR et al. Comparison of amino acids and acylcarnitines assay methods used in newborn screening assays by tandem mass spectrometry. 2010 Clin. Chim. Acta pmid:20122909
Libert R et al. Identification of undescribed medium-chain acylcarnitines present in urine of patients with propionic and methylmalonic acidemias. 2000 Clin. Chim. Acta pmid:10767396
Di Donato S et al. Propionylcarnitine excretion in propionic and methylmalonic acidurias: a cause of carnitine deficiency. 1984 Clin. Chim. Acta pmid:6723070
Aleisa AM et al. Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues. 2007 Clin. Exp. Pharmacol. Physiol. pmid:17973863
Al-Majed AA et al. Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus. 2006 Clin. Exp. Pharmacol. Physiol. pmid:16895547
Sethi R et al. Improvement of cardiac function and beta-adrenergic signal transduction by propionyl L-carnitine in congestive heart failure due to myocardial infarction. 2004 Coron. Artery Dis. pmid:15201623
Gentile V et al. Preliminary observations on the use of propionyl-L-carnitine in combination with sildenafil in patients with erectile dysfunction and diabetes. 2004 Curr Med Res Opin pmid:15383186
Gentile V et al. Effect of propionyl-L-carnitine, L-arginine and nicotinic acid on the efficacy of vardenafil in the treatment of erectile dysfunction in diabetes. 2009 Curr Med Res Opin pmid:19624286
Malaguarnera M Carnitine derivatives: clinical usefulness. 2012 Curr. Opin. Gastroenterol. pmid:22333562
Felix C et al. Effects of propionyl-L-carnitine on isolated mitochondrial function in the reperfused diabetic rat heart. 2001 Diabetes Res. Clin. Pract. pmid:11378209
Santo SS et al. Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD. 2006 Diabetes Res. Clin. Pract. pmid:16446007
Mancinelli A et al. Disposition of L-carnitine and its short-chain esters, acetyl-L-carnitine and propionyl-L-carnitine, in the rat isolated perfused liver. 2000 Drug Metab. Dispos. pmid:11095575
Signorelli SS et al. A randomised, controlled clinical trial evaluating changes in therapeutic efficacy and oxidative parameters after treatment with propionyl L-carnitine in patients with peripheral arterial disease requiring haemodialysis. 2006 Drugs Aging pmid:16608381
Wiseman LR and Brogden RN Propionyl-L-carnitine. 1998 Drugs Aging pmid:9534023
Broderick TL et al. Effects of propionyl-carnitine on mitochondrial respiration and post-ischaemic cardiac function in the ischaemic underperfused diabetic rat heart. 2004 Drugs R D pmid:15230624